JP2005507938A5 - - Google Patents
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- Publication number
- JP2005507938A5 JP2005507938A5 JP2003540136A JP2003540136A JP2005507938A5 JP 2005507938 A5 JP2005507938 A5 JP 2005507938A5 JP 2003540136 A JP2003540136 A JP 2003540136A JP 2003540136 A JP2003540136 A JP 2003540136A JP 2005507938 A5 JP2005507938 A5 JP 2005507938A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- compound
- aryl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 40
- 125000000217 alkyl group Chemical group 0.000 description 23
- 125000001072 heteroaryl group Chemical group 0.000 description 15
- 229910052799 carbon Inorganic materials 0.000 description 13
- 125000003118 aryl group Chemical group 0.000 description 11
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 11
- 125000002947 alkylene group Chemical group 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 125000005605 benzo group Chemical group 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 150000002772 monosaccharides Chemical class 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052717 sulfur Chemical group 0.000 description 4
- 125000001544 thienyl group Chemical group 0.000 description 4
- -1 C6-CTenAryl Chemical group 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000011593 sulfur Chemical group 0.000 description 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 125000005418 aryl aryl group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 208000030814 Eating disease Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 235000014632 disordered eating Nutrition 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/014,645 US6670358B2 (en) | 2000-05-16 | 2001-10-26 | Substituted thioacetamides |
| PCT/US2002/034188 WO2003037853A1 (en) | 2001-10-26 | 2002-10-25 | Substituted thioacetamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507938A JP2005507938A (ja) | 2005-03-24 |
| JP2005507938A5 true JP2005507938A5 (https=) | 2006-01-05 |
| JP4351533B2 JP4351533B2 (ja) | 2009-10-28 |
Family
ID=21766773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003540136A Expired - Fee Related JP4351533B2 (ja) | 2001-10-26 | 2002-10-25 | 置換チオアセトアミド |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US6670358B2 (https=) |
| EP (1) | EP1438288B1 (https=) |
| JP (1) | JP4351533B2 (https=) |
| KR (1) | KR100965640B1 (https=) |
| CN (1) | CN1575279A (https=) |
| AR (1) | AR037019A1 (https=) |
| AT (1) | ATE430129T1 (https=) |
| AU (1) | AU2002349923B2 (https=) |
| BR (1) | BR0213540A (https=) |
| CA (1) | CA2462206A1 (https=) |
| DE (1) | DE60232166D1 (https=) |
| EA (1) | EA007781B1 (https=) |
| ES (1) | ES2324024T3 (https=) |
| HU (1) | HUP0500831A3 (https=) |
| IL (2) | IL161015A0 (https=) |
| MX (1) | MXPA04003796A (https=) |
| NO (1) | NO329584B1 (https=) |
| NZ (1) | NZ532386A (https=) |
| PL (1) | PL373900A1 (https=) |
| UA (1) | UA77706C2 (https=) |
| WO (1) | WO2003037853A1 (https=) |
| ZA (1) | ZA200403097B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| ATE357228T1 (de) * | 2001-05-25 | 2007-04-15 | Cephalon Inc | Feste pharmazeutische formulierung enthaltend modafinil |
| US20080058424A1 (en) * | 2002-05-23 | 2008-03-06 | Cephalon, Inc. | Novel pharmaceutical formulations of modafinil |
| US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
| US20040116532A1 (en) * | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
| IL153098A0 (en) * | 2002-11-26 | 2003-06-24 | Chemagis Ltd | Pharmaceutical compositions containing modafinil |
| FR2849029B1 (fr) | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| US7244865B2 (en) * | 2003-02-24 | 2007-07-17 | Mallinckrodt Inc. | Process for preparing benzhydrylthioacetamide |
| JP2006520400A (ja) * | 2003-03-07 | 2006-09-07 | アボット・ラボラトリーズ | 縮合三および四環式ピラゾールキナーゼ阻害剤 |
