JP2011514169A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011514169A5 JP2011514169A5 JP2011500744A JP2011500744A JP2011514169A5 JP 2011514169 A5 JP2011514169 A5 JP 2011514169A5 JP 2011500744 A JP2011500744 A JP 2011500744A JP 2011500744 A JP2011500744 A JP 2011500744A JP 2011514169 A5 JP2011514169 A5 JP 2011514169A5
- Authority
- JP
- Japan
- Prior art keywords
- passages
- microcarrier
- stem cells
- cells
- microcarriers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 28
- 210000000130 stem cell Anatomy 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 14
- 239000011159 matrix material Substances 0.000 claims 10
- 238000012258 culturing Methods 0.000 claims 7
- 230000004069 differentiation Effects 0.000 claims 6
- 238000004114 suspension culture Methods 0.000 claims 6
- 210000001671 embryonic stem cell Anatomy 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 108010085895 Laminin Proteins 0.000 claims 3
- 102000007547 Laminin Human genes 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 108010082117 matrigel Proteins 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 210000002744 extracellular matrix Anatomy 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 108091016585 CD44 antigen Proteins 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 claims 1
- 102100037369 Nidogen-1 Human genes 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 108090000054 Syndecan-2 Proteins 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- -1 dextran sulfate Chemical compound 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108010008217 nidogen Proteins 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6969408P | 2008-03-17 | 2008-03-17 | |
| US11025608P | 2008-10-31 | 2008-10-31 | |
| US14806409P | 2009-01-29 | 2009-01-29 | |
| US15594009P | 2009-02-27 | 2009-02-27 | |
| PCT/SG2009/000088 WO2009116951A2 (en) | 2008-03-17 | 2009-03-17 | Microcarriers for stem cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012079873A Division JP2012147793A (ja) | 2008-03-17 | 2012-03-30 | 幹細胞培養のためのマイクロキャリア |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011514169A JP2011514169A (ja) | 2011-05-06 |
| JP2011514169A5 true JP2011514169A5 (enExample) | 2012-02-02 |
Family
ID=40872517
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500744A Pending JP2011514169A (ja) | 2008-03-17 | 2009-03-17 | 幹細胞培養のためのマイクロキャリア |
| JP2012079873A Pending JP2012147793A (ja) | 2008-03-17 | 2012-03-30 | 幹細胞培養のためのマイクロキャリア |
| JP2015151501A Pending JP2015226543A (ja) | 2008-03-17 | 2015-07-31 | 幹細胞培養のためのマイクロキャリア |
| JP2017222498A Pending JP2018068302A (ja) | 2008-03-17 | 2017-11-20 | 幹細胞培養のためのマイクロキャリア |
| JP2019211253A Active JP6943937B2 (ja) | 2008-03-17 | 2019-11-22 | 幹細胞培養のためのマイクロキャリア |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012079873A Pending JP2012147793A (ja) | 2008-03-17 | 2012-03-30 | 幹細胞培養のためのマイクロキャリア |
| JP2015151501A Pending JP2015226543A (ja) | 2008-03-17 | 2015-07-31 | 幹細胞培養のためのマイクロキャリア |
| JP2017222498A Pending JP2018068302A (ja) | 2008-03-17 | 2017-11-20 | 幹細胞培養のためのマイクロキャリア |
| JP2019211253A Active JP6943937B2 (ja) | 2008-03-17 | 2019-11-22 | 幹細胞培養のためのマイクロキャリア |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US8716018B2 (enExample) |
| EP (2) | EP2479260B1 (enExample) |
| JP (5) | JP2011514169A (enExample) |
| SG (1) | SG188918A1 (enExample) |
