JP2012006969A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012006969A5 JP2012006969A5 JP2011198277A JP2011198277A JP2012006969A5 JP 2012006969 A5 JP2012006969 A5 JP 2012006969A5 JP 2011198277 A JP2011198277 A JP 2011198277A JP 2011198277 A JP2011198277 A JP 2011198277A JP 2012006969 A5 JP2012006969 A5 JP 2012006969A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- protein
- antigen
- group
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 230000002163 immunogen Effects 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- 150000004676 glycans Chemical class 0.000 claims 10
- 229920001282 polysaccharide Polymers 0.000 claims 10
- 239000005017 polysaccharide Substances 0.000 claims 10
- 239000002671 adjuvant Substances 0.000 claims 9
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 8
- 101100453077 Botryococcus braunii HDR gene Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 206010033078 Otitis media Diseases 0.000 claims 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000037800 influenza D Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 229960001005 tuberculin Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0022742.1A GB0022742D0 (en) | 2000-09-15 | 2000-09-15 | Vaccine |
| GB0022742.1 | 2000-09-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526416A Division JP4903975B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012006969A JP2012006969A (ja) | 2012-01-12 |
| JP2012006969A5 true JP2012006969A5 (enExample) | 2012-12-06 |
Family
ID=9899575
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526417A Expired - Fee Related JP4880184B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
| JP2002526416A Expired - Fee Related JP4903975B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
| JP2011198277A Pending JP2012006969A (ja) | 2000-09-15 | 2011-09-12 | ワクチン |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002526417A Expired - Fee Related JP4880184B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
| JP2002526416A Expired - Fee Related JP4903975B2 (ja) | 2000-09-15 | 2001-09-12 | ワクチン |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20040081662A1 (enExample) |
| EP (6) | EP2140878B1 (enExample) |
| JP (3) | JP4880184B2 (enExample) |
| KR (5) | KR100991916B1 (enExample) |
| CN (3) | CN101502648B (enExample) |
| AT (1) | ATE516815T1 (enExample) |
| AU (4) | AU2054802A (enExample) |
| BR (2) | BR0113821A (enExample) |
| CA (2) | CA2422002C (enExample) |
| CY (1) | CY1111915T1 (enExample) |
| CZ (2) | CZ305343B6 (enExample) |
| DK (1) | DK1317279T3 (enExample) |
| ES (4) | ES2659400T3 (enExample) |
| GB (1) | GB0022742D0 (enExample) |
| HU (2) | HUP0301092A3 (enExample) |
| IL (4) | IL154607A0 (enExample) |
| MX (2) | MXPA03002265A (enExample) |
| NO (2) | NO337730B1 (enExample) |
| NZ (2) | NZ524287A (enExample) |
| PL (2) | PL210198B1 (enExample) |
| PT (1) | PT1317279E (enExample) |
| SI (1) | SI1317279T1 (enExample) |
| WO (2) | WO2002022167A2 (enExample) |
| ZA (2) | ZA200301524B (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US7081530B1 (en) | 1997-07-02 | 2006-07-25 | sanofi pasteur limitée | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US20010016200A1 (en) | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| KR100642044B1 (ko) * | 1999-03-19 | 2006-11-10 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| US7074415B2 (en) * | 2000-06-20 | 2006-07-11 | Id Biomedical Corporation | Streptococcus antigens |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| AU2002351623A1 (en) | 2001-12-20 | 2003-07-09 | Shire Biochem Inc. | Streptococcus antigens |
| EP2275120A3 (en) * | 2002-04-02 | 2011-06-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
