|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
US4235877A
(en)
|
1979-06-27 |
1980-11-25 |
Merck & Co., Inc. |
Liposome particle containing viral or bacterial antigenic subunit
|
|
EP0027888B1
(en)
|
1979-09-21 |
1986-04-16 |
Hitachi, Ltd. |
Semiconductor switch
|
|
US4673574A
(en)
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
|
US4459286A
(en)
|
1983-01-31 |
1984-07-10 |
Merck & Co., Inc. |
Coupled H. influenzae type B vaccine
|
|
US4695624A
(en)
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4808700A
(en)
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4709017A
(en)
|
1985-06-07 |
1987-11-24 |
President And Fellows Of Harvard College |
Modified toxic vaccines
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US5173294A
(en)
|
1986-11-18 |
1992-12-22 |
Research Foundation Of State University Of New York |
Dna probe for the identification of haemophilus influenzae
|
|
US4950740A
(en)
|
1987-03-17 |
1990-08-21 |
Cetus Corporation |
Recombinant diphtheria vaccines
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
WO1988009797A1
(en)
|
1987-06-05 |
1988-12-15 |
The United States Of America, As Represented By Th |
Autocrine motility factors in cancer diagnosis and management
|
|
US4940460A
(en)
|
1987-06-19 |
1990-07-10 |
Bioject, Inc. |
Patient-fillable and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US5339163A
(en)
|
1988-03-16 |
1994-08-16 |
Canon Kabushiki Kaisha |
Automatic exposure control device using plural image plane detection areas
|
|
US4912094B1
(en)
|
1988-06-29 |
1994-02-15 |
Ribi Immunochem Research Inc. |
Modified lipopolysaccharides and process of preparation
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
JP3237842B2
(ja)
|
1988-12-16 |
2001-12-10 |
オランダ国 |
ニューモリシンミュータント及びそれから製造されたニューモコッカルワクチン
|
|
CA2006700A1
(en)
|
1989-01-17 |
1990-07-17 |
Antonello Pessi |
Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
|
|
ATE115862T1
(de)
|
1989-02-04 |
1995-01-15 |
Akzo Nobel Nv |
Tocole als impfstoffadjuvans.
|
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
FR2649012B1
(fr)
|
1989-07-03 |
1991-10-25 |
Seppic Sa |
Emulsions multiphasiques injectables
|
|
FR2649013B1
(fr)
|
1989-07-03 |
1991-10-25 |
Seppic Sa |
Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable
|
|
AU651949B2
(en)
|
1989-07-14 |
1994-08-11 |
American Cyanamid Company |
Cytokine and hormone carriers for conjugate vaccines
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
ATE128628T1
(de)
|
1990-08-13 |
1995-10-15 |
American Cyanamid Co |
Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff.
|
|
US5153312A
(en)
|
1990-09-28 |
1992-10-06 |
American Cyanamid Company |
Oligosaccharide conjugate vaccines
|
|
FI933580L
(fi)
|
1991-02-15 |
1993-10-13 |
Uab Research Foundation |
Strukturgen av pneumokockprotein
|
|
US6592876B1
(en)
|
1993-04-20 |
2003-07-15 |
Uab Research Foundation |
Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
|
|
US5476929A
(en)
|
1991-02-15 |
1995-12-19 |
Uab Research Foundation |
Structural gene of pneumococcal protein
|
|
US5552146A
(en)
|
1991-08-15 |
1996-09-03 |
Board Of Regents, The University Of Texas System |
Methods and compositions relating to useful antigens of Moraxella catarrhalis
|
|
GB9118204D0
(en)
|
1991-08-23 |
1991-10-09 |
Weston Terence E |
Needle-less injector
|
|
EP0625910B1
(en)
|
1992-02-11 |
2003-07-23 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Dual carrier immunogenic construct
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
JP3506431B2
(ja)
|
1992-05-06 |
2004-03-15 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ジフテリア毒素受容体結合領域