| WO (1) | WO2009116951A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0222846D0 (en) * | 2002-10-03 | 2002-11-06 | Choo Yen | Cell culture |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| EP1888123B1 (en) | 2005-06-08 | 2013-01-09 | Janssen Biotech, Inc. | A cellular therapy for ocular degeneration |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| US9096832B2 (en) | 2007-07-31 | 2015-08-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| ATE523585T1 (de) | 2007-11-27 | 2011-09-15 | Lifescan Inc | Differenzierung menschlicher embryonaler stammzellen |
| CA2959401C (en) | 2008-02-21 | 2021-12-07 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US8691569B2 (en) | 2008-03-17 | 2014-04-08 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| SG188918A1 (enExample) | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| US8828720B2 (en) * | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US20110143433A1 (en) * | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| KR101651661B1 (ko) | 2008-06-30 | 2016-08-26 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 분화 |
| EP2318516A1 (en) * | 2008-06-30 | 2011-05-11 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| CN102272291B (zh) * | 2008-10-31 | 2018-01-16 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌谱系的分化 |
| MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| PL2366021T3 (pl) * | 2008-11-20 | 2017-12-29 | Janssen Biotech, Inc. | Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach |
| PL2366022T3 (pl) | 2008-11-20 | 2016-11-30 | Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych | |
| EP2408903B1 (en) | 2009-03-20 | 2014-08-06 | Agency For Science, Technology And Research | Culture of pluripotent and multipotent cells on microcarriers |
| AU2010276402B2 (en) | 2009-07-20 | 2014-07-03 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| ES2693088T3 (es) | 2009-07-20 | 2018-12-07 | Janssen Biotech, Inc. | Diferenciación de células madre embriónicas humanas |
| US9068182B2 (en) | 2009-07-28 | 2015-06-30 | Corning Incorporated | Synthetic polysaccharide microcarriers for culturing cells |
| EP2361968B1 (en) * | 2010-02-26 | 2014-11-19 | Corning Incorporated | Synthetic polysaccharide microcarriers for culturing cells |
| JP2013507959A (ja) * | 2009-10-22 | 2013-03-07 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 細胞培養／処理用製品、並びにそれらの製造及び使用方法 |
| AU2010333839C1 (en) * | 2009-12-23 | 2016-07-21 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
| MX339669B (es) * | 2009-12-23 | 2016-06-02 | Janssen Biotech Inc | Diferenciacion de celulas madres embrionarias humanas. |
| CN107189979B (zh) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
| CN102858381B (zh) * | 2010-03-01 | 2015-09-30 | 富士胶片株式会社 | 包括具有生物相容性的聚合物块和细胞的细胞构建体 |
| JP5777115B2 (ja) * | 2010-03-18 | 2015-09-09 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉細胞への分化誘導法 |
| KR101986176B1 (ko) | 2010-05-12 | 2019-06-05 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| EP3443991A1 (en) * | 2010-05-25 | 2019-02-20 | Cook Biotech Incorporated | Methods, substrates, and systems useful for cell seeding of medical grafts |
| US20130089928A1 (en) * | 2010-06-17 | 2013-04-11 | Songzhu An | Serum-Free Chemically Defined Cell Culture Medium |
| EP2606115A4 (en) * | 2010-08-16 | 2017-07-19 | Kiyatec Inc. | Bioreactor system |
| AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2012030540A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| WO2012030539A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| US20130164269A1 (en) * | 2010-09-02 | 2013-06-27 | Life Technologies Corporation | Cell culture system for bioreactor scale-up of cells |
| WO2012056997A1 (ja) * | 2010-10-28 | 2012-05-03 | 国立大学法人熊本大学 | 多能性幹細胞の分化誘導効率を改善するための方法及び培地 |
| US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
| US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
| US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
| US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| CN102174497B (zh) * | 2010-12-30 | 2013-05-22 | 北京民海生物科技有限公司 | 一种微载体的回收方法 |
| US20140329317A1 (en) | 2011-11-25 | 2014-11-06 | Kyoto University | Method for culturing pluripotent stem cell |
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| US9650602B2 (en) | 2012-03-13 | 2017-05-16 | Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences | Reprogramming cells by three-dimensional cultivation |
| CN102586173B (zh) * | 2012-03-20 | 2014-07-02 | 广东大华农动物保健品股份有限公司 | 一种提高微载体重复使用次数的回收处理方法 |
| WO2013184888A1 (en) | 2012-06-08 | 2013-12-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
| RU2684215C2 (ru) | 2012-12-31 | 2019-04-04 | Янссен Байотек, Инк. | Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток |
| RU2687379C2 (ru) * | 2012-12-31 | 2019-05-13 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| WO2014105543A1 (en) | 2012-12-31 | 2014-07-03 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| EP2966163B1 (en) | 2013-03-06 | 2018-01-17 | Kyoto University | Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells |
| JP2016516091A (ja) * | 2013-04-02 | 2016-06-02 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ |
| EP3004181B1 (en) * | 2013-05-27 | 2019-01-02 | Agency For Science, Technology And Research | Heparan sulphate |
| SG11201510462QA (en) * | 2013-06-18 | 2016-01-28 | Agency Science Tech & Res | Method of culturing cancer stem cells |
| JP2016526387A (ja) * | 2013-06-24 | 2016-09-05 | アントフロゲネシス コーポレーション | 細胞培養のための細胞外マトリクス組成物ビーズ |
| WO2015008275A1 (en) * | 2013-07-17 | 2015-01-22 | Kadimastem Ltd | Methods for large scale generation of stem cells |
| KR20160037170A (ko) * | 2013-08-01 | 2016-04-05 | 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 | 허혈성 심장의 치료를 필요로 하는 인간 또는 동물 대상의 허혈성 심장을 치료하는 방법에서 사용하기 위한 세포외 매트릭스의 글리코실화 단백질 |
| JP6353452B2 (ja) * | 2013-09-04 | 2018-07-04 | 株式会社大塚製薬工場 | 多能性幹細胞の調製方法 |
| KR20180128529A (ko) * | 2013-11-01 | 2018-12-03 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포로의 분화를 위한 인간 만능 줄기세포의 현탁 및 클러스터링 |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| WO2016020719A1 (en) * | 2014-08-04 | 2016-02-11 | Euroresearch S.R.L. | Novel collagen microcarriers |
| US20170335286A1 (en) * | 2014-10-30 | 2017-11-23 | Stembiosys, Inc. | Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers |
| WO2016121737A1 (ja) * | 2015-01-29 | 2016-08-04 | 株式会社カネカ | 細胞凝集塊の作製方法 |
| FR3035107A1 (fr) * | 2015-04-15 | 2016-10-21 | Celenys | Procede de preparation d'hydrogel a partir d'acide hyaluronique modifie et de collagene de type i |
| KR101705245B1 (ko) * | 2015-05-22 | 2017-02-09 | 건국대학교 글로컬산학협력단 | 마트리겔이 코팅된 신경줄기세포 배양용 플레이트 |
| US12402609B2 (en) * | 2016-01-13 | 2025-09-02 | Felix Pets, Llc | Methods for producing hypo-allergenic cats using gene editing technology |
