JP2003514025A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003514025A5 JP2003514025A5 JP2001537965A JP2001537965A JP2003514025A5 JP 2003514025 A5 JP2003514025 A5 JP 2003514025A5 JP 2001537965 A JP2001537965 A JP 2001537965A JP 2001537965 A JP2001537965 A JP 2001537965A JP 2003514025 A5 JP2003514025 A5 JP 2003514025A5
- Authority
- JP
- Japan
- Prior art keywords
- aplidine
- use according
- formulated
- infusion
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 description 16
- 229950008499 plitidepsin Drugs 0.000 description 16
- 108010049948 plitidepsin Proteins 0.000 description 16
- 238000001802 infusion Methods 0.000 description 14
- 238000001990 intravenous administration Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical group C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9927006.8A GB9927006D0 (en) | 1999-11-15 | 1999-11-15 | Aplidine treatment of cancers |
| GB9927006.8 | 1999-11-15 | ||
| GB0005701A GB0005701D0 (en) | 2000-03-09 | 2000-03-09 | Antitumor utility of aplidine |
| GB0005701.8 | 2000-03-09 | ||
| GB0007639A GB0007639D0 (en) | 2000-03-29 | 2000-03-29 | Antitumour and anti-angiogenic compound |
| GB0007639.8 | 2000-03-29 | ||
| GB0015496.3 | 2000-06-23 | ||
| GB0015496A GB0015496D0 (en) | 2000-06-23 | 2000-06-23 | Antitumour and anti-angiogenic compound |
| GB0025209.8 | 2000-10-13 | ||
| GB0025209A GB0025209D0 (en) | 2000-10-13 | 2000-10-13 | Treatment of cancers |
| PCT/GB2000/004349 WO2001035974A2 (en) | 1999-11-15 | 2000-11-15 | Aplidine treatment of cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514025A JP2003514025A (ja) | 2003-04-15 |
| JP2003514025A5 true JP2003514025A5 (https=) | 2008-01-10 |
Family
ID=27515929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001537965A Pending JP2003514025A (ja) | 1999-11-15 | 2000-11-15 | ガンのアプリジン治療 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20090298752A1 (https=) |
| EP (1) | EP1229922B1 (https=) |
| JP (1) | JP2003514025A (https=) |
| KR (1) | KR100518986B1 (https=) |
| CN (1) | CN1423564A (https=) |
| AT (1) | ATE363910T1 (https=) |
| AU (1) | AU780417B2 (https=) |
| BG (1) | BG65381B1 (https=) |
| BR (1) | BR0015811A (https=) |
| CA (1) | CA2391502A1 (https=) |
| CY (1) | CY1106825T1 (https=) |
| CZ (1) | CZ302498B6 (https=) |
| DE (1) | DE60035120T2 (https=) |
| DK (1) | DK1229922T3 (https=) |
| ES (1) | ES2288486T3 (https=) |
| HK (1) | HK1045648B (https=) |
| HU (1) | HUP0203906A2 (https=) |
| IL (1) | IL149488A0 (https=) |
| MX (1) | MXPA02004862A (https=) |
| NO (1) | NO330719B1 (https=) |
| NZ (1) | NZ518847A (https=) |
| PL (1) | PL200922B1 (https=) |
| PT (1) | PT1229922E (https=) |
| RU (1) | RU2261104C2 (https=) |
| SI (1) | SI1229922T1 (https=) |
| SK (1) | SK287762B6 (https=) |
| WO (1) | WO2001035974A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| IL155273A0 (en) | 2000-10-12 | 2003-11-23 | Pharma Mar Sa | Pharmaceutical compositions comprising an aplidine compound |
| DE60229414D1 (de) * | 2001-10-19 | 2008-11-27 | Pharma Mar Sa | Verwendung von aplidine in der behandlung von pankreaskrebs |
| PL368458A1 (en) * | 2001-10-19 | 2005-03-21 | Pharmamar S.A. | Improved use of antitumoral compound in cancer therapy |
| EP1620117A4 (en) * | 2003-03-12 | 2009-07-29 | Pharma Mar Sa | IMPROVED ANTITUMORAL TREATMENTS |
| AU2004218883B2 (en) | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| ATE479432T1 (de) * | 2006-11-03 | 2010-09-15 | Nerviano Medical Sciences Srl | Verfahren zur verabreichung einer antitumoralen verbindung |
