JP2002514598A5 - - Google Patents
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- JP2002514598A5 JP2002514598A5 JP2000547978A JP2000547978A JP2002514598A5 JP 2002514598 A5 JP2002514598 A5 JP 2002514598A5 JP 2000547978 A JP2000547978 A JP 2000547978A JP 2000547978 A JP2000547978 A JP 2000547978A JP 2002514598 A5 JP2002514598 A5 JP 2002514598A5
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- JP
- Japan
- Prior art keywords
- independently
- compound according
- linear
- bond
- branched alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 18
- 125000003342 alkenyl group Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 8
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 125000001475 halogen functional group Chemical group 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- -1 carboxylamino Chemical group 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 125000003435 aroyl group Chemical group 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000004442 acylamino group Chemical group 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/074,925 | 1998-05-08 | ||
| US09/074,925 US6245814B1 (en) | 1998-05-08 | 1998-05-08 | Diphenylethylene compounds |
| US09/287,237 | 1999-04-06 | ||
| US09/287,237 US6331633B1 (en) | 1998-05-08 | 1999-04-06 | Heterocyclic analogs of diphenylethylene compounds |
| PCT/US1999/009982 WO1999058127A1 (en) | 1998-05-08 | 1999-05-07 | Novel heterocyclic analogs of diphenylethylene compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002514598A JP2002514598A (ja) | 2002-05-21 |
| JP2002514598A5 true JP2002514598A5 (https=) | 2006-06-29 |
| JP4577985B2 JP4577985B2 (ja) | 2010-11-10 |
Family
ID=26756222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547978A Expired - Fee Related JP4577985B2 (ja) | 1998-05-08 | 1999-05-07 | ジフェニルエチレン化合物の新規な複素環類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6331633B1 (https=) |
| EP (1) | EP1007039B1 (https=) |
| JP (1) | JP4577985B2 (https=) |
| KR (1) | KR100595919B1 (https=) |
| CN (1) | CN1151139C (https=) |
| AT (1) | ATE260906T1 (https=) |
| AU (1) | AU751235C (https=) |
| CA (1) | CA2295599C (https=) |
| DE (1) | DE69915223T2 (https=) |
| DK (1) | DK1007039T3 (https=) |
| ES (1) | ES2216513T3 (https=) |
| PT (1) | PT1007039E (https=) |
| WO (1) | WO1999058127A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041941B2 (en) | 1997-04-07 | 2006-05-09 | Patented Medical Solutions, Llc | Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| JP2003508391A (ja) | 1999-08-31 | 2003-03-04 | マキシア・ファーマシューティカルズ・インコーポレイテッド | ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用 |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| EP1743655B1 (en) | 2000-01-21 | 2014-06-25 | Novartis AG | Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| AU2002252227A1 (en) | 2001-03-07 | 2002-09-24 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
| JP2004523571A (ja) | 2001-03-08 | 2004-08-05 | マキシア・ファーマシューティカルズ・インコーポレイテッド | Ｒｘｒ活性化分子 |
| JP4425628B2 (ja) | 2001-07-23 | 2010-03-03 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法 |
| KR100468429B1 (ko) * | 2001-09-07 | 2005-01-27 | 주식회사 엔바이오테크놀러지 | 알파-글루코시다제 저해활성이 있는 소나무 추출물 및 그추출방법 |
| JP2005513026A (ja) | 2001-11-15 | 2005-05-12 | インサイト サン ディエゴ インコーポレイテッド | 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 |
| US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7041693B2 (en) | 2002-10-04 | 2006-05-09 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| JP2007530417A (ja) | 2003-07-01 | 2007-11-01 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 細胞及び生物の寿命及びストレス応答を操作するための組成物 |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US20050171027A1 (en) | 2003-12-29 | 2005-08-04 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| JP2008528510A (ja) * | 2005-01-20 | 2008-07-31 | サートリス ファーマシューティカルズ， インコーポレイテッド | 紅潮および／または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用 |
| US20080267888A1 (en) * | 2005-05-26 | 2008-10-30 | Pandey Surendrakumar Satyanara | Heterocyclic Derivatives |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| US20090131420A1 (en) * | 2005-10-07 | 2009-05-21 | Pandey Surendrakumar S | Novel Heterocyclic Analogs of Biphenyl Ethers |
| KR101016875B1 (ko) * | 2006-06-23 | 2011-02-22 | 현대중공업 주식회사 | 밀폐형 방청유 도포장치 |
| CN112209896B (zh) * | 2019-07-10 | 2023-05-16 | 苏州泽璟生物制药股份有限公司 | 噻唑烷二酮衍生物以及包含其的药物组合物 |
| WO2022045836A1 (ko) * | 2020-08-28 | 2022-03-03 | (주)셀로스바이오텍 | 신규 티오히단토인 유도체 및 이의 용도 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683009A (en) | 1968-10-10 | 1972-08-08 | Du Pont | {60 , {62 -bis(trifluoromethyl) stilbenes |
| US3609183A (en) | 1969-01-08 | 1971-09-28 | Parke Davis & Co | {60 -{8 {11 -(dimethylaminoalkyl)phenyl{9 -4-methoxy-{60 {40 -nitrostilbene compounds |
| US4312855A (en) | 1970-11-16 | 1982-01-26 | Colgate-Palmolive Company | Compositions containing aminopolyureylene resin |
