JP2008519808A5 - - Google Patents

Info

Publication number

JP2008519808A5

JP2008519808A5 JP2007540652A JP2007540652A JP2008519808A5 JP 2008519808 A5 JP2008519808 A5 JP 2008519808A5 JP 2007540652 A JP2007540652 A JP 2007540652A JP 2007540652 A JP2007540652 A JP 2007540652A JP 2008519808 A5 JP2008519808 A5 JP 2008519808A5

Authority

JP

Japan

Prior art keywords

vitamin

compound

pharmaceutical composition

bladder cancer

composition according

Prior art date

2005-11-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
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• -1 vitamin D compound Chemical class 0.000 claims 21
• 229930003316 Vitamin D Natural products 0.000 claims 20
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 20
• 239000011710 vitamin D Substances 0.000 claims 20
• 235000019166 vitamin D Nutrition 0.000 claims 20
• 229940046008 vitamin d Drugs 0.000 claims 20
• 230000001028 anti-proliverative effect Effects 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 239000003814 drug Substances 0.000 claims 11
• 206010005003 Bladder cancer Diseases 0.000 claims 10
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 10
• 229940079593 drug Drugs 0.000 claims 10
• 201000005112 urinary bladder cancer Diseases 0.000 claims 10
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 7
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 7
• 229960001904 epirubicin Drugs 0.000 claims 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 229960004679 doxorubicin Drugs 0.000 claims 4
• 150000002148 esters Chemical class 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 239000003446 ligand Substances 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 102000009310 vitamin D receptors Human genes 0.000 claims 4
• 108050000156 vitamin D receptors Proteins 0.000 claims 4
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 238000001802 infusion Methods 0.000 claims 3
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• 208000014794 superficial urinary bladder carcinoma Diseases 0.000 claims 3
• 239000011612 calcitriol Substances 0.000 claims 2
• 229960005084 calcitriol Drugs 0.000 claims 2
• 235000020964 calcitriol Nutrition 0.000 claims 2
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 125000001188 haloalkyl group Chemical group 0.000 claims 2
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• LRLWXBHFPGSUOX-GJQYOBCGSA-N (1r,3z,5s)-3-[(2e)-2-[(3as,7as)-1-[(e,2s)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3h-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol Chemical compound C1(/[C@@H]2CC=C([C@]2(CCC1)C)[C@@H](C)C/C=C/C(O)(CC)CC)=C\C=C1\C[C@@H](O)C[C@H](F)C1=C LRLWXBHFPGSUOX-GJQYOBCGSA-N 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000011647 vitamin D3 Substances 0.000 claims 1
• 229940021056 vitamin d3 Drugs 0.000 claims 1
• 0 CC(C)(CCCC(CCCC(C)(*)O)[C@@](CC1)[C@@](C)(CCC2)[C@@]1C2=CC=*(CCC(C1)=*)*[C@]1O)O Chemical compound CC(C)(CCCC(CCCC(C)(*)O)[C@@](CC1)[C@@](C)(CCC2)[C@@]1C2=CC=*(CCC(C1)=*)*[C@]1O)O 0.000 description 1