JP2001515075A5 - - Google Patents
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- JP2001515075A5 JP2001515075A5 JP2000509705A JP2000509705A JP2001515075A5 JP 2001515075 A5 JP2001515075 A5 JP 2001515075A5 JP 2000509705 A JP2000509705 A JP 2000509705A JP 2000509705 A JP2000509705 A JP 2000509705A JP 2001515075 A5 JP2001515075 A5 JP 2001515075A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- chloro
- pharmaceutically acceptable
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 description 18
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 239000005557 antagonist Substances 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- XXLFLUJXWKXUGS-UHFFFAOYSA-N 6-methoxyquinoline-4-carboxylic acid Chemical compound N1=CC=C(C(O)=O)C2=CC(OC)=CC=C21 XXLFLUJXWKXUGS-UHFFFAOYSA-N 0.000 description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- VOIKVWNNWDFFMQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(7-chloroquinolin-4-yl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=NC2=CC(Cl)=CC=C12 VOIKVWNNWDFFMQ-UHFFFAOYSA-N 0.000 description 1
- JQCZOECASVNHMQ-UHFFFAOYSA-N 1-(7-chloroquinolin-4-yl)-3-(3,4,5-trimethoxyphenyl)urea Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)NC=2C3=CC=C(Cl)C=C3N=CC=2)=C1 JQCZOECASVNHMQ-UHFFFAOYSA-N 0.000 description 1
- CTZRSKUIEVVAJG-UHFFFAOYSA-N 1-(7-chloroquinolin-4-yl)-3-(4-methoxyphenyl)urea Chemical compound C1=CC(OC)=CC=C1NC(=O)NC1=CC=NC2=CC(Cl)=CC=C12 CTZRSKUIEVVAJG-UHFFFAOYSA-N 0.000 description 1
- RETJOGPFTCSHIR-UHFFFAOYSA-N 1-[3-chloro-4-(trifluoromethyl)phenyl]-3-(5-nitroquinolin-4-yl)urea Chemical compound C=12C([N+](=O)[O-])=CC=CC2=NC=CC=1NC(=O)NC1=CC=C(C(F)(F)F)C(Cl)=C1 RETJOGPFTCSHIR-UHFFFAOYSA-N 0.000 description 1
- ORRPEZHMWMSQGQ-UHFFFAOYSA-N 1-[3-chloro-4-(trifluoromethyl)phenyl]-3-quinolin-4-ylurea Chemical compound C1=C(Cl)C(C(F)(F)F)=CC=C1NC(=O)NC1=CC=NC2=CC=CC=C12 ORRPEZHMWMSQGQ-UHFFFAOYSA-N 0.000 description 1
- OPSKCKQXDKZQBK-UHFFFAOYSA-N 1-isoquinolin-1-yl-3-(1-methylindol-5-yl)urea Chemical compound C1=CC=C2C(NC(=O)NC=3C=C4C=CN(C4=CC=3)C)=NC=CC2=C1 OPSKCKQXDKZQBK-UHFFFAOYSA-N 0.000 description 1
- QEJVAJGAMCJITG-UHFFFAOYSA-N 5-chloroquinoline-4-carboxylic acid Chemical compound C1=CC(Cl)=C2C(C(=O)O)=CC=NC2=C1 QEJVAJGAMCJITG-UHFFFAOYSA-N 0.000 description 1
- ZRYMLJGLNAOPNK-UHFFFAOYSA-N 6-chloroquinoline-4-carboxylic acid Chemical compound C1=C(Cl)C=C2C(C(=O)O)=CC=NC2=C1 ZRYMLJGLNAOPNK-UHFFFAOYSA-N 0.000 description 1
- SUCSQKWIHAXNTM-UHFFFAOYSA-N 6-ethoxyquinoline-4-carboxylic acid Chemical compound N1=CC=C(C(O)=O)C2=CC(OCC)=CC=C21 SUCSQKWIHAXNTM-UHFFFAOYSA-N 0.000 description 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 1
- TXYVRYRRTQYTHJ-UHFFFAOYSA-N 7-chloroquinoline-4-carboxylic acid Chemical compound ClC1=CC=C2C(C(=O)O)=CC=NC2=C1 TXYVRYRRTQYTHJ-UHFFFAOYSA-N 0.000 description 1
- QIRLJMJLJXBUMP-UHFFFAOYSA-N 7-fluoroquinoline-4-carboxylic acid Chemical compound FC1=CC=C2C(C(=O)O)=CC=NC2=C1 QIRLJMJLJXBUMP-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9717178.9A GB9717178D0 (en) | 1997-08-14 | 1997-08-14 | Compounds |
| GB9717178.9 | 1997-08-14 | ||
| GBGB9807756.3A GB9807756D0 (en) | 1998-04-08 | 1998-04-08 | Compounds |
| GB9807756.3 | 1998-04-08 | ||
| PCT/GB1998/002437 WO1999009024A1 (en) | 1997-08-14 | 1998-08-13 | Phenyl urea and phenyl thiourea derivatives as hfgan72 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515075A JP2001515075A (ja) | 2001-09-18 |
| JP2001515075A5 true JP2001515075A5 (https=) | 2006-01-05 |
Family
ID=26312063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509705A Withdrawn JP2001515075A (ja) | 1997-08-14 | 1998-08-13 | Ｈｆｇａｎ７２アンタゴニストとしてのフェニルウレアおよびフェニルチオウレア誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6410529B1 (https=) |
| EP (1) | EP1003737A1 (https=) |
| JP (1) | JP2001515075A (https=) |
| AR (1) | AR016817A1 (https=) |
| AU (1) | AU8741198A (https=) |
| CA (1) | CA2300178A1 (https=) |
| WO (1) | WO1999009024A1 (https=) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| KR100567649B1 (ko) | 1996-09-25 | 2006-04-05 | 아스트라제네카 유케이 리미티드 | 혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체 |
| US6020157A (en) * | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
| US5935814A (en) * | 1997-04-30 | 1999-08-10 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72Y receptor |
