CN103446144B - Lycojaponicumin C在制备治疗胆管癌药物中的应用 - Google Patents
Lycojaponicumin C在制备治疗胆管癌药物中的应用 Download PDFInfo
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- CN103446144B CN103446144B CN201310435158.7A CN201310435158A CN103446144B CN 103446144 B CN103446144 B CN 103446144B CN 201310435158 A CN201310435158 A CN 201310435158A CN 103446144 B CN103446144 B CN 103446144B
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- Prior art keywords
- lycojaponicumin
- medicine
- bile duct
- cancer
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 206010028980 Neoplasm Diseases 0.000 title claims description 9
- 201000011510 cancer Diseases 0.000 title claims description 9
- UULHZQYEEKIMDO-CLROSIBMSA-N lycojaponicumin C Natural products CN1CCC[C@@]23[C@@H]1CC[C@]24[C@@H](CC3=O)C(=CCC4=O)C UULHZQYEEKIMDO-CLROSIBMSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 16
- 206010004593 Bile duct cancer Diseases 0.000 abstract description 10
- 201000007180 bile duct carcinoma Diseases 0.000 abstract description 8
- 230000001093 anti-cancer Effects 0.000 abstract description 7
- 230000012010 growth Effects 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 208000006990 cholangiocarcinoma Diseases 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000011156 evaluation Methods 0.000 abstract description 2
- 229930185194 lycojaponicumin Natural products 0.000 abstract 4
- 208000026900 bile duct neoplasm Diseases 0.000 abstract 2
- 229940079593 drug Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310435158.7A CN103446144B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗胆管癌药物中的应用 |
Applications Claiming Priority (1)
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CN201310435158.7A CN103446144B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗胆管癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103446144A CN103446144A (zh) | 2013-12-18 |
CN103446144B true CN103446144B (zh) | 2015-11-25 |
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CN201310435158.7A Expired - Fee Related CN103446144B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin C在制备治疗胆管癌药物中的应用 |
Country Status (1)
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CN (1) | CN103446144B (zh) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101422451A (zh) * | 2007-11-02 | 2009-05-06 | 陕西新生医药科技有限公司 | 具有广谱抗肿瘤活性的1’-乙酰氧基胡椒酚乙酸酯及其衍生物 |
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- 2013-09-23 CN CN201310435158.7A patent/CN103446144B/zh not_active Expired - Fee Related
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Publication number | Publication date |
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CN103446144A (zh) | 2013-12-18 |
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SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151027 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Wenjun Inventor after: Guan Sujun Inventor before: Wu Junhua Inventor before: Huang Rong |
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COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170126 Address after: Yang Kou Zhen Tai Ping Xi Lu 262700 Shandong city in Weifang Province, Shouguang City, No. 60 Patentee after: Li Wenjun Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Yongjuan Inventor after: Wang Jili Inventor after: Zheng Mingxin Inventor before: Li Wenjun Inventor before: Guan Sujun |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171214 Address after: 262700 Shandong street health city of Weifang province Shouguang City, No. 47 Patentee after: Wang Yongjuan Address before: Yang Kou Zhen Tai Ping Xi Lu 262700 Shandong city in Weifang Province, Shouguang City, No. 60 Patentee before: Li Wenjun |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20180923 |