| US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
| DK2353608T3 (da) | 2002-10-11 | 2020-02-10 | Novartis Vaccines And Diagnostics S R L | Polypeptid-vacciner til bred beskyttelse mod hypervirulente meningokok-linjer |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| US8229903B2 (en) * | 2002-12-19 | 2012-07-24 | International Business Machines Corporation | Suggesting data interpretations and patterns for updating policy documents |
| DK1587537T3 (da) * | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| PT1601689E (pt) | 2003-03-13 | 2008-01-04 | Glaxosmithkline Biolog Sa | Processo de purificação para citolisina bacteriana |
| EP1477802A1 (en) * | 2003-05-16 | 2004-11-17 | Erasmus Universiteit Rotterdam | Method for selecting and producing vaccine components and vaccines based thereon |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| SI1670506T1 (sl) | 2003-10-02 | 2013-03-29 | Novartis Ag | Tekoča cepiva proti multiplim meningokoknim seroskupinam |
| CA2580693A1 (en) * | 2004-09-21 | 2006-03-30 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| KR102378962B1 (ko) * | 2005-04-08 | 2022-03-28 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CN103251940A (zh) | 2005-12-22 | 2013-08-21 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| AU2006336520B2 (en) * | 2005-12-28 | 2011-09-15 | The Uab Research Foundation | Pneumococcal serotypes |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| EP2059807B1 (en) * | 2006-08-17 | 2013-02-20 | The UAB Research Foundation | Diagnosing pneumococcal pneumonia |
| CA2687632C (en) * | 2007-05-24 | 2013-01-15 | Glaxosmithkline Biologicals S.A. | Lyophilised antigen composition |
| MX2009013949A (es) | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| US8337846B2 (en) * | 2007-07-23 | 2012-12-25 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| US20160228500A9 (en) * | 2007-07-23 | 2016-08-11 | Martina Ochs | Immunogenic Polypeptides and Monoclonal Antibodies |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| EP2225265A2 (en) * | 2007-09-14 | 2010-09-08 | Katholieke Universiteit Leuven | Streptococcus pneumoniae vaccines |
| JP5697991B2 (ja) * | 2008-02-01 | 2015-04-08 | サノフィ パストゥール リミテッドＳａｎｏｆｉ Ｐａｓｔｅｕｒ Ｌｉｍｉｔｅｄ | 診断的アッセイ |
| EA018068B1 (ru) | 2008-03-03 | 2013-05-30 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности tlr |
| AU2010227220B2 (en) | 2009-03-24 | 2014-11-13 | Glaxosmithkline Biologicals S.A. | Combinations of meningococcal factor H binding protein and pneumococcal saccharide conjugates |
| WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為ｔｌｒ活性調節劑之化合物及組合物 |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| CN101690810B (zh) * | 2009-10-21 | 2011-08-17 | 辽宁益康生物股份有限公司 | 一种鸡新城疫、传染性支气管炎、减蛋综合征、禽流感四联灭活疫苗佐剂及其制备方法 |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| AU2010339921B2 (en) | 2009-12-15 | 2016-08-11 | Glaxosmithkline Biologicals S.A. | Homogeneous suspension of immunopotentiating compounds and uses thereof |
| US20130183350A1 (en) * | 2009-12-22 | 2013-07-18 | Kevin Harper | Immunogenic compositions |
| US9649372B2 (en) | 2009-12-22 | 2017-05-16 | Sanofi Pasteur Limited | Immunogenic compositions and related methods |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| GB201003920D0 (en) * | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| AU2011232421B2 (en) | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
| WO2012075428A1 (en) * | 2010-12-03 | 2012-06-07 | Sanofi Pasteur Limited | Composition for immunization against streptococcus pneumoniae |
| US20140072622A1 (en) * | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| EP2822586A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of streptococcus pneumoniae antigens |
