CA2378243C - Methods for treating or preventing pain and anxiety - Google Patents
Methods for treating or preventing pain and anxiety Download PDFInfo
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- CA2378243C CA2378243C CA2378243A CA2378243A CA2378243C CA 2378243 C CA2378243 C CA 2378243C CA 2378243 A CA2378243 A CA 2378243A CA 2378243 A CA2378243 A CA 2378243A CA 2378243 C CA2378243 C CA 2378243C
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14722199P | 1999-08-04 | 1999-08-04 | |
| US60/147,221 | 1999-08-04 | ||
| US15871299P | 1999-10-08 | 1999-10-08 | |
| US60/158,712 | 1999-10-08 | ||
| US16584799P | 1999-11-16 | 1999-11-16 | |
| US60/165,847 | 1999-11-16 | ||
| PCT/US2000/021309 WO2001010381A2 (en) | 1999-08-04 | 2000-08-04 | Methods for treating or preventing pain and anxiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2378243A1 CA2378243A1 (en) | 2001-02-15 |
| CA2378243C true CA2378243C (en) | 2012-05-15 |
Family
ID=27386536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2378243A Expired - Fee Related CA2378243C (en) | 1999-08-04 | 2000-08-04 | Methods for treating or preventing pain and anxiety |
Country Status (8)
| Country | Link |
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| US (2) | US6326385B1 (https=) |
| EP (1) | EP1200086A4 (https=) |
| JP (1) | JP2003506388A (https=) |
| AU (1) | AU772075B2 (https=) |
| BR (1) | BR0012934A (https=) |
| CA (1) | CA2378243C (https=) |
| NZ (2) | NZ527771A (https=) |
| WO (1) | WO2001010381A2 (https=) |
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| CA2438868A1 (en) * | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
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| EP1581510A4 (en) | 2002-11-22 | 2006-08-30 | Bristol Myers Squibb Co | 1-ARYL-2-HYDROXYETHYLAMIDEALS CALIUM CHANNEL OPENER |
| US7087609B2 (en) | 2002-11-22 | 2006-08-08 | Bristol-Myers Squibb Company | 3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers |
| EP1565190A4 (en) * | 2002-11-22 | 2006-04-26 | Bristol Myers Squibb Co | ARYLCYCLOPROPYLCARBOXYLIC ACID AMIDE AS A KALIUM CHANNEL OPENER |
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| JP2007526332A (ja) * | 2004-03-02 | 2007-09-13 | ニューロジェン・コーポレーション | ヘテロアルキル置換ビフェニル−４−カルボン酸アリールアミド類縁体 |
| TWI357901B (en) * | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
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| EP1963280B1 (en) * | 2005-12-22 | 2015-10-28 | Newron Pharmaceuticals S.p.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
| WO2007087424A2 (en) * | 2006-01-25 | 2007-08-02 | The Johns Hopkins University | Method of treating kcnq related disorders using organozinc compounds |
| CN102633783A (zh) * | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| CA2670966A1 (en) * | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| JP2010520875A (ja) | 2007-03-09 | 2010-06-17 | レノビス， インコーポレイテッド | Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用 |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| US20100323015A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| US20100120906A1 (en) * | 2008-07-18 | 2010-05-13 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| SI2609086T1 (sl) | 2010-08-27 | 2015-04-30 | Gruenenthal Gmbh | Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji |
| DK2609083T3 (da) | 2010-08-27 | 2015-03-30 | Gruenenthal Gmbh | Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer |
| TW201211007A (en) | 2010-08-27 | 2012-03-16 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
| MX2013002295A (es) | 2010-09-01 | 2013-05-09 | Gruenenthal Gmbh | 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US9458464B2 (en) | 2014-06-23 | 2016-10-04 | The Johns Hopkins University | Treatment of neuropathic pain |
| WO2018204765A1 (en) * | 2017-05-05 | 2018-11-08 | Pairnomix, Llc | Methods of treating epilepsy and kcnq2 related conditions |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| WO2021092439A1 (en) | 2019-11-08 | 2021-05-14 | Xenon Pharmaceuticals Inc. | Methods of treating depressive disorders |
| IL304920A (en) | 2021-02-09 | 2023-10-01 | Xenon Pharmaceuticals Inc | A voltage-gated potassium channel opener for use in the treatment of anhedonia |
| KR102863193B1 (ko) * | 2023-03-13 | 2025-09-22 | 대구가톨릭대학교산학협력단 | 리도카인 유도체를 유효성분으로 포함하는 항염증용 조성물 |
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| US5114947A (en) * | 1990-12-27 | 1992-05-19 | Erbamont Inc. | Method for alleviating anxiety using benzobicyclic carboxamides |
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| WO1998037068A1 (en) | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
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| US6413719B1 (en) * | 1997-10-24 | 2002-07-02 | University Of Utah Research Foundation | KCNQ2 and KCNQ3-potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies |
| GB9726339D0 (en) | 1997-12-13 | 1998-02-11 | Zeneca Ltd | Human-derived tissue-specific potassium channel |
| NZ516610A (en) * | 1999-08-04 | 2004-05-28 | Icagen Inc | Benzanilides as potassium channel openers |
| US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| NZ527771A (en) * | 1999-08-04 | 2005-04-29 | Icagen Inc | Methods for treating or preventing anxiety |
| US6593349B2 (en) * | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
-
2000
- 2000-08-04 NZ NZ527771A patent/NZ527771A/en not_active IP Right Cessation
- 2000-08-04 AU AU67586/00A patent/AU772075B2/en not_active Ceased
- 2000-08-04 EP EP00955368A patent/EP1200086A4/en not_active Withdrawn
- 2000-08-04 WO PCT/US2000/021309 patent/WO2001010381A2/en not_active Ceased
- 2000-08-04 CA CA2378243A patent/CA2378243C/en not_active Expired - Fee Related
- 2000-08-04 JP JP2001514906A patent/JP2003506388A/ja active Pending
- 2000-08-04 US US09/631,747 patent/US6326385B1/en not_active Expired - Lifetime
- 2000-08-04 BR BR0012934-8A patent/BR0012934A/pt not_active Application Discontinuation
- 2000-08-04 NZ NZ516743A patent/NZ516743A/en not_active IP Right Cessation
-
2001
- 2001-08-24 US US09/939,230 patent/US20020013349A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU6758600A (en) | 2001-03-05 |
| EP1200086A2 (en) | 2002-05-02 |
| NZ516743A (en) | 2004-02-27 |
| JP2003506388A (ja) | 2003-02-18 |
| WO2001010381A3 (en) | 2001-08-16 |
| US20020013349A1 (en) | 2002-01-31 |
| NZ527771A (en) | 2005-04-29 |
| WO2001010381A2 (en) | 2001-02-15 |
| US6326385B1 (en) | 2001-12-04 |
| BR0012934A (pt) | 2003-07-29 |
| AU772075B2 (en) | 2004-04-08 |
| CA2378243A1 (en) | 2001-02-15 |
| EP1200086A4 (en) | 2009-05-27 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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