JP2016521124A5 - - Google Patents
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- Publication number
- JP2016521124A5 JP2016521124A5 JP2016507519A JP2016507519A JP2016521124A5 JP 2016521124 A5 JP2016521124 A5 JP 2016521124A5 JP 2016507519 A JP2016507519 A JP 2016507519A JP 2016507519 A JP2016507519 A JP 2016507519A JP 2016521124 A5 JP2016521124 A5 JP 2016521124A5
- Authority
- JP
- Japan
- Prior art keywords
- pcl
- pcl microcarriers
- microcarrier
- microcarriers according
- microcarriers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001610 polycaprolactone Polymers 0.000 claims 20
- 239000004632 polycaprolactone Substances 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 238000004114 suspension culture Methods 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102100037369 Nidogen-1 Human genes 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108010008217 nidogen Proteins 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229920000867 polyelectrolyte Polymers 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2013026836 | 2013-04-10 | ||
| SG201302683-6 | 2013-04-10 | ||
| PCT/SG2014/000158 WO2014168585A1 (en) | 2013-04-10 | 2014-04-10 | Polycaprolactone microcarriers for stem cell culture and fabrication thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521124A JP2016521124A (ja) | 2016-07-21 |
| JP2016521124A5 true JP2016521124A5 (enExample) | 2017-06-08 |
| JP6416206B2 JP6416206B2 (ja) | 2018-10-31 |
Family
ID=51689856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507519A Expired - Fee Related JP6416206B2 (ja) | 2013-04-10 | 2014-04-10 | 幹細胞培養のためのポリカプロラクトン・マイクロキャリアーおよびその製造 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160083690A1 (enExample) |
| EP (1) | EP2983728B1 (enExample) |
| JP (1) | JP6416206B2 (enExample) |
| SG (1) | SG11201508387WA (enExample) |
| WO (1) | WO2014168585A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015134770A1 (en) * | 2014-03-07 | 2015-09-11 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Treating soft tissue via controlled drug release |
| WO2016070057A1 (en) * | 2014-10-30 | 2016-05-06 | Stembiosys, Inc. | Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers |
| TWI737614B (zh) * | 2015-06-11 | 2021-09-01 | 博錸生技股份有限公司 | 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件 |
| KR101745796B1 (ko) * | 2015-10-26 | 2017-06-09 | 동국대학교 산학협력단 | 전자기가 유도된 금속 나노입자를 이용한 신경세포로의 직접교차분화 리프로그래밍 방법 |
| SG11201804001RA (en) | 2015-11-30 | 2018-06-28 | Agency Science Tech & Res | A cell culture substrate and method of making thereof |
| HK1256807A1 (zh) * | 2016-01-14 | 2019-10-04 | R·阿南德 | 神经类器官组合物及使用方法 |
| WO2018026902A1 (en) * | 2016-08-03 | 2018-02-08 | Wake Forest University Health Sciences | Composition with polymer and ceramic and methods of use thereof |
| US12031026B2 (en) | 2016-08-03 | 2024-07-09 | Wake Forest University Health Sciences | Composition with polymer and ceramic and methods of use thereof |
| WO2018203651A2 (ko) | 2017-05-02 | 2018-11-08 | 가톨릭대학교 산학협력단 | 사람 코 하비갑개 유래 중간엽 줄기세포 기반 3d 바이오프린팅 조직체 및 이의 이용 |
| KR102104120B1 (ko) | 2017-05-02 | 2020-04-23 | 가톨릭대학교 산학협력단 | 사람 코 하비갑개 유래 중간엽 줄기세포 기반 3d 바이오프린팅 조직체 및 이의 이용 |
| KR102035022B1 (ko) * | 2017-08-07 | 2019-11-08 | 이희영 | 효소를 사용하지 않고 생체조직에서 기질세포를 분리하는 방법 및 장치 |
| SG11202001206YA (en) * | 2017-09-14 | 2020-03-30 | Agency Science Tech & Res | Emulsions, methods and uses thereof |
| GB201718556D0 (en) * | 2017-11-09 | 2017-12-27 | Univ Oxford Innovation Ltd | Macrocarrier |
| WO2019104154A1 (en) * | 2017-11-22 | 2019-05-31 | Rutgers, The State University Of New Jersey | A bioactive 3d encapsulation culture system for cell expansion |
| CN112384258A (zh) | 2018-05-09 | 2021-02-19 | 约翰·霍普金斯大学 | 用于细胞和组织递送的纳米纤维-水凝胶复合物 |
| IL307979B2 (en) | 2018-05-09 | 2025-08-01 | Univ Johns Hopkins | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| WO2020086001A1 (en) * | 2018-10-23 | 2020-04-30 | Agency For Science, Technology And Research | An implantable construct, methods of manufacturing, and uses thereof |