| RU2360712C1 (ru) * | 2007-10-02 | 2009-07-10 | Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" | Способ лечения местно-распространенного неоперабельного рака прямой кишки |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| CA2717409A1 (en) * | 2008-03-07 | 2009-09-11 | Pharma Mar, S.A. | Improved anticancer treatments |
| CN103463020B (zh) * | 2013-09-23 | 2015-11-25 | 李淑兰 | Lycojaponicumin A在制备治疗肾癌药物中的应用 |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342744A (en) * | 1979-07-19 | 1982-08-03 | Lever Brothers Company | Hair treatment products |
| DE3161556D1 (en) * | 1980-09-12 | 1984-01-05 | Univ Illinois | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
| DE3684868D1 (de) * | 1985-09-20 | 1992-05-21 | Cernitin Sa | Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung. |
| US20030148933A1 (en) * | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB8922026D0 (en) * | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
| US5580871A (en) * | 1992-11-20 | 1996-12-03 | The Dupont Merck Pharmaceutical Company | 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity |
| FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
| US5462726A (en) * | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
| JPH09507233A (ja) * | 1993-12-29 | 1997-07-22 | マトリクス ファーマスーティカル，インコーポレイティド | 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物 |
| US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
| US6365597B1 (en) * | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| ES2151277T3 (es) * | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
| US6156724A (en) * | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
| US6034058A (en) * | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
| US6030943A (en) * | 1997-05-07 | 2000-02-29 | Crumb; William J. | Dehydrodidemnin B as an L-type calcium channel enhancer |
| US6245759B1 (en) * | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20010021380A1 (en) * | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| CA2405779A1 (en) * | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
| US6509315B1 (en) * | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| AU1305302A (en) * | 2000-10-05 | 2002-04-15 | Immunex Corp | Nectin polypeptides, polynucleotides, methods of making and use thereof |
| IL155273A0 (en) * | 2000-10-12 | 2003-11-23 | Pharma Mar Sa | Pharmaceutical compositions comprising an aplidine compound |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US6610399B1 (en) * | 2000-11-17 | 2003-08-26 | Structural Technologies, Llc | Multi-layer, thermal protection and corrosion protection coating system for metallic tendons, especially for external post-tensioning systems |
| DE60229414D1 (de) * | 2001-10-19 | 2008-11-27 | Pharma Mar Sa | Verwendung von aplidine in der behandlung von pankreaskrebs |
| EP1620117A4 (en) * | 2003-03-12 | 2009-07-29 | Pharma Mar Sa | IMPROVED ANTITUMORAL TREATMENTS |
| AU2004218883B2 (en) * | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| JP2006523214A (ja) * | 2003-03-21 | 2006-10-12 | ジユーリー，マデレーン・エム | タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法 |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
-
2000
- 2000-11-15 CZ CZ20021697A patent/CZ302498B6/cs not_active IP Right Cessation
- 2000-11-15 BR BR0015811-9A patent/BR0015811A/pt not_active Application Discontinuation
- 2000-11-15 CA CA002391502A patent/CA2391502A1/en not_active Abandoned
- 2000-11-15 AU AU14023/01A patent/AU780417B2/en not_active Ceased
