SK287762B6 - Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny - Google Patents

Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny Download PDF

Info

Publication number
SK287762B6
SK287762B6 SK659-2002A SK6592002A SK287762B6 SK 287762 B6 SK287762 B6 SK 287762B6 SK 6592002 A SK6592002 A SK 6592002A SK 287762 B6 SK287762 B6 SK 287762B6
Authority
SK
Slovakia
Prior art keywords
aplidine
patients
weeks
dose
infusion
Prior art date
Application number
SK659-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK6592002A3 (en
Inventor
Glynn Thomas Faircloth
Chris Twelves
Luis Paz-Ares
Original Assignee
Pharma Mar, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927006.8A external-priority patent/GB9927006D0/en
Priority claimed from GB0005701A external-priority patent/GB0005701D0/en
Priority claimed from GB0007639A external-priority patent/GB0007639D0/en
Priority claimed from GB0015496A external-priority patent/GB0015496D0/en
Priority claimed from GB0025209A external-priority patent/GB0025209D0/en
Application filed by Pharma Mar, S. A. filed Critical Pharma Mar, S. A.
Publication of SK6592002A3 publication Critical patent/SK6592002A3/sk
Publication of SK287762B6 publication Critical patent/SK287762B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK659-2002A 1999-11-15 2000-11-15 Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny SK287762B6 (sk)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9927006.8A GB9927006D0 (en) 1999-11-15 1999-11-15 Aplidine treatment of cancers
GB0005701A GB0005701D0 (en) 2000-03-09 2000-03-09 Antitumor utility of aplidine
GB0007639A GB0007639D0 (en) 2000-03-29 2000-03-29 Antitumour and anti-angiogenic compound
GB0015496A GB0015496D0 (en) 2000-06-23 2000-06-23 Antitumour and anti-angiogenic compound
GB0025209A GB0025209D0 (en) 2000-10-13 2000-10-13 Treatment of cancers
PCT/GB2000/004349 WO2001035974A2 (en) 1999-11-15 2000-11-15 Aplidine treatment of cancers

Publications (2)

Publication Number Publication Date
SK6592002A3 SK6592002A3 (en) 2003-08-05
SK287762B6 true SK287762B6 (sk) 2011-09-05

Family

ID=27515929

Family Applications (1)

Application Number Title Priority Date Filing Date
SK659-2002A SK287762B6 (sk) 1999-11-15 2000-11-15 Použitie aplidínu na prípravu farmaceutického prostriedku na liečenie rakoviny

Country Status (27)

Country Link
US (1) US20090298752A1 (pt)
EP (1) EP1229922B1 (pt)
JP (1) JP2003514025A (pt)
KR (1) KR100518986B1 (pt)
CN (1) CN1423564A (pt)
AT (1) ATE363910T1 (pt)
AU (1) AU780417B2 (pt)
BG (1) BG65381B1 (pt)
BR (1) BR0015811A (pt)
CA (1) CA2391502A1 (pt)
CY (1) CY1106825T1 (pt)
CZ (1) CZ302498B6 (pt)
DE (1) DE60035120T2 (pt)
DK (1) DK1229922T3 (pt)
ES (1) ES2288486T3 (pt)
HK (1) HK1045648B (pt)
HU (1) HUP0203906A2 (pt)
IL (1) IL149488A0 (pt)
MX (1) MXPA02004862A (pt)
NO (1) NO330719B1 (pt)
NZ (1) NZ518847A (pt)
PL (1) PL200922B1 (pt)
PT (1) PT1229922E (pt)
RU (1) RU2261104C2 (pt)
SI (1) SI1229922T1 (pt)
SK (1) SK287762B6 (pt)
WO (1) WO2001035974A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
BR0114604A (pt) 2000-10-12 2003-10-14 Pharma Mar Sa Tratamento de c‰nceres
ES2315404T3 (es) * 2001-10-19 2009-04-01 Pharma Mar, S.A. Uso de aplidina para el tratamiento de cancer de pancreas.
DK1603584T3 (da) 2003-03-12 2009-01-05 Dana Farber Cancer Inst Inc Aplidine til behandling af multipelt myelom
US7576188B2 (en) * 2003-03-12 2009-08-18 Pharma Mar, S.A.U. Antitumoral treatments
RS54928B1 (sr) 2006-02-28 2016-10-31 Pharma Mar Sa Poboljšano lečenje multiplog mijeloma
ES2350803T3 (es) * 2006-11-03 2011-01-27 Nerviano Medical Sciences S.R.L. Procedimiento de administración de un compuesto antitumoral.
JP2011500650A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療
WO2009111698A1 (en) * 2008-03-07 2009-09-11 Pharma Mar, S.A. Improved anticancer treatments
CN103463020B (zh) * 2013-09-23 2015-11-25 李淑兰 Lycojaponicumin A在制备治疗肾癌药物中的应用
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