| JP2014000016A (ja) * | 2012-06-15 | 2014-01-09 | National Agriculture & Food Research Organization | 豚丹毒菌の新規な抗原タンパク質、その遺伝子、及び組換えベクターとその利用 |
| RU2510281C2 (ru) * | 2012-06-22 | 2014-03-27 | Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") | ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА |
| GB201218660D0 (en) | 2012-10-17 | 2012-11-28 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| JP6236086B2 (ja) * | 2012-10-17 | 2017-11-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | １種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Ｅおよび／またはＰｉｌＡを含むタンパク質成分とを含む免疫原性組成物 |
| WO2014106554A1 (en) | 2013-01-01 | 2014-07-10 | Agfa Graphics Nv | (ethylene, vinyl acetal) copolymers and their use in lithographic printing plate precursors |
| TR201807340T4 (tr) | 2013-02-01 | 2018-06-21 | Glaxosmithkline Biologicals Sa | Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi. |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2015183676A1 (en) * | 2014-05-29 | 2015-12-03 | Kapre Subhash V | Synthetic peptides as carriers for conjugation with polysaccharides |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US20190072856A1 (en) | 2016-03-16 | 2019-03-07 | Agfa Nv | Method for processing a lithographic printing plate |
| US11844829B2 (en) | 2016-12-28 | 2023-12-19 | Zalvac Ab | Microparticles from Streptococcus pneumoniae as vaccine antigens |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| EP3634481A4 (en) | 2017-06-10 | 2021-07-21 | Inventprise, LLC. | MULTIVALENT CONJUGATE VACCINES WITH BIVALENT OR MULTIVALENT CONJUGATE POLYSACCHARIDES THAT CONFIRM ENHANCED IMMUNOGENICITY AND AVIDITY |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| BR112020016314A2 (pt) | 2018-02-12 | 2020-12-15 | Inimmune Corporation | Compostos ou um sais farmaceuticamente aceitáveis, composição farmacêutica, kit, e, métodos para elicitar, intensificar ou modificar uma resposta imunológica, para tratar, prevenir ou reduzir a suscetibilidade a câncer, para tratar, prevenir ou reduzir a suscetibilidade a uma doença infecciosa, para tratar, prevenir ou reduzir a suscetibilidade a uma alergia, para tratar, prevenir ou reduzir a suscetibilidade a uma afecção autoimune, para tratar, prevenir ou reduzir a suscetibilidade em um sujeito à infecção bacteriana, viral, priônica, autoimunidade, câncer ou alergia, para tratar, prevenir ou reduzir a suscetibilidade à autoimunidade, alergia, reperfusão de isquemia ou sepse, para tratar, prevenir ou reduzir a gravidade de ataques epiléticos e para tratar, prevenir ou reduzir a suscetibilidade a doenças oculares como degeneração macular, hipertensão ocular e infecção ocular |
| CN113795306A (zh) * | 2019-03-13 | 2021-12-14 | 圣朱德儿童研究医院 | 用于减少肺炎链球菌传播的疫苗组合物和方法 |
| EP3778253A1 (en) | 2019-08-13 | 2021-02-17 | Agfa Nv | Method for processing a lithographic printing plate |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
| EP4240843A1 (en) | 2020-11-04 | 2023-09-13 | Eligo Bioscience | Cutibacterium acnes recombinant phages, method of production and uses thereof |
| CN121548426A (zh) * | 2023-05-22 | 2026-02-17 | Gpn疫苗有限公司 | 修饰的链球菌免疫原和其用途 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| US4761283A (en) * | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5006914A (en) * | 1988-12-02 | 1991-04-09 | Advanced Technology Materials, Inc. | Single crystal semiconductor substrate articles and semiconductor devices comprising same |
| DE68929323T2 (de) | 1988-12-16 | 2002-04-18 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Pneumolysin-mutanten und pneumokokken-impfstoffe daraus |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| EP0786521A1 (en) | 1991-02-15 | 1997-07-30 | Uab Research Foundation | Nucleic acid encoding PspA |