|
|
DK0652758T3
(da)
|
1992-06-18 |
2000-05-08 |
Harvard College |
Diferitoxin-vacciner
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
US5569189A
(en)
|
1992-09-28 |
1996-10-29 |
Equidyne Systems, Inc. |
hypodermic jet injector
|
|
US5334144A
(en)
|
1992-10-30 |
1994-08-02 |
Becton, Dickinson And Company |
Single use disposable needleless injector
|
|
GB9224584D0
(en)
|
1992-11-23 |
1993-01-13 |
Connaught Lab |
Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases
|
|
KR100310510B1
(ko)
|
1993-03-23 |
2002-07-04 |
장 스테판느 |
3-0-탈아세틸화모노포스포릴지질a를함유하는백신조성물
|
|
JP3429313B2
(ja)
|
1993-05-18 |
2003-07-22 |
オハイオ・ステイト・リサーチ・ファウンデーション |
中耳炎ワクチン
|
|
EP0720485B1
(en)
|
1993-09-22 |
2003-11-19 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
WO1995024176A1
(en)
|
1994-03-07 |
1995-09-14 |
Bioject, Inc. |
Ampule filling device
|
|
US5466220A
(en)
|
1994-03-08 |
1995-11-14 |
Bioject, Inc. |
Drug vial mixing and transfer device
|
|
US5917017A
(en)
|
1994-06-08 |
1999-06-29 |
President And Fellows Of Harvard College |
Diphtheria toxin vaccines bearing a mutated R domain
|
|
US6455673B1
(en)
|
1994-06-08 |
2002-09-24 |
President And Fellows Of Harvard College |
Multi-mutant diphtheria toxin vaccines
|
|
US5599302A
(en)
|
1995-01-09 |
1997-02-04 |
Medi-Ject Corporation |
Medical injection system and method, gas spring thereof and launching device using gas spring
|
|
DE69628418T2
(de)
|
1995-03-22 |
2004-04-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
US6440425B1
(en)
|
1995-05-01 |
2002-08-27 |
Aventis Pasteur Limited |
High molecular weight major outer membrane protein of moraxella
|
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
|
US5843464A
(en)
|
1995-06-02 |
1998-12-01 |
The Ohio State University |
Synthetic chimeric fimbrin peptides
|
|
GB9513074D0
(en)
|
1995-06-27 |
1995-08-30 |
Cortecs Ltd |
Novel anigen
|
|
US6290970B1
(en)
|
1995-10-11 |
2001-09-18 |
Aventis Pasteur Limited |
Transferrin receptor protein of Moraxella
|
|
US5893397A
(en)
|
1996-01-12 |
1999-04-13 |
Bioject Inc. |
Medication vial/syringe liquid-transfer apparatus
|
|
US6090576A
(en)
|
1996-03-08 |
2000-07-18 |
Connaught Laboratories Limited |
DNA encoding a transferrin receptor of Moraxella
|
|
GB9607549D0
(en)
|
1996-04-11 |
1996-06-12 |
Weston Medical Ltd |
Spring-powered dispensing device
|
|
WO1997041151A2
(en)
|
1996-05-01 |
1997-11-06 |
The Rockefeller University |
Choline binding proteins for anti-pneumococcal vaccines
|
|
US7341727B1
(en)
|
1996-05-03 |
2008-03-11 |
Emergent Product Development Gaithersburg Inc. |
M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
|
|
ATE234129T1
(de)
|
1996-06-18 |
2003-03-15 |
Alza Corp |
Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
|
|
EP0956289A4
(en)
|
1996-08-16 |
2004-10-13 |
Smithkline Beecham Corp |
NOVEL PROKARYOTA POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF
|
|
ATE348887T1
(de)
|
1996-10-31 |
2007-01-15 |
Human Genome Sciences Inc |
Streptococcus pneumoniae antigene und impfstoffe
|
|
AU5355398A
(en)
|
1996-11-12 |
1998-06-03 |
Regents Of The University Of Minnesota |
C3 binding protein of (streptococcus pneumoniae)
|
|
US5980898A
(en)
|
1996-11-14 |
1999-11-09 |
The United States Of America As Represented By The U.S. Army Medical Research & Material Command |
Adjuvant for transcutaneous immunization
|
|
KR100453132B1
(ko)
|
1996-12-20 |
2004-10-15 |
앨자 코포레이션 |
경피 약제 플럭스를 향상시키기 위한 장치 및 방법
|
|
DE19708537A1
(de)
|
1997-03-03 |
1998-09-10 |
Biotechnolog Forschung Gmbh |
Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc.
