ATE260906T1 - Neue heterocyclische analoge von diphenylethylenverbindungen - Google Patents
Neue heterocyclische analoge von diphenylethylenverbindungenInfo
- Publication number
- ATE260906T1 ATE260906T1 AT99922836T AT99922836T ATE260906T1 AT E260906 T1 ATE260906 T1 AT E260906T1 AT 99922836 T AT99922836 T AT 99922836T AT 99922836 T AT99922836 T AT 99922836T AT E260906 T1 ATE260906 T1 AT E260906T1
- Authority
- AT
- Austria
- Prior art keywords
- diphenylethylene compounds
- new heterocyclic
- heterocyclic analogues
- levels
- compounds
- Prior art date
Links
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 title abstract 2
- 102000016267 Leptin Human genes 0.000 abstract 2
- 108010092277 Leptin Proteins 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 2
- 229940039781 leptin Drugs 0.000 abstract 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 229940123464 Thiazolidinedione Drugs 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 231100000304 hepatotoxicity Toxicity 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000007056 liver toxicity Effects 0.000 abstract 1
- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical group O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/074,925 US6245814B1 (en) | 1998-05-08 | 1998-05-08 | Diphenylethylene compounds |
| US09/287,237 US6331633B1 (en) | 1998-05-08 | 1999-04-06 | Heterocyclic analogs of diphenylethylene compounds |
| PCT/US1999/009982 WO1999058127A1 (en) | 1998-05-08 | 1999-05-07 | Novel heterocyclic analogs of diphenylethylene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260906T1 true ATE260906T1 (de) | 2004-03-15 |
Family
ID=26756222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99922836T ATE260906T1 (de) | 1998-05-08 | 1999-05-07 | Neue heterocyclische analoge von diphenylethylenverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6331633B1 (https=) |
| EP (1) | EP1007039B1 (https=) |
| JP (1) | JP4577985B2 (https=) |
| KR (1) | KR100595919B1 (https=) |
| CN (1) | CN1151139C (https=) |
| AT (1) | ATE260906T1 (https=) |
| AU (1) | AU751235C (https=) |
| CA (1) | CA2295599C (https=) |
| DE (1) | DE69915223T2 (https=) |
| DK (1) | DK1007039T3 (https=) |
| ES (1) | ES2216513T3 (https=) |
| PT (1) | PT1007039E (https=) |
| WO (1) | WO1999058127A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041941B2 (en) | 1997-04-07 | 2006-05-09 | Patented Medical Solutions, Llc | Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements |
| US7105552B2 (en) | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| NZ517993A (en) | 1999-08-31 | 2004-03-26 | Incyte San Diego Inc | Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| PT1741446E (pt) | 2000-01-21 | 2008-05-09 | Novartis Pharma Ag | Combinações incluindo inibidores da dipeptidilpeptidase-iv e agentes anti-diabéticos |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| IL157740A0 (en) | 2001-03-07 | 2004-03-28 | Incyte San Diego Inc | Heterocyclic derivatives and pharmaceutical compositions containing the same |
| US7265139B2 (en) | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
| US20030073712A1 (en) | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| KR100468429B1 (ko) * | 2001-09-07 | 2005-01-27 | 주식회사 엔바이오테크놀러지 | 알파-글루코시다제 저해활성이 있는 소나무 추출물 및 그추출방법 |
| AU2002352706A1 (en) | 2001-11-15 | 2003-06-10 | Maxia Pharmaceuticals, Inc. | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
| US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| AU2003282920A1 (en) | 2002-10-04 | 2004-05-04 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| CA2529510A1 (en) | 2003-07-01 | 2005-01-13 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| EP1708689A2 (en) | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| WO2006079021A2 (en) * | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Use of sirtuin-activating compounds for treating flushing and drug induced weight gain |
| WO2006126074A2 (en) * | 2005-05-26 | 2006-11-30 | Orchid Research Laboratories Limited | Heterocyclic derivatives |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| WO2007042878A1 (en) * | 2005-10-07 | 2007-04-19 | Orchid Research Laboratories Limited | Novel heterocyclic analogs of biphenyl ethers |
| KR101016875B1 (ko) * | 2006-06-23 | 2011-02-22 | 현대중공업 주식회사 | 밀폐형 방청유 도포장치 |
| CN112209896B (zh) * | 2019-07-10 | 2023-05-16 | 苏州泽璟生物制药股份有限公司 | 噻唑烷二酮衍生物以及包含其的药物组合物 |
| JP7535657B2 (ja) * | 2020-08-28 | 2024-08-16 | セルロス バイオテック | 新規チオヒダントイン誘導体及びその用途 |
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-
1999
- 1999-04-06 US US09/287,237 patent/US6331633B1/en not_active Expired - Fee Related
- 1999-05-07 DE DE69915223T patent/DE69915223T2/de not_active Expired - Lifetime
- 1999-05-07 CN CNB998010170A patent/CN1151139C/zh not_active Expired - Fee Related
- 1999-05-07 CA CA002295599A patent/CA2295599C/en not_active Expired - Fee Related
- 1999-05-07 DK DK99922836T patent/DK1007039T3/da active
- 1999-05-07 AU AU39741/99A patent/AU751235C/en not_active Ceased
- 1999-05-07 ES ES99922836T patent/ES2216513T3/es not_active Expired - Lifetime
- 1999-05-07 PT PT99922836T patent/PT1007039E/pt unknown
- 1999-05-07 KR KR1020007000173A patent/KR100595919B1/ko not_active Expired - Fee Related
- 1999-05-07 AT AT99922836T patent/ATE260906T1/de active
- 1999-05-07 JP JP2000547978A patent/JP4577985B2/ja not_active Expired - Fee Related
- 1999-05-07 EP EP99922836A patent/EP1007039B1/en not_active Expired - Lifetime
- 1999-05-07 WO PCT/US1999/009982 patent/WO1999058127A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007039A4 (en) | 2002-05-22 |
| KR20010021615A (ko) | 2001-03-15 |
| CN1273528A (zh) | 2000-11-15 |
| HK1028348A1 (en) | 2001-02-16 |
| CN1151139C (zh) | 2004-05-26 |
| KR100595919B1 (ko) | 2006-07-03 |
| US6331633B1 (en) | 2001-12-18 |
| DE69915223T2 (de) | 2005-01-27 |
| EP1007039B1 (en) | 2004-03-03 |
| EP1007039A1 (en) | 2000-06-14 |
| ES2216513T3 (es) | 2004-10-16 |
| CA2295599A1 (en) | 1999-11-18 |
| JP2002514598A (ja) | 2002-05-21 |
| PT1007039E (pt) | 2004-07-30 |
| AU3974199A (en) | 1999-11-29 |
| AU751235B2 (en) | 2002-08-08 |
| AU751235C (en) | 2004-06-24 |
| DE69915223D1 (de) | 2004-04-08 |
| JP4577985B2 (ja) | 2010-11-10 |
| WO1999058127A1 (en) | 1999-11-18 |
| CA2295599C (en) | 2009-01-20 |
| DK1007039T3 (da) | 2004-07-12 |
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