JP2011521618A5 - - Google Patents
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- JP2011521618A5 JP2011521618A5 JP2010545281A JP2010545281A JP2011521618A5 JP 2011521618 A5 JP2011521618 A5 JP 2011521618A5 JP 2010545281 A JP2010545281 A JP 2010545281A JP 2010545281 A JP2010545281 A JP 2010545281A JP 2011521618 A5 JP2011521618 A5 JP 2011521618A5
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- 206010028980 Neoplasm Diseases 0.000 claims description 41
- 108090000623 proteins and genes Proteins 0.000 claims description 38
- 101000852483 Homo sapiens Interleukin-1 receptor-associated kinase 1 Proteins 0.000 claims description 13
- 102100036342 Interleukin-1 receptor-associated kinase 1 Human genes 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 claims description 10
- 210000000481 breast Anatomy 0.000 claims description 9
- 108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 claims description 8
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims 40
- 238000000034 method Methods 0.000 claims 35
- 201000011510 cancer Diseases 0.000 claims 32
- 101000837565 Homo sapiens Ubiquitin-conjugating enzyme E2 S Proteins 0.000 claims 21
- 102100028718 Ubiquitin-conjugating enzyme E2 S Human genes 0.000 claims 21
- 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 claims 20
- 102100038618 Thymidylate synthase Human genes 0.000 claims 20
- 102000004000 Aurora Kinase A Human genes 0.000 claims 18
- 108090000461 Aurora Kinase A Proteins 0.000 claims 18
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 13
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 13
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 12
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 12
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims 10
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims 10
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 10
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 10
- 208000009956 adenocarcinoma Diseases 0.000 claims 9
- 102100024746 Dihydrofolate reductase Human genes 0.000 claims 8
- 108020001096 dihydrofolate reductase Proteins 0.000 claims 8
- 210000004072 lung Anatomy 0.000 claims 8
- 210000001672 ovary Anatomy 0.000 claims 8
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 3
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 3
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 3
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000003679 cervix uteri Anatomy 0.000 claims 3
- 210000000664 rectum Anatomy 0.000 claims 3
- 210000002784 stomach Anatomy 0.000 claims 3
- 210000001685 thyroid gland Anatomy 0.000 claims 3
- 210000003932 urinary bladder Anatomy 0.000 claims 3
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- 108091008605 VEGF receptors Proteins 0.000 claims 2
- 238000002648 combination therapy Methods 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YPSXFMHXRZAGTG-UHFFFAOYSA-N 4-methoxy-2-[2-(5-methoxy-2-nitrosophenyl)ethyl]-1-nitrosobenzene Chemical compound COC1=CC=C(N=O)C(CCC=2C(=CC=C(OC)C=2)N=O)=C1 YPSXFMHXRZAGTG-UHFFFAOYSA-N 0.000 claims 1
- 208000004463 Follicular Adenocarcinoma Diseases 0.000 claims 1
- 208000005234 Granulosa Cell Tumor Diseases 0.000 claims 1
- 208000002163 Phyllodes Tumor Diseases 0.000 claims 1
- 206010071776 Phyllodes tumour Diseases 0.000 claims 1
- 201000008395 adenosquamous carcinoma Diseases 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims 1
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 1
- 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000003849 large cell carcinoma Diseases 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000010225 mixed cell type cancer Diseases 0.000 claims 1
- 208000029638 mixed neoplasm Diseases 0.000 claims 1
- 208000010492 mucinous cystadenocarcinoma Diseases 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 208000000649 small cell carcinoma Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 208000023965 endometrium neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2607708P | 2008-02-04 | 2008-02-04 | |
| US61/026,077 | 2008-02-04 | ||
| PCT/US2009/033117 WO2009100159A2 (en) | 2008-02-04 | 2009-02-04 | Methods of diagnosing and treating parp-mediated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521618A JP2011521618A (ja) | 2011-07-28 |
| JP2011521618A5 true JP2011521618A5 (enExample) | 2012-03-22 |
Family
ID=40952673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545281A Abandoned JP2011521618A (ja) | 2008-02-04 | 2009-02-04 | Parp仲介疾患を診断および治療する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090275608A1 (enExample) |
| EP (1) | EP2250282A4 (enExample) |
| JP (1) | JP2011521618A (enExample) |
| KR (1) | KR20100112192A (enExample) |
| CN (1) | CN101999002A (enExample) |
| AU (1) | AU2009212401A1 (enExample) |
| CA (1) | CA2713156A1 (enExample) |
| CO (1) | CO6331372A2 (enExample) |
| IL (1) | IL207360A0 (enExample) |
| MA (1) | MA32136B1 (enExample) |
| MX (1) | MX2010008572A (enExample) |
| RU (1) | RU2010136966A (enExample) |
| WO (1) | WO2009100159A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG164368A1 (en) | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
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| AU2007292387A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
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| US20120059228A1 (en) * | 2009-03-16 | 2012-03-08 | The Research Foundation Of State University Of New York | Methods for detecting endometriosis |
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| TWI449911B (zh) * | 2010-01-29 | 2014-08-21 | Nat Defense Medical Ct | 免疫球蛋白a型腎小球腎炎之分子標記及其應用 |
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| AU2014251043B2 (en) | 2013-04-09 | 2020-01-16 | The Board Of Regents Of The University Of Texas System | Tumor-selective combination therapy |
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2010
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