JP2007504223A5 - - Google Patents
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- Publication number
- JP2007504223A5 JP2007504223A5 JP2006525305A JP2006525305A JP2007504223A5 JP 2007504223 A5 JP2007504223 A5 JP 2007504223A5 JP 2006525305 A JP2006525305 A JP 2006525305A JP 2006525305 A JP2006525305 A JP 2006525305A JP 2007504223 A5 JP2007504223 A5 JP 2007504223A5
- Authority
- JP
- Japan
- Prior art keywords
- omeprazole
- salt
- cyclohexylethylammonium
- methoxy
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims 9
- 229960004770 esomeprazole Drugs 0.000 claims 9
- XBWOPGDJMAJJDG-UHFFFAOYSA-N 1-cyclohexylethanamine Chemical class CC(N)C1CCCCC1 XBWOPGDJMAJJDG-UHFFFAOYSA-N 0.000 claims 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- SUBDBMMJDZJVOS-XMMPIXPASA-N (R)-omeprazole Chemical compound C([S@@](=O)C=1NC2=CC=C(C=C2N=1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-XMMPIXPASA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 210000004211 gastric acid Anatomy 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- XBWOPGDJMAJJDG-SSDOTTSWSA-N (1r)-1-cyclohexylethanamine Chemical group C[C@@H](N)C1CCCCC1 XBWOPGDJMAJJDG-SSDOTTSWSA-N 0.000 claims 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- XBWOPGDJMAJJDG-ZETCQYMHSA-N (1s)-1-cyclohexylethanamine Chemical class C[C@H](N)C1CCCCC1 XBWOPGDJMAJJDG-ZETCQYMHSA-N 0.000 claims 1
- -1 (S) -5-methoxy 1-cyclohexylethylammonium salt Chemical class 0.000 claims 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960000381 omeprazole Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302382A SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | New salts II |
| PCT/SE2004/001259 WO2005023797A1 (en) | 2003-09-04 | 2004-09-01 | New salts of omeprazole and esomeprazole ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504223A JP2007504223A (ja) | 2007-03-01 |
| JP2007504223A5 true JP2007504223A5 (https=) | 2007-09-27 |
Family
ID=28787271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525305A Pending JP2007504223A (ja) | 2003-09-04 | 2004-09-01 | オメプラゾール及びエソメプラゾールｉｉの新規な塩 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7560472B2 (https=) |
| EP (1) | EP1664020A1 (https=) |
| JP (1) | JP2007504223A (https=) |
| CA (1) | CA2535983A1 (https=) |
| SE (1) | SE0302382D0 (https=) |
| WO (1) | WO2005023797A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE388628T1 (de) * | 2002-12-23 | 2008-03-15 | Cropdesign Nv | Automatisiertes behandlungssystem für pflanzbehälter |
| SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
| US7576219B2 (en) | 2005-10-26 | 2009-08-18 | Hanmi Pharm. Co., Ltd | Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same |
| EP1801110A1 (en) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Esomeprazole arginine salt |
| CN101460481A (zh) * | 2006-06-07 | 2009-06-17 | 阿斯利康(瑞典)有限公司 | 制备埃索美拉唑的铵盐的新方法 |
| EP2114919A2 (en) | 2007-01-31 | 2009-11-11 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic seperation |
| JP2010519284A (ja) | 2007-02-21 | 2010-06-03 | シプラ・リミテッド | エソメプラゾールマグネシウム二水和物の調製方法 |
| WO2010097583A1 (en) | 2009-02-24 | 2010-09-02 | Cipla Limited | Esomeprazole potassium polymorph and its preparation |
| WO2011058569A1 (en) * | 2009-11-12 | 2011-05-19 | Hetero Research Foundation | Process for the resolution of omeprazole |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SE504459C2 (sv) | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
| SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
| SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| JP3867433B2 (ja) * | 1998-03-11 | 2007-01-10 | 田辺製薬株式会社 | １，１’−ビナフチル−２，２’−ジカルボン酸の光学分割方法 |
| JP5412023B2 (ja) * | 2000-08-04 | 2014-02-12 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の塩およびその用途 |
| ES2286408T3 (es) | 2002-03-05 | 2007-12-01 | Astrazeneca Ab | Sales de alquilamonio de omeprazol e esomeprazol. |
| SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
-
2003
- 2003-09-04 SE SE0302382A patent/SE0302382D0/xx unknown
-
2004
- 2004-09-01 US US10/569,820 patent/US7560472B2/en not_active Expired - Fee Related
- 2004-09-01 CA CA002535983A patent/CA2535983A1/en not_active Abandoned
- 2004-09-01 EP EP04775365A patent/EP1664020A1/en not_active Ceased
- 2004-09-01 WO PCT/SE2004/001259 patent/WO2005023797A1/en not_active Ceased
- 2004-09-01 JP JP2006525305A patent/JP2007504223A/ja active Pending
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