| US6653086B1 (en) | 1998-04-14 | 2003-11-25 | Arena Pharmaceuticals, Inc. | Endogenous constitutively activated G protein-coupled orphan receptors |
| ES2196806T3 (es) * | 1998-05-08 | 2003-12-16 | Smithkline Beecham Plc | Derivados de fenilurea y de feniltiourea. |
| US6420563B1 (en) | 1998-07-31 | 2002-07-16 | Arena Pharmaceuticals, Inc. | Small molecule modulators of G protein-coupled receptor six |
| WO2000037434A1 (en) * | 1998-12-22 | 2000-06-29 | Mitsubishi Chemical Corporation | Amide derivatives |
| DE60015927T2 (de) | 1999-02-12 | 2005-04-07 | Smithkline Beecham P.L.C., Brentford | Phenylharnstoff und phenylthioharnstoffderivate |
| JP2002536425A (ja) * | 1999-02-12 | 2002-10-29 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | オレキシン受容体アンタゴニストの新規用途 |
| WO2000047576A1 (en) * | 1999-02-12 | 2000-08-17 | Smithkline Beecham Plc | Cinnamide derivatives as orexin-1 receptors antagonists |
| AU2804400A (en) | 1999-02-12 | 2000-08-29 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| AU6453501A (en) * | 1999-02-26 | 2001-09-03 | Arena Pharmaceuticals, Inc. | Small molecule modulators of G protein-coupled receptor six |
| US6806274B1 (en) | 1999-07-07 | 2004-10-19 | Astrazeneca Uk Limited | Quinazoline derivatives |
| US6764858B2 (en) | 1999-09-29 | 2004-07-20 | Pharmacia & Upjohn Company | Methods for creating a compound library |
| CA2400094A1 (en) * | 1999-09-29 | 2001-04-05 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
| US6677160B1 (en) | 1999-09-29 | 2004-01-13 | Pharmacia & Upjohn Company | Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules |
| CZ301689B6 (cs) | 1999-11-05 | 2010-05-26 | Astrazeneca Ab | Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje |
| AU2001235804A1 (en) | 2000-03-06 | 2001-09-17 | Astrazeneca Ab | Therapy |
| DE60108236T2 (de) | 2000-03-14 | 2005-12-22 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisochinolin-derivate |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| EP1288202A4 (en) | 2000-05-11 | 2003-07-02 | Banyu Pharma Co Ltd | N-acyltetrahydroisoquinoline derivatives |
| US6677354B2 (en) | 2000-06-16 | 2004-01-13 | Smithkline Beecham P.L.C. | Piperdines for use as orexin receptor antagonists |
| ATE413394T1 (de) | 2000-06-24 | 2008-11-15 | Astrazeneca Ab | Guanidin-derivate von chinazoin zur behandlung von autoimmunkrankheiten |
| WO2002002534A1 (en) * | 2000-07-03 | 2002-01-10 | Astrazeneca Ab | Quinazolines with therapeutic use |
| NZ526174A (en) | 2000-12-21 | 2004-12-24 | Schering Corp | Heteroaryl urea neuropeptide Y Y5 receptor antagonists |
| US6946476B2 (en) | 2000-12-21 | 2005-09-20 | Schering Corporation | Heteroaryl urea neuropeptide Y Y5 receptor antagonists |
| IL158463A0 (en) | 2001-05-05 | 2004-05-12 | Smithkline Beecham Plc | N-aroyl cyclic amines |
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| BR0210609A (pt) | 2001-06-28 | 2004-07-20 | Smithkline Beecham Plc | Derivados de amina cìclica n-aroila como antagonistas do receptor da orexina |
| ES2278197T3 (es) | 2002-07-09 | 2007-08-01 | Actelion Pharmaceuticals Ltd. | Derivados de 7,8,9,10-tetrahidro-6h-azepino, 6,7,8,9-tetrahidro-pirido y 2,3-dihidro-2h-pirrolo(1,2-b)-quinazolinona. |
| JP2006505533A (ja) * | 2002-09-17 | 2006-02-16 | アクテリオン ファマシューティカルズ リミテッド | １−ピリジン−４−イル−尿素誘導体 |
| US7279578B2 (en) | 2002-10-11 | 2007-10-09 | Actelion Pharmaceuticals Ltd. | Sulfonylamino-acetic acid derivatives |
| GB0230195D0 (en) * | 2002-12-24 | 2003-02-05 | Biofocus Plc | Compound Libraries |
| AU2003295158A1 (en) * | 2002-12-24 | 2004-07-22 | Biofocus Plc | Compound libraries of 1,3,5-substitute indazole derivatives as compounds for targetting compounds capable of binding to the g-protein coupled receptor |
| WO2004085433A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| CA2520763A1 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| EP1631546A1 (en) * | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
| DE602004011204T2 (de) | 2003-04-28 | 2008-12-24 | Actelion Pharmaceuticals Ltd. | Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten. |
| PT1751111E (pt) | 2004-03-01 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina substituída |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US7550499B2 (en) * | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| CA2584185C (en) * | 2004-10-13 | 2014-07-15 | Frank Stieber | Heterocyclic substituted bisarylurea derivates as kinase inhibitors |
