JP2002536445A5 - - Google Patents
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- Publication number
- JP2002536445A5 JP2002536445A5 JP2000598497A JP2000598497A JP2002536445A5 JP 2002536445 A5 JP2002536445 A5 JP 2002536445A5 JP 2000598497 A JP2000598497 A JP 2000598497A JP 2000598497 A JP2000598497 A JP 2000598497A JP 2002536445 A5 JP2002536445 A5 JP 2002536445A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- quinolinyl
- urea
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 description 17
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- -1 2-methyl-4-quinolinyl Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 101000598921 Homo sapiens Orexin Proteins 0.000 description 2
- 102000008834 Orexin receptor Human genes 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
- CRCXAJCHYKBUJH-UHFFFAOYSA-N 1-(1-methylindol-5-yl)-3-(2-methylquinolin-4-yl)urea Chemical compound C1=CC=CC2=NC(C)=CC(NC(=O)NC=3C=C4C=CN(C)C4=CC=3)=C21 CRCXAJCHYKBUJH-UHFFFAOYSA-N 0.000 description 1
- SNNOGMLIXXEHLG-UHFFFAOYSA-N 1-(2,3-dichlorophenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC(Cl)=C1Cl SNNOGMLIXXEHLG-UHFFFAOYSA-N 0.000 description 1
- IETIBXVXLAXJIM-UHFFFAOYSA-N 1-(2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound COC1=CC=CC=C1NC(=O)NC1=CC(C)=NC2=CC=CC=C12 IETIBXVXLAXJIM-UHFFFAOYSA-N 0.000 description 1
- LTRWPUIMHSZSHR-UHFFFAOYSA-N 1-(2-methylphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC=C1C LTRWPUIMHSZSHR-UHFFFAOYSA-N 0.000 description 1
- DAVPQZYWZTXBJN-UHFFFAOYSA-N 1-(2-methylquinolin-4-yl)-3-(3,4,5-trimethoxyphenyl)urea Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)NC=2C3=CC=CC=C3N=C(C)C=2)=C1 DAVPQZYWZTXBJN-UHFFFAOYSA-N 0.000 description 1
- XKBRBZVPYWSNJA-UHFFFAOYSA-N 1-(2-methylquinolin-4-yl)-3-(5,6,7,8-tetrahydronaphthalen-1-yl)urea Chemical compound C1=CC=CC2=NC(C)=CC(NC(=O)NC=3C=4CCCCC=4C=CC=3)=C21 XKBRBZVPYWSNJA-UHFFFAOYSA-N 0.000 description 1
- JKWVVRXLBAMQLY-UHFFFAOYSA-N 1-(2-methylquinolin-4-yl)-3-[3-(trifluoromethyl)phenyl]urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 JKWVVRXLBAMQLY-UHFFFAOYSA-N 0.000 description 1
- ISRXTIIGKBTICT-UHFFFAOYSA-N 1-(2-methylquinolin-4-yl)-3-phenylurea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC=C1 ISRXTIIGKBTICT-UHFFFAOYSA-N 0.000 description 1
- AVEATFGVCCGTSU-UHFFFAOYSA-N 1-(3,4-dimethylphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=C(C)C(C)=C1 AVEATFGVCCGTSU-UHFFFAOYSA-N 0.000 description 1
- LFUYJGPVNJFZCN-UHFFFAOYSA-N 1-(3,5-dimethylphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound CC1=CC(C)=CC(NC(=O)NC=2C3=CC=CC=C3N=C(C)C=2)=C1 LFUYJGPVNJFZCN-UHFFFAOYSA-N 0.000 description 1
- XGJCNQIEHUPXTE-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=C(C)C(Cl)=C1 XGJCNQIEHUPXTE-UHFFFAOYSA-N 0.000 description 1
- JOTMLYFNAICCPR-UHFFFAOYSA-N 1-(3-hydroxyphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC(O)=C1 JOTMLYFNAICCPR-UHFFFAOYSA-N 0.000 description 1
- YZCQXNQZRRVTOG-UHFFFAOYSA-N 1-(3-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound COC1=CC=CC(NC(=O)NC=2C3=CC=CC=C3N=C(C)C=2)=C1 YZCQXNQZRRVTOG-UHFFFAOYSA-N 0.000 description 1
- JQMQNDGGSXZDNL-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(=O)NC1=CC=C(Cl)C=C1 JQMQNDGGSXZDNL-UHFFFAOYSA-N 0.000 description 1
- AMNUXFGXHHMPGQ-UHFFFAOYSA-N 1-(4-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C1=CC(OC)=CC=C1NC(=O)NC1=CC(C)=NC2=CC=CC=C12 AMNUXFGXHHMPGQ-UHFFFAOYSA-N 0.000 description 1
- VPMCCWRZRPCNOA-UHFFFAOYSA-N 1-(4-methyl-2-nitrophenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound [O-][N+](=O)C1=CC(C)=CC=C1NC(=O)NC1=CC(C)=NC2=CC=CC=C12 VPMCCWRZRPCNOA-UHFFFAOYSA-N 0.000 description 1
- HPZZLUMHLOCFLV-UHFFFAOYSA-N 1-(4-methylphenyl)-3-(2-methylquinolin-4-yl)urea Chemical compound C1=CC(C)=CC=C1NC(=O)NC1=CC(C)=NC2=CC=CC=C12 HPZZLUMHLOCFLV-UHFFFAOYSA-N 0.000 description 1
- YBLWOZUPHDKFOT-UHFFFAOYSA-N 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea Chemical compound COC1=CC=C(Cl)C=C1NC(=O)NC1=CC(C)=NC2=CC=CC=C12 YBLWOZUPHDKFOT-UHFFFAOYSA-N 0.000 description 1