| GB201615517D0 (en) | 2016-09-13 | 2016-10-26 | Micromatrices Ass L | Spheroid tissue miroarray and method of manufacture |
| JP6705911B2 (ja) | 2016-04-14 | 2020-06-03 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の中腸内胚葉細胞への分化 |
| JP2020521459A (ja) | 2017-05-24 | 2020-07-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | サテライト細胞および組成物ならびにそれらの生産方法 |
| WO2018225703A1 (ja) * | 2017-06-05 | 2018-12-13 | テルモ株式会社 | 分化誘導細胞の調製方法 |
| GB201718556D0 (en) * | 2017-11-09 | 2017-12-27 | Univ Oxford Innovation Ltd | Macrocarrier |
| CN112041428B (zh) * | 2018-01-18 | 2024-05-24 | 新加坡科技研究局 | 用于在悬浮培养物中分化人多能干细胞系的方法 |
| WO2019163948A1 (ja) * | 2018-02-23 | 2019-08-29 | 学校法人創価大学 | 細胞培養用基材及び培養方法 |
| EP3816279A4 (en) * | 2018-06-27 | 2022-04-20 | Ajinomoto Co., Inc. | STEM CELL CULTURE ADDITIVE, CULTURE MEDIUM, AND CULTURE METHOD |
| TW202020144A (zh) * | 2018-07-31 | 2020-06-01 | 日商Ｊｃｒ製藥股份有限公司 | 源自齒髓的細胞之製造方法 |
| JP7588591B2 (ja) * | 2019-01-31 | 2024-11-22 | 北京華龕生物科技有限公司 | 幹細胞の大規模調製のための三次元培養方法 |
| JP7284985B2 (ja) * | 2019-03-29 | 2023-06-01 | 国立大学法人 長崎大学 | 肝前駆細胞を含む細胞集団を製造する方法 |
| CN110564674B (zh) * | 2019-09-29 | 2021-05-11 | 广东工业大学 | 一种干细胞铺底工作液及其应用 |
| WO2021118226A1 (ko) * | 2019-12-09 | 2021-06-17 | 주식회사 대웅제약 | 인간 만능줄기세포로부터 중간엽 줄기세포의 제조방법 및 이에 의해 제조된 중간엽 줄기세포 |
| FR3106141B1 (fr) * | 2020-01-09 | 2024-12-20 | Carroucell | Microporteurs pour culture cellulaire et procédé de fabrication de microporteurs |
| US20230116083A1 (en) | 2020-03-10 | 2023-04-13 | Life & Brain Gmbh | Up-scaled production of microglia-like/-precursor cells and macrophage cells using mesh macrocarriers |
| CN111467579B (zh) * | 2020-04-03 | 2021-10-26 | 北京臻溪谷医学研究中心（有限合伙） | 基于合金内核的治疗动脉瘤与血管狭窄用干细胞支架及其制法 |
| JPWO2022004822A1 (enExample) * | 2020-06-30 | 2022-01-06 | ||
| JP2023537969A (ja) * | 2020-08-10 | 2023-09-06 | リネージ セル セラピューティクス インコーポレイテッド | 胚性幹細胞増殖のための組成物及び方法 |
| CN114761533A (zh) * | 2020-09-15 | 2022-07-15 | 株式会社Lg化学 | 细胞培养用微载体和用于制备其的方法 |
| KR102864804B1 (ko) * | 2020-09-15 | 2025-09-25 | 주식회사 엘지화학 | 세포 배양용 마이크로-캐리어 및 그 제조방법 |
| JP2025506848A (ja) * | 2022-02-25 | 2025-03-13 | カンステム バイオテック カンパニー リミテッド | マイクロキャリアを用いた幹細胞の培養方法 |
| WO2023208212A1 (zh) * | 2022-04-29 | 2023-11-02 | 北京华龛生物科技有限公司 | 基于三维多孔微载体的病毒载体生产方法 |
| WO2024102777A2 (en) * | 2022-11-08 | 2024-05-16 | Lineage Cell Therapeutics, Inc. | Compositions and method for expansion of embryonic stem cells |
| WO2024253069A1 (ja) * | 2023-06-06 | 2024-12-12 | 東ソー株式会社 | 温度応答性マイクロキャリア |
| WO2025059779A1 (en) * | 2023-09-22 | 2025-03-27 | Spiderwort Biotechnologies Inc. | Plant-based or fungal-based micro-carrier scaffolds optimized for large-scale cell-culture production and other applications |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| US4975377A (en) | 1987-05-14 | 1990-12-04 | Key Marc E | Cell growth chambers and method of use thereof |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| DE4117305C2 (de) | 1991-05-27 | 1994-07-21 | Weidmueller Interface | Zange zum Ergreifen und/oder Verpressen von Bearbeitungsgegenständen |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5661034A (en) | 1991-07-18 | 1997-08-26 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium |
| US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| WO1994007913A1 (en) | 1992-09-25 | 1994-04-14 | Warner-Lambert Company | Peptide antagonists of sh2 binding and therapeutic uses thereof |
