JP2007533635A5 - - Google Patents
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- Publication number
- JP2007533635A5 JP2007533635A5 JP2006534094A JP2006534094A JP2007533635A5 JP 2007533635 A5 JP2007533635 A5 JP 2007533635A5 JP 2006534094 A JP2006534094 A JP 2006534094A JP 2006534094 A JP2006534094 A JP 2006534094A JP 2007533635 A5 JP2007533635 A5 JP 2007533635A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- ring
- halo
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 390
- 229920006395 saturated elastomer Polymers 0.000 claims 46
- 229910052760 oxygen Inorganic materials 0.000 claims 45
- 125000005843 halogen group Chemical group 0.000 claims 43
- 125000004093 cyano group Chemical group *C#N 0.000 claims 37
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 37
- 125000001424 substituent group Chemical group 0.000 claims 31
- 229910052717 sulfur Inorganic materials 0.000 claims 24
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 23
- 125000004429 atom Chemical group 0.000 claims 21
- 125000004043 oxo group Chemical group O=* 0.000 claims 21
- 125000004430 oxygen atom Chemical group O* 0.000 claims 21
- 125000004434 sulfur atom Chemical group 0.000 claims 21
- 125000000464 thioxo group Chemical group S=* 0.000 claims 21
- 125000002950 monocyclic group Chemical group 0.000 claims 20
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000002619 bicyclic group Chemical group 0.000 claims 14
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 208000004454 Hyperalgesia Diseases 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 238000010276 construction Methods 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 150000003536 tetrazoles Chemical class 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010053552 allodynia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- JCTZPTZFCXNVOE-UHFFFAOYSA-N 4-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxy-1,3-benzothiazol-2-amine Chemical compound C1=CC=C2SC(N)=NC2=C1OC(C=1)=CN=CC=1C1=CC=C(C(F)(F)F)C=C1 JCTZPTZFCXNVOE-UHFFFAOYSA-N 0.000 claims 1
- PXUBGCBDJQTOHA-UHFFFAOYSA-N 7-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxyquinoline Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CN=CC(OC=2C=C3N=CC=CC3=CC=2)=C1 PXUBGCBDJQTOHA-UHFFFAOYSA-N 0.000 claims 1
- 208000014181 Bronchial disease Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000029162 bladder disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- HXVBXOGCECWFCB-UHFFFAOYSA-N n-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-(trifluoromethyl)phenyl]pyridin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC(NC=2C=C3OCCOC3=CC=2)=CC=N1 HXVBXOGCECWFCB-UHFFFAOYSA-N 0.000 claims 1
- RYTKNUSWGRLFHY-UHFFFAOYSA-N n-[4-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxy-1,3-benzothiazol-2-yl]acetamide Chemical compound C1=CC=C2SC(NC(=O)C)=NC2=C1OC(C=1)=CN=CC=1C1=CC=C(C(F)(F)F)C=C1 RYTKNUSWGRLFHY-UHFFFAOYSA-N 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000009092 tissue dysfunction Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 230000036269 ulceration Effects 0.000 claims 1
- 230000006492 vascular dysfunction Effects 0.000 claims 1
- 230000001457 vasomotor Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50786303P | 2003-09-30 | 2003-09-30 | |
| US60/507,863 | 2003-09-30 | ||
| PCT/US2004/032132 WO2005033105A2 (en) | 2003-09-30 | 2004-09-30 | Vanilloid receptor ligands and their use in treatments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533635A JP2007533635A (ja) | 2007-11-22 |
| JP2007533635A5 true JP2007533635A5 (https=) | 2008-01-10 |
Family
ID=34421675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534094A Pending JP2007533635A (ja) | 2003-09-30 | 2004-09-30 | バニロイド受容体リガンドおよび治療おけるこれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7390907B2 (https=) |
| EP (1) | EP1670794A2 (https=) |
| JP (1) | JP2007533635A (https=) |
| AU (1) | AU2004278382B2 (https=) |
| CA (1) | CA2540640A1 (https=) |
| MX (1) | MXPA06003615A (https=) |
| WO (1) | WO2005033105A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011671B1 (ru) * | 2004-06-04 | 2009-04-28 | Арена Фармасьютикалз, Инк. | Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств |
| US7820654B2 (en) | 2004-09-23 | 2010-10-26 | Dr. Reddy's Laboratories Ltd. | Pyrimidine compounds, process for their preparation and compositions containing them |
| EP1962853A1 (en) * | 2005-12-22 | 2008-09-03 | Alcon Research, Ltd. | (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)- pyrazines for treating rho kinase-mediated diseases and conditions |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| WO2008005303A2 (en) * | 2006-06-30 | 2008-01-10 | Janssen Pharmaceutica N.V. | Thiazolopyrimidine modulators of trpv1 |
| EP2170848B1 (en) | 2007-06-27 | 2014-10-22 | AstraZeneca AB | Pyrazinone derivatives and their use in the treatment of lung diseases |
| WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
