DE69333575D1 - Quinone-derivate zur verbesserung der zellulare bioenergie - Google Patents

Quinone-derivate zur verbesserung der zellulare bioenergie

Info

Publication number
DE69333575D1
DE69333575D1 DE69333575T DE69333575T DE69333575D1 DE 69333575 D1 DE69333575 D1 DE 69333575D1 DE 69333575 T DE69333575 T DE 69333575T DE 69333575 T DE69333575 T DE 69333575T DE 69333575 D1 DE69333575 D1 DE 69333575D1
Authority
DE
Germany
Prior art keywords
pct
animal
present
sec
therapeutic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333575T
Other languages
English (en)
Other versions
DE69333575T2 (de
Inventor
Phillip Nagley
William Linnane
Dennis Martinus
Francois Vaillant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre for Molecular Biology and Medicine
Original Assignee
Centre for Molecular Biology and Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre for Molecular Biology and Medicine filed Critical Centre for Molecular Biology and Medicine
Application granted granted Critical
Publication of DE69333575D1 publication Critical patent/DE69333575D1/de
Publication of DE69333575T2 publication Critical patent/DE69333575T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/02—Quinones with monocyclic quinoid structure
    • C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
DE69333575T 1992-05-28 1993-05-28 Quinone-derivate zur verbesserung der zellulare bioenergie Expired - Lifetime DE69333575T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPL264192 1992-05-28
AUPL264192 1992-05-28
AUPL264292 1992-05-28
AUPL264292 1992-05-28
PCT/AU1993/000251 WO1993024650A1 (en) 1992-05-28 1993-05-28 Therapeutic compositions

Publications (2)

Publication Number Publication Date
DE69333575D1 true DE69333575D1 (de) 2004-08-26
DE69333575T2 DE69333575T2 (de) 2005-08-25

Family

ID=25644259

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333575T Expired - Lifetime DE69333575T2 (de) 1992-05-28 1993-05-28 Quinone-derivate zur verbesserung der zellulare bioenergie

Country Status (10)

Country Link
US (1) US5981601A (de)
EP (1) EP0643775B1 (de)
JP (1) JP3859699B2 (de)
AT (1) ATE271614T1 (de)
AU (1) AU666372B2 (de)
DE (1) DE69333575T2 (de)
DK (1) DK0643775T3 (de)
ES (1) ES2224098T3 (de)
PT (1) PT643775E (de)
WO (1) WO1993024650A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9626177D0 (en) * 1996-12-17 1997-02-05 Univ Aberdeen Channel mediating substrates
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
AU9393398A (en) * 1997-09-16 1999-04-05 Egea Biosciences, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) * 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US20050019268A1 (en) * 1999-02-11 2005-01-27 Mse Pharmazeutika Gmbh Spray containing ubiquinone Qn
RU2268732C2 (ru) 1999-02-23 2006-01-27 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Способы лечения митохондриальных нарушений
US20040224920A1 (en) * 1999-02-23 2004-11-11 The Regents Of The University Of California Methods of treatment of mitochondrial disorders
AUPR177300A0 (en) * 2000-11-29 2000-12-21 Centre For Molecular Biology And Medicine Therapeutic methods
DE60227361D1 (de) * 2001-01-19 2008-08-14 Centocor Inc Computer vermitteltes assembly von polynucleotiden kodierend für ein zielgerichtetes polypeptide
US7629329B2 (en) * 2001-06-04 2009-12-08 Tsi Health Sciences, Inc. Method for increasing muscle mass and strength through administration of adenosine triphosphate
CA2451163A1 (en) * 2001-06-28 2003-01-09 Takeda Chemical Industries, Ltd. Agent for preventing or treating organ functional disorders and order dysfunction
TW200304372A (en) * 2002-03-20 2003-10-01 Kanegafuchi Chemical Ind Compositions for diabetes
WO2003083689A1 (en) * 2002-03-25 2003-10-09 Myriagon Corporation Information management system
DK1594456T3 (da) * 2003-01-20 2009-01-19 Auriga Internat S A Anvendelse af en sammensætning indeholdende vitamin K1-oxid eller et derivat deraf til behandling og/eller forebyggelse af dermatologiske læsioner hos pattedyr
DK1888059T3 (en) 2005-06-01 2015-03-30 Edison Pharmaceuticals Inc Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers
LT1933821T (lt) 2005-09-15 2020-11-10 Ptc Therapeutics, Inc. Šoninės grandinės variantai redoks aktyviųjų terapijos priemonių, skirtų mitochondrinių ligų ir kitokių būklių gydymui ir energijos biologinių žymenų moduliavimui
EP1986636B1 (de) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien
JP2011513420A (ja) * 2008-03-05 2011-04-28 エジソン ファーマシューティカルズ， インコーポレイテッド レドックス活性治療薬を用いる聴覚機能障害および平衡機能障害の処置
EP3827815B1 (de) 2008-09-10 2023-09-06 PTC Therapeutics, Inc. Behandlung von pervasiven entwicklungsstörungen mit redox-aktiven therapeutika
KR100977638B1 (ko) * 2009-06-29 2010-08-24 서울대학교산학협력단 독성분이 있는 배출가스 혼합체에 생존하면서 온실가스를 흡수한 수생식물의 포식자를 이용하는 온실가스 제거 및 바이오 에너지 제조 방법
KR101636946B1 (ko) * 2013-07-29 2016-07-06 한국생명공학연구원 오로트산을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
WO2018218287A1 (en) * 2017-05-29 2018-12-06 Woodlinda Pty Ltd Treatment and/or prevention of neuropathic symptoms associated with diabetes mellitus type ii

