JP2004515458A5 - - Google Patents
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- JP2004515458A5 JP2004515458A5 JP2001584227A JP2001584227A JP2004515458A5 JP 2004515458 A5 JP2004515458 A5 JP 2004515458A5 JP 2001584227 A JP2001584227 A JP 2001584227A JP 2001584227 A JP2001584227 A JP 2001584227A JP 2004515458 A5 JP2004515458 A5 JP 2004515458A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- compound
- ring
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 37
- 125000000217 alkyl group Chemical group 0.000 description 25
- 125000000623 heterocyclic group Chemical group 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 125000004433 nitrogen atom Chemical group N* 0.000 description 14
- 229910052757 nitrogen Inorganic materials 0.000 description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 12
- 125000004432 carbon atom Chemical group C* 0.000 description 11
- 125000001072 heteroaryl group Chemical group 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 10
- -1 C6-CTenAryl Chemical group 0.000 description 9
- 229910052799 carbon Inorganic materials 0.000 description 9
- 229910052717 sulfur Inorganic materials 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 7
- 125000000304 alkynyl group Chemical group 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 6
- 239000011593 sulfur Chemical group 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 150000002148 esters Chemical group 0.000 description 4
- 125000001786 isothiazolyl group Chemical group 0.000 description 4
- 125000000842 isoxazolyl group Chemical group 0.000 description 4
- 150000002772 monosaccharides Chemical class 0.000 description 4
- 125000002971 oxazolyl group Chemical group 0.000 description 4
- 125000004076 pyridyl group Chemical group 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000000335 thiazolyl group Chemical group 0.000 description 4
- 125000002947 alkylene group Chemical group 0.000 description 3
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 3
- 235000008206 alpha-amino acids Nutrition 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 125000005549 heteroarylene group Chemical group 0.000 description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000005418 aryl aryl group Chemical group 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000002883 imidazolyl group Chemical group 0.000 description 2
- 125000004193 piperazinyl group Chemical group 0.000 description 2
- 125000003386 piperidinyl group Chemical group 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 description 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 description 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 0 CCCCN=C(N)N(C)* Chemical compound CCCCN=C(N)N(C)* 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 208000030814 Eating disease Diseases 0.000 description 1
- 208000019454 Feeding and Eating disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 1
- 125000000732 arylene group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000014632 disordered eating Nutrition 0.000 description 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000005564 oxazolylene group Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000005551 pyridylene group Chemical group 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000005557 thiazolylene group Chemical group 0.000 description 1
- 125000005556 thienylene group Chemical group 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20478900P | 2000-05-16 | 2000-05-16 | |
| US26828301P | 2001-02-13 | 2001-02-13 | |
| US09/855,228 US6492396B2 (en) | 2000-05-16 | 2001-05-15 | Substituted thioacetamides |
| PCT/US2001/015752 WO2001087830A2 (en) | 2000-05-16 | 2001-05-16 | Substituted thioacetamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004515458A JP2004515458A (ja) | 2004-05-27 |
| JP2004515458A5 true JP2004515458A5 (https=) | 2008-07-17 |
Family
ID=27394698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001584227A Pending JP2004515458A (ja) | 2000-05-16 | 2001-05-16 | 置換チオアセトアミド |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6492396B2 (https=) |
| EP (2) | EP2186803A3 (https=) |
| JP (1) | JP2004515458A (https=) |
| KR (2) | KR100839265B1 (https=) |
| CN (1) | CN1429210A (https=) |
| AR (1) | AR030061A1 (https=) |
| AT (1) | ATE493385T1 (https=) |
| AU (2) | AU2001263165B2 (https=) |
