DE69825981D1 - 4,5-dihydroxy-2-cyclopenten-1-on für die Behandlung von Diabetes Mellitus - Google Patents

4,5-dihydroxy-2-cyclopenten-1-on für die Behandlung von Diabetes Mellitus

Info

Publication number
DE69825981D1
DE69825981D1 DE69825981T DE69825981T DE69825981D1 DE 69825981 D1 DE69825981 D1 DE 69825981D1 DE 69825981 T DE69825981 T DE 69825981T DE 69825981 T DE69825981 T DE 69825981T DE 69825981 D1 DE69825981 D1 DE 69825981D1
Authority
DE
Germany
Prior art keywords
cyclopenten
dihydroxy
diabetes mellitus
treatment
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69825981T
Other languages
English (en)
Other versions
DE69825981T2 (de
Inventor
Hua-Kang Wu
Nobuto Koyama
Eiji Nishiyama
Takanari Tominaga
Michio Hagiya
Ikunoshin Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Bio Inc
Original Assignee
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc filed Critical Takara Bio Inc
Publication of DE69825981D1 publication Critical patent/DE69825981D1/de
Application granted granted Critical
Publication of DE69825981T2 publication Critical patent/DE69825981T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/707—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a three- to five-membered ring
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69825981T 1997-03-28 1998-03-18 4,5-dihydroxy-2-cyclopenten-1-on für die Behandlung von Diabetes Mellitus Expired - Fee Related DE69825981T2 (de)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP9287097 1997-03-28
JP9287097 1997-03-28
JP11177397 1997-04-15
JP11177397 1997-04-15
JP15732497 1997-06-02
JP15732497 1997-06-02
JP16347397 1997-06-06
JP16347397 1997-06-06
JP28320497 1997-10-01
JP28320497 1997-10-01
JP36328197 1997-12-16
JP36328197 1997-12-16
PCT/JP1998/001151 WO1998043624A1 (fr) 1997-03-28 1998-03-18 Medicaments anti-diabetiques

Publications (2)

Publication Number Publication Date
DE69825981D1 true DE69825981D1 (de) 2004-10-07
DE69825981T2 DE69825981T2 (de) 2005-09-01

Family

ID=27551886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825981T Expired - Fee Related DE69825981T2 (de) 1997-03-28 1998-03-18 4,5-dihydroxy-2-cyclopenten-1-on für die Behandlung von Diabetes Mellitus

Country Status (13)

Country Link
US (1) US6194467B1 (de)
EP (1) EP0978278B1 (de)
JP (1) JP3664737B2 (de)
KR (1) KR100459581B1 (de)
CN (1) CN1123339C (de)
AT (1) ATE274904T1 (de)
AU (1) AU736516B2 (de)
CA (1) CA2285316A1 (de)
DE (1) DE69825981T2 (de)
EA (1) EA001763B1 (de)
ES (1) ES2227811T3 (de)
TW (1) TW515714B (de)
WO (1) WO1998043624A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020687A1 (en) * 1996-01-14 2005-01-27 Consiglio Nazionale Ricerche Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds
WO1998041196A1 (fr) 1997-03-17 1998-09-24 Takara Shuzo Co., Ltd. Agents antiviraux
US6194467B1 (en) 1997-03-28 2001-02-27 Takara Shuzo Co., Ltd. Diabetes remedies
US6284801B1 (en) 1997-04-01 2001-09-04 Takara Shuzo Co., Ltd. Antirheumatic agents
EP1008345A4 (de) * 1997-07-02 2000-09-13 Takara Shuzo Co Antiallergische mittel
AU1890399A (en) * 1998-01-19 1999-08-02 Takara Shuzo Co., Ltd. Substances capable of inducing apoptosis
WO2000048586A1 (fr) * 1999-02-19 2000-08-24 Takara Shuzo Co., Ltd. Medicaments
CA2366877A1 (en) * 1999-03-22 2000-09-28 Stanley Michael Roberts Chemical compounds and their uses
GB9929702D0 (en) * 1999-12-16 2000-02-09 Charterhouse Therapeutics Ltd Chemical compounds and their uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2608089B2 (ja) * 1988-03-09 1997-05-07 帝人株式会社 ４−ヒドロキシ−２−シクロペンテノン類およびそれを含有する薬剤組成物
JP2571950B2 (ja) * 1988-03-11 1997-01-16 財団法人野口研究所 シクロペンテノン誘導体及びその製造法
JPH0768163B2 (ja) * 1989-03-17 1995-07-26 財団法人野口研究所 シクロペンテノン誘導体の製法
CN1117057C (zh) * 1996-09-27 2003-08-06 宝酒造株式会社 环戊烯酮及其生产方法和应用
WO1998041196A1 (fr) 1997-03-17 1998-09-24 Takara Shuzo Co., Ltd. Agents antiviraux
US6194467B1 (en) 1997-03-28 2001-02-27 Takara Shuzo Co., Ltd. Diabetes remedies
US6284801B1 (en) 1997-04-01 2001-09-04 Takara Shuzo Co., Ltd. Antirheumatic agents
EP1008345A4 (de) 1997-07-02 2000-09-13 Takara Shuzo Co Antiallergische mittel

Also Published As

Publication number Publication date
US6194467B1 (en) 2001-02-27
EP0978278B1 (de) 2004-09-01
JP3664737B2 (ja) 2005-06-29
EA001763B1 (ru) 2001-08-27
KR20000076070A (ko) 2000-12-26
ES2227811T3 (es) 2005-04-01
CA2285316A1 (en) 1998-10-08
EP0978278A4 (de) 2002-08-21
WO1998043624A1 (fr) 1998-10-08
ATE274904T1 (de) 2004-09-15
EA199900881A1 (ru) 2000-04-24
KR100459581B1 (ko) 2004-12-03
CN1123339C (zh) 2003-10-08
EP0978278A1 (de) 2000-02-09
AU6418898A (en) 1998-10-22
AU736516B2 (en) 2001-07-26
TW515714B (en) 2003-01-01
CN1249680A (zh) 2000-04-05
DE69825981T2 (de) 2005-09-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee