SG188918A1 - - Google Patents

Download PDF

Info

Publication number
SG188918A1
SG188918A1 SG2013019898A SG2013019898A SG188918A1 SG 188918 A1 SG188918 A1 SG 188918A1 SG 2013019898 A SG2013019898 A SG 2013019898A SG 2013019898 A SG2013019898 A SG 2013019898A SG 188918 A1 SG188918 A1 SG 188918A1
Authority
SG
Singapore
Prior art keywords
microcarriers
stem cells
cells
microcarrier
passages
Prior art date
Application number
SG2013019898A
Other languages
English (en)
Inventor
Steve Oh
Marti Lecina
Andre Choo
Shaul Reuveny
Robert Zweigert
Allen Chen
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40872517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG188918(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG188918A1 publication Critical patent/SG188918A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062General methods for three-dimensional culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068General culture methods using substrates
    • C12N5/0075General culture methods using substrates using microcarriers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
SG2013019898A 2008-03-17 2009-03-17 SG188918A1 (enExample)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6969408P 2008-03-17 2008-03-17
US11025608P 2008-10-31 2008-10-31
US14806409P 2009-01-29 2009-01-29
US15594009P 2009-02-27 2009-02-27

Publications (1)

Publication Number Publication Date
SG188918A1 true SG188918A1 (enExample) 2013-04-30

Family

ID=40872517

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2013019898A SG188918A1 (enExample) 2008-03-17 2009-03-17

Country Status (5)

Country Link
US (4) US8716018B2 (enExample)
EP (2) EP2479260B1 (enExample)
JP (5) JP2011514169A (enExample)
SG (1) SG188918A1 (enExample)
WO (1) WO2009116951A2 (enExample)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222846D0 (en) * 2002-10-03 2002-11-06 Choo Yen Cell culture
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
EP1888123B1 (en) 2005-06-08 2013-01-09 Janssen Biotech, Inc. A cellular therapy for ocular degeneration
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
ATE523585T1 (de) 2007-11-27 2011-09-15 Lifescan Inc Differenzierung menschlicher embryonaler stammzellen
CA2959401C (en) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8691569B2 (en) 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
SG188918A1 (enExample) 2008-03-17 2013-04-30 Agency Science Tech & Res
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20110143433A1 (en) * 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
KR101651661B1 (ko) 2008-06-30 2016-08-26 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
EP2318516A1 (en) * 2008-06-30 2011-05-11 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
CN102272291B (zh) * 2008-10-31 2018-01-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
MX2011004563A (es) 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
PL2366021T3 (pl) * 2008-11-20 2017-12-29 Janssen Biotech, Inc. Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach
PL2366022T3 (pl) 2008-11-20 2016-11-30 Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych
EP2408903B1 (en) 2009-03-20 2014-08-06 Agency For Science, Technology And Research Culture of pluripotent and multipotent cells on microcarriers
AU2010276402B2 (en) 2009-07-20 2014-07-03 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
KR20170118969A (ko) 2009-07-20 2017-10-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
ES2693088T3 (es) 2009-07-20 2018-12-07 Janssen Biotech, Inc. Diferenciación de células madre embriónicas humanas
US9068182B2 (en) 2009-07-28 2015-06-30 Corning Incorporated Synthetic polysaccharide microcarriers for culturing cells
EP2361968B1 (en) * 2010-02-26 2014-11-19 Corning Incorporated Synthetic polysaccharide microcarriers for culturing cells
JP2013507959A (ja) * 2009-10-22 2013-03-07 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養/処理用製品、並びにそれらの製造及び使用方法
AU2010333839C1 (en) * 2009-12-23 2016-07-21 Janssen Biotech Inc. Differentiation of human embryonic stem cells
MX339669B (es) * 2009-12-23 2016-06-02 Janssen Biotech Inc Diferenciacion de celulas madres embrionarias humanas.
CN107189979B (zh) 2010-03-01 2021-05-04 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
CN102858381B (zh) * 2010-03-01 2015-09-30 富士胶片株式会社 包括具有生物相容性的聚合物块和细胞的细胞构建体
JP5777115B2 (ja) * 2010-03-18 2015-09-09 国立大学法人京都大学 多能性幹細胞から中胚葉細胞への分化誘導法
KR101986176B1 (ko) 2010-05-12 2019-06-05 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
EP3443991A1 (en) * 2010-05-25 2019-02-20 Cook Biotech Incorporated Methods, substrates, and systems useful for cell seeding of medical grafts
US20130089928A1 (en) * 2010-06-17 2013-04-11 Songzhu An Serum-Free Chemically Defined Cell Culture Medium
EP2606115A4 (en) * 2010-08-16 2017-07-19 Kiyatec Inc. Bioreactor system
AU2011296381B2 (en) 2010-08-31 2016-03-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2012030540A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
WO2012030539A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US20130164269A1 (en) * 2010-09-02 2013-06-27 Life Technologies Corporation Cell culture system for bioreactor scale-up of cells
WO2012056997A1 (ja) * 2010-10-28 2012-05-03 国立大学法人熊本大学 多能性幹細胞の分化誘導効率を改善するための方法及び培地
US9453196B2 (en) 2010-12-16 2016-09-27 General Electric Company Cell carrier, methods of making and use
US9453197B2 (en) 2010-12-16 2016-09-27 General Electric Company Methods of making cell carrier
US9518249B2 (en) 2010-12-16 2016-12-13 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US9926523B2 (en) 2010-12-16 2018-03-27 General Electric Company Cell carriers and methods for culturing cells
US9534206B2 (en) 2010-12-16 2017-01-03 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
CN102174497B (zh) * 2010-12-30 2013-05-22 北京民海生物科技有限公司 一种微载体的回收方法
US20140329317A1 (en) 2011-11-25 2014-11-06 Kyoto University Method for culturing pluripotent stem cell
US9388386B2 (en) 2011-12-22 2016-07-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
US9650602B2 (en) 2012-03-13 2017-05-16 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Reprogramming cells by three-dimensional cultivation
