WO2000054760A3 - Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia - Google Patents

Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia Download PDF

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Publication number
WO2000054760A3
WO2000054760A3 PCT/US2000/006624 US0006624W WO0054760A3 WO 2000054760 A3 WO2000054760 A3 WO 2000054760A3 US 0006624 W US0006624 W US 0006624W WO 0054760 A3 WO0054760 A3 WO 0054760A3
Authority
WO
WIPO (PCT)
Prior art keywords
nonenes
bicyclo
useful
hypertriglyceridemia
diabetes
Prior art date
Application number
PCT/US2000/006624
Other languages
French (fr)
Other versions
WO2000054760A2 (en
Inventor
Diana M Fort
Original Assignee
Shaman Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaman Pharmaceuticals Inc filed Critical Shaman Pharmaceuticals Inc
Priority to AU37441/00A priority Critical patent/AU3744100A/en
Publication of WO2000054760A2 publication Critical patent/WO2000054760A2/en
Publication of WO2000054760A3 publication Critical patent/WO2000054760A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Bicyclo[3.3.1]nonenes, pharmaceutical compositions containing the nonenes and methods of using the compounds and compositions as hypoglycemic or hypotriglyceridemic agents are described. The bicyclo[3.3.1]nonenes and corresponding compositions are useful for lowering blood glucose levels, treating hyperglycemia and treating diabetes. The nonenes and corresponding compositions are also useful for lowering serum triglyceride levels and treating hypertriglyceridemia.
PCT/US2000/006624 1999-03-15 2000-03-14 Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia WO2000054760A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37441/00A AU3744100A (en) 1999-03-15 2000-03-14 Bicyclo(3.3.1)nonenes useful for the treatment of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27048999A 1999-03-15 1999-03-15
US09/270,489 1999-03-15

Publications (2)

Publication Number Publication Date
WO2000054760A2 WO2000054760A2 (en) 2000-09-21
WO2000054760A3 true WO2000054760A3 (en) 2001-03-08

Family

ID=23031516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006624 WO2000054760A2 (en) 1999-03-15 2000-03-14 Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia

Country Status (2)

Country Link
AU (1) AU3744100A (en)
WO (1) WO2000054760A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054785A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Stabilized bicyclo[3.3.1]nonenes and methods of use
FR2865652B1 (en) * 2004-02-02 2009-10-02 Greenpharma Sas USE OF PLANT EXTRACTS AND PURIFIED MOLECULES FOR LIPOLYTICALLY SLIMMING, COSMETIC, NUTRACEUTICAL OR PHARMACEUTICAL COMPOSITIONS.
WO2012167021A2 (en) * 2011-06-03 2012-12-06 President And Fellows Of Harvard College Hyperforin analogs, methods of synthesis, and uses thereof
CN114605242A (en) * 2022-04-11 2022-06-10 澳门大学 Preparation method of phloroglucinol compound, medicine, health-care product and food

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599307A1 (en) * 1992-11-27 1994-06-01 Dr. Willmar Schwabe GmbH & Co. St.-John's-wort dry extract, process for its preparation and its use
WO1997013489A2 (en) * 1995-09-29 1997-04-17 Dr. Willmar Schwabe Gmbh & Co. Stable extract of hypericum perforatum l., process for preparing the same and pharmaceutical compositions
JPH09227545A (en) * 1996-02-26 1997-09-02 Mitsubishi Chem Corp Phloroglucin derivative
JPH09227398A (en) * 1996-02-20 1997-09-02 Zeria Pharmaceut Co Ltd Antiobese agent
JPH1036257A (en) * 1996-05-22 1998-02-10 Kikkoman Corp Maillard reaction inhibitor
DE19700788A1 (en) * 1997-01-11 1998-07-16 Michael O Ruepp Use of a dry extract of St. John's wort
US5972357A (en) * 1996-12-19 1999-10-26 Kikkoman Corporation Healthy foods and cosmetics
WO2000002455A1 (en) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericin and hypericum extract: specific t-type calcium channel blocker, and their use as t-type calcium channel targeted therapeutics

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599307A1 (en) * 1992-11-27 1994-06-01 Dr. Willmar Schwabe GmbH & Co. St.-John's-wort dry extract, process for its preparation and its use
WO1997013489A2 (en) * 1995-09-29 1997-04-17 Dr. Willmar Schwabe Gmbh & Co. Stable extract of hypericum perforatum l., process for preparing the same and pharmaceutical compositions
JPH09227398A (en) * 1996-02-20 1997-09-02 Zeria Pharmaceut Co Ltd Antiobese agent
JPH09227545A (en) * 1996-02-26 1997-09-02 Mitsubishi Chem Corp Phloroglucin derivative
JPH1036257A (en) * 1996-05-22 1998-02-10 Kikkoman Corp Maillard reaction inhibitor
US5972357A (en) * 1996-12-19 1999-10-26 Kikkoman Corporation Healthy foods and cosmetics
DE19700788A1 (en) * 1997-01-11 1998-07-16 Michael O Ruepp Use of a dry extract of St. John's wort
WO2000002455A1 (en) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericin and hypericum extract: specific t-type calcium channel blocker, and their use as t-type calcium channel targeted therapeutics

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 128, no. 14, 6 April 1998, Columbus, Ohio, US; abstract no. 172103, YAMAGUCHI, NORIO ET AL.: "Maillard reaction inhibitors for cosmetics or pharmaceuticals" *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FUKUYAMA, YOSHIYASU: "Tricyclic phloroglucin derivatives of Garcinia subelliptica activating the enzyme activity of acetylcholine synthase", XP002152172, retrieved from STN Database accession no. 127:195469 *
DATABASE WPI Section Ch Week 199750, Derwent World Patents Index; Class B04, AN 1997-539685, XP002152173 *

Also Published As

Publication number Publication date
AU3744100A (en) 2000-10-04
WO2000054760A2 (en) 2000-09-21

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