PE20141263A1 - Metodo de tratamiento de la fiebre dengue - Google Patents
Metodo de tratamiento de la fiebre dengueInfo
- Publication number
- PE20141263A1 PE20141263A1 PE2013002781A PE2013002781A PE20141263A1 PE 20141263 A1 PE20141263 A1 PE 20141263A1 PE 2013002781 A PE2013002781 A PE 2013002781A PE 2013002781 A PE2013002781 A PE 2013002781A PE 20141263 A1 PE20141263 A1 PE 20141263A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dengue fever
- treatment
- haloalkyl
- aryl
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 2
- 206010012310 Dengue fever Diseases 0.000 title abstract 2
- 208000025729 dengue disease Diseases 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A UN METODO PARA TRATAR LA FIEBRE DEL DENGUE, QUE COMPRENDE ADMINISTRAR A UN PACIENTE UN COMPUESTO DE FORMULA (I) DONDE: R1 ES H, HALOALQUILO C1-6 O ARILO, DICHO ARILO ES FENILO O NAFTILO OPCIONALMENTE SUSTITUIDOS; R2a Y R2b SON INDEPENDIENTEMENTE H, ALQUILO C1-10, HIDROXIALQUILO C1-6, -CH2SH, -(CH2)3NHC(=NH)NH2, (1H-INDOL-3-IL)METILO, ENTRE OTROS; R4 ES H, ALQUILO C1-3, O R2b Y R4 JUNTOS SON (CH2)3; R6 ES a), b) ENTRE OTROS, DONDE R8 ES H O ALQUILO C1-3; R5 Y R7 SON INDEPENDIENTEMENTE H, C(=O)ALQUILO C1-6, ENTRE OTROS; R3 ES H, ALQUILO C1-10, HALOALQUILO C1-10, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161495472P | 2011-06-10 | 2011-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141263A1 true PE20141263A1 (es) | 2014-09-29 |
Family
ID=46229500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002781A PE20141263A1 (es) | 2011-06-10 | 2012-06-07 | Metodo de tratamiento de la fiebre dengue |
Country Status (15)
Country | Link |
---|---|
US (2) | US20130018011A1 (es) |
EP (1) | EP2717881A1 (es) |
JP (1) | JP6072016B2 (es) |
KR (1) | KR20140041706A (es) |
CN (1) | CN103608020B (es) |
CA (1) | CA2837242A1 (es) |
CL (1) | CL2013003487A1 (es) |
CO (1) | CO6811865A2 (es) |
CR (1) | CR20130610A (es) |
EC (1) | ECSP13013075A (es) |
MX (1) | MX2013014389A (es) |
MY (1) | MY173636A (es) |
PE (1) | PE20141263A1 (es) |
RU (1) | RU2605904C2 (es) |
WO (1) | WO2012168348A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130018011A1 (en) * | 2011-06-10 | 2013-01-17 | Hassan Javanbakht | Method of treating dengue fever |
WO2015158913A1 (en) * | 2014-04-17 | 2015-10-22 | Katholieke Universiteit Leuven | Novel antiviral and antitumoral compounds |
US10358458B2 (en) * | 2014-09-26 | 2019-07-23 | Riboscience Llc | 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication |
CN106132972B (zh) * | 2015-02-06 | 2018-08-31 | 银杏树药业(苏州)有限公司 | 用于治疗hcv感染的氨基磷酸酯 |
WO2017142984A1 (en) * | 2016-02-16 | 2017-08-24 | Riboscience Llc | Inhibitors of zika virus |
US20180098828A1 (en) | 2016-10-07 | 2018-04-12 | 3M Innovative Properties Company | Ceramic dental restorations made by additive manufacturing |
TW202322824A (zh) * | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1633766T1 (sl) * | 2003-05-30 | 2019-06-28 | Gilead Pharmasset Llc | Modificirani analogi fluoriranih nukleozidov |
CN101287472B (zh) * | 2005-08-15 | 2011-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物 |
US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
EP2166016A1 (en) * | 2008-09-18 | 2010-03-24 | Centocor Ortho Biotech Products L.P. | Phosphoramidate Derivatives of Nucleosides |
MX2011006891A (es) * | 2008-12-23 | 2011-10-06 | Pharmasset Inc | Fosforamidatos de nucleosidos. |
BR112012007122A2 (pt) * | 2009-09-29 | 2016-07-12 | Janssen Products Lp | derivados de fosforamidatos de nucleosídeos |
CA2812962C (en) * | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
US20130018011A1 (en) * | 2011-06-10 | 2013-01-17 | Hassan Javanbakht | Method of treating dengue fever |
-
2012
- 2012-06-05 US US13/488,802 patent/US20130018011A1/en not_active Abandoned
- 2012-06-07 CA CA2837242A patent/CA2837242A1/en not_active Abandoned
- 2012-06-07 CN CN201280029465.9A patent/CN103608020B/zh not_active Expired - Fee Related
- 2012-06-07 MY MYPI2013702389A patent/MY173636A/en unknown
- 2012-06-07 PE PE2013002781A patent/PE20141263A1/es active IP Right Grant
- 2012-06-07 WO PCT/EP2012/060781 patent/WO2012168348A1/en active Application Filing
- 2012-06-07 MX MX2013014389A patent/MX2013014389A/es unknown
- 2012-06-07 EP EP12726438.0A patent/EP2717881A1/en not_active Withdrawn
- 2012-06-07 RU RU2013156939/04A patent/RU2605904C2/ru not_active IP Right Cessation
- 2012-06-07 JP JP2014514062A patent/JP6072016B2/ja not_active Expired - Fee Related
- 2012-06-07 KR KR1020147000613A patent/KR20140041706A/ko not_active Application Discontinuation
-
2013
- 2013-11-21 CR CR20130610A patent/CR20130610A/es unknown
- 2013-11-29 CO CO13281371A patent/CO6811865A2/es unknown
- 2013-12-05 CL CL2013003487A patent/CL2013003487A1/es unknown
- 2013-12-10 EC ECSP13013075 patent/ECSP13013075A/es unknown
-
2015
- 2015-10-09 US US14/879,463 patent/US20160168186A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20160168186A1 (en) | 2016-06-16 |
ECSP13013075A (es) | 2014-01-31 |
EP2717881A1 (en) | 2014-04-16 |
CN103608020A (zh) | 2014-02-26 |
RU2605904C2 (ru) | 2016-12-27 |
JP2014519507A (ja) | 2014-08-14 |
CO6811865A2 (es) | 2013-12-16 |
KR20140041706A (ko) | 2014-04-04 |
CR20130610A (es) | 2014-02-18 |
JP6072016B2 (ja) | 2017-02-01 |
RU2013156939A (ru) | 2015-07-20 |
MY173636A (en) | 2020-02-12 |
CN103608020B (zh) | 2016-11-23 |
CA2837242A1 (en) | 2012-12-13 |
MX2013014389A (es) | 2014-03-21 |
US20130018011A1 (en) | 2013-01-17 |
CL2013003487A1 (es) | 2014-09-05 |
WO2012168348A1 (en) | 2012-12-13 |
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Legal Events
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FG | Grant, registration |