CN102586173B (zh) * 2012-03-20 2014-07-02 广东大华农动物保健品股份有限公司 一种提高微载体重复使用次数的回收处理方法
WO2013184888A1 (en) 2012-06-08 2013-12-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
RU2684215C2 (ru) 2012-12-31 2019-04-04 Янссен Байотек, Инк. Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток
RU2687379C2 (ru) * 2012-12-31 2019-05-13 Янссен Байотек, Инк. Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
WO2014105543A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
EP2966163B1 (en) 2013-03-06 2018-01-17 Kyoto University Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
JP2016516091A (ja) * 2013-04-02 2016-06-02 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ
EP3004181B1 (en) * 2013-05-27 2019-01-02 Agency For Science, Technology And Research Heparan sulphate
SG11201510462QA (en) * 2013-06-18 2016-01-28 Agency Science Tech & Res Method of culturing cancer stem cells
JP2016526387A (ja) * 2013-06-24 2016-09-05 アントフロゲネシス コーポレーション 細胞培養のための細胞外マトリクス組成物ビーズ
WO2015008275A1 (en) * 2013-07-17 2015-01-22 Kadimastem Ltd Methods for large scale generation of stem cells
KR20160037170A (ko) * 2013-08-01 2016-04-05 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 허혈성 심장의 치료를 필요로 하는 인간 또는 동물 대상의 허혈성 심장을 치료하는 방법에서 사용하기 위한 세포외 매트릭스의 글리코실화 단백질
JP6353452B2 (ja) * 2013-09-04 2018-07-04 株式会社大塚製薬工場 多能性幹細胞の調製方法
KR20180128529A (ko) * 2013-11-01 2018-12-03 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 인간 만능 줄기세포의 현탁 및 클러스터링
JP6588969B2 (ja) 2014-05-16 2019-10-09 ヤンセン バイオテツク,インコーポレーテツド 膵内分泌細胞内のmafa発現を強化するための小分子の使用
WO2016020719A1 (en) * 2014-08-04 2016-02-11 Euroresearch S.R.L. Novel collagen microcarriers
US20170335286A1 (en) * 2014-10-30 2017-11-23 Stembiosys, Inc. Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers
WO2016121737A1 (ja) * 2015-01-29 2016-08-04 株式会社カネカ 細胞凝集塊の作製方法
FR3035107A1 (fr) * 2015-04-15 2016-10-21 Celenys Procede de preparation d'hydrogel a partir d'acide hyaluronique modifie et de collagene de type i
KR101705245B1 (ko) * 2015-05-22 2017-02-09 건국대학교 글로컬산학협력단 마트리겔이 코팅된 신경줄기세포 배양용 플레이트
US12402609B2 (en) * 2016-01-13 2025-09-02 Felix Pets, Llc Methods for producing hypo-allergenic cats using gene editing technology
GB201615517D0 (en) 2016-09-13 2016-10-26 Micromatrices Ass L Spheroid tissue miroarray and method of manufacture
JP6705911B2 (ja) 2016-04-14 2020-06-03 ヤンセン バイオテツク,インコーポレーテツド 多能性幹細胞の中腸内胚葉細胞への分化
JP2020521459A (ja) 2017-05-24 2020-07-27 プレジデント アンド フェローズ オブ ハーバード カレッジ サテライト細胞および組成物ならびにそれらの生産方法
WO2018225703A1 (ja) * 2017-06-05 2018-12-13 テルモ株式会社 分化誘導細胞の調製方法
GB201718556D0 (en) * 2017-11-09 2017-12-27 Univ Oxford Innovation Ltd Macrocarrier
CN112041428B (zh) * 2018-01-18 2024-05-24 新加坡科技研究局 用于在悬浮培养物中分化人多能干细胞系的方法
WO2019163948A1 (ja) * 2018-02-23 2019-08-29 学校法人創価大学 細胞培養用基材及び培養方法
EP3816279A4 (en) * 2018-06-27 2022-04-20 Ajinomoto Co., Inc. STEM CELL CULTURE ADDITIVE, CULTURE MEDIUM, AND CULTURE METHOD
TW202020144A (zh) * 2018-07-31 2020-06-01 日商Jcr製藥股份有限公司 源自齒髓的細胞之製造方法
JP7588591B2 (ja) * 2019-01-31 2024-11-22 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
JP7284985B2 (ja) * 2019-03-29 2023-06-01 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
CN110564674B (zh) * 2019-09-29 2021-05-11 广东工业大学 一种干细胞铺底工作液及其应用
WO2021118226A1 (ko) * 2019-12-09 2021-06-17 주식회사 대웅제약 인간 만능줄기세포로부터 중간엽 줄기세포의 제조방법 및 이에 의해 제조된 중간엽 줄기세포
FR3106141B1 (fr) * 2020-01-09 2024-12-20 Carroucell Microporteurs pour culture cellulaire et procédé de fabrication de microporteurs
US20230116083A1 (en) 2020-03-10 2023-04-13 Life & Brain Gmbh Up-scaled production of microglia-like/-precursor cells and macrophage cells using mesh macrocarriers
CN111467579B (zh) * 2020-04-03 2021-10-26 北京臻溪谷医学研究中心(有限合伙) 基于合金内核的治疗动脉瘤与血管狭窄用干细胞支架及其制法
JPWO2022004822A1 (enExample) * 2020-06-30 2022-01-06
JP2023537969A (ja) * 2020-08-10 2023-09-06 リネージ セル セラピューティクス インコーポレイテッド 胚性幹細胞増殖のための組成物及び方法
CN114761533A (zh) * 2020-09-15 2022-07-15 株式会社Lg化学 细胞培养用微载体和用于制备其的方法
KR102864804B1 (ko) * 2020-09-15 2025-09-25 주식회사 엘지화학 세포 배양용 마이크로-캐리어 및 그 제조방법
JP2025506848A (ja) * 2022-02-25 2025-03-13 カンステム バイオテック カンパニー リミテッド マイクロキャリアを用いた幹細胞の培養方法
WO2023208212A1 (zh) * 2022-04-29 2023-11-02 北京华龛生物科技有限公司 基于三维多孔微载体的病毒载体生产方法
WO2024102777A2 (en) * 2022-11-08 2024-05-16 Lineage Cell Therapeutics, Inc. Compositions and method for expansion of embryonic stem cells
WO2024253069A1 (ja) * 2023-06-06 2024-12-12 東ソー株式会社 温度応答性マイクロキャリア
WO2025059779A1 (en) * 2023-09-22 2025-03-27 Spiderwort Biotechnologies Inc. Plant-based or fungal-based micro-carrier scaffolds optimized for large-scale cell-culture production and other applications

