ME02450B - POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA - Google Patents

POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA

Info

Publication number
ME02450B
ME02450B MEP-2016-115A MEP11516A ME02450B ME 02450 B ME02450 B ME 02450B ME P11516 A MEP11516 A ME P11516A ME 02450 B ME02450 B ME 02450B
Authority
ME
Montenegro
Prior art keywords
aplidine
dexamethasone
improved anti
tumor treatments
use according
Prior art date
Application number
MEP-2016-115A
Other languages
English (en)
French (fr)
Inventor
Glynn Thomas Faircloth
Marin Pablo Manuel Aviles
Doreen Lepage
Miguel Izquierdo Jesus San
Atanasio Pandiella
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of ME02450B publication Critical patent/ME02450B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (4)

1. Aplidin za primjenu u metodi za liječenje multiplog mijeloma pomoću kombinovane terapije korišćenjem Aplidina u sinergističkoj kombinaciji sa deksametazonom.
2. Aplidin za primjenu prema patentnom zahtjevu 1, gde Aplidin i deksametazon formiraju dio iste kompozicije.
3. Aplidin za primjenu prema patentnom zahtjevu 1, gde su Aplidin i deksametazon obezbijeđeni kao zasebne kompozicije gde je deksametazon administriran prije, za vrijeme, ili nakon administriranja Aplidina.
4. Aplidin za primjenu prema patentnom zahtjevu 3, gde su Aplidin i deksametazon obezbijeđeni kao zasebne kompozicije u kojima je deksametazon administriran pre, ili nakon administriranja Aplidina.
MEP-2016-115A 2006-02-28 2007-02-28 POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA ME02450B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81360606P 2006-02-28 2006-02-28
EP07757603.1A EP2029155B1 (en) 2006-02-28 2007-02-28 Improved treatment of multiple myeloma
PCT/US2007/062936 WO2007101235A2 (en) 2006-02-28 2007-02-28 Improved antitumoral treatments

Publications (1)

Publication Number Publication Date
ME02450B true ME02450B (me) 2016-09-20

Family

ID=38459806

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2016-115A ME02450B (me) 2006-02-28 2007-02-28 POBOLJŠANO LIJEČENJE MULTlPLOG MIJELOMA

Country Status (23)

Country Link
US (1) US8258098B2 (me)
EP (1) EP2029155B1 (me)
JP (2) JP5393159B2 (me)
KR (2) KR101512503B1 (me)
CN (1) CN101389347B (me)
AU (1) AU2007220050B2 (me)
CA (1) CA2643238C (me)
CY (1) CY1117722T1 (me)
DK (1) DK2029155T3 (me)
ES (1) ES2575518T3 (me)
HR (1) HRP20160646T1 (me)
HU (1) HUE028055T2 (me)
IL (1) IL193094A (me)
ME (1) ME02450B (me)
MX (1) MX2008010999A (me)
NO (1) NO342012B1 (me)
NZ (1) NZ571043A (me)
PL (1) PL2029155T3 (me)
PT (1) PT2029155E (me)
RS (1) RS54928B1 (me)
RU (1) RU2481853C2 (me)
SI (1) SI2029155T1 (me)
WO (1) WO2007101235A2 (me)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1045648B (en) * 1999-11-15 2007-09-21 Pharma Mar, S.A. Aplidine treatment of cancers
WO2007101235A2 (en) 2006-02-28 2007-09-07 Pharma Mar, S.A. Improved antitumoral treatments
WO2008135793A1 (en) * 2007-05-04 2008-11-13 Pharma Mar S.A. Combination of aplidine and carboplatin in anticancer treatments
JP2011500650A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療
AU2009221720A1 (en) * 2008-03-07 2009-09-11 Pharma Mar, S.A. Improved anticancer treatments
CN101965192A (zh) * 2008-03-07 2011-02-02 法马马有限公司 改善的抗肿瘤治疗
WO2011084968A1 (en) 2010-01-05 2011-07-14 Celgene Corporation A combination of an immunomodulatory compound and an artemisinin or a derivative thereof for treating cancer
EP2786756B1 (en) * 2010-11-12 2020-03-11 Pharma Mar, S.A. Combination therapy with a topoisomerase inhibitor
JP6116482B2 (ja) * 2010-12-01 2017-04-19 ニーキ ファーマ インコーポレイテッド ガリウム錯体を用いる併用療法
HUE043001T2 (hu) 2011-11-09 2019-07-29 Bristol Myers Squibb Co Hematológiai malignómák kezelése anti-CXCR4 antitesttel
KR101369936B1 (ko) * 2011-12-28 2014-03-06 연세대학교 산학협력단 탈리도마이드를 포함하는 루프스 신염 치료용 약학 조성물
RU2547999C1 (ru) * 2013-10-28 2015-04-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения аденогенного местно-распространенного рака нижнеампулярного отдела прямой кишки
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020122102A1 (ja) * 2018-12-14 2020-06-18 コニカミノルタ株式会社 病変組織内への薬剤到達を予測する方法
CN113018415B (zh) * 2021-03-17 2022-07-01 遵义医科大学 一种药物组合及其应用

