JP2005513017A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005513017A5 JP2005513017A5 JP2003544013A JP2003544013A JP2005513017A5 JP 2005513017 A5 JP2005513017 A5 JP 2005513017A5 JP 2003544013 A JP2003544013 A JP 2003544013A JP 2003544013 A JP2003544013 A JP 2003544013A JP 2005513017 A5 JP2005513017 A5 JP 2005513017A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- nhc
- para
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 46
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 14
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 125000004093 cyano group Chemical group *C#N 0.000 description 4
- 125000001475 halogen functional group Chemical group 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 102000004274 CCR5 Receptors Human genes 0.000 description 1
- 108010017088 CCR5 Receptors Proteins 0.000 description 1
- 102000009410 Chemokine receptor Human genes 0.000 description 1
- 108050000299 Chemokine receptor Proteins 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000005549 heteroarylene group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0103819A SE0103819D0 (sv) | 2001-11-15 | 2001-11-15 | Chemical compounds |
| PCT/SE2002/002054 WO2003042177A1 (en) | 2001-11-15 | 2002-11-12 | Piperidine derivatives and their use as modulators of chemokine receptor activity (especially ccr5) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513017A JP2005513017A (ja) | 2005-05-12 |
| JP2005513017A5 true JP2005513017A5 (https=) | 2006-01-12 |
Family
ID=20286006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003544013A Pending JP2005513017A (ja) | 2001-11-15 | 2002-11-12 | ケモカイン受容体（特にｃｃｒ）活性のモジュレーターとしてのピペリジン誘導体とその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050014788A1 (https=) |
| EP (1) | EP1448524A1 (https=) |
| JP (1) | JP2005513017A (https=) |
| KR (1) | KR20050013526A (https=) |
| CN (1) | CN1589261A (https=) |
| AR (1) | AR037350A1 (https=) |
| BR (1) | BR0214141A (https=) |
| CA (1) | CA2464861A1 (https=) |
| HU (1) | HUP0402567A2 (https=) |
| IL (1) | IL161594A0 (https=) |
| IS (1) | IS7257A (https=) |
| MX (1) | MXPA04004497A (https=) |
| NO (1) | NO20042156L (https=) |
| PL (1) | PL370910A1 (https=) |
| RU (1) | RU2004112781A (https=) |
| SE (1) | SE0103819D0 (https=) |
| TW (1) | TW200407140A (https=) |
| WO (1) | WO2003042177A1 (https=) |
| ZA (1) | ZA200403681B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| SE0202483D0 (sv) * | 2002-08-21 | 2002-08-21 | Astrazeneca Ab | Chemical compounds |
| SE0301369D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| SE0302090D0 (sv) * | 2003-07-16 | 2003-07-16 | Astrazeneca Ab | Chemical compounds |
| ATE361911T1 (de) * | 2003-07-31 | 2007-06-15 | Astrazeneca Ab | Piperidinderivate als ccr5-rezeptormodulatoren |
| EP1786816A4 (en) | 2003-09-10 | 2009-11-04 | Virochem Pharma Inc | SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY |
| SE0303396D0 (sv) * | 2003-12-16 | 2003-12-16 | Astrazeneca Ab | Chemical compounds |
| KR100905260B1 (ko) | 2004-06-09 | 2009-06-30 | 상해 타킷 드러그 주식회사 | 씨씨알5 길항제로서의 화합물 |
| CN1329374C (zh) * | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
| SE0401657D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| SE0403084D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Chemical process |
| JP2009525269A (ja) | 2006-01-30 | 2009-07-09 | ユーロ−セルティーク エス．エイ． | カルシウムチャネルブロッカーとしての環状尿素化合物 |
| GB0625523D0 (en) * | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
