BR0015811A - Tratamento de c nceres com aplidina - Google Patents

Tratamento de c nceres com aplidina

Info

Publication number
BR0015811A
BR0015811A BR0015811-9A BR0015811A BR0015811A BR 0015811 A BR0015811 A BR 0015811A BR 0015811 A BR0015811 A BR 0015811A BR 0015811 A BR0015811 A BR 0015811A
Authority
BR
Brazil
Prior art keywords
aplidine
treatment
tumor
cancers
nceres
Prior art date
Application number
BR0015811-9A
Other languages
English (en)
Inventor
Glynn Thomas Faircloth
Chris Twelves
Luis Paz-Ares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927006.8A external-priority patent/GB9927006D0/en
Priority claimed from GB0005701A external-priority patent/GB0005701D0/en
Priority claimed from GB0007639A external-priority patent/GB0007639D0/en
Priority claimed from GB0015496A external-priority patent/GB0015496D0/en
Priority claimed from GB0025209A external-priority patent/GB0025209D0/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of BR0015811A publication Critical patent/BR0015811A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

"TRATAMENTO DE C NCERES COM APLIDINA". Aplidina demostra considerável esperança em testes clínicos de fase (I) para tratamento de tumores, onde são dados vários regimes de dosagem. A redução do tumor foi observada em vários tipos de tumor incluindo carcinoma renal, câncer coloretal, carcinóide pulmonar, carcinomas da tireóide medulares e melanoma. Descobriu-se também, que a aplidina possui um papel na inibição da angiogênese, complementando a atividade anti-tumoral."
BR0015811-9A 1999-11-15 2000-11-15 Tratamento de c nceres com aplidina BR0015811A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9927006.8A GB9927006D0 (en) 1999-11-15 1999-11-15 Aplidine treatment of cancers
GB0005701A GB0005701D0 (en) 2000-03-09 2000-03-09 Antitumor utility of aplidine
GB0007639A GB0007639D0 (en) 2000-03-29 2000-03-29 Antitumour and anti-angiogenic compound
GB0015496A GB0015496D0 (en) 2000-06-23 2000-06-23 Antitumour and anti-angiogenic compound
GB0025209A GB0025209D0 (en) 2000-10-13 2000-10-13 Treatment of cancers
PCT/GB2000/004349 WO2001035974A2 (en) 1999-11-15 2000-11-15 Aplidine treatment of cancers

Publications (1)

Publication Number Publication Date
BR0015811A true BR0015811A (pt) 2002-08-06

Family

ID=27515929

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015811-9A BR0015811A (pt) 1999-11-15 2000-11-15 Tratamento de c nceres com aplidina

Country Status (27)