| EP0600831A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Phthalazinonderivate |
| EP0600832A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren |
| US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| US5631159A (en) | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
| US5853717A (en) * | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5919449A (en) | 1995-05-30 | 1999-07-06 | Diacrin, Inc. | Porcine cardiomyocytes and their use in treatment of insufficient cardiac function |
| US6015554A (en) | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
| CA2251983C (en) | 1996-04-19 | 2003-12-16 | Sudhakar Kadiyala | Regeneration and augmentation of bone using mesenchymal stem cells |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6361996B1 (en) | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
| ES2285779T3 (es) | 1997-07-03 | 2007-11-16 | Osiris Therapeutics, Inc. | Celulas madre mesenquimatosas humanas de sangre periferica. |
| WO1999001159A1 (en) | 1997-07-04 | 1999-01-14 | University Of Utah Research Foundation | Lineage-restricted neuronal precursors |
| ATE307195T1 (de) | 1997-07-14 | 2005-11-15 | Osiris Therapeutics Inc | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| JP3880795B2 (ja) | 1997-10-23 | 2007-02-14 | ジェロン・コーポレーション | フィーダー細胞を含まない培養物中で、霊長類由来始原幹細胞を増殖させるための方法 |
| US6637437B1 (en) | 1998-04-08 | 2003-10-28 | Johns Hopkins University | Cell-culture and polymer constructs |
| US6886568B2 (en) | 1998-04-08 | 2005-05-03 | The Johns Hopkins University | Method for fabricating cell-containing implants |
| US20040044408A1 (en) | 1998-04-08 | 2004-03-04 | Hungerford David S. | Cell-culture and polymer constructs |
| EP0953633A1 (en) | 1998-04-28 | 1999-11-03 | Livercell L.L.C. | Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells |
| IL145002A0 (en) | 1999-03-10 | 2002-06-30 | Univ Pittsburgh | Adipose-derived stem cells and lattices |
| US6662805B2 (en) | 1999-03-24 | 2003-12-16 | The Johns Hopkins University | Method for composite cell-based implants |
| AU2001276846A1 (en) | 2000-06-29 | 2002-01-14 | Mitokor | Methods for identifying mitochondrial divalent cation transporters |
| JP4252451B2 (ja) | 2001-08-30 | 2009-04-08 | 浜松ホトニクス株式会社 | 混合液の液滴形成方法及び混合液の液滴形成装置 |
| JP2005506839A (ja) | 2001-10-02 | 2005-03-10 | ベクトン・ディキンソン・アンド・カンパニー | 細胞外マトリックスおよび他の分子を使用する幹細胞の増殖および分化 |
| AU2003223416A1 (en) | 2002-03-25 | 2003-10-13 | Condros, Inc. | Tissue analogs for in vitro testing and method of use therefor |
| US20050129776A1 (en) | 2002-05-03 | 2005-06-16 | Inserm | Microparticles supporting cells and active substances |
| WO2005007799A2 (en) | 2003-07-17 | 2005-01-27 | Gamida-Cell Ltd. | Methods for ex-vivo expanding stem/progenitor cells |
| AU2004260106C1 (en) | 2003-07-17 | 2010-12-09 | Global Cell Solutions, Llc. | Automated cell culture system and process |
| CA2540657A1 (en) | 2003-10-20 | 2005-04-28 | Jms Co., Ltd. | Cell handling device, human tissue regeneration composition, and human tissue regeneration method |
| WO2005065354A2 (en) * | 2003-12-31 | 2005-07-21 | The Burnham Institute | Defined media for pluripotent stem cell culture |
| JP4147306B2 (ja) * | 2004-02-03 | 2008-09-10 | 国立大学法人 熊本大学 | 唾液腺由来の内胚葉系細胞および外胚葉系細胞の双方に分化可能な未分化な多分化能を有する新規細胞およびその細胞の調製方法 |
| WO2005085422A1 (en) | 2004-02-27 | 2005-09-15 | Michigan State University | Adult stem cells and uses thereof |
