CN103494812B - Lycojaponicumin A在制备治疗卵巢癌药物中的应用 - Google Patents
Lycojaponicumin A在制备治疗卵巢癌药物中的应用 Download PDFInfo
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- CN103494812B CN103494812B CN201310437402.3A CN201310437402A CN103494812B CN 103494812 B CN103494812 B CN 103494812B CN 201310437402 A CN201310437402 A CN 201310437402A CN 103494812 B CN103494812 B CN 103494812B
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- ovarian cancer
- lycojaponicumin
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- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 17
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000003814 drug Substances 0.000 abstract description 12
- 230000012010 growth Effects 0.000 abstract description 7
- 108700024827 HOC1 Proteins 0.000 abstract description 6
- 101100178273 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HOC1 gene Proteins 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229930185194 lycojaponicumin Natural products 0.000 abstract 4
- 230000002611 ovarian Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310437402.3A CN103494812B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗卵巢癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310437402.3A CN103494812B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗卵巢癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103494812A CN103494812A (zh) | 2014-01-08 |
CN103494812B true CN103494812B (zh) | 2015-12-02 |
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CN201310437402.3A Expired - Fee Related CN103494812B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备治疗卵巢癌药物中的应用 |
Country Status (1)
Country | Link |
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CN (1) | CN103494812B (zh) |
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2013
- 2013-09-23 CN CN201310437402.3A patent/CN103494812B/zh not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
"Lycojaponicumin A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum";Xiao-Jing Wang,et al.;《Organic Letters》;20120508;第14卷(第10期);第2614-2617页 * |
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CN103494812A (zh) | 2014-01-08 |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Niu Zhaoyuan Inventor after: Yuan Fang Inventor after: Liu Na Inventor after: Lin Wei Inventor after: Sun Xin Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
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Effective date of registration: 20151106 Address after: 266100 district two, medical school, 8 Haier Road, Laoshan District, Shandong, Qingdao Applicant after: Niu Zhaoyuan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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Address after: 210000 No. 181 Hunan Road, Gulou District, Nanjing City, Jiangsu Province Patentee after: Niu Zhaoyuan Address before: 266100 Second District of Gynecology, 8th Floor, Medical College Affiliated to Qingdao University, 59 Haier Road, Laoshan District, Qingdao City, Shandong Province Patentee before: Niu Zhaoyuan |
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Effective date of registration: 20190329 Address after: 233090 Zhongchuang Space A-43, 1st Floor, Chuangchuang Space, No. 8 Roadway 2595, Donghai Avenue, Bengbu City, Anhui Province Patentee after: Bengbu Yongyuan Electronic Technology Co., Ltd. Address before: 210000 No. 181 Hunan Road, Gulou District, Nanjing City, Jiangsu Province Patentee before: Niu Zhaoyuan |
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Effective date of registration: 20191211 Address after: 239000 room 1602 and 1604, 3 building, 82 business center, Huayuan Road, Chuzhou, Anhui. Patentee after: Anhui Bodhi biological medicine science and Technology Co Ltd Address before: 233090 Zhongchuang Space A-43, 1st Floor, Chuangchuang Space, No. 8 Roadway 2595, Donghai Avenue, Bengbu City, Anhui Province Patentee before: Bengbu Yongyuan Electronic Technology Co., Ltd. |
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