Country Link
US (1) US20090298752A1 (pt)
EP (1) EP1229922B1 (pt)
JP (1) JP2003514025A (pt)
KR (1) KR100518986B1 (pt)
CN (1) CN1423564A (pt)
AT (1) ATE363910T1 (pt)
AU (1) AU780417B2 (pt)
BG (1) BG65381B1 (pt)
BR (1) BR0015811A (pt)
CA (1) CA2391502A1 (pt)
CY (1) CY1106825T1 (pt)
CZ (1) CZ302498B6 (pt)
DE (1) DE60035120T2 (pt)
DK (1) DK1229922T3 (pt)
ES (1) ES2288486T3 (pt)
HK (1) HK1045648B (pt)
HU (1) HUP0203906A2 (pt)
IL (1) IL149488A0 (pt)
MX (1) MXPA02004862A (pt)
NO (1) NO330719B1 (pt)
NZ (1) NZ518847A (pt)
PL (1) PL200922B1 (pt)
PT (1) PT1229922E (pt)
RU (1) RU2261104C2 (pt)
SI (1) SI1229922T1 (pt)
SK (1) SK287762B6 (pt)
WO (1) WO2001035974A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
RU2003113210A (ru) 2000-10-12 2004-11-27 Фарма Мар, С.А. (Es) Лечение раковых заболеваний
ATE411036T1 (de) * 2001-10-19 2008-10-15 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
CN101579520A (zh) * 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine
SI1603584T1 (sl) 2003-03-12 2009-02-28 Dana Farber Cancer Inst Inc Aplidin za zdravljenje multiple mieloma
ME02450B (me) 2006-02-28 2016-09-20 Pharma Mar Sa POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA
ATE479432T1 (de) * 2006-11-03 2010-09-15 Nerviano Medical Sciences Srl Verfahren zur verabreichung einer antitumoralen verbindung
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments
CN101965191A (zh) * 2008-03-07 2011-02-02 法马马有限公司 改善的抗癌治疗
CN103463020B (zh) * 2013-09-23 2015-11-25 李淑兰 Lycojaponicumin A在制备治疗肾癌药物中的应用
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342744A (en) * 1979-07-19 1982-08-03 Lever Brothers Company Hair treatment products
DE3161556D1 (en) * 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3684868D1 (de) * 1985-09-20 1992-05-21 Cernitin Sa Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung.
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
US5580871A (en) * 1992-11-20 1996-12-03 The Dupont Merck Pharmaceutical Company 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity
FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US5462726A (en) * 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
JPH09507233A (ja) * 1993-12-29 1997-07-22 マトリクス ファーマスーティカル，インコーポレイティド 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US6365597B1 (en) * 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
JP4172726B2 (ja) * 1996-05-22 2008-10-29 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤
US6156724A (en) * 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
US6034058A (en) * 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
CA2288639A1 (en) * 1997-05-07 1998-11-12 Pharma Mar, S.A. Aplidine as an l-type calcium channel enhancer
US6245759B1 (en) * 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US20010021380A1 (en) * 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
JP2003535048A (ja) * 2000-04-07 2003-11-25 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア タマンダリンおよびジデムニン同族体およびそれらの作成および使用法
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
JP2004528008A (ja) * 2000-10-05 2004-09-16 イミュネックス・コーポレーション ネクチンポリペプチド、ポリヌクレオチド、該ポリペプチドおよびポリヌクレオチドを作成し、そして使用する方法
RU2003113210A (ru) * 2000-10-12 2004-11-27 Фарма Мар, С.А. (Es) Лечение раковых заболеваний
WO2002032374A2 (en) * 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
US6610399B1 (en) * 2000-11-17 2003-08-26 Structural Technologies, Llc Multi-layer, thermal protection and corrosion protection coating system for metallic tendons, especially for external post-tensioning systems
ATE411036T1 (de) * 2001-10-19 2008-10-15 Pharma Mar Sa Verwendung von aplidine in der behandlung von pankreaskrebs
CN101579520A (zh) * 2003-03-12 2009-11-18 达纳-法伯癌症协会有限公司 用于多发性骨髓瘤的治疗的aplidine
SI1603584T1 (sl) * 2003-03-12 2009-02-28 Dana Farber Cancer Inst Inc Aplidin za zdravljenje multiple mieloma
EP1613338A4 (en) * 2003-03-21 2009-06-24 Madeleine M Joullie TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME
US20060019256A1 (en) * 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
ME02450B (me) * 2006-02-28 2016-09-20 Pharma Mar Sa POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA
US20100240595A1 (en) * 2007-10-19 2010-09-23 Pharma Mar ,S.A. Improved Antitumoral Treatments

Also Published As

Publication number Publication date
DK1229922T3 (da) 2007-10-08
NO20022293L (no) 2002-07-05
HUP0203906A2 (en) 2003-03-28
CN1423564A (zh) 2003-06-11
DE60035120D1 (de) 2007-07-19
CZ20021697A3 (cs) 2003-02-12
NZ518847A (en) 2004-02-27
HK1045648B (zh) 2007-09-21
RU2261104C2 (ru) 2005-09-27
NO20022293D0 (no) 2002-05-14
SI1229922T1 (sl) 2008-04-30
KR20020064313A (ko) 2002-08-07
BG106714A (en) 2003-02-28
WO2001035974A3 (en) 2001-11-01
AU780417B2 (en) 2005-03-17
PT1229922E (pt) 2007-09-12
DE60035120T2 (de) 2008-01-31
NO330719B1 (no) 2011-06-20
EP1229922A2 (en) 2002-08-14
PL355335A1 (en) 2004-04-19
JP2003514025A (ja) 2003-04-15
CZ302498B6 (cs) 2011-06-15
ATE363910T1 (de) 2007-06-15
KR100518986B1 (ko) 2005-10-06
CA2391502A1 (en) 2001-05-25
WO2001035974A2 (en) 2001-05-25
BG65381B1 (bg) 2008-05-30
IL149488A0 (en) 2002-11-10
MXPA02004862A (es) 2003-01-28
ES2288486T3 (es) 2008-01-16
CY1106825T1 (el) 2012-05-23
SK6592002A3 (en) 2003-08-05
PL200922B1 (pl) 2009-02-27
HK1045648A1 (en) 2002-12-06
US20090298752A1 (en) 2009-12-03
EP1229922B1 (en) 2007-06-06
RU2002115864A (ru) 2004-01-20
SK287762B6 (sk) 2011-09-05
AU1402301A (en) 2001-05-30