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705239A (en) * 1970-10-16 1972-12-05 Roy B Gregory Pain removing compositions and methods
JPS5697223A (en) * 1979-12-30 1981-08-05 Takeda Chem Ind Ltd Tissue metabolism activator
CH655005A5 (it) * 1983-02-16 1986-03-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica ad azione metabolica ed energetica utilizzabile in terapia cardiaca e vascolare.
JPS59163316A (ja) * 1983-03-08 1984-09-14 Eisai Co Ltd けいれんの治療・予防剤
JPS60100517A (ja) * 1983-11-08 1985-06-04 Eisai Co Ltd 放射線潰瘍治療剤および方法
IL78611A0 (en) * 1986-04-23 1986-08-31 Yeda Res & Dev Production of polyprenoid and ubiquinone-type compounds
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
JPH01165522A (ja) * 1987-12-23 1989-06-29 M S C:Kk 鼻及びのどの疾患の治療剤
WO1992003052A1 (en) * 1990-08-23 1992-03-05 Jariwalla Raxit J Method for suppression of hiv replication by ascorbate for chronic and acute hiv infection
FR2674753B1 (fr) * 1991-04-02 1995-03-10 Jean Berque Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables.
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5460819A (en) * 1991-12-13 1995-10-24 Children's Medical Center Corporation Method for treating PQQ-responsive heavy metal toxicity
JPH1165522A (ja) * 1997-08-25 1999-03-09 Mitsubishi Electric Corp プラズマディスプレイパネルの駆動方法

Also Published As

Publication number Publication date
PT643775E (pt) 2004-10-29
DE69333575T2 (de) 2005-08-25
JPH08500091A (ja) 1996-01-09
EP0643775A1 (de) 1995-03-22
WO1993024650A1 (en) 1993-12-09
ES2224098T3 (es) 2005-03-01
AU666372B2 (en) 1996-02-08
US5981601A (en) 1999-11-09
DK0643775T3 (da) 2004-09-06
EP0643775B1 (de) 2004-07-21
EP0643775A4 (de) 1995-12-27
ATE271614T1 (de) 2004-08-15
JP3859699B2 (ja) 2006-12-20
AU4054593A (en) 1993-12-30

Similar Documents

Publication Publication Date Title
DE69333575D1 (de) Quinone-derivate zur verbesserung der zellulare bioenergie
KR19980700976A (de)
ATE84414T1 (de) Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eines arneimittels zur behandlung von komplikationen bei diabetes mellitus.
EA199800943A1 (ru) Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
TR200000481T2 (tr) N-Alkonoilfenilalenin türevleri.
ATE442851T1 (de) 1-deoxy-galactonojirimycin-derivate zur vewendung bei der behandlung von lysosomalen speicherkrankheiten mittels steigerung der lysosomalen alpha galactosidase a
TR200101539T2 (tr) Serum glukoz ve trigliserid seviyelerini düşürme yöntemleri.
ES8603455A1 (es) Un metodo para preparar derivados de piperazina
NO954440D0 (no) 2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidler
ATE218868T1 (de) Hustenhemmende, theobromine enthaltende zusammensetzungen
MX9307509A (es) Metodo y preparacion farmaceutica para reducir la actividad de las celulas.
ATE84045T1 (de) Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
ATE39357T1 (de) Derivate von griseolicsaeure und ihre verwendung.
KR950031085A (ko) 표피증식 질환 치료용 의약 조성물
ES8407321A1 (es) "un procedimiento para preparar un compuesto organico de selenio"
GB1474424A (en) Pharmaceutical composition for treating diabetic ketoacidosis
ATE43140T1 (de) Derivate von enzym-hemmender griseolsaeure und deren verwendung.
ATE551058T1 (de) Zusammensetzungen enthaltend tempamine und deren verwendung zum schutz vor oxidativer schädigung
SU665912A1 (ru) Реактиватор холинэстеразы
JPH07258024A (ja) メラニン生成阻害剤
TH29868A (th) วิธีการและองค์ประกอบของสารสำหรับทำให้สีของผิวหนังจางลง
UA32157A (uk) Спосіб лікування діабетичної ретинопатії
GEP20033130B (en) Inhibitors of IMPDH Enzyme

Legal Events

Date Code Title Description
8364 No opposition during term of opposition