| US7662910B2 (en) | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| US7501395B2 (en) | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
| AR059826A1 (es) * | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
| CA2657623A1 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Bridged diazepan orexin receptor antagonists |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| WO2008101030A1 (en) * | 2007-02-13 | 2008-08-21 | The Regents Of The University Of California | Methods for amplifying steroid hormone effects |
| CA2688776A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| WO2008150364A1 (en) | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| JP4881476B2 (ja) | 2007-05-23 | 2012-02-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| CN102015645B (zh) * | 2008-04-30 | 2012-11-14 | 埃科特莱茵药品有限公司 | 哌啶和吡咯烷化合物 |
| AR074426A1 (es) | 2008-12-02 | 2011-01-19 | Glaxo Group Ltd | Compuesto de n-(((1s,4s,6s)-3-(2-piridinilcarbonil)3-azabiciclo (4,1.0)hept-4-il) metil)-2-heteroarilamina, su uso para la prepracion de un medicamento para el tratamiento de una enfermedad que requiere un antagonista de un receptor de orexina humana y composicion farmaceutica que lo comprende |
| GB0823467D0 (en) | 2008-12-23 | 2009-01-28 | Glaxo Group Ltd | Novel Compounds |
| NZ595087A (en) * | 2009-02-11 | 2013-03-28 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
| WO2010122151A1 (en) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | 3 -azabicyclo [4.1.0] heptanes used as orexin antagonists |
| WO2011023585A1 (en) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | Piperidine derivatives used as orexin antagonists |
| WO2011023578A1 (en) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2528604B1 (en) | 2010-01-29 | 2017-11-22 | The Regents of the University of California | Acyl piperidine inhibitors of soluble epoxide hydrolase |
| CA2792068A1 (en) | 2010-04-02 | 2011-10-06 | Senomyx, Inc. | Sweet flavor modifier |
| US9586938B2 (en) | 2010-07-29 | 2017-03-07 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| UA110113C2 (xx) * | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| WO2012089606A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists |
| WO2012089607A1 (en) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors |
| MX336378B (es) | 2011-08-12 | 2016-01-15 | Senomyx Inc | Modificador del sabor dulce. |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| CA2963901A1 (en) | 2014-11-07 | 2016-05-12 | Senomyx, Inc. | Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers |
| WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
| EP3937919A4 (en) | 2019-03-14 | 2023-04-12 | Board of Regents, The University of Texas System | SMALL MOLECULES GRB2 STABILIZER FOR INHIBITION OF RAS-MAP KINASE |
| WO2021161230A1 (en) * | 2020-02-12 | 2021-08-19 | Curadev Pharma Pvt. Ltd. | Small molecule sting antagonists |
| WO2025067473A1 (zh) * | 2023-09-28 | 2025-04-03 | 四川大学华西医院 | 一种含苯环的具有镇痛功效的化合物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4009020A (en) * | 1975-05-06 | 1977-02-22 | Amchem Products, Inc. | Method of regulating plant growth |
| US5552411A (en) * | 1995-05-26 | 1996-09-03 | Warner-Lambert Company | Sulfonylquinolines as central nervous system and cardiovascular agents |
| US5731315A (en) * | 1995-06-07 | 1998-03-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds |
| EA002817B1 (ru) | 1996-12-13 | 2002-10-31 | Авентис Фармасьютикалз Продактс Инк. | Соединения сульфоновой кислоты или сульфониламино-n-(гетероаралкил)азагетероциклиламида |
-
1998
- 1998-08-12 AR ARP980104002A patent/AR016817A1/es unknown
- 1998-08-13 AU AU87411/98A patent/AU8741198A/en not_active Abandoned
- 1998-08-13 WO PCT/GB1998/002437 patent/WO1999009024A1/en not_active Ceased
- 1998-08-13 EP EP98938812A patent/EP1003737A1/en not_active Withdrawn
- 1998-08-13 CA CA002300178A patent/CA2300178A1/en not_active Abandoned
- 1998-08-13 US US09/485,623 patent/US6410529B1/en not_active Expired - Fee Related
- 1998-08-13 JP JP2000509705A patent/JP2001515075A/ja not_active Withdrawn
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