- HLMVPRYBEVSPFB-UHFFFAOYSA-N 1-(6-amino-2-methylquinolin-4-yl)-3-(2-nitrophenyl)urea Chemical compound C=12C=C(N)C=CC2=NC(C)=CC=1NC(=O)NC1=CC=CC=C1[N+]([O-])=O HLMVPRYBEVSPFB-UHFFFAOYSA-N 0.000 description 1
- IKKJPORHYUTNHI-UHFFFAOYSA-N 1-[3-(dimethylamino)phenyl]-3-(2-methylquinolin-4-yl)urea Chemical compound CN(C)C1=CC=CC(NC(=O)NC=2C3=CC=CC=C3N=C(C)C=2)=C1 IKKJPORHYUTNHI-UHFFFAOYSA-N 0.000 description 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903266.6A GB9903266D0 (en) | 1999-02-12 | 1999-02-12 | Compounds |
| GBGB9926430.1A GB9926430D0 (en) | 1999-11-08 | 1999-11-08 | Compounds |
| GB9903266.6 | 1999-11-08 | ||
| GB9926430.1 | 1999-11-08 | ||
| PCT/EP2000/001150 WO2000047577A1 (en) | 1999-02-12 | 2000-02-10 | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002536445A JP2002536445A (ja) | 2002-10-29 |
| JP2002536445A5 true JP2002536445A5 (https=) | 2007-02-01 |
Family
ID=26315129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598497A Withdrawn JP2002536445A (ja) | 1999-02-12 | 2000-02-10 | オレキシン受容体アンタゴニストとしてのフェニル尿素およびフェニルチオ尿素誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6699879B1 (https=) |
| EP (1) | EP1150977B1 (https=) |
| JP (1) | JP2002536445A (https=) |
| AT (1) | ATE274512T1 (https=) |
| AU (1) | AU2804400A (https=) |
| DE (1) | DE60013250T2 (https=) |
| ES (1) | ES2226785T3 (https=) |
| WO (1) | WO2000047577A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
| CA2380389A1 (en) * | 1999-07-26 | 2001-02-01 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
| JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
| WO2002018326A1 (en) * | 2000-08-31 | 2002-03-07 | Wakunaga Pharmaceutical Co., Ltd. | Novel propenohydroxamic acid derivatives |
| WO2002044172A1 (en) * | 2000-11-28 | 2002-06-06 | Smithkline Beecham P.L.C. | Morpholine derivatives as antagonists of orexin receptors |
| EP1379505B1 (en) * | 2001-04-20 | 2007-02-28 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US7371763B2 (en) | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| WO2002090355A1 (en) | 2001-05-05 | 2002-11-14 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
| US20040259912A1 (en) * | 2001-09-28 | 2004-12-23 | Takahiro Matsumoto | Benzine derivatives, process for preparing the same and use thereof |
| GB0130341D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
| CA2460051A1 (en) | 2002-07-09 | 2004-01-15 | Actelion Pharmaceuticals Ltd. | 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives |
| KR20050043967A (ko) * | 2002-09-17 | 2005-05-11 | 액테리온 파마슈티칼 리미티드 | 1-피리딘-4-일-요소 유도체 |
| RU2334735C2 (ru) | 2002-10-11 | 2008-09-27 | Актелион Фармасьютиклз Лтд. | Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина |
| GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| WO2004085433A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| ES2297413T3 (es) * | 2003-04-28 | 2008-05-01 | Actelion Pharmaceuticals Ltd. | Derivados de quinoxalinona-3-ona utilizados como antagonistas del receptor de orexina. |
| EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| CA2557163C (en) | 2004-03-01 | 2011-08-16 | Idorsia Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
| WO2006081522A2 (en) * | 2005-01-26 | 2006-08-03 | The Regents Of The Unversity Of California | Modulation of nmda receptor currents via orexin receptor and/or crf receptor |
| US7501395B2 (en) | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
| WO2007024754A1 (en) * | 2005-08-22 | 2007-03-01 | Amgen Inc. | Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes |
| FR2896799B1 (fr) * | 2006-02-02 | 2008-03-28 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| EP2049110B1 (en) | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| CA2672196A1 (en) | 2006-12-20 | 2008-07-03 | Abbott Laboratories | Antagonists of the trpv1 receptor and uses thereof |
