IL182812A0 - Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer - Google Patents

Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer

Info

Publication number
IL182812A0
IL182812A0 IL182812A IL18281207A IL182812A0 IL 182812 A0 IL182812 A0 IL 182812A0 IL 182812 A IL182812 A IL 182812A IL 18281207 A IL18281207 A IL 18281207A IL 182812 A0 IL182812 A0 IL 182812A0
Authority
IL
Israel
Prior art keywords
vitamin
derivatives
bladder cancer
combined use
proliferative agents
Prior art date
Application number
IL182812A
Other languages
English (en)
Original Assignee
Bioxell Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0424965A external-priority patent/GB0424965D0/en
Application filed by Bioxell Spa filed Critical Bioxell Spa
Publication of IL182812A0 publication Critical patent/IL182812A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL182812A 2004-11-12 2007-04-26 Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer IL182812A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0424965A GB0424965D0 (en) 2004-11-12 2004-11-12 Novel method
US66840805P 2005-04-04 2005-04-04
PCT/EP2005/055931 WO2006051106A1 (en) 2004-11-12 2005-11-11 Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer

Publications (1)

Publication Number Publication Date
IL182812A0 true IL182812A0 (en) 2007-09-20

Family

ID=35520127

Family Applications (1)

Application Number Title Priority Date Filing Date
IL182812A IL182812A0 (en) 2004-11-12 2007-04-26 Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer

Country Status (7)

Country Link
US (1) US20080293647A1 (https=)
EP (1) EP1812011A1 (https=)
JP (1) JP2008519808A (https=)
AU (1) AU2005303773A1 (https=)
CA (1) CA2586679A1 (https=)
IL (1) IL182812A0 (https=)
WO (1) WO2006051106A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006230A2 (en) 2011-07-01 2013-01-10 Fox Chase Cancer Center Combined inhibition of the vitamin d receptor and dna replication in the treatment of cancer
US9889141B2 (en) 2014-10-14 2018-02-13 Institute For Cancer Research Combined inhibition of the vitamin D receptor and poly(ADP) ribose polymerase (PARP) in the treatment of cancer