| KR101599082B1 (ko) * | 2008-02-01 | 2016-03-02 | 어키니언 파마슈티칼스 아베 | 피라진 유도체 및 단백질 키나아제 억제제로서의 이의 용도 |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| KR20130097813A (ko) | 2008-04-21 | 2013-09-03 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| JP5421366B2 (ja) | 2008-07-21 | 2014-02-19 | オトノミ―，インク． | 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法 |
| AU2009289317A1 (en) * | 2008-09-02 | 2010-03-11 | Novartis Ag | Heterocyclic PIM-kinase inhibitors |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| KR20180099933A (ko) | 2010-11-19 | 2018-09-05 | 리간드 파마슈티칼스 인코포레이티드 | 복소환 아민 및 이의 용도 |
| AU2014370407B2 (en) * | 2013-12-23 | 2018-03-29 | Purdue Pharma L.P. | Indazoles and use thereof |
| HRP20201384T1 (hr) * | 2014-01-01 | 2020-11-27 | Medivation Technologies Llc | Spojevi i postupci njihove upotrebe |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| EA202092441A1 (ru) | 2016-06-07 | 2021-05-21 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| KR20240026521A (ko) | 2017-03-23 | 2024-02-28 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| PT4182308T (pt) | 2020-07-15 | 2024-12-04 | Chiesi Farm Spa | Derivados de piridazinil amino como inibidores de alk5 |
| AU2022351219A1 (en) | 2021-09-21 | 2024-05-02 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| US20250032476A1 (en) * | 2021-11-05 | 2025-01-30 | The Regents Of The University Of California | Alpha-2a adrenergic receptor modulators and uses thereof |
| EP4463448A1 (en) | 2022-01-11 | 2024-11-20 | Chiesi Farmaceutici S.p.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US38969A (en) * | 1863-06-23 | Improvement in harvesters | ||
| US82780A (en) * | 1868-10-06 | Improvement in machine foe scouring sheet metal | ||
| US204386A (en) * | 1878-05-28 | Improvement in wrenches | ||
| US195201A (en) * | 1877-09-18 | Improvement in flumes for establishing permanent channels in rivers | ||
| IL118469A (en) * | 1995-06-15 | 2000-08-13 | Tanabe Seiyaku Co | Naphthalene derivatives their preparation and intermediates thereof |
| JPH10251255A (ja) * | 1997-03-14 | 1998-09-22 | Nissan Chem Ind Ltd | アジン誘導体 |
| WO2000010997A1 (en) * | 1998-08-25 | 2000-03-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
| JP2003529547A (ja) * | 1999-09-14 | 2003-10-07 | アボット・ラボラトリーズ | 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物 |
| JP2003534344A (ja) * | 2000-05-25 | 2003-11-18 | ターガセプト，インコーポレイテッド | ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン |
| CA2423050A1 (en) * | 2000-09-20 | 2002-03-28 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazine derivatives as modulators of tyrosine kinases |
| JP4272338B2 (ja) * | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| DE60137273D1 (de) * | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| BR0115400A (pt) | 2000-11-20 | 2003-09-30 | Biovitrum Ab | Compostos de piperazinilpirazina atuando como agonistas ou antagonistas do receptor 5ht-2 de serotonina |
| US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| EP1373257B9 (en) | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| MXPA04005427A (es) * | 2001-12-10 | 2005-04-19 | Amgen Inc | Ligandos de receptor vainilloide y su uso en tratamientos. |
| WO2003099284A1 (en) | 2002-05-22 | 2003-12-04 | Amgen Inc. | Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain |
| DE60317198T2 (de) | 2002-05-23 | 2008-12-04 | Cytopia Research Pty. Ltd., Richmond | Proteinkinaseinhibitoren |
| NZ537156A (en) | 2002-05-23 | 2007-06-29 | Cytopia Pty Ltd | Kinase inhibitors |
| BR0313255A (pt) | 2002-08-08 | 2005-07-12 | Amgen Inc | Composto, composição farmacêutica, uso de um composto e métodos de fabricar um medicamento e de preparar um composto |
| US7419984B2 (en) | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| ATE552253T1 (de) | 2002-11-08 | 2012-04-15 | Novartis Int Pharm Ltd | 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren |
| GB0226724D0 (en) | 2002-11-15 | 2002-12-24 | Merck Sharp & Dohme | Therapeutic agents |
| US7691905B2 (en) * | 2002-12-24 | 2010-04-06 | New York University | Inhibition of melanogenesis and melanoma metastasis with p-aminobenzoic acid (PABA) |
| EP1590341B1 (en) | 2003-01-17 | 2009-06-17 | Warner-Lambert Company LLC | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US20050014753A1 (en) | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
-
2004
- 2004-09-30 AU AU2004278382A patent/AU2004278382B2/en not_active Ceased
- 2004-09-30 JP JP2006534094A patent/JP2007533635A/ja active Pending
- 2004-09-30 MX MXPA06003615A patent/MXPA06003615A/es unknown
- 2004-09-30 WO PCT/US2004/032132 patent/WO2005033105A2/en not_active Ceased
- 2004-09-30 EP EP04789334A patent/EP1670794A2/en not_active Withdrawn
- 2004-09-30 US US10/956,648 patent/US7390907B2/en not_active Expired - Fee Related
- 2004-09-30 CA CA002540640A patent/CA2540640A1/en not_active Abandoned
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