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
US4975377A (en) 1987-05-14 1990-12-04 Key Marc E Cell growth chambers and method of use thereof
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
DE4117305C2 (de) 1991-05-27 1994-07-21 Weidmueller Interface Zange zum Ergreifen und/oder Verpressen von Bearbeitungsgegenständen
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5661034A (en) 1991-07-18 1997-08-26 Fuji Yakuhin Kogyo Kabushiki Kaisha Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium
US5654183A (en) 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
WO1994007913A1 (en) 1992-09-25 1994-04-14 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US5853717A (en) * 1994-07-20 1998-12-29 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5919449A (en) 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US6015554A (en) 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
CA2251983C (en) 1996-04-19 2003-12-16 Sudhakar Kadiyala Regeneration and augmentation of bone using mesenchymal stem cells
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6361996B1 (en) 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
ES2285779T3 (es) 1997-07-03 2007-11-16 Osiris Therapeutics, Inc. Celulas madre mesenquimatosas humanas de sangre periferica.
WO1999001159A1 (en) 1997-07-04 1999-01-14 University Of Utah Research Foundation Lineage-restricted neuronal precursors
ATE307195T1 (de) 1997-07-14 2005-11-15 Osiris Therapeutics Inc Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
JP3880795B2 (ja) 1997-10-23 2007-02-14 ジェロン・コーポレーション フィーダー細胞を含まない培養物中で、霊長類由来始原幹細胞を増殖させるための方法
US6637437B1 (en) 1998-04-08 2003-10-28 Johns Hopkins University Cell-culture and polymer constructs
US6886568B2 (en) 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
EP0953633A1 (en) 1998-04-28 1999-11-03 Livercell L.L.C. Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells
IL145002A0 (en) 1999-03-10 2002-06-30 Univ Pittsburgh Adipose-derived stem cells and lattices
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
AU2001276846A1 (en) 2000-06-29 2002-01-14 Mitokor Methods for identifying mitochondrial divalent cation transporters
JP4252451B2 (ja) 2001-08-30 2009-04-08 浜松ホトニクス株式会社 混合液の液滴形成方法及び混合液の液滴形成装置
JP2005506839A (ja) 2001-10-02 2005-03-10 ベクトン・ディキンソン・アンド・カンパニー 細胞外マトリックスおよび他の分子を使用する幹細胞の増殖および分化
AU2003223416A1 (en) 2002-03-25 2003-10-13 Condros, Inc. Tissue analogs for in vitro testing and method of use therefor
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
WO2005007799A2 (en) 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
AU2004260106C1 (en) 2003-07-17 2010-12-09 Global Cell Solutions, Llc. Automated cell culture system and process
CA2540657A1 (en) 2003-10-20 2005-04-28 Jms Co., Ltd. Cell handling device, human tissue regeneration composition, and human tissue regeneration method
WO2005065354A2 (en) * 2003-12-31 2005-07-21 The Burnham Institute Defined media for pluripotent stem cell culture
JP4147306B2 (ja) * 2004-02-03 2008-09-10 国立大学法人 熊本大学 唾液腺由来の内胚葉系細胞および外胚葉系細胞の双方に分化可能な未分化な多分化能を有する新規細胞およびその細胞の調製方法
WO2005085422A1 (en) 2004-02-27 2005-09-15 Michigan State University Adult stem cells and uses thereof
WO2005113749A2 (en) 2004-05-14 2005-12-01 Becton, Dickinson And Company Stem cell populations and methods of use
DE102004043256B4 (de) * 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
DK3196296T3 (en) 2004-09-08 2019-02-04 Wisconsin Alumini Res Foundation Cultivation of human embryonic stem cells
US20070280989A1 (en) 2004-09-21 2007-12-06 Nvr Labs Ltd Compositions and Methods for Stem Cell Expansion and Differentiation
WO2006091921A2 (en) 2005-02-25 2006-08-31 Drexel University Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications
JP2006230316A (ja) * 2005-02-25 2006-09-07 Japan Health Science Foundation 瘢痕のない創傷治癒能を有する細胞およびその調製方法
JP2006288244A (ja) * 2005-04-07 2006-10-26 Espec Corp 培養装置並びに細胞の製造方法
EP1888123B1 (en) * 2005-06-08 2013-01-09 Janssen Biotech, Inc. A cellular therapy for ocular degeneration
JP5560391B2 (ja) * 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド ヒト胚性幹細胞の懸濁培養法
AU2006274438A1 (en) 2005-07-29 2007-02-01 Australian Stem Cell Centre Limited Compositions and methods for growth of pluripotent cells
WO2007030469A2 (en) 2005-09-06 2007-03-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Transplantable cell growth niche and related compositions and methods
AU2006292021B2 (en) 2005-09-12 2012-05-31 Es Cell International Pte Ltd. Cardiomyocyte production
WO2007038471A2 (en) 2005-09-27 2007-04-05 Regenetech, Inc. Rotatable time varying electromagnetic force bioreactor and method of using the same
JP5122973B2 (ja) * 2005-11-15 2013-01-16 独立行政法人科学技術振興機構 Es細胞からすい臓を生産する方法
AU2006326853B2 (en) 2005-12-22 2012-02-16 Es Cell International Pte Ltd Direct differentiation of cardiomyocytes from human embryonic stem cells
ES2708933T3 (es) 2005-12-29 2019-04-12 Celularity Inc Poblaciones de células madre placentarias
WO2007149926A1 (en) 2006-06-20 2007-12-27 Wisconsin Alumni Research Foundation Method for culturing stem cells
WO2008004990A2 (en) 2006-07-06 2008-01-10 Es Cell International Pte Ltd Method for stem cell culture and cells derived therefrom
CA2657013A1 (en) 2006-07-06 2008-01-10 Organogenesis Inc. Temperature-responsive microcarrier
ES2704401T3 (es) 2006-08-02 2019-03-18 Technion Res & Dev Foundation Métodos de expansión de células madre embrionarias en un cultivo en suspensión
US20080138415A1 (en) 2006-09-26 2008-06-12 Mehboob Hussain Composition and method for producing composition for constructing tissue, and tissue construct
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores
US20100291219A1 (en) 2007-06-21 2010-11-18 Massachusetts Institute Of Technology Methods and compositions relating to progenitor cells
DK2173863T3 (en) 2007-06-29 2019-01-21 Fujifilm Cellular Dynamics Inc Automated method and apparatus for embryonic stem cell culture
US8691569B2 (en) * 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20120028352A1 (en) * 2008-03-17 2012-02-02 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
SG188918A1 (enExample) * 2008-03-17 2013-04-30 Agency Science Tech & Res
US20110143433A1 (en) * 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
WO2009139703A1 (en) 2008-05-15 2009-11-19 Ge Healthcare Bio-Sciences Ab Method for cell expansion
PL2366021T3 (pl) * 2008-11-20 2017-12-29 Janssen Biotech, Inc. Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach
JP2013500717A (ja) 2009-07-28 2013-01-10 コーニング インコーポレイテッド 細胞を培養するための合成マイクロキャリア
WO2012059775A2 (en) 2010-11-05 2012-05-10 Intesis D.O.O. System for reproducing a 3d color image using narrowband modulation of monochromatic components of the image