|
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
|
US5993412A
(en)
|
1997-05-19 |
1999-11-30 |
Bioject, Inc. |
Injection apparatus
|
|
BR9809914A
(pt)
|
1997-06-03 |
2001-09-18 |
Connaught Lab |
Genes de moracella receptores de lactoferrina
|
|
GB9711990D0
(en)
|
1997-06-11 |
1997-08-06 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
US6800744B1
(en)
|
1997-07-02 |
2004-10-05 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
|
|
AU740956B2
(en)
|
1997-07-21 |
2001-11-15 |
Baxter Healthcare Sa |
Modified immunogenic pneumolysin compositions as vaccines
|
|
GB9718901D0
(en)
|
1997-09-05 |
1997-11-12 |
Smithkline Beecham Biolog |
Vaccine
|
|
EP1279401B1
(en)
|
1997-09-05 |
2008-01-09 |
GlaxoSmithKline Biologicals S.A. |
Oil in water emulsions containing saponins
|
|
EP1017828A1
(en)
|
1997-09-24 |
2000-07-12 |
Regents Of The University Of Minnesota |
HUMAN COMPLEMENT C3-DEGRADING PROTEINASE FROM $i(STREPTOCOCCUS PNEUMONIAE)
|
|
CN1285753A
(zh)
|
1997-12-02 |
2001-02-28 |
鲍德杰克特疫苗公司 |
透皮给药微粒疫苗组合物
|
|
IT1298087B1
(it)
|
1998-01-08 |
1999-12-20 |
Fiderm S R L |
Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
|
|
NZ530277A
(en)
|
1998-04-07 |
2005-08-26 |
Medimmune Inc |
Derivatives of pneumococcal choline binding proteins for vaccines
|
|
AU3479699A
(en)
|
1998-04-07 |
1999-10-25 |
St. Jude Children's Research Hospital |
A polypeptide comprising the amino acid of an n-terminal choline binding proteina truncate, vaccine derived therefrom and uses thereof
|
|
WO1999053940A1
(en)
|
1998-04-23 |
1999-10-28 |
Uab Research Foundation |
PNEUMOCOCCAL SURFACE PROTEIN C(PspC), EPITOPIC REGIONS AND STRAIN SELECTION THEREOF, AND USES THEREFOR
|
|
GB9812613D0
(en)
|
1998-06-11 |
1998-08-12 |
Smithkline Beecham Biolog |
Vaccine
|
|
CN1263510C
(zh)
|
1998-08-19 |
2006-07-12 |
巴克斯特健康护理股份有限公司 |
多糖－蛋白质缀合物或寡糖－蛋白质缀合物、其制备方法及其应用
|
|
EP1115875A1
(en)
|
1998-09-24 |
2001-07-18 |
Regents Of The University Of Minnesota |
Human complement c3-degrading polypeptide from streptococcus pneumoniae
|
|
US6541616B1
(en)
|
1998-10-01 |
2003-04-01 |
Antex Biologics Inc. |
Moraxella catarrhalis protein, gene sequence and uses thereof
|
|
WO2000030299A1
(en)
|
1998-11-17 |
2000-05-25 |
Schlumberger Technology Corporation |
Transmitting information over a communication link
|
|
CA2355364C
(en)
|
1998-12-21 |
2014-03-18 |
Medimmune, Inc. |
Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
|
|
PL205041B1
(pl)
|
1998-12-23 |
2010-03-31 |
Id Biomedical Corp |
Izolowany polinukleotyd, wektor zawierający izolowany polinukleotyd, komórka gospodarza transfekowana lub transformowana za pomocą tego wektora, sposób wytwarzania polipeptydu kodowanego przez izolowany polinukleotyd, izolowany polipeptyd, chimeryczny polipeptyd, kompozycja do szczepionek zawierająca polipeptyd oraz jej zastosowanie w leczeniu lub zapobieganiu zakażeniu osobnika paciorkowcem
|
|
CA2366152A1
(en)
