JP2014519507A5 - - Google Patents

Info

Publication number

JP2014519507A5

JP2014519507A5 JP2014514062A JP2014514062A JP2014519507A5 JP 2014519507 A5 JP2014519507 A5 JP 2014519507A5 JP 2014514062 A JP2014514062 A JP 2014514062A JP 2014514062 A JP2014514062 A JP 2014514062A JP 2014519507 A5 JP2014519507 A5 JP 2014519507A5

Authority

JP

Japan

Prior art keywords

alkyl

hydrogen

aryl

azido

furan

Prior art date

2012-06-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 39
• 229910052739 hydrogen Inorganic materials 0.000 claims 27
• 239000001257 hydrogen Substances 0.000 claims 27
• 125000003118 aryl group Chemical group 0.000 claims 19
• -1 —COR 1b Chemical group 0.000 claims 19
• 150000002431 hydrogen Chemical class 0.000 claims 16
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 11
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
• 125000001624 naphthyl group Chemical group 0.000 claims 8
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
• 125000003545 alkoxy group Chemical group 0.000 claims 6
• 125000004093 cyano group Chemical group *C#N 0.000 claims 6
• 229910052736 halogen Inorganic materials 0.000 claims 6
• 150000002367 halogens Chemical class 0.000 claims 6
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
• 150000001875 compounds Chemical class 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• VCDALMMJMVIYAS-PISJKROCSA-N N(=[N+]=[N-])[C@@]1(O[C@H]([C@@H]([C@@H]1O)O)N1C(NC(C=C1)=O)=O)COC1=C(C2=CC=CC=C2C=C1)OP(=O)=N[C@H](C(=O)O)CC1=CC=CC=C1 Chemical compound N(=[N+]=[N-])[C@@]1(O[C@H]([C@@H]([C@@H]1O)O)N1C(NC(C=C1)=O)=O)COC1=C(C2=CC=CC=C2C=C1)OP(=O)=N[C@H](C(=O)O)CC1=CC=CC=C1 VCDALMMJMVIYAS-PISJKROCSA-N 0.000 claims 4
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 4
• 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
• 125000004442 acylamino group Chemical group 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 125000001188 haloalkyl group Chemical group 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 208000001490 Dengue Diseases 0.000 claims 2
• 206010012310 Dengue fever Diseases 0.000 claims 2
• 208000025729 dengue disease Diseases 0.000 claims 2
• 239000003443 antiviral agent Substances 0.000 claims 1
• 0 *C(*)(C(O*)=O)N(*)P(OC[C@](*)([C@]([C@]1O*)O*)O[C@@]1N(C=C(*)C(N1)=O)C1=O)(O**=C)=O Chemical compound *C(*)(C(O*)=O)N(*)P(OC[C@](*)([C@]([C@]1O*)O*)O[C@@]1N(C=C(*)C(N1)=O)C1=O)(O**=C)=O 0.000 description 1