| BG (1) | BG66080B1 (https=) |
| BR (1) | BR0111358A (https=) |
| CA (1) | CA2409116A1 (https=) |
| CZ (1) | CZ20023753A3 (https=) |
| DE (1) | DE60143746D1 (https=) |
| EA (1) | EA006135B1 (https=) |
| HK (1) | HK1054544A1 (https=) |
| HU (1) | HUP0302297A3 (https=) |
| IL (1) | IL152811A0 (https=) |
| MX (1) | MXPA02011288A (https=) |
| NO (1) | NO329201B1 (https=) |
| NZ (1) | NZ522589A (https=) |
| PL (1) | PL207492B1 (https=) |
| SK (1) | SK16162002A3 (https=) |
| WO (1) | WO2001087830A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| US6670358B2 (en) * | 2000-05-16 | 2003-12-30 | Cephalon, Inc. | Substituted thioacetamides |
| US20080058424A1 (en) * | 2002-05-23 | 2008-03-06 | Cephalon, Inc. | Novel pharmaceutical formulations of modafinil |
| ATE357228T1 (de) * | 2001-05-25 | 2007-04-15 | Cephalon Inc | Feste pharmazeutische formulierung enthaltend modafinil |
| US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
| US6992219B2 (en) * | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| US20040116532A1 (en) * | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
| FR2849029B1 (fr) * | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| US7244865B2 (en) * | 2003-02-24 | 2007-07-17 | Mallinckrodt Inc. | Process for preparing benzhydrylthioacetamide |
| CA2519117C (en) * | 2003-03-17 | 2010-03-02 | Neurohealing Pharmaceuticals, Inc. | High potency dopaminergic treatment of neurological impairment associated with brain injury |
| US7943632B2 (en) * | 2003-03-17 | 2011-05-17 | Neurohealing Pharmaceuticals, Inc. | High potency dopaminergic treatment of neurological impairment associated with brain injury |
| US20050031688A1 (en) * | 2003-08-04 | 2005-02-10 | Ayala William J. | Positive wakeup pharmaceutical sleep system with compatible pre-bedtime administration |
| CN101972240B (zh) * | 2003-09-04 | 2012-07-25 | 赛福伦公司 | 莫达芬尼组合物 |
| AR046410A1 (es) | 2003-09-18 | 2005-12-07 | Cephalon Inc | Composiciones farmaceuticas para la liberacion modificada de modafinilo |
| US20050137264A1 (en) * | 2003-12-22 | 2005-06-23 | Patel Ashish A. | Modafinil compositions |
| US7297817B2 (en) * | 2004-04-13 | 2007-11-20 | Cephalon France | Thio-substituted arylmethanesulfinyl derivatives |
| EP1586559A1 (en) * | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Biaryl-methanethio-, -sulphinyl- and sulphonyl derivatives |
| US7314875B2 (en) * | 2004-04-13 | 2008-01-01 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| EP1586561A1 (en) * | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7423176B2 (en) * | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| EP1586560A1 (en) * | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Thio-substituted arylmethanesulfinyl derivatives |
| EP1589001A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon, Inc. | Tricyclic aromatic and bis-phenyl sulfinyl derivatives |
| US20050240166A1 (en) * | 2004-04-26 | 2005-10-27 | Microsolutions, Inc. | Implantable device, formulation and method for anti-psychotic therapy using risperidone |
| CA2632722A1 (en) * | 2005-12-09 | 2007-06-21 | Mallinckrodt Inc. | Processes for the preparation of modafinil and analogs thereof |
| CN101641090B (zh) * | 2006-12-19 | 2012-12-05 | 亚勒斯有限公司 | 莫达非尼在制备治疗多动腿综合征的药物中的应用 |
| CA2693594A1 (en) | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| CN108349920A (zh) | 2015-09-17 | 2018-07-31 | 微麦德斯公司 | 呋喃醛上的氧化化学 |
| CN107522693B (zh) * | 2017-08-15 | 2018-12-04 | 北京豪思生物科技有限公司 | 一种6-元芳香环或杂芳香环化合物及其制备方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US612379A (en) * | 1898-10-11 | Claffey and orie p | ||
| GB1520812A (en) | 1975-10-02 | 1978-08-09 | Lafon Labor | Benzhydrylsulphinyl derivatives |
| DE2708449C3 (de) * | 1977-02-26 | 1981-01-08 | Hoechst Ag, 6000 Frankfurt | Verfahren zum gleichmäßigen Färben von bahnförmigen Textilien aus modifizierten Polyesterfasern auf Baumfärbeapparaten |
| GB1584462A (en) | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
| FR2528041A1 (fr) | 1982-06-04 | 1983-12-09 | Lafon Labor | Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique |
| FR2528038B2 (fr) * | 1982-06-04 | 1985-08-09 | Lafon Labor | Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique |
| FR2593809B1 (fr) | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| US4965893A (en) * | 1986-03-24 | 1990-10-30 | Henkin Melvyn Lane | Hydrotherapy massage method and apparatus |