| US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
| US5980909A (en) * | 1991-02-15 | 1999-11-09 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
| US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| US5371197A (en) * | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
| PT652758E (pt) | 1992-06-18 | 2000-04-28 | Harvard College | Vacinas de toxina da difteria |
| NZ253137A (en) | 1992-06-25 | 1996-08-27 | Smithkline Beecham Biolog | Vaccine comprising antigen and/or antigenic composition, qs21 (quillaja saponaria molina extract) and 3 de-o-acylated monophosphoryl lipid a. |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| CA2123580C (en) * | 1992-09-16 | 2005-04-26 | James B. Dale | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
| EP0689454B2 (en) | 1993-03-23 | 2005-02-23 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine compositions containing 3-o deacylated monophosphoryl lipid a |
| DK0699076T3 (da) | 1993-05-18 | 2003-03-03 | Univ Ohio State Res Found | Vaccine mod mellemørebetændelse |
| DE69433341T2 (de) | 1993-09-22 | 2004-04-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5866135A (en) * | 1994-04-21 | 1999-02-02 | North American Vaccine, Inc. | Group A streptococcal polysaccharide immunogenic compositions and methods |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| DE69535905D1 (de) | 1994-07-15 | 2009-02-26 | Coley Pharm Group Inc | Immunomodulatorische Oligonukleotide |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
| JPH11507214A (ja) | 1995-06-07 | 1999-06-29 | バイオケム ヴァシーンズ インク． | Ｈｓｐ７０ファミリーに属する連鎖球菌の熱ショック蛋白質メンバー |
| GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
| US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US6245335B1 (en) * | 1996-05-01 | 2001-06-12 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| EP0912608B1 (en) | 1996-05-01 | 2006-04-19 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| US5744417A (en) | 1996-05-02 | 1998-04-28 | Lyondell Petrochemical Company | Supported catalyst |
| US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
| DK0914178T3 (da) | 1996-06-18 | 2003-04-22 | Alza Corp | Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel |
| WO1998006734A1 (en) | 1996-08-16 | 1998-02-19 | Smithkline Beecham Corporation | Novel prokaryotic polynucleotides, polypeptides and their uses |
| US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| US5882871A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| PT942983E (pt) * | 1996-10-31 | 2007-02-28 | Human Genome Sciences Inc | Antigénios e vacinas de streptococcus pneumoniae |
| EP0942984A2 (en) | 1996-11-12 | 1999-09-22 | Regents Of The University Of Minnesota | C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE) |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| ATE234649T1 (de) | 1996-12-20 | 2003-04-15 | Alza Corp | Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses |
| DE19708537A1 (de) | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc. |
| FR2763244B1 (fr) * | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| JP2001502925A (ja) | 1997-06-03 | 2001-03-06 | コノート ラボラトリーズ リミテッド | モラクセラのラクトフェリン受容体遺伝子 |
| EP0998557A2 (en) * | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Modified immunogenic pneumolysin, compositions and their use as vaccines |
| US6224880B1 (en) * | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
| BR9812525A (pt) | 1997-09-24 | 2000-07-25 | Univ Minnesota | Proteinase degradadora de complemento humano c3 de streptococcus pneumoniae |
| EP0916726A1 (en) * | 1997-11-13 | 1999-05-19 | Rijksuniversiteit te Groningen | Attaching substances to micro-organisms |