| WO2005113749A2 (en) | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Stem cell populations and methods of use |
| DE102004043256B4 (de) * | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| DK3196296T3 (en) | 2004-09-08 | 2019-02-04 | Wisconsin Alumini Res Foundation | Cultivation of human embryonic stem cells |
| US20070280989A1 (en) | 2004-09-21 | 2007-12-06 | Nvr Labs Ltd | Compositions and Methods for Stem Cell Expansion and Differentiation |
| WO2006091921A2 (en) | 2005-02-25 | 2006-08-31 | Drexel University | Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications |
| JP2006230316A (ja) * | 2005-02-25 | 2006-09-07 | Japan Health Science Foundation | 瘢痕のない創傷治癒能を有する細胞およびその調製方法 |
| JP2006288244A (ja) * | 2005-04-07 | 2006-10-26 | Espec Corp | 培養装置並びに細胞の製造方法 |
| EP1888123B1 (en) * | 2005-06-08 | 2013-01-09 | Janssen Biotech, Inc. | A cellular therapy for ocular degeneration |
| JP5560391B2 (ja) * | 2005-06-22 | 2014-07-23 | アステリアス バイオセラピューティクス インコーポレイテッド | ヒト胚性幹細胞の懸濁培養法 |
| AU2006274438A1 (en) | 2005-07-29 | 2007-02-01 | Australian Stem Cell Centre Limited | Compositions and methods for growth of pluripotent cells |
| WO2007030469A2 (en) | 2005-09-06 | 2007-03-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Transplantable cell growth niche and related compositions and methods |
| AU2006292021B2 (en) | 2005-09-12 | 2012-05-31 | Es Cell International Pte Ltd. | Cardiomyocyte production |
| WO2007038471A2 (en) | 2005-09-27 | 2007-04-05 | Regenetech, Inc. | Rotatable time varying electromagnetic force bioreactor and method of using the same |
| JP5122973B2 (ja) * | 2005-11-15 | 2013-01-16 | 独立行政法人科学技術振興機構 | Ｅｓ細胞からすい臓を生産する方法 |
| AU2006326853B2 (en) | 2005-12-22 | 2012-02-16 | Es Cell International Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| ES2708933T3 (es) | 2005-12-29 | 2019-04-12 | Celularity Inc | Poblaciones de células madre placentarias |
| WO2007149926A1 (en) | 2006-06-20 | 2007-12-27 | Wisconsin Alumni Research Foundation | Method for culturing stem cells |
| WO2008004990A2 (en) | 2006-07-06 | 2008-01-10 | Es Cell International Pte Ltd | Method for stem cell culture and cells derived therefrom |
| CA2657013A1 (en) | 2006-07-06 | 2008-01-10 | Organogenesis Inc. | Temperature-responsive microcarrier |
| ES2704401T3 (es) | 2006-08-02 | 2019-03-18 | Technion Res & Dev Foundation | Métodos de expansión de células madre embrionarias en un cultivo en suspensión |
| US20080138415A1 (en) | 2006-09-26 | 2008-06-12 | Mehboob Hussain | Composition and method for producing composition for constructing tissue, and tissue construct |
| ES2524443T3 (es) | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
| US20100291219A1 (en) | 2007-06-21 | 2010-11-18 | Massachusetts Institute Of Technology | Methods and compositions relating to progenitor cells |
| DK2173863T3 (en) | 2007-06-29 | 2019-01-21 | Fujifilm Cellular Dynamics Inc | Automated method and apparatus for embryonic stem cell culture |
| US8691569B2 (en) * | 2008-03-17 | 2014-04-08 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US20120028352A1 (en) * | 2008-03-17 | 2012-02-02 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| SG188918A1 (enExample) * | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| US20110143433A1 (en) * | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| US8828720B2 (en) * | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| WO2009139703A1 (en) | 2008-05-15 | 2009-11-19 | Ge Healthcare Bio-Sciences Ab | Method for cell expansion |