Also Published As

Publication number Publication date
US8716018B2 (en) 2014-05-06
JP2015226543A (ja) 2015-12-17
JP6943937B2 (ja) 2021-10-06
WO2009116951A2 (en) 2009-09-24
JP2020039356A (ja) 2020-03-19
EP2479260A1 (en) 2012-07-25
US20110014693A1 (en) 2011-01-20
US20140193903A1 (en) 2014-07-10
US9340770B2 (en) 2016-05-17
US20110294210A1 (en) 2011-12-01
US20100093053A1 (en) 2010-04-15
JP2018068302A (ja) 2018-05-10
EP2271747B1 (en) 2016-09-07
JP2012147793A (ja) 2012-08-09
EP2271747A2 (en) 2011-01-12
WO2009116951A3 (en) 2009-11-26
US8637309B2 (en) 2014-01-28
JP2011514169A (ja) 2011-05-06
EP2479260B1 (en) 2016-01-06

Similar Documents

Publication Publication Date Title
US8716018B2 (en) Microcarriers for stem cell culture
US8828720B2 (en) Microcarriers for stem cell culture
US20110143433A1 (en) Microcarriers for Stem Cell Culture
US8691569B2 (en) Microcarriers for stem cell culture
EP2408903B1 (en) Culture of pluripotent and multipotent cells on microcarriers
US20120219531A1 (en) Microcarriers for Stem Cell Culture
US9458431B2 (en) Microcarriers for stem cell culture
US20120028352A1 (en) Microcarriers for Stem Cell Culture
EP2983728B1 (en) Polycaprolactone microcarriers for stem cell culture and fabrication thereof
JP2022058686A (ja) 多能性幹細胞を培養するための新規な方法および培養培地
JP2012509085A (ja) マイクロキャリア上での多能性幹細胞の培養
US20090239298A1 (en) Methods of generating embryoid bodies using three dimensional scaffolds
Sidhu et al. Derivation of a new human embryonic stem cell line, endeavour-1, and its clonal propagation
WO2015008275A1 (en) Methods for large scale generation of stem cells
Chattong et al. Human dental pulp stem cells as a potential feeder layer for human embryonic stem cell culture