DE60035120T2 - Behandlung von krebserkrankungen durch aplidin - Google Patents
Behandlung von krebserkrankungen durch aplidin Download PDFInfo
- Publication number
- DE60035120T2 DE60035120T2 DE60035120T DE60035120T DE60035120T2 DE 60035120 T2 DE60035120 T2 DE 60035120T2 DE 60035120 T DE60035120 T DE 60035120T DE 60035120 T DE60035120 T DE 60035120T DE 60035120 T2 DE60035120 T2 DE 60035120T2
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- aplidine
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- 230000002062 proliferating effect Effects 0.000 description 1
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- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
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- 230000002285 radioactive effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 238000012552 review Methods 0.000 description 1
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- 210000001044 sensory neuron Anatomy 0.000 description 1
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- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000025185 skeletal muscle atrophy Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- 238000013518 transcription Methods 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
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- 230000005751 tumor progression Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9927006.8A GB9927006D0 (en) | 1999-11-15 | 1999-11-15 | Aplidine treatment of cancers |
| GB9927006 | 1999-11-15 | ||
| GB0005701 | 2000-03-09 | ||
| GB0005701A GB0005701D0 (en) | 2000-03-09 | 2000-03-09 | Antitumor utility of aplidine |
| GB0007639A GB0007639D0 (en) | 2000-03-29 | 2000-03-29 | Antitumour and anti-angiogenic compound |
| GB0007639 | 2000-03-29 | ||
| GB0015496 | 2000-06-23 | ||
| GB0015496A GB0015496D0 (en) | 2000-06-23 | 2000-06-23 | Antitumour and anti-angiogenic compound |
| GB0025209A GB0025209D0 (en) | 2000-10-13 | 2000-10-13 | Treatment of cancers |
| GB0025209 | 2000-10-13 | ||
| PCT/GB2000/004349 WO2001035974A2 (en) | 1999-11-15 | 2000-11-15 | Aplidine treatment of cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60035120D1 DE60035120D1 (de) | 2007-07-19 |
| DE60035120T2 true DE60035120T2 (de) | 2008-01-31 |
Family
ID=27515929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60035120T Expired - Lifetime DE60035120T2 (de) | 1999-11-15 | 2000-11-15 | Behandlung von krebserkrankungen durch aplidin |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20090298752A1 (https=) |
| EP (1) | EP1229922B1 (https=) |
| JP (1) | JP2003514025A (https=) |
| KR (1) | KR100518986B1 (https=) |
| CN (1) | CN1423564A (https=) |
| AT (1) | ATE363910T1 (https=) |
| AU (1) | AU780417B2 (https=) |
| BG (1) | BG65381B1 (https=) |
| BR (1) | BR0015811A (https=) |
| CA (1) | CA2391502A1 (https=) |
| CY (1) | CY1106825T1 (https=) |
| CZ (1) | CZ302498B6 (https=) |
| DE (1) | DE60035120T2 (https=) |
| DK (1) | DK1229922T3 (https=) |
| ES (1) | ES2288486T3 (https=) |
| HK (1) | HK1045648B (https=) |
| HU (1) | HUP0203906A2 (https=) |
| IL (1) | IL149488A0 (https=) |
| MX (1) | MXPA02004862A (https=) |
| NO (1) | NO330719B1 (https=) |
| NZ (1) | NZ518847A (https=) |
| PL (1) | PL200922B1 (https=) |
| PT (1) | PT1229922E (https=) |
| RU (1) | RU2261104C2 (https=) |
| SI (1) | SI1229922T1 (https=) |
| SK (1) | SK287762B6 (https=) |
| WO (1) | WO2001035974A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| IL155273A0 (en) | 2000-10-12 | 2003-11-23 | Pharma Mar Sa | Pharmaceutical compositions comprising an aplidine compound |
| DE60229414D1 (de) * | 2001-10-19 | 2008-11-27 | Pharma Mar Sa | Verwendung von aplidine in der behandlung von pankreaskrebs |
| PL368458A1 (en) * | 2001-10-19 | 2005-03-21 | Pharmamar S.A. | Improved use of antitumoral compound in cancer therapy |
| EP1620117A4 (en) * | 2003-03-12 | 2009-07-29 | Pharma Mar Sa | IMPROVED ANTITUMORAL TREATMENTS |
| AU2004218883B2 (en) | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| ATE479432T1 (de) * | 2006-11-03 | 2010-09-15 | Nerviano Medical Sciences Srl | Verfahren zur verabreichung einer antitumoralen verbindung |
| RU2360712C1 (ru) * | 2007-10-02 | 2009-07-10 | Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" | Способ лечения местно-распространенного неоперабельного рака прямой кишки |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
| CA2717409A1 (en) * | 2008-03-07 | 2009-09-11 | Pharma Mar, S.A. | Improved anticancer treatments |
| CN103463020B (zh) * | 2013-09-23 | 2015-11-25 | 李淑兰 | Lycojaponicumin A在制备治疗肾癌药物中的应用 |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342744A (en) * | 1979-07-19 | 1982-08-03 | Lever Brothers Company | Hair treatment products |
| DE3161556D1 (en) * | 1980-09-12 | 1984-01-05 | Univ Illinois | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
| DE3684868D1 (de) * | 1985-09-20 | 1992-05-21 | Cernitin Sa | Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung. |
| US20030148933A1 (en) * | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
| GB8922026D0 (en) * | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