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639596A (en) 1969-07-14 1972-02-01 Wisconsin Alumni Res Found Method of treating leg weakness in fowl with 25-hydroxycholecalciferol
US3739001A (en) 1971-10-22 1973-06-12 Wisconsin Alumni Res Found 25,26-dihydroxycholecalciferol
US3741996A (en) 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US3715374A (en) 1972-05-05 1973-02-06 Wisconsin Alumni Res Found 24,25-dihydroxycholecalciferol
US3856780A (en) 1973-06-18 1974-12-24 T Narwid Synthesis of 25-hydroxycholesterol and derivatives thereof
US3847955A (en) 1973-07-16 1974-11-12 Wisconsin Alumni Res Found 1,24,25-trihydroxycholecalciferol
JPS5126858A (en) 1974-08-22 1976-03-05 Teijin Ltd 24 * s * hidorokishikorekarushifuerooruno seizoho
JPS5126859A (en) 1974-08-22 1976-03-05 Teijin Ltd 24 * r * hidorokishikorekarushifuerooruno seizoho
US3994878A (en) 1975-10-10 1976-11-30 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof
JPS5271456A (en) 1975-12-12 1977-06-14 Chugai Pharmaceut Co Ltd Synthesis of 1alpha-hydroxysteroid derivatives
US4021423A (en) 1976-03-08 1977-05-03 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholecalciferol
US4028349A (en) 1976-03-08 1977-06-07 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol 24,25-ketals and alkanoyl derivatives thereof
US4026882A (en) 1976-03-08 1977-05-31 Hoffmann-La Roche Inc. Syntheses of 3,24R,25- and 3,24S,25-trihydroxy-5,7-cholestadiene 24,25-ketals and alkanoyl derivatives thereof
US4225525A (en) 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4308264A (en) 1981-01-28 1981-12-29 Abbott Laboratories Stabilized, dilute aqueous preparation of 1α,25-dihydroxycholecalciferol for neonatal administration
US4502991A (en) 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
DE3590488C2 (https=) 1984-10-04 1992-10-01 Wisconsin Alumni Research Foundation, Madison, Wis., Us
US4613594A (en) 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
DE3577552D1 (de) 1984-11-27 1990-06-13 Chugai Pharmaceutical Co Ltd Vitamin d-derivate und verfahren zu deren herstellung.
US5039671A (en) 1984-12-19 1991-08-13 Hoffmann-La Roche Inc. Trifluorinated-1α,25S-dihydroxy vitamin D3 compounds
US4717721A (en) 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
JPH07100685B2 (ja) 1985-08-02 1995-11-01 レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ/エス(レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ) 新規ビタミンd類似体
US5247123A (en) 1987-09-14 1993-09-21 Hoffmann-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4898855A (en) 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US5087619A (en) 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4927815A (en) 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US4847012A (en) 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4851401A (en) 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
GB8904154D0 (en) 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
GB8915770D0 (en) 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5030772A (en) 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
GB9007236D0 (en) 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
US6538037B2 (en) * 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
HU221008B1 (hu) 1991-11-07 2002-07-29 Research Institute For Medicine And Chemistry D-vitamin-származékok és azokat tartalmazó gyógyászati készítmények
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
GB9214202D0 (en) 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
CA2096105A1 (en) 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
GB9223061D0 (en) 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (https=) 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US5565589A (en) 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5428029A (en) 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
EP0793649B1 (en) 1994-11-21 1999-02-03 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
ATE210642T1 (de) 1995-01-23 2001-12-15 Chugai Pharmaceutical Co Ltd 2-substituierte vitamin-d3-derivate
US5749845A (en) 1995-01-25 1998-05-12 Iotek, Inc. Delivering an agent to an organ
AU5861396A (en) 1995-05-19 1996-11-29 Abbott Laboratories Stable aqueous formulations of 1alpha,25-dihydroxycholecalci ferol for parenteral administration
JP3372259B2 (ja) 1995-09-21 2003-01-27 ウィスコンシン・アルムニ・リサーチ・ファウンデーション カルシトリオール誘導体およびそれらの用途
US5747479A (en) 1996-01-03 1998-05-05 Hoffmann-La Roche Inc. Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
GB9607034D0 (en) 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
NO971934L (no) 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
DK0947504T3 (da) 1996-12-20 2003-11-24 Chugai Pharmaceutical Co Ltd 16-en-vitamin D-derivater
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US5843928A (en) 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6030962A (en) 1997-04-28 2000-02-29 Synttex (U.S.A.) Inc. Vitamin D3 analogs with bis C-20 side chains
AU743514B2 (en) 1997-05-16 2002-01-24 Women & Infants Hospital Cyclic ether vitamin D3 compounds, 1alpha (OH) 3-EPI-vitamin D3 compounds and uses thereof
US20010007907A1 (en) 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
ATE322477T1 (de) 1997-05-16 2006-04-15 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
US5811414A (en) 1997-05-16 1998-09-22 Hoffmann-La Roche Inc. Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
US5872113A (en) 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
JPH1112175A (ja) * 1997-06-27 1999-01-19 Nisshin Flour Milling Co Ltd 白血病治療剤
US5939406A (en) 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
WO1999012894A1 (en) 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
AU9095398A (en) 1997-09-19 1999-04-12 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives and process for producing the same
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
JP4357114B2 (ja) 1998-02-24 2009-11-04 中外製薬株式会社 24−ヒドロキシビタミンd誘導体
AU3167699A (en) 1998-04-10 1999-11-01 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives substituted at the 2beta-position
US5962707A (en) 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
WO2000061776A1 (en) 1999-04-14 2000-10-19 Mercian Corporation Vitamin d derivatives and process for producing the same
KR20010102330A (ko) 1999-04-23 2001-11-15 나가야마 오사무 3-메틸 비타민 d 유도체
US6331642B1 (en) 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
WO2001030751A2 (en) 1999-10-25 2001-05-03 Strakan Limited USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
WO2001040177A2 (en) 1999-12-02 2001-06-07 Women And Infants Hospital Esters of vitamin d3 and uses thereof
AU2001228330A1 (en) 2000-01-31 2001-08-14 Leo Pharma A/S Vitamin d-derivatives and their use in treating osteoporosis and related bone disorders
EP1275643A4 (en) 2000-04-19 2009-06-03 Chugai Pharmaceutical Co Ltd VITAMIN D DERIVATIVES
US6806262B2 (en) 2000-05-31 2004-10-19 Wisconsin Alumni Research Foundation 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
WO2002005823A2 (en) 2000-07-14 2002-01-24 Wisconsin Alumni Research Foundation USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH
WO2002014268A1 (fr) 2000-08-14 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Derive de 1-methyl-20-epivitamine d
JPWO2002066424A1 (ja) 2001-02-23 2004-06-17 中外製薬株式会社 2位に置換基を有するビタミンd誘導体
US6683219B2 (en) 2001-07-30 2004-01-27 Wisconsin Alumni Research Foundation Synthesis of A-ring synthon of 19-nor-1α,25-dihydroxyvitamin D3 from (D)-glucose
US6559138B1 (en) 2001-09-21 2003-05-06 Syntex (U.S.A.) Llc 3-Desoxy-vitamin D3 analog esters
US7491711B2 (en) 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
MXPA04002640A (es) 2001-09-21 2004-06-07 Hoffmann La Roche Esteres de analogos de 3-desoxi-vitamina d3.
BR0307896A (pt) 2002-03-29 2004-12-07 Wisconsin Alumni Res Found Método de produção de 1(alfa)-hidroxi-2-metileno-19-nor-homopregnacalcif erol
US6846811B2 (en) 2002-04-22 2005-01-25 Wisconsin Alumni Research Foundation (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
JP2004026811A (ja) 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンd3誘導体を含有する抗癌作用を増強させるための薬剤
WO2004067504A1 (ja) 2003-01-31 2004-08-12 Chugai Seiyaku Kabushiki Kaisha 2位置換ビタミンd誘導体
CA2540325A1 (en) 2003-09-24 2005-04-07 Bioxell Spa Methods for treating bladder dysfunction
EP1734972A4 (en) * 2004-03-29 2007-08-22 Roswell Park Cancer Inst METHOD FOR THE TREATMENT OF SOLID TUMORS AND LEUKIES THROUGH VITAMIN D COMBINATION THERAPY AND ANTI-CHANGE NUCLEOSIDE ANALOGS

Also Published As

Publication number Publication date
AU2005303773A1 (en) 2006-05-18
WO2006051106A1 (en) 2006-05-18
JP2008519808A (ja) 2008-06-12
US20080293647A1 (en) 2008-11-27
EP1812011A1 (en) 2007-08-01
CA2586679A1 (en) 2006-05-18

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