CN103463020B - Lycojaponicumin A在制备治疗肾癌药物中的应用 - Google Patents
Lycojaponicumin A在制备治疗肾癌药物中的应用 Download PDFInfo
- Publication number
- CN103463020B CN103463020B CN201310435463.6A CN201310435463A CN103463020B CN 103463020 B CN103463020 B CN 103463020B CN 201310435463 A CN201310435463 A CN 201310435463A CN 103463020 B CN103463020 B CN 103463020B
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- Prior art keywords
- lycojaponicumin
- renal carcinoma
- medicine
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- preparation treatment
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- 206010038389 Renal cancer Diseases 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 208000006265 Renal cell carcinoma Diseases 0.000 title claims abstract description 16
- 201000010174 renal carcinoma Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 208000008839 Kidney Neoplasms Diseases 0.000 abstract description 9
- 201000010982 kidney cancer Diseases 0.000 abstract description 9
- 230000012010 growth Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229930185194 lycojaponicumin Natural products 0.000 abstract 4
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310435463.6A CN103463020B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肾癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310435463.6A CN103463020B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肾癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103463020A CN103463020A (zh) | 2013-12-25 |
CN103463020B true CN103463020B (zh) | 2015-11-25 |
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CN201310435463.6A Expired - Fee Related CN103463020B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗肾癌药物中的应用 |
Country Status (1)
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CN (1) | CN103463020B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1423564A (zh) * | 1999-11-15 | 2003-06-11 | 法马马有限公司 | 癌症的aplidine治疗 |
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2013
- 2013-09-23 CN CN201310435463.6A patent/CN103463020B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1423564A (zh) * | 1999-11-15 | 2003-06-11 | 法马马有限公司 | 癌症的aplidine治疗 |
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CN103463020A (zh) | 2013-12-25 |
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Effective date of registration: 20151026 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Zhiqiang Inventor after: Guo Jianjun Inventor after: Li Lezhen Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
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COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170120 Address after: 262700 Shandong city in Weifang Province, Shouguang City Street No. 23 Patentee after: Wang Zhiqiang Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20170923 |