| PL2366021T3 (pl) * | 2008-11-20 | 2017-12-29 | Janssen Biotech, Inc. | Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach |
| JP2013500717A (ja) | 2009-07-28 | 2013-01-10 | コーニング インコーポレイテッド | 細胞を培養するための合成マイクロキャリア |
| WO2012059775A2 (en) | 2010-11-05 | 2012-05-10 | Intesis D.O.O. | System for reproducing a 3d color image using narrowband modulation of monochromatic components of the image |
-
2009
- 2009-03-17 SG SG2013019898A patent/SG188918A1/en unknown
- 2009-03-17 EP EP12161297.2A patent/EP2479260B1/en not_active Revoked
- 2009-03-17 WO PCT/SG2009/000088 patent/WO2009116951A2/en not_active Ceased
- 2009-03-17 US US12/921,599 patent/US8716018B2/en active Active
- 2009-03-17 EP EP09723143.5A patent/EP2271747B1/en not_active Not-in-force
- 2009-03-17 JP JP2011500744A patent/JP2011514169A/ja active Pending
- 2009-07-03 US US12/497,591 patent/US20100093053A1/en not_active Abandoned
-
2011
- 2011-08-16 US US13/210,475 patent/US8637309B2/en not_active Expired - Fee Related
-
2012
- 2012-03-30 JP JP2012079873A patent/JP2012147793A/ja active Pending
-
2013
- 2013-12-19 US US14/134,275 patent/US9340770B2/en active Active
-
2015
- 2015-07-31 JP JP2015151501A patent/JP2015226543A/ja active Pending
-
2017
- 2017-11-20 JP JP2017222498A patent/JP2018068302A/ja active Pending
-
2019
- 2019-11-22 JP JP2019211253A patent/JP6943937B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016521124A5 (enExample) | ||
| JP2012520672A5 (enExample) | ||
| Ouyang et al. | Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation | |
| Chen et al. | Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells | |
| US9458431B2 (en) | Microcarriers for stem cell culture | |
| US8828720B2 (en) | Microcarriers for stem cell culture | |
| US20120028352A1 (en) | Microcarriers for Stem Cell Culture | |
| JP2020039356A (ja) | 幹細胞培養のためのマイクロキャリア | |
| JP2022537278A5 (enExample) | ||
| Heydarkhan-Hagvall et al. | The effect of vitronectin on the differentiation of embryonic stem cells in a 3D culture system | |
| US20110143433A1 (en) | Microcarriers for Stem Cell Culture | |
| JP7742836B2 (ja) | ヒト多能性幹細胞から間葉系幹細胞の製造方法およびこれによって製造された間葉系幹細胞 | |
| JP2013138678A (ja) | ヒト胚盤胞由来幹細胞に由来する多能性非収縮心臓前駆細胞の新規の集団 | |
| KR101490671B1 (ko) | 나노구배패턴을 포함하는 배양용기를 이용한 배아줄기세포 배양에 적합한 표면구조의 스크리닝 방법 | |
| Dehdilani et al. | Improved survival and hematopoietic differentiation of murine embryonic stem cells on electrospun polycaprolactone nanofiber | |
| Yamamoto et al. | Time-dependent changes in adhesive force between chondrocytes and silk fibroin substrate | |
| KR101175175B1 (ko) | 인간 줄기세포에서 고활성 줄기세포를 분리하는 방법 및상기 방법에 의해 분리된 고활성 줄기 세포 | |
| Vallabhaneni et al. | Suspension culture on microcarriers and as aggregates enables expansion and differentiation of pluripotent stem cells (PSCs) | |
| US20120202261A1 (en) | 3d trophoblast matrix for preparing organ-specific stem cells | |
| JP4936937B2 (ja) | マウスｅｓ細胞培養用未分化細胞培養担体 | |
| JPWO2019078278A1 (ja) | 心筋細胞に分化させるための多能性幹細胞の製造方法 | |
| Enam et al. | Substrates for clinical applicability of stem cells | |
| Guo et al. | Proliferation and neurogenesis of neural stem cells enhanced by cerebral microvascular endothelial cells | |
| Tabata et al. | Stem cell culture and differentiation in 3-D scaffolds | |
| CN209923357U (zh) | 一种用于细胞三维培养的接种装置 |