| US4326055A (en) | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| JPS6045632B2 (ja) | 1978-03-09 | 1985-10-11 | 三菱化学株式会社 | ω−アミノアルコキシスチルベン類及びその酸付加塩 |
| US4284637A (en) | 1978-03-09 | 1981-08-18 | Mitsubishi Chemical Ind., Limited | Pharmaceutically active 2-(4-aminobutoxy)stilbenes |
| DE2832213A1 (de) | 1978-07-21 | 1980-01-31 | Bayer Ag | Stilbenderivate, verfahren zu ihrer herstellung und ihre verwendung als insektizide |
| JPS5629548A (en) | 1979-08-16 | 1981-03-24 | Mitsubishi Chem Ind Ltd | Omega-aminoalkoxystilbenes and their acid addition salts |
| FR2562539B1 (fr) | 1984-04-06 | 1987-04-17 | Chauvin Blache Lab | Nouveaux derives de l'acide vinyl-4 benzoique, leur procede de preparation et leurs applications en therapeutique et comme ligands |
| US4716905A (en) | 1985-09-25 | 1988-01-05 | Fluorochrome, Inc. | Method of retrograde fluorescent labeling of neurons |
| CA1338645C (en) | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
| GB8716650D0 (en) | 1987-07-15 | 1987-08-19 | Ici Plc | Use of olefinic compounds |
| CA1340955C (en) | 1988-02-24 | 2000-04-11 | Michael Klaus | Stilbene derivatives |
| US5250562A (en) | 1988-02-24 | 1993-10-05 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| DE3926148A1 (de) | 1989-08-08 | 1991-02-28 | Basf Ag | Diarylacetylene, ihre herstellung und verwendung |
| US5189056A (en) | 1989-12-19 | 1993-02-23 | University Of North Carolina At Chapel Hill | Protection of moist stratified squamous epithelia against damage from noxious luminal agents |
| US5162337A (en) | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
| EP0498095B1 (en) | 1991-02-05 | 1995-01-04 | Merrell Dow Pharmaceuticals Inc. | Sulfonic stilbene derivatives in the treatment of viral diseases |
| CH683151A5 (de) | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| US5171753A (en) | 1991-05-15 | 1992-12-15 | A. H. Robins Company, Incorporated | Derivatives of 2-amino-1-phenylethanol having antiulcer activity |
| EP1067134B1 (en) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| US5246936A (en) | 1991-12-20 | 1993-09-21 | American Cyanamid Company | Methods and compositions containing pesticides and stilbene compounds for enhanced pesticidal activity |
| NO302471B1 (no) * | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
| US5314693A (en) | 1992-02-07 | 1994-05-24 | Kioritz Corporation | Pest control chemicals against pine wood nematodes |
| US5430062A (en) | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| AU669279B2 (en) | 1993-03-10 | 1996-05-30 | Morinaga Milk Industry Company Limited | Stilbene derivative and stilbene analog derivative, and use thereof |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5731353A (en) | 1993-09-08 | 1998-03-24 | Ajinomoto Co., Inc. | Stilbene derivatives and pharmaceutical compositions containing them |
| IT1264988B1 (it) | 1993-12-14 | 1996-10-17 | Sigma Prod Chim | Composizioni cosmetiche e dermatologiche per la protezione da radiazioni uv contenenti derivati dallo stilbene |
| TW308598B (https=) | 1994-01-14 | 1997-06-21 | Hoffmann La Roche | |
| JPH08143566A (ja) * | 1994-11-25 | 1996-06-04 | Terumo Corp | キナゾリン誘導体及びそれを含有する医薬組成物 |
| US5559151A (en) | 1994-11-30 | 1996-09-24 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers |
| TW334418B (en) | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| CA2174582A1 (en) | 1995-05-05 | 1996-11-06 | Alexander Chucholowski | Sulphuric acid esters of amino-sugars |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5770620A (en) | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
| US5733909A (en) | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
| US5827898A (en) | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
-
1999
- 1999-04-06 US US09/287,237 patent/US6331633B1/en not_active Expired - Fee Related
- 1999-05-07 PT PT99922836T patent/PT1007039E/pt unknown
- 1999-05-07 CA CA002295599A patent/CA2295599C/en not_active Expired - Fee Related
- 1999-05-07 KR KR1020007000173A patent/KR100595919B1/ko not_active Expired - Fee Related
- 1999-05-07 AT AT99922836T patent/ATE260906T1/de active
- 1999-05-07 CN CNB998010170A patent/CN1151139C/zh not_active Expired - Fee Related
- 1999-05-07 EP EP99922836A patent/EP1007039B1/en not_active Expired - Lifetime
- 1999-05-07 DK DK99922836T patent/DK1007039T3/da active
- 1999-05-07 ES ES99922836T patent/ES2216513T3/es not_active Expired - Lifetime
- 1999-05-07 JP JP2000547978A patent/JP4577985B2/ja not_active Expired - Fee Related
- 1999-05-07 DE DE69915223T patent/DE69915223T2/de not_active Expired - Lifetime
- 1999-05-07 WO PCT/US1999/009982 patent/WO1999058127A1/en not_active Ceased
- 1999-05-07 AU AU39741/99A patent/AU751235C/en not_active Ceased
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