- 2000-11-15 IL IL14948800A patent/IL149488A0/xx unknown
- 2000-11-15 AT AT00976137T patent/ATE363910T1/de active
- 2000-11-15 RU RU2002115864/14A patent/RU2261104C2/ru not_active IP Right Cessation
- 2000-11-15 SI SI200030960T patent/SI1229922T1/sl unknown
- 2000-11-15 EP EP00976137A patent/EP1229922B1/en not_active Expired - Lifetime
- 2000-11-15 PL PL355335A patent/PL200922B1/pl not_active IP Right Cessation
- 2000-11-15 KR KR10-2002-7006155A patent/KR100518986B1/ko not_active Expired - Fee Related
- 2000-11-15 NZ NZ518847A patent/NZ518847A/en not_active IP Right Cessation
- 2000-11-15 DK DK00976137T patent/DK1229922T3/da active
- 2000-11-15 HU HU0203906A patent/HUP0203906A2/hu unknown
- 2000-11-15 JP JP2001537965A patent/JP2003514025A/ja active Pending
- 2000-11-15 ES ES00976137T patent/ES2288486T3/es not_active Expired - Lifetime
- 2000-11-15 MX MXPA02004862A patent/MXPA02004862A/es active IP Right Grant
- 2000-11-15 PT PT00976137T patent/PT1229922E/pt unknown
- 2000-11-15 WO PCT/GB2000/004349 patent/WO2001035974A2/en not_active Ceased
- 2000-11-15 DE DE60035120T patent/DE60035120T2/de not_active Expired - Lifetime
- 2000-11-15 SK SK659-2002A patent/SK287762B6/sk not_active IP Right Cessation
- 2000-11-15 HK HK02106981.6A patent/HK1045648B/en not_active IP Right Cessation
- 2000-11-15 CN CN00818404A patent/CN1423564A/zh active Pending
-
2002
- 2002-05-14 NO NO20022293A patent/NO330719B1/no not_active IP Right Cessation
- 2002-05-18 BG BG106714A patent/BG65381B1/bg unknown
-
2007
- 2007-08-30 CY CY20071101110T patent/CY1106825T1/el unknown
-
2008
- 2008-12-23 US US12/342,478 patent/US20090298752A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY124853A (en) | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives. | |
| MY127422A (en) | Low dose entecavir formulation and use | |
| JP2003514025A5 (https=) | ||
| HUP0100437A2 (hu) | Szabályzott felszabadulású gyógyszerkészítmény tolterodin adagolására | |
| JP2001515712A5 (https=) | ||
| JP2002528502A5 (https=) | ||
| CA2066403A1 (en) | Transmucosal dosage form | |
| CA2389235A1 (en) | Controlled release hydrocodone formulations | |
| RU98111594A (ru) | Фармацевтические композиции, включающие флурбипрофен | |
| JP2006514092A5 (https=) | ||
| CZ176495A3 (en) | The use of riluzol for preparing a medicament suitable for treating parkinson's disease and parkinson's syndromes | |
| BG106171A (en) | Compositions and uses of et743 for treating cancer | |
| WO2000041504A3 (en) | Use of tertbutylhydroquinone for lowering blood cholesterol and/or blood triblycerides | |
| RU95101385A (ru) | Продукты, содержащие g-csf и tnf связующие протеина | |
| CA2143610A1 (en) | Use of norastemizole for the treatment of allergic disorders | |
| JP2004537500A5 (https=) | ||
| CA2401000A1 (en) | Method of treating and diagnosing sleep disordered breathing and means for carrying out the method | |
| JP2002522501A5 (https=) | ||
| MY124465A (en) | Reduction of infarct volume using citicoline | |
| JP2002530353A5 (https=) | ||
| JP2002540148A5 (https=) | ||
| WO2001012214A3 (en) | MYCOPHENOLATE MOFETIL IN ASSOCIATION WITH PEG-IFN-$g(a) | |
| EP1561462A3 (en) | Anti arrhytmic composition and methods of treatment | |
| CA2474430A1 (en) | A combination of a thrombolytic agent and levosimendan for the treatment of acute myocardial infarction | |
| WO1990004977A3 (en) | Treatment of genital warts with a combination of liquid nitrogen and recombinant dna human alpha interferon |