JP2003506388A5 - - Google Patents
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- JP2003506388A5 JP2003506388A5 JP2001514906A JP2001514906A JP2003506388A5 JP 2003506388 A5 JP2003506388 A5 JP 2003506388A5 JP 2001514906 A JP2001514906 A JP 2001514906A JP 2001514906 A JP2001514906 A JP 2001514906A JP 2003506388 A5 JP2003506388 A5 JP 2003506388A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pharmaceutical composition
- alkyl
- aryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 description 94
- 238000000034 method Methods 0.000 description 57
- 150000001875 compounds Chemical class 0.000 description 52
- 125000001072 heteroaryl group Chemical group 0.000 description 48
- 125000003107 substituted aryl group Chemical group 0.000 description 32
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 28
- 125000000217 alkyl group Chemical group 0.000 description 24
- 125000003118 aryl group Chemical group 0.000 description 24
- 229910052739 hydrogen Inorganic materials 0.000 description 18
- 239000001257 hydrogen Substances 0.000 description 16
- 108091006146 Channels Proteins 0.000 description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- -1 2-indolyl Chemical group 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 10
- 125000005842 heteroatom Chemical group 0.000 description 10
- 102000012359 KCNQ Potassium Channels Human genes 0.000 description 8
- 108010022282 KCNQ Potassium Channels Proteins 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 102000004257 Potassium Channel Human genes 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 125000004093 cyano group Chemical group *C#N 0.000 description 6
- 229910052731 fluorine Inorganic materials 0.000 description 6
- 230000004907 flux Effects 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical group 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 108020001213 potassium channel Proteins 0.000 description 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 4
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 description 4
- 102100034354 Potassium voltage-gated channel subfamily KQT member 2 Human genes 0.000 description 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 125000002541 furyl group Chemical group 0.000 description 4
- 125000004404 heteroalkyl group Chemical group 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 4
- 125000001041 indolyl group Chemical group 0.000 description 4
- 125000001786 isothiazolyl group Chemical group 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000004076 pyridyl group Chemical group 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000001544 thienyl group Chemical group 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 108010038888 KCNQ3 Potassium Channel Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102100034360 Potassium voltage-gated channel subfamily KQT member 3 Human genes 0.000 description 2
- 208000013200 Stress disease Diseases 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000011688 Generalised anxiety disease Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 206010065433 Ligament rupture Diseases 0.000 description 1
- 206010028331 Muscle rupture Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000010362 Protozoan Infections Diseases 0.000 description 1
- 206010043248 Tendon rupture Diseases 0.000 description 1
- 208000031674 Traumatic Acute Stress disease Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 208000026345 acute stress disease Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 208000029364 generalized anxiety disease Diseases 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 208000028173 post-traumatic stress disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14722199P | 1999-08-04 | 1999-08-04 | |
| US60/147,221 | 1999-08-04 | ||
| US15871299P | 1999-10-08 | 1999-10-08 | |
| US60/158,712 | 1999-10-08 | ||
| US16584799P | 1999-11-16 | 1999-11-16 | |
| US60/165,847 | 1999-11-16 | ||
