JP2006528621A5 - - Google Patents
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- Publication number
- JP2006528621A5 JP2006528621A5 JP2006520928A JP2006520928A JP2006528621A5 JP 2006528621 A5 JP2006528621 A5 JP 2006528621A5 JP 2006520928 A JP2006520928 A JP 2006520928A JP 2006520928 A JP2006520928 A JP 2006520928A JP 2006528621 A5 JP2006528621 A5 JP 2006528621A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- nhch
- cycloalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49001203P | 2003-07-24 | 2003-07-24 | |
| US60/490,012 | 2003-07-24 | ||
| PCT/IB2004/002355 WO2005009975A2 (en) | 2003-07-24 | 2004-07-12 | Benzimidazole derivatives as mek inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528621A JP2006528621A (ja) | 2006-12-21 |
| JP2006528621A5 true JP2006528621A5 (https=) | 2007-08-30 |
| JP4896717B2 JP4896717B2 (ja) | 2012-03-14 |
Family
ID=34102957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520928A Expired - Fee Related JP4896717B2 (ja) | 2003-07-24 | 2004-07-12 | Ｎ−メチル−置換ベンゾアミダゾール |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7160915B2 (https=) |
| EP (1) | EP1651214B1 (https=) |
| JP (1) | JP4896717B2 (https=) |
| AT (1) | ATE442847T1 (https=) |
| BR (1) | BRPI0412851A (https=) |
| CA (1) | CA2532067C (https=) |
| DE (1) | DE602004023207D1 (https=) |
| ES (1) | ES2331246T3 (https=) |
| MX (1) | MXPA06000921A (https=) |
| WO (1) | WO2005009975A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG2013013339A (en) | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| EP1904061B1 (en) * | 2005-06-23 | 2018-12-26 | Array Biopharma, Inc. | SNAr PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS |
| US8039637B2 (en) * | 2005-06-23 | 2011-10-18 | Array Biopharma Inc. | Process for preparing benzimidazole compounds |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| WO2007025090A2 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
| HRP20110498T1 (hr) | 2005-10-07 | 2011-08-31 | Exelixis | Azetidini kao inhibitori mek za liječenje proliferativnih bolesti |
| GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
| WO2008076415A1 (en) | 2006-12-14 | 2008-06-26 | Exelixis, Inc. | Methods of using mek inhibitors |
| JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
| GB0714384D0 (en) | 2007-07-23 | 2007-09-05 | Ucb Pharma Sa | theraputic agents |
| MX2010001581A (es) * | 2007-08-16 | 2010-03-15 | Hoffmann La Roche | Hidantoinas substituidas. |
| WO2009037705A2 (en) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| WO2009064675A1 (en) | 2007-11-12 | 2009-05-22 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
| US8063085B2 (en) | 2007-12-20 | 2011-11-22 | Hoffmann-La Roche Inc. | Substituted hydantoins |
| WO2009093008A1 (en) | 2008-01-21 | 2009-07-30 | Ucb Pharma S.A. | Thieno-pyridine derivatives as mek inhibitors |
| GB0811304D0 (en) | 2008-06-19 | 2008-07-30 | Ucb Pharma Sa | Therapeutic agents |
| MX2010014565A (es) * | 2008-07-01 | 2011-03-04 | Genentech Inc | Isoindolona y metodos de uso. |
| US8993630B2 (en) | 2008-11-10 | 2015-03-31 | Bayer Intellectual Property Gmbh | Substituted sulphonamido phenoxybenzamides |
| EP2370568B1 (en) | 2008-12-10 | 2017-07-19 | Dana-Farber Cancer Institute, Inc. | Mek mutations conferring resistance to mek inhibitors |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| EP2491015A1 (en) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituted benzosulphonamides |
| US20120269803A1 (en) | 2009-10-21 | 2012-10-25 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
| US20120263714A1 (en) | 2009-10-21 | 2012-10-18 | Bayer Intellectual Property Gmbh | Substituted halophenoxybenzamide derivatives |
| EP3028699B1 (en) | 2010-02-25 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
| CN103038364A (zh) | 2010-03-09 | 2013-04-10 | 达纳－法伯癌症研究所公司 | 诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法 |
| CN103282351A (zh) | 2010-10-29 | 2013-09-04 | 拜耳知识产权有限责任公司 | 取代的苯氧基吡啶 |
| CN103204827B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| AU2013269809B2 (en) | 2012-05-31 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Biomarkers for determining effective response of treatments of Hepatocellular carcinoma (HCC) patients |
| MA38085B1 (fr) | 2012-10-12 | 2018-11-30 | Exelixis Inc | Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer |
| AR099630A1 (es) * | 2012-10-19 | 2016-08-10 | Novartis Ag | Preparación de un inhibidor de mek y formulación que lo comprende |
| CN111518031B (zh) * | 2020-05-29 | 2023-01-17 | 中国药科大学 | 一种含有异羟肟酸的化合物及其制备方法、应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
| US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
| WO1998037881A1 (en) | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
| US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| NZ501276A (en) | 1997-07-01 | 2000-10-27 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders |
| IL125425A (en) | 1998-07-20 | 2008-12-29 | Israel State | ADPGPPase CONTROL OF STARCH SYNTHESIS IN TOMATOES |
| AU776788C (en) | 1998-12-16 | 2005-10-27 | Warner-Lambert Company | Treatment of arthritis with MEK inhibitors |
| CA2355470C (en) * | 1999-01-13 | 2008-09-30 | Warner-Lambert Company | Benzoheterocycles and their use as mek inhibitors |
| JP2000204079A (ja) * | 1999-01-13 | 2000-07-25 | Warner Lambert Co | ジアリ―ルアミン |
| JP2003504400A (ja) | 1999-07-16 | 2003-02-04 | ワーナー−ランバート・カンパニー | Ｍｅｋ阻害剤を用いた慢性痛の治療方法 |
| CA2377092A1 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
| DE60239097D1 (de) | 2001-03-02 | 2011-03-17 | Gpc Biotech Ag | Drei-hybrid-assaysystem |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| SG2013013339A (en) * | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| EP1482944A4 (en) | 2002-03-13 | 2006-04-19 | Array Biopharma Inc | NZ ALKYL BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS |
-
2004
- 2004-07-12 CA CA2532067A patent/CA2532067C/en not_active Expired - Fee Related
- 2004-07-12 JP JP2006520928A patent/JP4896717B2/ja not_active Expired - Fee Related
- 2004-07-12 MX MXPA06000921A patent/MXPA06000921A/es unknown
- 2004-07-12 EP EP04744015A patent/EP1651214B1/en not_active Expired - Lifetime
- 2004-07-12 ES ES04744015T patent/ES2331246T3/es not_active Expired - Lifetime
- 2004-07-12 WO PCT/IB2004/002355 patent/WO2005009975A2/en not_active Ceased
- 2004-07-12 AT AT04744015T patent/ATE442847T1/de not_active IP Right Cessation
- 2004-07-12 BR BRPI0412851-6A patent/BRPI0412851A/pt not_active IP Right Cessation
- 2004-07-12 DE DE602004023207T patent/DE602004023207D1/de not_active Expired - Lifetime
- 2004-07-22 US US10/897,464 patent/US7160915B2/en not_active Expired - Fee Related
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