AU751235C - Novel heterocyclic analogs of diphenylethylene compounds - Google Patents

Novel heterocyclic analogs of diphenylethylene compounds

Info

Publication number
AU751235C
AU751235C AU39741/99A AU3974199A AU751235C AU 751235 C AU751235 C AU 751235C AU 39741/99 A AU39741/99 A AU 39741/99A AU 3974199 A AU3974199 A AU 3974199A AU 751235 C AU751235 C AU 751235C
Authority
AU
Australia
Prior art keywords
linear
independently
compound
halo
branched alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU39741/99A
Other languages
English (en)
Other versions
AU3974199A (en
AU751235B2 (en
Inventor
Debendranath Dey
Satyanarayana Medicherla
Bishwajit Nag
Partha Neogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theracos Inc
Original Assignee
Calyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/074,925 external-priority patent/US6245814B1/en
Application filed by Calyx Therapeutics Inc filed Critical Calyx Therapeutics Inc
Publication of AU3974199A publication Critical patent/AU3974199A/en
Application granted granted Critical
Publication of AU751235B2 publication Critical patent/AU751235B2/en
Publication of AU751235C publication Critical patent/AU751235C/en
Assigned to THERACOS, INC. reassignment THERACOS, INC. Alteration of Name(s) in Register under S187 Assignors: CALYX THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU39741/99A 1998-05-08 1999-05-07 Novel heterocyclic analogs of diphenylethylene compounds Ceased AU751235C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/074,925 US6245814B1 (en) 1998-05-08 1998-05-08 Diphenylethylene compounds
US09/074925 1998-05-08
US09/287237 1999-04-06
US09/287,237 US6331633B1 (en) 1998-05-08 1999-04-06 Heterocyclic analogs of diphenylethylene compounds
PCT/US1999/009982 WO1999058127A1 (en) 1998-05-08 1999-05-07 Novel heterocyclic analogs of diphenylethylene compounds

Publications (3)

Publication Number Publication Date
AU3974199A AU3974199A (en) 1999-11-29
AU751235B2 AU751235B2 (en) 2002-08-08
AU751235C true AU751235C (en) 2004-06-24

Family

ID=26756222

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39741/99A Ceased AU751235C (en) 1998-05-08 1999-05-07 Novel heterocyclic analogs of diphenylethylene compounds

Country Status (13)