| PCT/US2000/021309 WO2001010381A2 (en) | 1999-08-04 | 2000-08-04 | Methods for treating or preventing pain and anxiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003506388A JP2003506388A (ja) | 2003-02-18 |
| JP2003506388A5 true JP2003506388A5 (https=) | 2006-01-05 |
Family
ID=27386536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001514906A Pending JP2003506388A (ja) | 1999-08-04 | 2000-08-04 | 疼痛および不安症を処置または予防するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6326385B1 (https=) |
| EP (1) | EP1200086A4 (https=) |
| JP (1) | JP2003506388A (https=) |
| AU (1) | AU772075B2 (https=) |
| BR (1) | BR0012934A (https=) |
| CA (1) | CA2378243C (https=) |
| NZ (2) | NZ527771A (https=) |
| WO (1) | WO2001010381A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60022333T2 (de) * | 1999-04-09 | 2006-07-06 | Euro-Celtique S.A. | Natrium kanalblocker zusammensetzungen und deren verwendung |
| NZ527771A (en) * | 1999-08-04 | 2005-04-29 | Icagen Inc | Methods for treating or preventing anxiety |
| US20030181507A1 (en) * | 2000-06-29 | 2003-09-25 | Jensen Bo Skaaning | Use of 3-substituted oxindole derivatives as kcnq potassium channel modulators |
| US6589986B2 (en) | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
| US20020183335A1 (en) * | 2001-02-20 | 2002-12-05 | Piyasena Hewawasam | 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators |
| CA2438868A1 (en) * | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| JP2004535413A (ja) | 2001-05-31 | 2004-11-25 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャンネルモジュレーターとしてのシンナミド誘導体 |
| IL160523A0 (en) | 2001-09-03 | 2004-07-25 | Newron Pharm Spa | PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE |
| US7205307B2 (en) * | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
| AU2003259846A1 (en) * | 2002-08-16 | 2004-03-03 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| US7632866B2 (en) * | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| AU2003294442A1 (en) | 2002-11-22 | 2004-06-18 | Bristol-Myers Squibb Company | 3-heterocyclic benzylamide derivatives as potassium channel openers |
| AU2003295782A1 (en) | 2002-11-22 | 2004-06-18 | Bristol-Myers Squibb Company | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers |
| EP1581510A4 (en) | 2002-11-22 | 2006-08-30 | Bristol Myers Squibb Co | 1-ARYL-2-HYDROXYETHYLAMIDEALS CALIUM CHANNEL OPENER |
| US7087609B2 (en) | 2002-11-22 | 2006-08-08 | Bristol-Myers Squibb Company | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers |
| EP1565190A4 (en) * | 2002-11-22 | 2006-04-26 | Bristol Myers Squibb Co | ARYLCYCLOPROPYLCARBOXYLIC ACID AMIDE AS A KALIUM CHANNEL OPENER |
| WO2004056774A2 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| US20050009733A1 (en) * | 2003-04-22 | 2005-01-13 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage |
| US20040229803A1 (en) * | 2003-04-22 | 2004-11-18 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of pain, inflammation or inflammation mediated disorders |
| ITMI20031467A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco attivo nel dolore neuropatico |
| EP1664041B1 (en) * | 2003-09-22 | 2008-07-02 | Euro-Celtique S.A. | Phenyl-carboxamide compounds useful for treating pain |
| BRPI0415179A (pt) | 2003-10-07 | 2006-11-28 | Renovis Inc | derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas |
| US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| JP2007526332A (ja) * | 2004-03-02 | 2007-09-13 | ニューロジェン・コーポレーション | ヘテロアルキル置換ビフェニル−４−カルボン酸アリールアミド類縁体 |
| TWI357901B (en) * | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| ATE471147T1 (de) * | 2004-09-10 | 2010-07-15 | Newron Pharm Spa | Verwendung von (r)-(halogenbenzyloxy)-benzylamino-propanamiden als natrium- und/oder calciumkanal- selektive modulatoren |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| EP1963280B1 (en) * | 2005-12-22 | 2015-10-28 | Newron Pharmaceuticals S.p.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
| WO2007087424A2 (en) * | 2006-01-25 | 2007-08-02 | The Johns Hopkins University | Method of treating kcnq related disorders using organozinc compounds |
| CN102633783A (zh) * | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| CA2670966A1 (en) * | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| JP2010520875A (ja) | 2007-03-09 | 2010-06-17 | レノビス， インコーポレイテッド | Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用 |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| US20100323015A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| US20100120906A1 (en) * | 2008-07-18 | 2010-05-13 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| SI2609086T1 (sl) | 2010-08-27 | 2015-04-30 | Gruenenthal Gmbh | Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji |
| DK2609083T3 (da) | 2010-08-27 | 2015-03-30 | Gruenenthal Gmbh | Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer |
| TW201211007A (en) | 2010-08-27 | 2012-03-16 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US9458464B2 (en) | 2014-06-23 | 2016-10-04 | The Johns Hopkins University | Treatment of neuropathic pain |
| WO2018204765A1 (en) * | 2017-05-05 | 2018-11-08 | Pairnomix, Llc | Methods of treating epilepsy and kcnq2 related conditions |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| WO2021092439A1 (en) | 2019-11-08 | 2021-05-14 | Xenon Pharmaceuticals Inc. | Methods of treating depressive disorders |
| IL304920A (en) | 2021-02-09 | 2023-10-01 | Xenon Pharmaceuticals Inc | A voltage-gated potassium channel opener for use in the treatment of anhedonia |
| KR102863193B1 (ko) * | 2023-03-13 | 2025-09-22 | 대구가톨릭대학교산학협력단 | 리도카인 유도체를 유효성분으로 포함하는 항염증용 조성물 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845107A (en) * | 1987-10-29 | 1989-07-04 | Ici Americas Inc. | Fungicidal N-pyridyl haloamides |
| US4931430A (en) * | 1987-12-14 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Method for preventing or treating anxiety employing an ACE inhibitor |
| US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
| US5114947A (en) * | 1990-12-27 | 1992-05-19 | Erbamont Inc. | Method for alleviating anxiety using benzobicyclic carboxamides |
| GB9212693D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| EP1195372A1 (en) * | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
| RO115522B1 (ro) * | 1995-02-02 | 2000-03-30 | Smithkline Beecham P.L.C. | Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament |
| JP4058129B2 (ja) * | 1996-03-18 | 2008-03-05 | 株式会社資生堂 | ピリジン誘導体及び抗潰瘍剤、抗菌剤 |
| WO1998037068A1 (en) | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
| ID23053A (id) * | 1997-06-04 | 2000-01-20 | Lilly Co Eli | Karboksamida yang digunakan sebagai agonis 5-ht <if> |
| JP2001512673A (ja) | 1997-08-12 | 2001-08-28 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャンネルおよびそれの活性調節方法 |
| US6413719B1 (en) * | 1997-10-24 | 2002-07-02 | University Of Utah Research Foundation | KCNQ2 and KCNQ3-potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies |
| GB9726339D0 (en) | 1997-12-13 | 1998-02-11 | Zeneca Ltd | Human-derived tissue-specific potassium channel |
| NZ516610A (en) * | 1999-08-04 | 2004-05-28 | Icagen Inc | Benzanilides as potassium channel openers |
| US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| NZ527771A (en) * | 1999-08-04 | 2005-04-29 | Icagen Inc | Methods for treating or preventing anxiety |
| US6593349B2 (en) * | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
-
2000
- 2000-08-04 NZ NZ527771A patent/NZ527771A/en not_active IP Right Cessation
- 2000-08-04 AU AU67586/00A patent/AU772075B2/en not_active Ceased
- 2000-08-04 EP EP00955368A patent/EP1200086A4/en not_active Withdrawn
- 2000-08-04 WO PCT/US2000/021309 patent/WO2001010381A2/en not_active Ceased
- 2000-08-04 CA CA2378243A patent/CA2378243C/en not_active Expired - Fee Related
- 2000-08-04 JP JP2001514906A patent/JP2003506388A/ja active Pending
- 2000-08-04 US US09/631,747 patent/US6326385B1/en not_active Expired - Lifetime
- 2000-08-04 BR BR0012934-8A patent/BR0012934A/pt not_active Application Discontinuation
- 2000-08-04 NZ NZ516743A patent/NZ516743A/en not_active IP Right Cessation
-
2001
- 2001-08-24 US US09/939,230 patent/US20020013349A1/en not_active Abandoned
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