|
1999-03-19 |
2000-09-28 |
Smithkline Beecham Biologicals S.A. |
Streptococcus pneumoniae vaccine
|
|
WO2000061761A2
(en)
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
US6319224B1
(en)
|
1999-08-20 |
2001-11-20 |
Bioject Medical Technologies Inc. |
Intradermal injection system for injecting DNA-based injectables into humans
|
|
US6494865B1
(en)
|
1999-10-14 |
2002-12-17 |
Becton Dickinson And Company |
Intradermal delivery device including a needle assembly
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
WO2001098334A2
(en)
|
2000-06-20 |
2001-12-27 |
Shire Biochem Inc. |
Streptococcus antigens
|
|
US20030031684A1
(en)
|
2001-03-30 |
2003-02-13 |
Corixa Corporation |
Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
|
|
AU2002309706A1
(en)
|
2001-05-11 |
2002-11-25 |
Aventis Pasteur, Inc. |
Novel meningitis conjugate vaccine
|
|
US7262024B2
(en)
|
2001-12-20 |
2007-08-28 |
Id Biomedical Corporation |
Streptococcus antigens
|
|
MXPA05009579A
(es)
|
2003-03-13 |
2005-11-17 |
Glaxosmithkline Biolog Sa |
Proceso de purificacion para citolisina bacteriana.
|
|
EP1603950A2
(en)
|
2003-03-17 |
2005-12-14 |
Wyeth Holdings Corporation |
Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
|
|
IL308456A
(en)
*
|
2005-04-08 |
2024-01-01 |
Wyeth Llc |
A multivalent pneumomuroral protein-polysaccharide conjugate preparation
|
|
TWI457133B
(zh)
|
2005-12-13 |
2014-10-21 |
Glaxosmithkline Biolog Sa |
新穎組合物
|
|
JP5792920B2
(ja)
|
2005-12-22 |
2015-10-14 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
EA200901578A1
(ru)
*
|
2007-06-26 |
2010-08-30 |
Глаксосмитклайн Байолоджикалс С.А. |
Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
|
|
CA2694466A1
(en)
|
2007-07-23 |
2009-01-29 |
Sanofi Pasteur Limited |
Immunogenic polypeptides and monoclonal antibodies
|
|
JP2010534622A
(ja)
|
2007-07-26 |
2010-11-11 |
サノフィ パストゥール リミテッド |
抗原−アジュバント組成物および方法
|
|
US7818466B2
(en)
*
|
2007-12-31 |
2010-10-19 |
Synopsys, Inc. |
HDMI controller circuit for transmitting digital data to compatible audio device using address decoder where values are written to registers of sub-circuits
|
|
CN101785857B
(zh)
|
2010-03-05 |
2012-09-26 |
成都安特金生物技术有限公司 |
一种新的肺炎球菌结合疫苗及其制备方法
|
|
GB201003924D0
(en)
*
|
2010-03-09 |
2010-04-21 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
|
GB201003922D0
(en)
*
|
2010-03-09 |
2010-04-21 |
Glaxosmithkline Biolog Sa |
Conjugation process
|
|
WO2014060385A1
(en)
*
|
2012-10-17 |
2014-04-24 |
Glaxosmithkline Biologicals S.A. |
Immunogenic composition
|
|
CN103830723A
(zh)
*
|
2012-11-26 |
2014-06-04 |
天士力制药集团股份有限公司 |
一种肺炎链球菌荚膜多糖蛋白结合疫苗的制备方法
|
|
IL312327B2
(en)
*
|
2014-01-21 |
2026-02-01 |
Pfizer |
Immunogenic preparations comprising conjugated capsular saccharide antigens and their uses
|
|
GB201518684D0
(en)
|
2015-10-21 |
2015-12-02 |
Glaxosmithkline Biolog Sa |
Vaccine
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