Country Link
US (1) US6331633B1 (https=)
EP (1) EP1007039B1 (https=)
JP (1) JP4577985B2 (https=)
KR (1) KR100595919B1 (https=)
CN (1) CN1151139C (https=)
AT (1) ATE260906T1 (https=)
AU (1) AU751235C (https=)
CA (1) CA2295599C (https=)
DE (1) DE69915223T2 (https=)
DK (1) DK1007039T3 (https=)
ES (1) ES2216513T3 (https=)
PT (1) PT1007039E (https=)
WO (1) WO1999058127A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041941B2 (en) 1997-04-07 2006-05-09 Patented Medical Solutions, Llc Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
JP2003508391A (ja) 1999-08-31 2003-03-04 マキシア・ファーマシューティカルズ・インコーポレイテッド ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
EP1743655B1 (en) 2000-01-21 2014-06-25 Novartis AG Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
AU2002252227A1 (en) 2001-03-07 2002-09-24 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
JP2004523571A (ja) 2001-03-08 2004-08-05 マキシア・ファーマシューティカルズ・インコーポレイテッド Ｒｘｒ活性化分子
JP4425628B2 (ja) 2001-07-23 2010-03-03 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法
KR100468429B1 (ko) * 2001-09-07 2005-01-27 주식회사 엔바이오테크놀러지 알파-글루코시다제 저해활성이 있는 소나무 추출물 및 그추출방법
JP2005513026A (ja) 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US7041693B2 (en) 2002-10-04 2006-05-09 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
JP2007530417A (ja) 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
US7087576B2 (en) * 2003-10-07 2006-08-08 Bexel Pharmaceuticals, Inc. Dipeptide phenyl ethers
US20050171027A1 (en) 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
JP2008528510A (ja) * 2005-01-20 2008-07-31 サートリス ファーマシューティカルズ， インコーポレイテッド 紅潮および／または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用
US20080267888A1 (en) * 2005-05-26 2008-10-30 Pandey Surendrakumar Satyanara Heterocyclic Derivatives
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
US20090131420A1 (en) * 2005-10-07 2009-05-21 Pandey Surendrakumar S Novel Heterocyclic Analogs of Biphenyl Ethers
KR101016875B1 (ko) * 2006-06-23 2011-02-22 현대중공업 주식회사 밀폐형 방청유 도포장치
CN112209896B (zh) * 2019-07-10 2023-05-16 苏州泽璟生物制药股份有限公司 噻唑烷二酮衍生物以及包含其的药物组合物
WO2022045836A1 (ko) * 2020-08-28 2022-03-03 (주)셀로스바이오텍 신규 티오히단토인 유도체 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246936A (en) * 1991-12-20 1993-09-21 American Cyanamid Company Methods and compositions containing pesticides and stilbene compounds for enhanced pesticidal activity
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683009A (en) 1968-10-10 1972-08-08 Du Pont {60 , {62 -bis(trifluoromethyl) stilbenes
US3609183A (en) 1969-01-08 1971-09-28 Parke Davis & Co {60 -{8 {11 -(dimethylaminoalkyl)phenyl{9 -4-methoxy-{60 {40 -nitrostilbene compounds
US4312855A (en) 1970-11-16 1982-01-26 Colgate-Palmolive Company Compositions containing aminopolyureylene resin
US4326055A (en) 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
JPS6045632B2 (ja) 1978-03-09 1985-10-11 三菱化学株式会社 ω−アミノアルコキシスチルベン類及びその酸付加塩
US4284637A (en) 1978-03-09 1981-08-18 Mitsubishi Chemical Ind., Limited Pharmaceutically active 2-(4-aminobutoxy)stilbenes
DE2832213A1 (de) 1978-07-21 1980-01-31 Bayer Ag Stilbenderivate, verfahren zu ihrer herstellung und ihre verwendung als insektizide
JPS5629548A (en) 1979-08-16 1981-03-24 Mitsubishi Chem Ind Ltd Omega-aminoalkoxystilbenes and their acid addition salts
FR2562539B1 (fr) 1984-04-06 1987-04-17 Chauvin Blache Lab Nouveaux derives de l'acide vinyl-4 benzoique, leur procede de preparation et leurs applications en therapeutique et comme ligands
US4716905A (en) 1985-09-25 1988-01-05 Fluorochrome, Inc. Method of retrograde fluorescent labeling of neurons
CA1338645C (en) 1987-01-06 1996-10-15 George R. Pettit Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
GB8716650D0 (en) 1987-07-15 1987-08-19 Ici Plc Use of olefinic compounds
CA1340955C (en) 1988-02-24 2000-04-11 Michael Klaus Stilbene derivatives
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
DE3926148A1 (de) 1989-08-08 1991-02-28 Basf Ag Diarylacetylene, ihre herstellung und verwendung
US5189056A (en) 1989-12-19 1993-02-23 University Of North Carolina At Chapel Hill Protection of moist stratified squamous epithelia against damage from noxious luminal agents
US5162337A (en) 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
EP0498095B1 (en) 1991-02-05 1995-01-04 Merrell Dow Pharmaceuticals Inc. Sulfonic stilbene derivatives in the treatment of viral diseases
CH683151A5 (de) 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
US5171753A (en) 1991-05-15 1992-12-15 A. H. Robins Company, Incorporated Derivatives of 2-amino-1-phenylethanol having antiulcer activity
EP1067134B1 (en) 1991-11-07 2004-07-28 Nanotronics, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
NO302471B1 (no) * 1991-12-26 1998-03-09 Sankyo Co Tiazolidinforbindelser og farmasöytisk preparat
US5314693A (en) 1992-02-07 1994-05-24 Kioritz Corporation Pest control chemicals against pine wood nematodes
US5430062A (en) 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
AU669279B2 (en) 1993-03-10 1996-05-30 Morinaga Milk Industry Company Limited Stilbene derivative and stilbene analog derivative, and use thereof
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5731353A (en) 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
IT1264988B1 (it) 1993-12-14 1996-10-17 Sigma Prod Chim Composizioni cosmetiche e dermatologiche per la protezione da radiazioni uv contenenti derivati dallo stilbene
TW308598B (https=) 1994-01-14 1997-06-21 Hoffmann La Roche
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
US5559151A (en) 1994-11-30 1996-09-24 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers
TW334418B (en) 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
CA2174582A1 (en) 1995-05-05 1996-11-06 Alexander Chucholowski Sulphuric acid esters of amino-sugars
US5716928A (en) 1995-06-07 1998-02-10 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US5770620A (en) 1995-06-19 1998-06-23 Ontogen Corporation Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
US5733909A (en) 1996-02-01 1998-03-31 Merck Frosst Canada, Inc. Diphenyl stilbenes as prodrugs to COX-2 inhibitors
US5827898A (en) 1996-10-07 1998-10-27 Shaman Pharmaceuticals, Inc. Use of bisphenolic compounds to treat type II diabetes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
US5378705A (en) * 1988-02-24 1995-01-03 Hoffmann-La Roche Inc. Stilbene derivatives
US5246936A (en) * 1991-12-20 1993-09-21 American Cyanamid Company Methods and compositions containing pesticides and stilbene compounds for enhanced pesticidal activity

Also Published As

Publication number Publication date
EP1007039B1 (en) 2004-03-03
AU3974199A (en) 1999-11-29
KR20010021615A (ko) 2001-03-15
EP1007039A4 (en) 2002-05-22
JP4577985B2 (ja) 2010-11-10
ATE260906T1 (de) 2004-03-15
PT1007039E (pt) 2004-07-30
CA2295599A1 (en) 1999-11-18
DE69915223D1 (de) 2004-04-08
KR100595919B1 (ko) 2006-07-03
CN1151139C (zh) 2004-05-26
US6331633B1 (en) 2001-12-18
ES2216513T3 (es) 2004-10-16
DK1007039T3 (da) 2004-07-12
HK1028348A1 (en) 2001-02-16
JP2002514598A (ja) 2002-05-21
WO1999058127A1 (en) 1999-11-18
EP1007039A1 (en) 2000-06-14
AU751235B2 (en) 2002-08-08
DE69915223T2 (de) 2005-01-27
CA2295599C (en) 2009-01-20
CN1273528A (zh) 2000-11-15

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20030923

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20031030

PC Assignment registered

Owner name: THERACOS, INC.

Free format text: FORMER OWNER WAS: CALYX THERAPEUTICS, INC.