Similar Documents

Publication Publication Date Title
BR0015811A (pt) Tratamento de c nceres com aplidina
PT674630E (pt) 7-halo- e 7beta,8beta-metano-taxois utilizacao antineoplasica e composicoes farmaceuticas que os contem
DE69327788D1 (de) Pharmazeutische zusammenstezungen zur hemmung von tumoren in verbindung mit prostaten adenokarzinom magenkrebs und brustkrebs
TR199902053T2 (xx) Prostat kanserinin immunoterapisine y�nelik bile�ikler ve bunlar�n kullan�lmas�na matuf metodlar.
PL354540A1 (en) Drugs for the treatment of malignant tumours
WO2002045653A3 (en) Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
IL138330A0 (en) Polynucleotides, polypeptides and pharmaceutical compositions for treating lung cancer
BR9407956A (pt) Composiçao farmacêutica vetor de express o de adenovirus recombinante e kit par reduzir a proliferaçao de células tumorais
AR029763A1 (es) Uso de una combinacion de una nsaid y un inhibidor de quinasa egfr para la manufactura de un medicamento para el tratamiento o inhibicion de polipos colonicos y cancer colorectal, composicion farmaceutica y medicamento
TR199701535T1 (xx) Bis-1,2,4- triazolleri, kanserlerin tedavisi i�in bir ila� �retilmesinde kullan�m�.
TR200001687T2 (tr) Neopleasyo için N-benzil-3-indenilasetamid türevleri.
HUP9802677A2 (hu) 1,2,4-Triazol-származékok felhasználása rák kezelésére szolgáló gyógyszerkészítmények előállítására
Pourmorteza et al. Evofosfamide, a new horizon in the treatment of pancreatic cancer
PL322732A1 (en) Pharmaceutic agent containing n-chlorophenyl carbaminates and n-chlorophenyl thiocarbaminates for inhibiting development of viruses and carcinoma
TR200103786T2 (tr) Güğüs kanserinin tehisi ve imünoterapisi için bileşikler ve bunların kullanımı
IL97055A0 (en) Pharmaceutical compositions for sensitizing tumor cells comprising quinazolinedione derivatives
CY1106525T1 (el) ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΜΕ hCG ΓΙΑ ΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΟΥ ΜΕΤΑΣΤΑΤΙΚΟΥ ΚΑΡΚΙΝΟΥ ΤΟΥ ΜΑΣΤΟΥ
NO20021011D0 (no) Fremgangsmåte og formulering for tumorremisjon og suppresjon av cancer
DK1135169T3 (da) Anvendelse af et farmaceutisk præparat indeholdende et anticancermiddel og mindst et peptid.
ZA200106725B (en) Use of an enterobacterium protein ompa associated with an antigen for generating an antiviral antiparasitic or antitumoral cytotoxic response.
DE69835167D1 (de) 1,2,4-benzotriazin-oxide enthaltende zubereitungen
WO2000040752A3 (en) Cancer associated genes and their products
AU1991901A (en) Pharmaceutical composition for treating and preventing human tumors, which express the tumor antigen mucin and/or the carcinoembryonic antigen (cea), and the use thereof
Dahan et al. Postoperative chemoradiotherapy after surgical resection of gastric adenocarcinoma: can LV5FU2 reduce the toxic effects of the MacDonald regimen?: A report on 23 patients
AU2001256440A1 (en) Medicines for treating tumoral pathologies containing the ro5-4864 compound and an apoptosis-inducing agent

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA A CLASSIFICACAO DA INT. CL.: A61K 38/00.

Ipc: A61K 38/15 (2010.01), A61P 35/00 (2010.01)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10 (VIII) DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.