| JP2010527924A (ja) | 2007-05-18 | 2010-08-19 | メルク・シャープ・エンド・ドーム・コーポレイション | オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト |
| NZ580887A (en) | 2007-05-23 | 2012-03-30 | Merck Sharp & Dohme | Pyridyl piperidine orexin receptor antagonists |
| AU2008260647A1 (en) | 2007-05-23 | 2008-12-11 | Merck Sharp & Dohme Corp. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| US8455648B2 (en) | 2008-04-24 | 2013-06-04 | Abbott Gmbh & Co. Kg | 1-(7-(hexahydropyrrolo [3,4-c] pyrrol-2 (1H)-yl) quinolin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3) |
| EP2161266A1 (en) | 2008-08-22 | 2010-03-10 | EVOTEC Neurosciences GmbH | Benzofuran derivatives as orexin receptor antagonists |
| AU2009324238A1 (en) | 2008-12-02 | 2010-06-10 | Glaxo Group Limited | N-{[(IR,4S,6R-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0] hept-4-yl] methyl}-2-heteroarylamine derivatives and uses thereof |
| EP2421850A1 (en) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | 3 -azabicyclo [4.1.0]heptanes used as orexin antagonists |
| WO2011023585A1 (en) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | Piperidine derivatives used as orexin antagonists |
| JP2013502447A (ja) | 2009-08-24 | 2013-01-24 | グラクソ グループ リミテッド | 睡眠障害の治療のためのオレキシン受容体アンタゴニストとしての５−メチル−ピペリジン誘導体 |
| WO2011138265A2 (en) | 2010-05-03 | 2011-11-10 | Evotec Ag | Indole and indazole derivatives as orexin receptor antagonists |
| WO2011138266A1 (en) | 2010-05-03 | 2011-11-10 | Evotec Ag | Indolizine and imidazopyridine derivatives as orexin receptor antagonists |
| WO2012089607A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors |
| WO2012089606A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| CA2863413A1 (en) | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| US20160250224A1 (en) * | 2013-09-24 | 2016-09-01 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
| US20170037028A1 (en) * | 2013-12-20 | 2017-02-09 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| UY36272A (es) | 2014-08-13 | 2016-02-29 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores de los receptores de orexinas |
| WO2016075134A1 (en) * | 2014-11-12 | 2016-05-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
| AU2017217931B2 (en) | 2016-02-12 | 2020-10-22 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| WO2020252240A1 (en) * | 2019-06-14 | 2020-12-17 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| CN114656406B (zh) * | 2022-01-25 | 2023-09-05 | 阿里生物新材料（常州）有限公司 | 一种2-氟代嘧啶-4-羧酸的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9302275D0 (en) * | 1993-02-05 | 1993-03-24 | Smithkline Beecham Plc | Novel compounds |
| US5552411A (en) * | 1995-05-26 | 1996-09-03 | Warner-Lambert Company | Sulfonylquinolines as central nervous system and cardiovascular agents |
| ZA96497B (en) * | 1996-01-23 | 1996-08-13 | Bnfl Fluorchem Ltd | Halogenated compounds |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| AU7933098A (en) | 1997-06-25 | 1999-01-04 | Yamanouchi Pharmaceutical Co., Ltd. | Novel amidrazone derivatives having antifungal activity |
| AR016817A1 (es) * | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| US6083944A (en) | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| WO1999038846A1 (en) | 1998-01-30 | 1999-08-05 | Procept, Inc. | Immunosuppressive agents |
-
2000
- 2000-02-10 EP EP00906324A patent/EP1150977B1/en not_active Expired - Lifetime
- 2000-02-10 WO PCT/EP2000/001150 patent/WO2000047577A1/en not_active Ceased
- 2000-02-10 DE DE60013250T patent/DE60013250T2/de not_active Expired - Fee Related
- 2000-02-10 AT AT00906324T patent/ATE274512T1/de not_active IP Right Cessation
- 2000-02-10 JP JP2000598497A patent/JP2002536445A/ja not_active Withdrawn
- 2000-02-10 US US09/913,236 patent/US6699879B1/en not_active Expired - Fee Related
- 2000-02-10 AU AU28044/00A patent/AU2804400A/en not_active Abandoned
- 2000-02-10 ES ES00906324T patent/ES2226785T3/es not_active Expired - Lifetime
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