|
JP2764680B2
(ja)
|
1993-07-20 |
1998-06-11 |
重良 長沼 |
フォーミングローラ装置
|
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
|
WO2003103475A2
(en)
|
2002-06-07 |
2003-12-18 |
Dyax Corp. |
Prevention and reduction of blood loss
|
|
US7153829B2
(en)
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
|
JP2005537006A
(ja)
|
2002-08-28 |
2005-12-08 |
ダイアックス、コープ |
臓器及び組織の保存方法
|
|
JP2008512364A
(ja)
*
|
2004-09-06 |
2008-04-24 |
エフ.ホフマン−ラ ロシュ アーゲー |
4−アミノメチルベンズアミジン誘導体及び第VIIa因子阻害剤としてのその使用
|
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
|
EP2500031A3
(en)
*
|
2005-02-24 |
2012-12-26 |
Joslin Diabetes Center, Inc. |
Compositions and Methods for Treating Vascular Permeability
|
|
US20070213275A1
(en)
*
|
2006-03-10 |
2007-09-13 |
Dyax Corp. |
Formulations for ecallantide
|
|
EP2374472B9
(en)
|
2006-03-16 |
2019-06-12 |
Dyax Corp. |
Compositions and methods for treating ophthalmic disorders
|
|
JP5322935B2
(ja)
|
2006-07-31 |
2013-10-23 |
アクティベサイト ファーマシューティカルズ インコーポレイティッド |
血漿カリクレインの阻害薬
|
|
US8524917B2
(en)
*
|
2007-01-11 |
2013-09-03 |
Allergan, Inc. |
6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
|
|
US20100119512A1
(en)
*
|
2007-01-25 |
2010-05-13 |
Joslin Diabetes Center |
Methods of diagnosing, treating, and preventing increased vascular permeability
|
|
US8563594B2
(en)
|
2007-05-08 |
2013-10-22 |
Allergan, Inc. |
S1P3 receptor inhibitors for treating pain
|
|
EP2259679A4
(en)
*
|
2008-01-31 |
2011-09-14 |
Joslin Diabetes Ct |
METHODS OF TREATING KALLIKREIN RELATED DISORDERS
|
|
EP2369930A4
(en)
*
|
2008-12-02 |
2012-10-03 |
Joslin Diabetes Ct |
METHOD OF REDUCING BLOOD PRESSURE USING PLASMATIC KALLICREIN INHIBITORS
|
|
CA2744235A1
(en)
|
2009-01-06 |
2010-07-15 |
Dyax Corp. |
Treatment of mucositis with kallikrein inhibitors
|
|
EP2411042A4
(en)
*
|
2009-03-25 |
2012-12-12 |
Diamedica Inc |
Tissue kallikrein for the treatment of pancreatic cell dysfunction
|
|
GB0918924D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Azaindole derivatives
|
|
GB0918923D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Aminothiazole derivatives
|
|
GB0918922D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Aminopyridine derivatives
|
|
EP2512466A4
(en)
*
|
2009-12-18 |
2013-07-03 |
Activesite Pharmaceuticals Inc |
PRODRUGS OF INHIBITORS OF PLASMATIC KALLICREIN
|
|
US9206123B2
(en)
|
2009-12-18 |
2015-12-08 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
EP3459564B1
(en)
|
2010-01-06 |
2021-10-27 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein binding proteins
|
|
JP6155187B2
(ja)
|
2010-03-30 |
2017-06-28 |
ヴァーセオン コーポレイション |
トロンビンの阻害剤としての多置換芳香族化合物
|
|
US9290485B2
(en)
*
|
2010-08-04 |
2016-03-22 |
Novartis Ag |
N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
|
|
CA2823776A1
(en)
|
2011-01-06 |
2012-07-12 |
Dyax Corp. |
Plasma kallikrein binding proteins
|
|
WO2012142308A1
(en)
|
2011-04-13 |
2012-10-18 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
US9315811B2
(en)
|
2011-06-10 |
2016-04-19 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (KLKB1) expression
|
|
CA2840614A1
(en)
|
2011-06-29 |
2013-01-03 |
Isis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
|
GB2494851A
(en)
|
2011-07-07 |
2013-03-27 |
Kalvista Pharmaceuticals Ltd |
Plasma kallikrein inhibitors
|
|
WO2013101836A1
(en)
*
|
2011-12-31 |
2013-07-04 |
The University Of Vermont And State Agriculture College |