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Publication number Priority date Publication date Assignee Title
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
EP0220453B1 (de) * 1985-09-20 1992-04-15 Cernitin S.A. Verwendung von Pflanzenpollenextrakten zur Herstellung von das Wachstum von Tumorzellen hemmenden pharmazeutischen Präparaten und Verfahren zu ihrer Herstellung
US4948791A (en) 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB8922026D0 (en) * 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
DE4120327A1 (de) 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
US5580871A (en) * 1992-11-20 1996-12-03 The Dupont Merck Pharmaceutical Company 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity
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DK0956033T3 (da) 1996-10-24 2003-10-06 Univ Illinois Totalsyntese af amino-Hip-analogen af didemnin A
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WO2004080421A2 (en) * 2003-03-12 2004-09-23 Pharma Mar, S.A. Improved antitumoral treatments
MXPA05010064A (es) 2003-03-21 2006-05-17 Madeleine M Joullie Analogos de tamandarin y fragmentos de los mismos y metodos para hacerlos y usarlos.
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
WO2007101235A2 (en) 2006-02-28 2007-09-07 Pharma Mar, S.A. Improved antitumoral treatments
DE102006061344A1 (de) * 2006-12-22 2008-06-26 Robert Bosch Gmbh Kupplungshydraulikkreis
WO2008080956A1 (en) 2006-12-29 2008-07-10 Pharma Mar, S.A. Prognostic molecular markers for the cancer therapy with aplidine
WO2008135793A1 (en) 2007-05-04 2008-11-13 Pharma Mar S.A. Combination of aplidine and carboplatin in anticancer treatments
JP2011500650A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ 改良された抗腫瘍治療
WO2010029158A1 (en) 2008-09-12 2010-03-18 Pharma Mar, S.A. Aplidine in the treatment of chronic myeloproliferative disorders

Also Published As

Publication number Publication date
EP2029155B1 (en) 2016-04-13
CN101389347A (zh) 2009-03-18
SI2029155T1 (sl) 2016-06-30
DK2029155T3 (en) 2016-08-01
JP2013199500A (ja) 2013-10-03
RU2008138560A (ru) 2010-04-10
US8258098B2 (en) 2012-09-04
PL2029155T3 (pl) 2016-09-30
NZ571043A (en) 2012-06-29
AU2007220050A1 (en) 2007-09-07
IL193094A (en) 2015-06-30
RU2481853C2 (ru) 2013-05-20
WO2007101235A3 (en) 2008-04-03
WO2007101235A2 (en) 2007-09-07
EP2029155A4 (en) 2009-10-14
IL193094A0 (en) 2011-08-01
EP2029155A2 (en) 2009-03-04
US20090246168A1 (en) 2009-10-01
NO20084047L (no) 2008-11-25
KR20080105123A (ko) 2008-12-03
JP2009528379A (ja) 2009-08-06
RS54928B1 (sr) 2016-10-31
JP5393159B2 (ja) 2014-01-22
CA2643238A1 (en) 2007-09-07
HK1127294A1 (zh) 2009-09-25
ES2575518T3 (es) 2016-06-29
CN101389347B (zh) 2013-03-27
MX2008010999A (es) 2008-09-08
HRP20160646T1 (hr) 2016-08-12
PT2029155E (pt) 2016-06-17
KR101512503B1 (ko) 2015-04-15
NO342012B1 (no) 2018-03-12
AU2007220050B2 (en) 2013-08-29
KR20140101014A (ko) 2014-08-18
HUE028055T2 (en) 2016-11-28
CA2643238C (en) 2016-05-03
CY1117722T1 (el) 2017-05-17

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