| US4964893A (en) | 1986-04-17 | 1990-10-23 | Monsanto Company | Benzhydryl compounds as herbicide antidotes |
| FR2601673B2 (fr) * | 1986-07-21 | 1989-06-02 | Lafon Labor | Derives de l'acetamide et medicaments qui en contiennent |
| DE3872937T2 (de) | 1987-05-11 | 1993-01-21 | Ono Pharmaceutical Co | Benzoylaminophenoxybuttersaeure-derivate. |
| US4935240A (en) | 1987-06-04 | 1990-06-19 | Ono Pharmaceutical Co., Ltd. | Benzoylaminophenoxybutanoic acid derivatives |
| US5204358A (en) | 1987-11-25 | 1993-04-20 | Merck Frosst Canada, Inc. | Hetaryl styryl quinolines as leukotriene inhibitors |
| NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
| FR2663225B1 (fr) | 1990-06-14 | 1994-11-04 | Lafon Labor | Nouvelle utilisation du modafinil. |
| ES2036926B1 (es) | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
| US5563169A (en) | 1991-09-13 | 1996-10-08 | Sankyo Company, Limited | Tricyclic heterocyclic compound |
| FR2684875B1 (fr) | 1991-12-13 | 1995-05-24 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique. |
| FR2697162B1 (fr) | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
| FR2706767B1 (https=) | 1993-06-22 | 1995-09-08 | Lafon Labor | |
| FR2708201B1 (fr) | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
| FR2707637B1 (fr) | 1993-06-30 | 1995-10-06 | Lafon Labor | Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique. |
| US5618845A (en) | 1994-10-06 | 1997-04-08 | Cephalon, Inc. | Acetamide derivative having defined particle size |
| US5571825A (en) | 1995-03-31 | 1996-11-05 | Warner-Lambert Company | Method of selectively inhibiting prostaglandin G/H synthase-2 |
| CA2227829A1 (en) | 1995-07-31 | 1997-02-13 | Shionogi & Co., Ltd. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| WO1997032854A1 (en) | 1996-03-04 | 1997-09-12 | Dainippon Pharmaceutical Co., Ltd. | 2-sulfinylnicotinamide derivatives, intermediate thereof, process for producing 2-sulfinylnicotinamide derivatives, and medicinal composition containing the same as active ingredient |
| FR2771004B1 (fr) | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| US6492396B2 (en) * | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
| US6670358B2 (en) * | 2000-05-16 | 2003-12-30 | Cephalon, Inc. | Substituted thioacetamides |
-
2001
- 2001-05-15 US US09/855,228 patent/US6492396B2/en not_active Ceased
- 2001-05-16 EP EP10002284A patent/EP2186803A3/en not_active Withdrawn
- 2001-05-16 PL PL365181A patent/PL207492B1/pl not_active IP Right Cessation
- 2001-05-16 CZ CZ20023753A patent/CZ20023753A3/cs unknown
- 2001-05-16 AU AU2001263165A patent/AU2001263165B2/en not_active Ceased
- 2001-05-16 DE DE60143746T patent/DE60143746D1/de not_active Expired - Lifetime
- 2001-05-16 HU HU0302297A patent/HUP0302297A3/hu unknown
- 2001-05-16 IL IL15281101A patent/IL152811A0/xx unknown
- 2001-05-16 EP EP01937424A patent/EP1292573B1/en not_active Expired - Lifetime
- 2001-05-16 SK SK1616-2002A patent/SK16162002A3/sk not_active Application Discontinuation
- 2001-05-16 AT AT01937424T patent/ATE493385T1/de not_active IP Right Cessation
- 2001-05-16 BR BR0111358-5A patent/BR0111358A/pt not_active Application Discontinuation
- 2001-05-16 WO PCT/US2001/015752 patent/WO2001087830A2/en not_active Ceased
- 2001-05-16 JP JP2001584227A patent/JP2004515458A/ja active Pending
- 2001-05-16 EA EA200201214A patent/EA006135B1/ru not_active IP Right Cessation
- 2001-05-16 MX MXPA02011288A patent/MXPA02011288A/es active IP Right Grant
- 2001-05-16 AU AU6316501A patent/AU6316501A/xx active Pending
- 2001-05-16 KR KR1020027015408A patent/KR100839265B1/ko not_active Expired - Fee Related
- 2001-05-16 CA CA002409116A patent/CA2409116A1/en not_active Abandoned
- 2001-05-16 NZ NZ522589A patent/NZ522589A/en unknown
- 2001-05-16 CN CN01809625A patent/CN1429210A/zh active Pending
- 2001-05-16 HK HK03106713.0A patent/HK1054544A1/zh unknown
- 2001-05-16 KR KR1020077014424A patent/KR100836300B1/ko not_active Expired - Fee Related
- 2001-05-17 AR ARP010102335A patent/AR030061A1/es not_active Application Discontinuation
-
2002
- 2002-11-15 NO NO20025508A patent/NO329201B1/no not_active IP Right Cessation
- 2002-12-10 BG BG107367A patent/BG66080B1/bg unknown
-
2004
- 2004-11-23 US US10/996,325 patent/USRE39575E1/en not_active Expired - Fee Related
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