| US5580871A (en) * | 1992-11-20 | 1996-12-03 | The Dupont Merck Pharmaceutical Company | 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity |
| FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
| US5462726A (en) * | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
| JPH09507233A (ja) * | 1993-12-29 | 1997-07-22 | マトリクス ファーマスーティカル，インコーポレイティド | 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物 |
| US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
| US6365597B1 (en) * | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| ES2151277T3 (es) * | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
| US6156724A (en) * | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
| US6034058A (en) * | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
| US6030943A (en) * | 1997-05-07 | 2000-02-29 | Crumb; William J. | Dehydrodidemnin B as an L-type calcium channel enhancer |
| US6245759B1 (en) * | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20010021380A1 (en) * | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| CA2405779A1 (en) * | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
| US6509315B1 (en) * | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| AU1305302A (en) * | 2000-10-05 | 2002-04-15 | Immunex Corp | Nectin polypeptides, polynucleotides, methods of making and use thereof |
| IL155273A0 (en) * | 2000-10-12 | 2003-11-23 | Pharma Mar Sa | Pharmaceutical compositions comprising an aplidine compound |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US6610399B1 (en) * | 2000-11-17 | 2003-08-26 | Structural Technologies, Llc | Multi-layer, thermal protection and corrosion protection coating system for metallic tendons, especially for external post-tensioning systems |
| DE60229414D1 (de) * | 2001-10-19 | 2008-11-27 | Pharma Mar Sa | Verwendung von aplidine in der behandlung von pankreaskrebs |
| EP1620117A4 (en) * | 2003-03-12 | 2009-07-29 | Pharma Mar Sa | IMPROVED ANTITUMORAL TREATMENTS |
| AU2004218883B2 (en) * | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| JP2006523214A (ja) * | 2003-03-21 | 2006-10-12 | ジユーリー，マデレーン・エム | タマンダリン類似物およびこれらのフラグメントそして製造方法および使用方法 |
| US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| AU2008313627A1 (en) * | 2007-10-19 | 2009-04-23 | Pharma Mar, S.A. | Improved antitumoral treatments |
-
2000
- 2000-11-15 CZ CZ20021697A patent/CZ302498B6/cs not_active IP Right Cessation
- 2000-11-15 BR BR0015811-9A patent/BR0015811A/pt not_active Application Discontinuation
- 2000-11-15 CA CA002391502A patent/CA2391502A1/en not_active Abandoned
- 2000-11-15 AU AU14023/01A patent/AU780417B2/en not_active Ceased
- 2000-11-15 IL IL14948800A patent/IL149488A0/xx unknown
- 2000-11-15 AT AT00976137T patent/ATE363910T1/de active
- 2000-11-15 RU RU2002115864/14A patent/RU2261104C2/ru not_active IP Right Cessation
- 2000-11-15 SI SI200030960T patent/SI1229922T1/sl unknown
- 2000-11-15 EP EP00976137A patent/EP1229922B1/en not_active Expired - Lifetime
- 2000-11-15 PL PL355335A patent/PL200922B1/pl not_active IP Right Cessation
- 2000-11-15 KR KR10-2002-7006155A patent/KR100518986B1/ko not_active Expired - Fee Related
- 2000-11-15 NZ NZ518847A patent/NZ518847A/en not_active IP Right Cessation
- 2000-11-15 DK DK00976137T patent/DK1229922T3/da active
- 2000-11-15 HU HU0203906A patent/HUP0203906A2/hu unknown
- 2000-11-15 JP JP2001537965A patent/JP2003514025A/ja active Pending
- 2000-11-15 ES ES00976137T patent/ES2288486T3/es not_active Expired - Lifetime
- 2000-11-15 MX MXPA02004862A patent/MXPA02004862A/es active IP Right Grant
- 2000-11-15 PT PT00976137T patent/PT1229922E/pt unknown
- 2000-11-15 WO PCT/GB2000/004349 patent/WO2001035974A2/en not_active Ceased
- 2000-11-15 DE DE60035120T patent/DE60035120T2/de not_active Expired - Lifetime
- 2000-11-15 SK SK659-2002A patent/SK287762B6/sk not_active IP Right Cessation
- 2000-11-15 HK HK02106981.6A patent/HK1045648B/en not_active IP Right Cessation
- 2000-11-15 CN CN00818404A patent/CN1423564A/zh active Pending
-
2002
- 2002-05-14 NO NO20022293A patent/NO330719B1/no not_active IP Right Cessation
- 2002-05-18 BG BG106714A patent/BG65381B1/bg unknown
-
2007
- 2007-08-30 CY CY20071101110T patent/CY1106825T1/el unknown
-
2008
- 2008-12-23 US US12/342,478 patent/US20090298752A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: FAIRCLOTH, GLYNN THOMAS, CAMBRIDGE, MA, US Inventor name: TWELVES, CHRIS, BEARSDEN, GLASGOW, GB Inventor name: PAZ-ARES, LUIS, MADRID, ES |
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| 8327 | Change in the person/name/address of the patent owner |
Owner name: PHARMA MAR, S.A., COLMENAR VIEJO, MADRID, ES |
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| 8328 | Change in the person/name/address of the agent |
Representative=s name: SERWE, K., DIPL.-ING., PAT.-ANW., 54290 TRIER |
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| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: MOSELPATENT TRIERPATENT, 54290 TRIER |
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| 8328 | Change in the person/name/address of the agent |
Representative=s name: PATENTANWAELTE SERWE & DR. WAGNER, 54290 TRIER |