| US7320986B2 (en) * | 2003-03-07 | 2008-01-22 | Abbott Labortories | Fused tri and tetra-cyclic pyrazole kinase inhibitors |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| US7297817B2 (en) | 2004-04-13 | 2007-11-20 | Cephalon France | Thio-substituted arylmethanesulfinyl derivatives |
| EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7314875B2 (en) * | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| EP1589001A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| EP1586560A1 (en) * | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Thio-substituted arylmethanesulfinyl derivatives |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7423176B2 (en) * | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| US7033861B1 (en) | 2005-05-18 | 2006-04-25 | Staktek Group L.P. | Stacked module systems and method |
| CA2632722A1 (en) * | 2005-12-09 | 2007-06-21 | Mallinckrodt Inc. | Processes for the preparation of modafinil and analogs thereof |
| KR20090031618A (ko) * | 2006-07-12 | 2009-03-26 | 엘란 코포레이션, 피엘씨 | 나노입자형 모다피닐 제제 |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| WO2012145112A2 (en) | 2011-04-18 | 2012-10-26 | Immunogen, Inc. | Novel maytansinoid derivatives with sulfoxide linker |
| EP2964611B1 (en) * | 2013-03-08 | 2022-10-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof |
| US9459194B2 (en) | 2013-03-14 | 2016-10-04 | Cardio Metrix | Apparatuses, processes, and systems for measuring particle size distribution and concentration |
| ES2645483T3 (es) | 2014-08-13 | 2017-12-05 | Red Bull Gmbh | Compuestos heterocíclicos con actividad de mejora de la memoria de trabajo |
| WO2016023997A1 (en) * | 2014-08-13 | 2016-02-18 | Red Bull Gmbh | Heterocyclic compounds with working memory enhancing activity |
| US11365195B2 (en) | 2017-11-13 | 2022-06-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Atypical inhibitors of monoamine transporters; method of making; and use thereof |
| EP3553053A1 (en) | 2018-04-12 | 2019-10-16 | Red Bull GmbH | (s)-enantiomeric form of a heterocyclic compound having motivation improving and/or reference memory enhancing activity |
| EP3792252A1 (en) | 2019-09-13 | 2021-03-17 | Red Bull GmbH | Thiazole and diphenyl substituted sulfoxides for use in improving cognition functions and against addictions to substances. |
| EP3929184A1 (en) | 2020-06-23 | 2021-12-29 | Red Bull GmbH | ((((3-halophenyl)(phenyl)methyl)sulfinyl)methyl)thiophene compounds and diastereomeric forms thereof for use in improving cognitive functions |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE286742C (https=) | ||||
| GB1520812A (en) * | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| GB1584462A (en) * | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
| DE3100387A1 (de) | 1981-01-09 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Substituierte diphenylether, diese enthaltende herbizide und ihre anwendung als herbizide |
| FR2528041A1 (fr) | 1982-06-04 | 1983-12-09 | Lafon Labor | Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique |
| FR2593809B1 (fr) * | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| US4964893A (en) * | 1986-04-17 | 1990-10-23 | Monsanto Company | Benzhydryl compounds as herbicide antidotes |
| US4957537A (en) * | 1987-03-24 | 1990-09-18 | Fujisawa Pharmaceutical Company, Ltd | Method for regulating plant growth |
| DE3872937T2 (de) * | 1987-05-11 | 1993-01-21 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersaeure-derivate. |
| US4935240A (en) * | 1987-06-04 | 1990-06-19 | Ono Pharmaceutical Co., Ltd. | Benzoylaminophenoxybutanoic acid derivatives |
| US5204358A (en) * | 1987-11-25 | 1993-04-20 | Merck Frosst Canada, Inc. | Hetaryl styryl quinolines as leukotriene inhibitors |
| ES2036926B1 (es) | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