| WO1999027961A1 (en) | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6709658B1 (en) * | 1998-02-12 | 2004-03-23 | Wyeth Holdings Corporation | Pneumococcal vaccines formulated with interleukin-12 |
| US6503511B1 (en) * | 1998-04-07 | 2003-01-07 | Medimmune, Inc. | Derivatives of choline binding proteins for vaccines |
| IL138939A0 (en) * | 1998-04-07 | 2001-11-25 | St Jude Childrens Res Hospital | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| JP2002516251A (ja) | 1998-04-23 | 2002-06-04 | ユーエイビー リサーチ ファンデーション | 肺炎球菌表面プロテインＣ（ＰｓｐＣ）のエピトープ領域およびその菌株選択、ならびにそのための使用法 |
| GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
| IL142017A0 (en) | 1998-09-24 | 2002-03-10 | Univ Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
| WO2000030299A1 (en) | 1998-11-17 | 2000-05-25 | Schlumberger Technology Corporation | Transmitting information over a communication link |
| AU2027400A (en) | 1998-11-19 | 2000-06-05 | St. Jude Children's Research Hospital | Identification and characterization of novel pneumococcal choline binding proteins, cbpg and cbpd, and diagnostic and therapeutic uses thereof |
| DK1140157T3 (da) * | 1998-12-21 | 2009-06-08 | Medimmune Inc | Streptococcus pneumoniae-proteiner og immunogene fragmenter til vacciner |
| EP1034792A1 (en) * | 1999-03-11 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Intranasal delivery of pneumococcal polysaccharide vaccines |
| KR100642044B1 (ko) * | 1999-03-19 | 2006-11-10 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| ATE325620T1 (de) | 1999-06-10 | 2006-06-15 | Medimmune Inc | Streptococcus pneumoniae proteine und impfstoffe |
| CA2379327A1 (en) * | 1999-06-10 | 2000-12-21 | Uab Research Foundation | Pneumococcal surface protein combination vaccine |
| US6319224B1 (en) | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
| US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
-
2000
- 2000-09-15 GB GBGB0022742.1A patent/GB0022742D0/en not_active Ceased
-
2001
- 2001-09-12 HU HU0301092A patent/HUP0301092A3/hu unknown
- 2001-09-12 EP EP09173889.8A patent/EP2140878B1/en not_active Expired - Lifetime
- 2001-09-12 KR KR1020087020661A patent/KR100991916B1/ko not_active Expired - Fee Related
- 2001-09-12 US US10/380,563 patent/US20040081662A1/en not_active Abandoned
- 2001-09-12 PL PL361401A patent/PL210198B1/pl unknown
- 2001-09-12 IL IL15460701A patent/IL154607A0/xx unknown
- 2001-09-12 US US10/380,575 patent/US20060051361A1/en not_active Abandoned
- 2001-09-12 PT PT01984626T patent/PT1317279E/pt unknown
- 2001-09-12 EP EP01984627.8A patent/EP1317280B1/en not_active Expired - Lifetime
- 2001-09-12 CZ CZ2003-757A patent/CZ305343B6/cs not_active IP Right Cessation
- 2001-09-12 SI SI200131001T patent/SI1317279T1/sl unknown
- 2001-09-12 AU AU2054802A patent/AU2054802A/xx active Pending
- 2001-09-12 KR KR10-2003-7003732A patent/KR20030031188A/ko not_active Ceased
- 2001-09-12 EP EP10179133A patent/EP2305297A1/en not_active Ceased
- 2001-09-12 KR KR1020107014638A patent/KR20100091241A/ko not_active Ceased
- 2001-09-12 EP EP01984626A patent/EP1317279B1/en not_active Revoked
- 2001-09-12 ES ES10178332.2T patent/ES2659400T3/es not_active Expired - Lifetime
- 2001-09-12 NZ NZ524287A patent/NZ524287A/en not_active IP Right Cessation
- 2001-09-12 WO PCT/EP2001/010568 patent/WO2002022167A2/en not_active Ceased
- 2001-09-12 EP EP10178332.2A patent/EP2314313B1/en not_active Expired - Lifetime
- 2001-09-12 CN CN2009101285337A patent/CN101502648B/zh not_active Expired - Fee Related
- 2001-09-12 MX MXPA03002265A patent/MXPA03002265A/es active IP Right Grant
- 2001-09-12 ES ES01984627.8T patent/ES2545876T3/es not_active Expired - Lifetime
- 2001-09-12 AU AU3819302A patent/AU3819302A/xx active Pending
- 2001-09-12 MX MXPA03002264A patent/MXPA03002264A/es active IP Right Grant
- 2001-09-12 AU AU2002238193A patent/AU2002238193B2/en not_active Ceased