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US4342744A (en) * 1979-07-19 1982-08-03 Lever Brothers Company Hair treatment products
DE3161556D1 (en) * 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
ATE74761T1 (de) * 1985-09-20 1992-05-15 Cernitin Sa Verwendung von pflanzenpollenextrakten zur herstellung von das wachstum von tumorzellen hemmenden pharmazeutischen praeparaten und verfahren zu ihrer herstellung.
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
US5580871A (en) * 1992-11-20 1996-12-03 The Dupont Merck Pharmaceutical Company 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity
FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US5462726A (en) * 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
EP0739210B1 (en) * 1993-12-29 2002-07-24 Matrix Pharmaceutical, Inc. Compositions for local delivery of cytostatic agents
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US6365597B1 (en) * 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
CA2255615C (en) * 1996-05-22 2006-08-29 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and docetaxel
US6156724A (en) * 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
US6034058A (en) * 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
US6030943A (en) * 1997-05-07 2000-02-29 Crumb; William J. Dehydrodidemnin B as an L-type calcium channel enhancer
US6245759B1 (en) * 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
US20010021380A1 (en) * 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US6509315B1 (en) * 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
DE60123232T2 (de) * 2000-04-07 2007-11-08 Trustees Of The University Of Pennsylvania Tamandarin und didemnin analoga und methoden zu deren herstellung und verwendung
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
AU1305302A (en) * 2000-10-05 2002-04-15 Immunex Corp Nectin polypeptides, polynucleotides, methods of making and use thereof
BR0114604A (pt) * 2000-10-12 2003-10-14 Pharma Mar Sa Tratamento de c‰nceres
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
US6610399B1 (en) * 2000-11-17 2003-08-26 Structural Technologies, Llc Multi-layer, thermal protection and corrosion protection coating system for metallic tendons, especially for external post-tensioning systems
ES2315404T3 (es) * 2001-10-19 2009-04-01 Pharma Mar, S.A. Uso de aplidina para el tratamiento de cancer de pancreas.
DK1603584T3 (da) * 2003-03-12 2009-01-05 Dana Farber Cancer Inst Inc Aplidine til behandling af multipelt myelom
US7576188B2 (en) * 2003-03-12 2009-08-18 Pharma Mar, S.A.U. Antitumoral treatments
EP1613338A4 (en) * 2003-03-21 2009-06-24 Madeleine M Joullie TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME
EP2003196A3 (en) * 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
RS54928B1 (sr) * 2006-02-28 2016-10-31 Pharma Mar Sa Poboljšano lečenje multiplog mijeloma
JP2011500650A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療

Also Published As

Publication number Publication date
AU780417B2 (en) 2005-03-17
CZ20021697A3 (cs) 2003-02-12
CA2391502A1 (en) 2001-05-25
JP2003514025A (ja) 2003-04-15
HK1045648A1 (en) 2002-12-06
AU1402301A (en) 2001-05-30
HUP0203906A2 (en) 2003-03-28
WO2001035974A2 (en) 2001-05-25
BR0015811A (pt) 2002-08-06
SI1229922T1 (sl) 2008-04-30
RU2261104C2 (ru) 2005-09-27
RU2002115864A (ru) 2004-01-20
SK6592002A3 (en) 2003-08-05
ES2288486T3 (es) 2008-01-16
BG106714A (en) 2003-02-28
KR100518986B1 (ko) 2005-10-06
CN1423564A (zh) 2003-06-11
DE60035120T2 (de) 2008-01-31
DE60035120D1 (de) 2007-07-19
ATE363910T1 (de) 2007-06-15
EP1229922A2 (en) 2002-08-14
CZ302498B6 (cs) 2011-06-15
NO20022293D0 (no) 2002-05-14
KR20020064313A (ko) 2002-08-07
NO20022293L (no) 2002-07-05
PL200922B1 (pl) 2009-02-27
MXPA02004862A (es) 2003-01-28
US20090298752A1 (en) 2009-12-03
IL149488A0 (en) 2002-11-10
BG65381B1 (bg) 2008-05-30
CY1106825T1 (el) 2012-05-23
PT1229922E (pt) 2007-09-12
NO330719B1 (no) 2011-06-20
HK1045648B (zh) 2007-09-21
WO2001035974A3 (en) 2001-11-01
DK1229922T3 (da) 2007-10-08
EP1229922B1 (en) 2007-06-06
NZ518847A (en) 2004-02-27
PL355335A1 (en) 2004-04-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110711