| WO2009010478A2 (en) * | 2007-07-13 | 2009-01-22 | Euroscreen S.A. | Use of piperidine derivatives as agonists of chemokine receptor activity |
| WO2015043713A1 (en) * | 2013-09-25 | 2015-04-02 | Merck Patent Gmbh | Compounds and mesogenic media |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL135488A0 (en) * | 1997-11-18 | 2001-05-20 | Teijin Ltd | Cyclic amine derivatives |
| EP1013276A1 (en) * | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
| SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| GB0011838D0 (en) * | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
-
2001
- 2001-11-15 SE SE0103819A patent/SE0103819D0/xx unknown
-
2002
- 2002-11-01 TW TW091132377A patent/TW200407140A/zh unknown
- 2002-11-12 CN CNA028227409A patent/CN1589261A/zh active Pending
- 2002-11-12 WO PCT/SE2002/002054 patent/WO2003042177A1/en not_active Ceased
- 2002-11-12 HU HU0402567A patent/HUP0402567A2/hu unknown
- 2002-11-12 KR KR10-2004-7007365A patent/KR20050013526A/ko not_active Withdrawn
- 2002-11-12 IL IL16159402A patent/IL161594A0/xx unknown
- 2002-11-12 PL PL02370910A patent/PL370910A1/xx not_active Application Discontinuation
- 2002-11-12 BR BR0214141-8A patent/BR0214141A/pt not_active IP Right Cessation
- 2002-11-12 RU RU2004112781/04A patent/RU2004112781A/ru not_active Application Discontinuation
- 2002-11-12 JP JP2003544013A patent/JP2005513017A/ja active Pending
- 2002-11-12 CA CA002464861A patent/CA2464861A1/en not_active Abandoned
- 2002-11-12 MX MXPA04004497A patent/MXPA04004497A/es unknown
- 2002-11-12 AR ARP020104332A patent/AR037350A1/es unknown
- 2002-11-12 EP EP02786316A patent/EP1448524A1/en not_active Withdrawn
- 2002-11-12 US US10/495,405 patent/US20050014788A1/en not_active Abandoned
-
2004
- 2004-05-10 IS IS7257A patent/IS7257A/is unknown
- 2004-05-13 ZA ZA200403681A patent/ZA200403681B/en unknown
- 2004-05-25 NO NO20042156A patent/NO20042156L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005513017A5 (https=) | ||
| US20230365542A1 (en) | Selective Agonists of 5-HT2A Receptor and Methods of Use | |
| JP4698591B2 (ja) | 非鎮静ａ−２アゴニスト１−（２，３−ジメチル−フェニル）−エチル−１、３−ジヒドロ−イミダゾール−２−チオン | |
| CN1711085A (zh) | 含乙酸酰基苯胺衍生物作为活性成分的膀胱活动过度的治疗药物 | |
| MXPA05007857A (es) | Moduladores derivados de indol de receptores nucleares de hormonas esteroideas. | |
| JP2016128481A (ja) | 肺高血圧症の処置のためのニトロキシル供与体 | |
| JP2009538873A5 (https=) | ||
| ZA200603181B (en) | 3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety | |
| RU2004112781A (ru) | Производные пиперидина и их применение в качестве модуляторов активности рецепторов хемокинов (в частности ccr5) | |
| TW201026684A (en) | Phosphodiesterase type III (PDE III) inhibitors or Ca2+ -sensitizing agents for the treatment of hypertrophic cardiomyopathy | |
| JPWO2004089410A1 (ja) | 神経因性疼痛の予防及び／または治療剤 | |
| EP1852112A1 (en) | Anti-tumor agent | |
| JP5571072B2 (ja) | アルファアドレナリン介在症状の治療方法 | |
| RU2056416C1 (ru) | Производные тиомочевины, фармацевтическая композиция и способ лечения | |
| KR100916160B1 (ko) | 약제학적 항암 조성물 | |
| KR20030086288A (ko) | 정신신경질환 치료약 | |
| US20090306398A1 (en) | Methods of treating alpha adrenergic mediated conditions | |
| CN1930123B (zh) | 用于预防或治疗伴有神经障碍的膀胱过度活动症的医药组合物 | |
| KR102069395B1 (ko) | 제i형 및 제ii형 당뇨병의 치료 | |
| US20250057828A1 (en) | Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea | |
| KR20250029790A (ko) | 혈중 마이오스타틴 저하제 | |
| JP4741131B2 (ja) | 低血圧およびショックの治療または予防 | |
| WO2023118123A1 (en) | Combination of an α2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea | |
| CN1165000A (zh) | 缓解由缺血引起的组织损伤的方法 | |
| JP2008519808A5 (https=) |