| US5563169A (en) * | 1991-09-13 | 1996-10-08 | Sankyo Company, Limited | Tricyclic heterocyclic compound |
| DE4317651A1 (de) * | 1993-05-27 | 1994-12-01 | Hoechst Ag | Substituierte Bernsteinsäureimide |
| FR2708201B1 (fr) * | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
| FR2707637B1 (fr) * | 1993-06-30 | 1995-10-06 | Lafon Labor | Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique. |
| US5605914A (en) * | 1993-07-02 | 1997-02-25 | Celgene Corporation | Imides |
| US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| US5571825A (en) * | 1995-03-31 | 1996-11-05 | Warner-Lambert Company | Method of selectively inhibiting prostaglandin G/H synthase-2 |
| US5699182A (en) | 1995-05-25 | 1997-12-16 | Xytronyx, Inc. | Light fatigue resistant photochromic formulations |
| CA2227829A1 (en) * | 1995-07-31 | 1997-02-13 | Shionogi & Co., Ltd. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| WO1997032854A1 (en) | 1996-03-04 | 1997-09-12 | Dainippon Pharmaceutical Co., Ltd. | 2-sulfinylnicotinamide derivatives, intermediate thereof, process for producing 2-sulfinylnicotinamide derivatives, and medicinal composition containing the same as active ingredient |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| WO1998055153A1 (en) | 1997-06-04 | 1998-12-10 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| FR2771004B1 (fr) * | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| WO2001087930A2 (en) | 2000-05-18 | 2001-11-22 | Bayer Aktiengesellschaft | Human galanin receptor-like g protein coupled receptor |
| MXPA03011558A (es) | 2001-06-12 | 2004-03-26 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
| US7119214B2 (en) | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
-
2001
- 2001-10-26 US US10/014,645 patent/US6670358B2/en not_active Expired - Fee Related
-
2002
- 2002-10-25 AT AT02786511T patent/ATE430129T1/de not_active IP Right Cessation
- 2002-10-25 AR ARP020104045A patent/AR037019A1/es unknown
- 2002-10-25 HU HU0500831A patent/HUP0500831A3/hu unknown
- 2002-10-25 UA UA20040504017A patent/UA77706C2/uk unknown
- 2002-10-25 KR KR1020047006180A patent/KR100965640B1/ko not_active Expired - Fee Related
- 2002-10-25 NZ NZ532386A patent/NZ532386A/en not_active IP Right Cessation
- 2002-10-25 ES ES02786511T patent/ES2324024T3/es not_active Expired - Lifetime
- 2002-10-25 IL IL16101502A patent/IL161015A0/xx unknown
- 2002-10-25 EP EP02786511A patent/EP1438288B1/en not_active Expired - Lifetime
- 2002-10-25 CN CNA028212290A patent/CN1575279A/zh active Pending
- 2002-10-25 BR BR0213540-0A patent/BR0213540A/pt not_active Application Discontinuation
- 2002-10-25 DE DE60232166T patent/DE60232166D1/de not_active Expired - Lifetime
- 2002-10-25 PL PL02373900A patent/PL373900A1/xx not_active Application Discontinuation
- 2002-10-25 EA EA200400586A patent/EA007781B1/ru not_active IP Right Cessation
- 2002-10-25 MX MXPA04003796A patent/MXPA04003796A/es active IP Right Grant
- 2002-10-25 WO PCT/US2002/034188 patent/WO2003037853A1/en not_active Ceased
- 2002-10-25 CA CA002462206A patent/CA2462206A1/en not_active Abandoned
- 2002-10-25 AU AU2002349923A patent/AU2002349923B2/en not_active Ceased
- 2002-10-25 JP JP2003540136A patent/JP4351533B2/ja not_active Expired - Fee Related
-
2003
- 2003-11-18 US US10/716,238 patent/US6919367B2/en not_active Expired - Fee Related
-
2004
- 2004-03-22 IL IL161015A patent/IL161015A/en not_active IP Right Cessation
- 2004-04-22 ZA ZA200403097A patent/ZA200403097B/en unknown
- 2004-04-23 NO NO20041689A patent/NO329584B1/no not_active IP Right Cessation
-
2005
- 2005-04-28 US US11/116,755 patent/US7268132B2/en not_active Expired - Fee Related
-
2007
- 2007-07-03 US US11/825,079 patent/US20080027228A1/en not_active Abandoned
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