ES2632515T3 - Moléculas biológicas conjugadas y su preparación - Google Patents

Moléculas biológicas conjugadas y su preparación Download PDF

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Publication number
ES2632515T3
ES2632515T3 ES09167191.7T ES09167191T ES2632515T3 ES 2632515 T3 ES2632515 T3 ES 2632515T3 ES 09167191 T ES09167191 T ES 09167191T ES 2632515 T3 ES2632515 T3 ES 2632515T3
Authority
ES
Spain
Prior art keywords
group
solution
general formula
protein
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09167191.7T
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English (en)
Spanish (es)
Inventor
Antony Robert Godwin
Elisa Pedone
Ji-Won Choi
Stephen James Brocchini
Sunil Shaunak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abzena UK Ltd
Original Assignee
Polytherics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27742023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2632515(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polytherics Ltd filed Critical Polytherics Ltd
Application granted granted Critical
Publication of ES2632515T3 publication Critical patent/ES2632515T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91Polymers modified by chemical after-treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F10/00Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES09167191.7T 2003-07-11 2004-07-12 Moléculas biológicas conjugadas y su preparación Expired - Lifetime ES2632515T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0316294 2003-07-11
GBGB0316294.8A GB0316294D0 (en) 2003-07-11 2003-07-11 Conjugated biological molecules and their preparation

Publications (1)

Publication Number Publication Date
ES2632515T3 true ES2632515T3 (es) 2017-09-13

Family

ID=27742023

Family Applications (4)

Application Number Title Priority Date Filing Date
ES09167191.7T Expired - Lifetime ES2632515T3 (es) 2003-07-11 2004-07-12 Moléculas biológicas conjugadas y su preparación
ES10175143.6T Expired - Lifetime ES2542531T3 (es) 2003-07-11 2004-07-12 Procedimiento de preparación de moléculas biológicas conjugadas
ES04743335T Expired - Lifetime ES2331004T3 (es) 2003-07-11 2004-07-12 Moleculas biologicas conjugadas y su preparacion.
ES10175140.2T Expired - Lifetime ES2549427T3 (es) 2003-07-11 2004-07-12 Moléculas biológicas conjugadas y su preparación

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES10175143.6T Expired - Lifetime ES2542531T3 (es) 2003-07-11 2004-07-12 Procedimiento de preparación de moléculas biológicas conjugadas
ES04743335T Expired - Lifetime ES2331004T3 (es) 2003-07-11 2004-07-12 Moleculas biologicas conjugadas y su preparacion.
ES10175140.2T Expired - Lifetime ES2549427T3 (es) 2003-07-11 2004-07-12 Moléculas biológicas conjugadas y su preparación

Country Status (13)

Country Link
US (4) US7595292B2 (https=)
EP (4) EP2253330B1 (https=)
JP (2) JP4958549B2 (https=)
KR (1) KR101152500B1 (https=)
CN (2) CN1822860B (https=)
AT (1) ATE440620T1 (https=)
AU (2) AU2004257448B2 (https=)
DE (1) DE602004022824D1 (https=)
DK (4) DK2253330T3 (https=)
ES (4) ES2632515T3 (https=)
GB (1) GB0316294D0 (https=)
PL (2) PL2253330T3 (https=)
WO (1) WO2005007197A2 (https=)

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AU2004257448A1 (en) 2005-01-27
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EP2133099B1 (en) 2017-04-19
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KR20060054286A (ko) 2006-05-22
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EP1648518A2 (en) 2006-04-26
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