- 2001-09-12 CA CA2422002A patent/CA2422002C/en not_active Expired - Fee Related
- 2001-09-12 BR BR0113821-9A patent/BR0113821A/pt not_active Application Discontinuation
- 2001-09-12 CN CNB018157483A patent/CN1253205C/zh not_active Expired - Fee Related
- 2001-09-12 ES ES09173889.8T patent/ES2551097T3/es not_active Expired - Lifetime
- 2001-09-12 WO PCT/EP2001/010570 patent/WO2002022168A2/en not_active Ceased
- 2001-09-12 DK DK01984626.0T patent/DK1317279T3/da active
- 2001-09-12 AT AT01984626T patent/ATE516815T1/de active
- 2001-09-12 PL PL361395A patent/PL209247B1/pl unknown
- 2001-09-12 NZ NZ524286A patent/NZ524286A/en not_active IP Right Cessation
- 2001-09-12 KR KR1020037003731A patent/KR100805991B1/ko not_active Expired - Fee Related
- 2001-09-12 CN CNB018157467A patent/CN100486642C/zh not_active Expired - Fee Related
- 2001-09-12 CA CA2421998A patent/CA2421998C/en not_active Expired - Fee Related
- 2001-09-12 BR BR0113822-7A patent/BR0113822A/pt not_active IP Right Cessation
- 2001-09-12 JP JP2002526417A patent/JP4880184B2/ja not_active Expired - Fee Related
- 2001-09-12 IL IL15460801A patent/IL154608A0/xx unknown
- 2001-09-12 JP JP2002526416A patent/JP4903975B2/ja not_active Expired - Fee Related
- 2001-09-12 KR KR1020117026231A patent/KR101268790B1/ko not_active Expired - Fee Related
- 2001-09-12 ES ES01984626T patent/ES2368902T3/es not_active Expired - Lifetime
- 2001-09-12 EP EP10179135A patent/EP2305298A1/en not_active Withdrawn
- 2001-09-12 CZ CZ2003-756A patent/CZ305324B6/cs not_active IP Right Cessation
- 2001-09-12 HU HU0301043A patent/HUP0301043A3/hu not_active Application Discontinuation
- 2001-09-12 AU AU2002220548A patent/AU2002220548B2/en not_active Ceased
-
2003
- 2003-02-24 IL IL154607A patent/IL154607A/en not_active IP Right Cessation
- 2003-02-24 IL IL154608A patent/IL154608A/en not_active IP Right Cessation
- 2003-02-25 ZA ZA200301524A patent/ZA200301524B/en unknown
- 2003-02-25 ZA ZA200301526A patent/ZA200301526B/en unknown
- 2003-03-14 NO NO20031184A patent/NO337730B1/no not_active IP Right Cessation
- 2003-03-14 NO NO20031183A patent/NO336186B1/no not_active IP Right Cessation
-
2007
- 2007-05-07 US US11/745,006 patent/US20080081050A1/en not_active Abandoned
-
2010
- 2010-08-13 US US12/855,734 patent/US20110008419A1/en not_active Abandoned
-
2011
- 2011-09-12 JP JP2011198277A patent/JP2012006969A/ja active Pending
- 2011-10-06 CY CY20111100958T patent/CY1111915T1/el unknown
-
2013
- 2013-12-10 US US14/101,995 patent/US20140099339A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012006969A5 (enExample) | ||
| US11883502B2 (en) | Methods for production of capsular polysaccharide protein conjugates from Streptococcus pneumoniae serotype 19F | |
| CA2816182C (en) | Pneumococcal polysaccharide conjugate vaccine | |
| CA2690710C (en) | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates | |
| TWI281403B (en) | Vaccine | |
| ES2385100T3 (es) | Composición de vacuna multivalente con dosis reducida de Haemophilus influenzae de tipo B | |
| AU2002220548B2 (en) | Vaccine against streptococcus penumoniae | |
| ES2398451T3 (es) | Coadyuvante para vacunas | |
| JP2018531315A5 (enExample) | ||
| JP2014515035A5 (enExample) | ||
| RU2014147491A (ru) | Антигены и антигенные композиции | |
| JP2019504623A5 (enExample) | ||
| Al-Jadiry | Childhood Immunization | |
| Baxter et al. | 1086; 5-year Antibody Persistence and Booster Response to a Meningococcal ACWY Tetanus Toxoid Conjugate Vaccine in Healthy Adolescents and Young Adults | |
| TW201008578A (en) | Vaccine composition | |
| HK1157667A (en) | Streptococcus pneumoniae vaccine | |
| MX2008008139A (en) | Pneumococcal polysaccharide conjugate vaccine |