Methods for dynamic visualization of clinical parameters over time
|
|
EP2807156A1
(en)
|
2012-01-27 |
2014-12-03 |
Novartis AG |
Aminopyridine derivatives as plasma kallikrein inhibitors
|
|
US20140378474A1
(en)
|
2012-01-27 |
2014-12-25 |
Novartis Ag |
5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
|
|
US20130315891A1
(en)
|
2012-05-25 |
2013-11-28 |
Matthew Charles |
Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
|
|
EP2854841B1
(en)
|
2012-06-04 |
2017-02-22 |
Diamedica Inc. |
Human tissue kallikrein 1 glycosylation isoforms
|
|
GB201212081D0
(en)
|
2012-07-06 |
2012-08-22 |
Kalvista Pharmaceuticals Ltd |
New polymorph
|
|
CA2893239A1
(en)
*
|
2012-12-03 |
2014-06-12 |
F. Hoffmann-La Roche Ag |
Substituted triazole and imidazole compounds
|
|
IL239682B
(en)
|
2013-01-08 |
2018-10-31 |
Kalvista Pharmaceuticals Ltd |
History of benzylamine and 2-(aminomethyl)pyridine
|
|
GB201300304D0
(en)
*
|
2013-01-08 |
2013-02-20 |
Kalvista Pharmaceuticals Ltd |
Benzylamine derivatives
|
|
GB2510407A
(en)
|
2013-02-04 |
2014-08-06 |
Kalvista Pharmaceuticals Ltd |
Aqueous suspensions of kallikrein inhibitors for parenteral administration
|
|
WO2014113712A1
(en)
|
2013-01-20 |
2014-07-24 |
Dyax Corp. |
Evaluation and treatment of bradykinin-mediated disorders
|
|
HK1214252A1
(zh)
|
2013-03-15 |
2016-07-22 |
Verseon Corporation |
作為凝血酶抑制劑的鹵代吡唑
|
|
CN110179795A
(zh)
|
2013-03-15 |
2019-08-30 |
维颂公司 |
作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途
|
|
MY174018A
(en)
|
2013-05-23 |
2020-03-04 |
Kalvista Pharmaceuticals Ltd |
Heterocyclic derivates
|
|
GB2517908A
(en)
|
2013-08-14 |
2015-03-11 |
Kalvista Pharmaceuticals Ltd |
Bicyclic inhibitors
|
|
CA2920815C
(en)
|
2013-08-14 |
2021-09-21 |
Kalvista Pharmaceuticals Limited |
Inhibitors of plasma kallikrein
|
|
TWI636047B
(zh)
|
2013-08-14 |
2018-09-21 |
英商卡爾維斯塔製藥有限公司 |
雜環衍生物
|
|
KR102365486B1
(ko)
|
2013-08-28 |
2022-02-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
프리칼리크레인 (pkk) 발현의 조절
|
|
JP6757252B2
(ja)
|
2013-10-21 |
2020-09-16 |
ダイアックス コーポレーション |
血漿カリクレイン系バイオマーカーを決定するためのアッセイ
|
|
CA2927695C
(en)
|
2013-10-21 |
2022-03-01 |
Dyax Corp. |
Diagnosis and treatment of autoimmune diseases
|
|
AU2015209481C1
(en)
|
2014-01-21 |
2020-10-29 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
|
|
CN106257976B
(zh)
|
2014-03-07 |
2021-02-02 |
拜奥克里斯特制药公司 |
人类血浆激肽释放酶抑制剂
|
|
IL295414B2
(en)
|
2014-03-27 |
2026-02-01 |
Takeda Pharmaceuticals Co |
Compositions and methods for treating macular edema due to diabetes
|
|
EP3862362A3
(en)
|
2014-05-01 |
2021-10-27 |
Ionis Pharmaceuticals, Inc. |
Conjugates of modified antisense oligonucleotides and their use for modulating pkk expression
|
|
US10189810B2
(en)
|
2014-09-17 |
2019-01-29 |
Verseon Corporation |
Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
|
|
GB201421085D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
GB201421083D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
Enzyme inhibitors
|
|
GB201421088D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
CN107405333A
(zh)
|
2015-02-27 |
2017-11-28 |
维颂公司 |
作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物
|
|
KR20240133761A
(ko)
|
2015-10-19 |
2024-09-04 |
다케다 파머수티컬 컴패니 리미티드 |
절단된 고분자량 키니노겐의 검출을 위한 면역검정법
|
|
AU2016366557B2
(en)
|
2015-12-11 |
2024-01-25 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
|
|
IL263235B
(en)
|
2016-05-31 |
2022-07-01 |
Kalvista Pharmaceuticals Ltd |
