JP2006511484A5 - - Google Patents
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- Publication number
- JP2006511484A5 JP2006511484A5 JP2004543510A JP2004543510A JP2006511484A5 JP 2006511484 A5 JP2006511484 A5 JP 2006511484A5 JP 2004543510 A JP2004543510 A JP 2004543510A JP 2004543510 A JP2004543510 A JP 2004543510A JP 2006511484 A5 JP2006511484 A5 JP 2006511484A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- group
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 biphenylyl Chemical group 0.000 claims 66
- 125000000217 alkyl group Chemical group 0.000 claims 46
- 125000000753 cycloalkyl group Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 31
- 125000000304 alkynyl group Chemical group 0.000 claims 31
- 125000004404 heteroalkyl group Chemical group 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 28
- 125000003710 aryl alkyl group Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000004103 aminoalkyl group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 14
- 150000003857 carboxamides Chemical class 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 14
- 229940124530 sulfonamide Drugs 0.000 claims 13
- 150000003456 sulfonamides Chemical class 0.000 claims 13
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 239000005977 Ethylene Substances 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003435 aroyl group Chemical group 0.000 claims 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims 3
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 3
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000005032 thiofuranyl group Chemical group S1C(=CC=C1)* 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 229940122746 Fatty acid amide hydrolase inhibitor Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003940 fatty acid amidase inhibitor Substances 0.000 claims 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims 1
- 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 0 C*(CCNCC=*(C)C1)C1(C)C=C Chemical compound C*(CCNCC=*(C)C1)C1(C)C=C 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41700802P | 2002-10-07 | 2002-10-07 | |
| PCT/US2003/031844 WO2004033422A2 (en) | 2002-10-07 | 2003-10-07 | Modulation of anxiety through blockade of anandamide hydrolysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511484A JP2006511484A (ja) | 2006-04-06 |
| JP2006511484A5 true JP2006511484A5 (https=) | 2006-11-24 |
| JP4515911B2 JP4515911B2 (ja) | 2010-08-04 |
Family
ID=32093946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543510A Expired - Fee Related JP4515911B2 (ja) | 2002-10-07 | 2003-10-07 | アナンダミド加水分解の遮断による不安の調節 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7176201B2 (https=) |
| EP (1) | EP1558591B1 (https=) |
| JP (1) | JP4515911B2 (https=) |
| KR (1) | KR20050088992A (https=) |
| CN (1) | CN100408556C (https=) |
| AU (1) | AU2003279877B2 (https=) |
| CA (1) | CA2501506C (https=) |
| EA (1) | EA010267B1 (https=) |
| MX (1) | MXPA05003715A (https=) |
| UA (1) | UA80841C2 (https=) |
| WO (1) | WO2004033422A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US20050054730A1 (en) * | 2001-03-27 | 2005-03-10 | The Regents Of The University Of California | Compounds, compositions and treatment of oleoylethanolamide-like modulators of PPARalpha |
| AU2002311784B2 (en) * | 2001-03-29 | 2007-11-22 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| AU2003296895A1 (en) * | 2002-08-20 | 2004-05-04 | The Regents Of The University Of California | Combination therapy for controlling appetites |
| EP1558591B1 (en) * | 2002-10-07 | 2014-05-07 | The Regents of The University of California | Modulation of anxiety through blockade of anandamide hydrolysis |
| CA2520763A1 (en) * | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| JP2007509066A (ja) * | 2003-10-16 | 2007-04-12 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 体脂肪を減らし、食欲を抑制し、脂肪酸代謝を調節するための食物および他の組成物、化合物ならびに方法 |
| FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| CN100554244C (zh) | 2004-06-23 | 2009-10-28 | 弗·哈夫曼-拉罗切有限公司 | 新的mao-b抑制剂 |
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| US7662910B2 (en) * | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
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| WO2010097479A2 (en) * | 2010-05-25 | 2010-09-02 | Symrise Gmbh & Co. Kg | Cyclohexyl carbamate compounds as active anti-cellulite ingredients |
| KR101783374B1 (ko) | 2010-05-25 | 2017-10-23 | 시므라이즈 아게 | 피부 및/또는 모발 라이트닝 활성성분으로서의 사이클로헥실 카바메이트 화합물 |
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| CN103153946B (zh) * | 2010-07-28 | 2015-11-25 | 加利福尼亚大学董事会 | 外周限制性 faah 抑制剂 |
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| WO2013028570A2 (en) | 2011-08-19 | 2013-02-28 | The Regents Of The University Of California | Meta-substituted biphenyl peripherally restricted faah inhibitors |
| WO2014023325A1 (en) * | 2012-08-06 | 2014-02-13 | Fondazione Istituto Italiano Di Tecnologia | Multitarget faah and cox inhibitors and therapeutical uses thereof |
| ITMI20131180A1 (it) | 2013-07-15 | 2015-01-16 | Fond Istituto Italiano Di Tecnologia | O-alchil triazolil carbammati come inibitori di idrolasi delle ammidi degli acidi grassi (faah) |
| RU2693457C2 (ru) * | 2013-07-18 | 2019-07-03 | Фондацьоне Иституто Итальяно Ди Текнолоджия | Фенилкарбаматы и их применения в качестве ингибиторов фермента гидролазы амидов жирных кислот (faah) и модуляторов d3 допаминового рецептора (d3dr) |
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| US10220061B1 (en) | 2017-09-26 | 2019-03-05 | Cynthia Denapoli | Method of reducing stress and anxiety in equines |
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| US10414721B1 (en) | 2018-06-04 | 2019-09-17 | University Of Bern | Inhibitor of endocannabinoid cellular reuptake |
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| US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| US6251931B1 (en) * | 1998-11-24 | 2001-06-26 | The Scripps Research Institute | Inhibitors of gap junction communication |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| US6359010B1 (en) | 1999-11-23 | 2002-03-19 | Thomas D. Geracioti, Jr. | Methods of treating anxiety and mood disorders with oleamide |
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| FR2812876B1 (fr) | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| KR100566175B1 (ko) | 2000-08-16 | 2006-03-29 | 에프. 호프만-라 로슈 아게 | 신규한 아미노사이클로헥산 유도체 |
| DE60216830T2 (de) * | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
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| US6908939B2 (en) | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
| US6949574B2 (en) | 2002-02-08 | 2005-09-27 | Bristol-Myers Squibb Company | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors |
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-
2003
- 2003-10-07 EP EP03773201.3A patent/EP1558591B1/en not_active Expired - Lifetime
- 2003-10-07 AU AU2003279877A patent/AU2003279877B2/en not_active Ceased
- 2003-10-07 CN CNB2003801052130A patent/CN100408556C/zh not_active Expired - Fee Related
- 2003-10-07 US US10/681,858 patent/US7176201B2/en not_active Expired - Lifetime
- 2003-10-07 WO PCT/US2003/031844 patent/WO2004033422A2/en not_active Ceased
- 2003-10-07 JP JP2004543510A patent/JP4515911B2/ja not_active Expired - Fee Related
- 2003-10-07 MX MXPA05003715A patent/MXPA05003715A/es unknown
- 2003-10-07 CA CA2501506A patent/CA2501506C/en not_active Expired - Fee Related
- 2003-10-07 KR KR1020057005995A patent/KR20050088992A/ko not_active Ceased
- 2003-10-07 UA UAA200504339A patent/UA80841C2/xx unknown
- 2003-10-07 EA EA200500615A patent/EA010267B1/ru not_active IP Right Cessation
-
2006
- 2006-07-28 US US11/496,051 patent/US8003693B2/en active Active
-
2011
- 2011-08-16 US US13/211,219 patent/US20120010283A1/en not_active Abandoned
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