| WO2020101461A1 (ko) | 2018-11-13 | 2020-05-22 | 한국화학연구원 | 세포 배양용 캐리어를 이용하여 제조된 오가노이드 및 이를 이용한 약물 독성 평가방법 |
| CN112771150B (zh) * | 2018-11-13 | 2023-12-26 | 韩国化学研究院 | 包含含有天然油的微胶囊的细胞培养用载体 |
| WO2021009777A2 (en) * | 2019-07-18 | 2021-01-21 | Pandorum Technologies Private Limited | Methods of stem cell culture for obtaining products, and implementations thereof |
| WO2021041991A1 (en) * | 2019-08-29 | 2021-03-04 | Diomics Corporation | Hydrophilic biopolymer medicament delivery mechanism |
| CN111467579B (zh) * | 2020-04-03 | 2021-10-26 | 北京臻溪谷医学研究中心（有限合伙） | 基于合金内核的治疗动脉瘤与血管狭窄用干细胞支架及其制法 |
| CN113651989B (zh) * | 2020-05-12 | 2025-10-03 | 北京华龛生物科技有限公司 | 适用于细胞三维培养的微载体的制备方法及反应装置 |
| WO2021231904A1 (en) * | 2020-05-14 | 2021-11-18 | Diomics Corporation | Detection and indication of covid-19, other viruses and pathogens and vaccine associated efficacy |
| CN114269813B (zh) | 2020-06-01 | 2024-01-02 | 株式会社Lg化学 | 制备聚合物微粒的方法，聚合物微粒，使用其的医用组合物、美容组合物、医用制品和美容制品 |
| CN111588912B (zh) * | 2020-06-10 | 2021-06-29 | 四川大学 | 一种用于骨组织再生的多功能纤维膜及其制备方法 |
| CA3181611A1 (en) * | 2020-06-11 | 2021-12-16 | Paul Simmons | 3d culture of mesenchymal lineage precursor or stem cells |
| WO2022072597A1 (en) * | 2020-09-30 | 2022-04-07 | Diomics Corporation | Transdermal medicament delivery device |
| CN112294846B (zh) * | 2020-10-22 | 2023-03-21 | 清华大学深圳国际研究生院 | 干细胞微球及其应用 |
| CN113684177A (zh) * | 2021-07-02 | 2021-11-23 | 中国肉类食品综合研究中心 | 用于细胞培育肉制造的复合微载体及其制备方法 |
| KR20230047294A (ko) * | 2021-09-30 | 2023-04-07 | 주식회사 엘지화학 | 마이크로 캐리어, 세포 복합체 및 이를 포함하는 의료용 조성물, 미용 조성물, 의료 용품 및 미용 용품 |
| WO2023192991A1 (en) * | 2022-03-31 | 2023-10-05 | Edge Foods Co. | Systems and processes for culturing cells using microcarriers |
| CN115089614A (zh) * | 2022-06-28 | 2022-09-23 | 中国人民解放军军事科学院军事医学研究院 | 一种增强骨骼干细胞性能的方法及其在治疗骨关节炎中的应用 |
| WO2024052913A1 (en) * | 2022-09-06 | 2024-03-14 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) | Surface modified hydrogels comprising viable cells, methods of manufacture and use thereof |
| EP4587182A1 (en) * | 2022-09-12 | 2025-07-23 | LUMICKS CA Holding B.V. | Microfluidic device with a multiple-coated surface comprising at least two different polypeptides |
| EP4349486A1 (en) * | 2022-10-03 | 2024-04-10 | LUMICKS CA Holding B.V. | Microfluidic device with a multiple-coated surface comprising at least two different polypeptides |
| CN115368626B (zh) * | 2022-10-25 | 2023-02-21 | 北京同创正业生物科技有限公司 | 一种用于细胞体外培养的复合型材料及培养方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US6886568B2 (en) * | 1998-04-08 | 2005-05-03 | The Johns Hopkins University | Method for fabricating cell-containing implants |
| US20020155559A1 (en) | 2001-01-17 | 2002-10-24 | Laurencin Cato T. | Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof |
| WO2006091921A2 (en) * | 2005-02-25 | 2006-08-31 | Drexel University | Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications |
| US20080020049A1 (en) * | 2005-02-25 | 2008-01-24 | Andrew Darling | Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications |
| US9422521B2 (en) | 2005-09-12 | 2016-08-23 | Es Cell International Pte Ltd. | Differentiation of pluripotent stem cells with a kinase inhibitor or PGI2 |
| GB2447191B (en) | 2005-12-22 | 2011-08-03 | Es Cell Int Pte Ltd | Direct differentiation of cardiomyocytes from human embryonic stem cells |
| EP2698173A1 (en) * | 2008-02-29 | 2014-02-19 | Coloplast A/S | Compositions and methods for augmentation and regeneration of living tissue in a subject |
| WO2013169374A1 (en) * | 2012-05-10 | 2013-11-14 | The Trustees Of The Stevens Institute Of Technology | Biphasic osteochondral scaffold for reconstruction of articular cartilage |
-
2014
- 2014-04-10 SG SG11201508387WA patent/SG11201508387WA/en unknown
- 2014-04-10 US US14/783,545 patent/US20160083690A1/en not_active Abandoned
- 2014-04-10 JP JP2016507519A patent/JP6416206B2/ja not_active Expired - Fee Related
- 2014-04-10 EP EP14783395.8A patent/EP2983728B1/en not_active Not-in-force
- 2014-04-10 WO PCT/SG2014/000158 patent/WO2014168585A1/en not_active Ceased
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