History of pyrazoles as plasma kallikrein inhibitors
|
|
GB201609607D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
|
|
GB201609603D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
AU2017325986B2
(en)
*
|
2016-09-16 |
2023-12-14 |
Takeda Pharmaceutical Company Limited |
Metabolite biomarkers for diseases associated with the contact activation system
|
|
CN110446501A
(zh)
|
2017-03-09 |
2019-11-12 |
代阿麦迪卡股份有限公司 |
组织激肽释放酶1的剂型
|
|
HUE057912T2
(hu)
|
2017-11-29 |
2022-06-28 |
Kalvista Pharmaceuticals Ltd |
Plazma kallikrein inhibitort tartalmazó dózisformák
|
|
GB201719881D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of plasma kallikrein inhibitor and salts thereof
|
|
KR20200143376A
(ko)
*
|
2018-03-13 |
2020-12-23 |
샤이어 휴먼 지네틱 테라피즈 인크. |
혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도
|
|
AR116951A1
(es)
|
2018-11-02 |
2021-06-30 |
Biocryst Pharm Inc |
Sales cristalinas de un inhibidor de calicreína plasmática
|
|
GB201910116D0
(en)
|
2019-07-15 |
2019-08-28 |
Kalvista Pharmaceuticals Ltd |
Treatments of hereditary angioedema
|
|
GB201910125D0
(en)
|
2019-07-15 |
2019-08-28 |
Kalvista Pharmaceuticals Ltd |
Treatments of angioedema
|
|
JP7693644B2
(ja)
*
|
2019-07-08 |
2025-06-17 |
リゾルート,インコーポレイティド |
血漿カリクレイン阻害薬の調製プロセス
|
|
WO2021007189A1
(en)
*
|
2019-07-08 |
2021-01-14 |
Rezolute, Inc. |
Crystalline forms of plasma kallikrein inhibitors
|
|
WO2021028645A1
(en)
|
2019-08-09 |
2021-02-18 |
Kalvista Pharmaceuticals Limited |
Plasma kallikrein inhibitors
|
|
CN114667289B
(zh)
|
2019-09-18 |
2025-08-26 |
武田药品工业有限公司 |
杂芳基血浆激肽释放酶抑制剂
|
|
EP4031547B1
(en)
|
2019-09-18 |
2024-07-17 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof
|
|
GB201918994D0
(en)
|
2019-12-20 |
2020-02-05 |
Kalvista Pharmaceuticals Ltd |
Treatments of diabetic macular edema and impaired visual acuity
|
|
GB2591730A
(en)
|
2019-12-09 |
2021-08-11 |
Kalvista Pharmaceuticals Ltd |
New polymorphs
|
|
US12528880B2
(en)
|
2020-01-13 |
2026-01-20 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
|
|
JP7245397B2
(ja)
|
2020-03-04 |
2023-03-23 |
メッドシャイン ディスカバリー インコーポレイテッド |
複素環化合物
|
|
WO2021217053A1
(en)
*
|
2020-04-24 |
2021-10-28 |
Rezolute, Inc. |
Plasma kallikrein inhibitors for the treatment of ards and related conditions
|
|
TW202228686A
(zh)
|
2020-10-15 |
2022-08-01 |
英商卡爾維斯塔製藥有限公司 |
血管性水腫之治療
|
|
US20230381162A1
(en)
|
2020-10-23 |
2023-11-30 |
Kalvista Pharmaceuticals Limited |
Treatments of angioedema
|
|
JP2024505596A
(ja)
|
2021-02-09 |
2024-02-06 |
カルビスタ・ファーマシューティカルズ・リミテッド |
遺伝性血管性浮腫の治療
|
|
WO2023002219A1
(en)
|
2021-07-23 |
2023-01-26 |
Kalvista Pharmaceuticals Limited |
Treatments of hereditary angioedema
|
|
US20250281397A1
(en)
|
2022-04-27 |
2025-09-11 |
Kalvista Pharmaceuticals Limited |
Formulations of a plasma kallikrein inhibitor
|
|
WO2024180100A1
(en)
|
2023-02-27 |
2024-09-06 |
Kalvista Pharmaceuticals Limited |
New solid form of a plasma kallikrein inhibitor
|
|
WO2025153806A1
(en)
|
2024-01-15 |
2025-07-24 |
Kalvista Pharmaceuticals Limited |
Methods for determining amidolytic activity
|
|
WO2025172693A1
(en)
|
2024-02-13 |
2025-08-21 |
Kalvista Pharmaceuticals Limited |
Oral sebetralstat for the treatment of an attack of hereditary angioedema
|
|
WO2025172692A1
(en)
|
2024-02-13 |
2025-08-21 |
Kalvista Pharmaceuticals Limited |
Oral sebetralstat for the treatment of an attack of hereditary angioedema
|