JP2017518070A5 - - Google Patents
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- JP2017518070A5 JP2017518070A5 JP2017503766A JP2017503766A JP2017518070A5 JP 2017518070 A5 JP2017518070 A5 JP 2017518070A5 JP 2017503766 A JP2017503766 A JP 2017503766A JP 2017503766 A JP2017503766 A JP 2017503766A JP 2017518070 A5 JP2017518070 A5 JP 2017518070A5
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- Prior art keywords
- tumor
- tissue
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- 206010028980 Neoplasm Diseases 0.000 claims description 236
- 210000004027 cell Anatomy 0.000 claims description 67
- 206010006187 Breast cancer Diseases 0.000 claims description 64
- 208000026310 Breast neoplasm Diseases 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 42
- 210000002889 endothelial cell Anatomy 0.000 claims description 40
- 210000001789 adipocyte Anatomy 0.000 claims description 39
- 201000011510 cancer Diseases 0.000 claims description 30
- 210000002950 fibroblast Anatomy 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 25
- 238000000151 deposition Methods 0.000 claims description 25
- 210000000229 preadipocyte Anatomy 0.000 claims description 24
- 210000000481 breast Anatomy 0.000 claims description 23
- 210000002536 stromal cell Anatomy 0.000 claims description 19
- 239000006143 cell culture medium Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 12
- 229940124597 therapeutic agent Drugs 0.000 claims description 12
- 238000001125 extrusion Methods 0.000 claims description 11
- 230000004069 differentiation Effects 0.000 claims description 8
- 238000012203 high throughput assay Methods 0.000 claims description 6
- 230000004083 survival effect Effects 0.000 claims description 5
- 230000021164 cell adhesion Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000035899 viability Effects 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461975640P | 2014-04-04 | 2014-04-04 | |
| US61/975,640 | 2014-04-04 | ||
| US201461976895P | 2014-04-08 | 2014-04-08 | |
| US61/976,895 | 2014-04-08 | ||
| PCT/US2014/041419 WO2015152954A1 (en) | 2014-04-04 | 2014-06-06 | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017518070A JP2017518070A (ja) | 2017-07-06 |
| JP2017518070A5 true JP2017518070A5 (enExample) | 2017-08-17 |
Family
ID=54208710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503766A Withdrawn JP2017518070A (ja) | 2014-04-04 | 2014-06-06 | 人工的な三次元の乳房組織、脂肪組織、および腫瘍疾患モデル |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20170023550A1 (enExample) |
| EP (2) | EP3126490B1 (enExample) |
| JP (1) | JP2017518070A (enExample) |
| KR (1) | KR20170013865A (enExample) |
| CN (1) | CN106536720B (enExample) |
| AU (1) | AU2014389440A1 (enExample) |
| CA (2) | CA3177480A1 (enExample) |
| DK (1) | DK3126490T3 (enExample) |
| IL (1) | IL248164A0 (enExample) |
| WO (1) | WO2015152954A1 (enExample) |
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| US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| KR101711354B1 (ko) | 2008-06-24 | 2017-02-28 | 더 큐레이터스 오브 더 유니버시티 오브 미주리 | 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법 |
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP2629975B1 (en) | 2010-10-21 | 2022-03-09 | Organovo, Inc. | Devices for the fabrication of tissue |
| US20140099709A1 (en) * | 2012-06-19 | 2014-04-10 | Organovo, Inc. | Engineered three-dimensional connective tissue constructs and methods of making the same |
| CA3177480A1 (en) | 2014-04-04 | 2015-10-08 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
| EP3712254A1 (en) | 2014-05-28 | 2020-09-23 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| US11529436B2 (en) | 2014-11-05 | 2022-12-20 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
| WO2017083402A1 (en) | 2015-11-09 | 2017-05-18 | Organovo, Inc. | Improved methods for tissue fabrication |
| KR101803618B1 (ko) * | 2015-12-10 | 2017-12-01 | 포항공과대학교 산학협력단 | 종양 조직 배양 장치 및 종양 조직 배양 방법 |
| WO2017123722A1 (en) * | 2016-01-12 | 2017-07-20 | Cleveland State University | 3d-printed miniature biological constructs |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| US10345208B2 (en) | 2016-07-12 | 2019-07-09 | Deka Products Limited Partnership | System and method for applying force to a device |
| US11254901B2 (en) | 2016-07-12 | 2022-02-22 | Deka Products Limited Partnership | System and method for printing tissue |
| EP4478049A3 (en) * | 2016-08-03 | 2024-12-25 | Wake Forest University Health Sciences | Cancer modeling platforms and methods of using the same |
| JP2019530435A (ja) * | 2016-08-15 | 2019-10-24 | オルガノボ インコーポレイテッド | 薬物試験のための三次元バイオプリント腫瘍モデル |
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| GB2555787A (en) | 2016-11-07 | 2018-05-16 | Landberg Goran | Diagnostic methods |
| US11299705B2 (en) | 2016-11-07 | 2022-04-12 | Deka Products Limited Partnership | System and method for creating tissue |
| EP3538643A4 (en) * | 2016-11-10 | 2020-07-08 | Organovo, Inc. | GENETICALLY MODIFIED INTESTINAL TISSUE AND USES THEREOF |
| CA3043708A1 (en) | 2016-11-17 | 2018-05-24 | Cleveland State University | Chip platforms for microarray 3d bioprinting |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| IL249977A0 (en) | 2017-01-08 | 2017-04-30 | Ramot At Tel-Aviv Univ Ltd | 3D models of crops, methods for their preparation and their uses |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| WO2019002912A1 (en) * | 2017-06-27 | 2019-01-03 | ETH Zürich | NANOCOMPOSITE MATERIALS COMPRISING CATIONIC NANOPARTICLES AND ANIONIC POLYMERS USEFUL IN METHODS FOR THEIR 3D PRINTING |
| US12297416B2 (en) | 2017-07-12 | 2025-05-13 | Deka Products Limited Partneship | System and method for transferring tissue |
| US10570362B2 (en) | 2017-07-12 | 2020-02-25 | Deka Products Limited Partnership | System and method for transferring tissue |
| CN111051495A (zh) * | 2017-08-21 | 2020-04-21 | 凸版印刷株式会社 | 原代培养方法 |
| JP6915692B2 (ja) * | 2017-08-21 | 2021-08-04 | 凸版印刷株式会社 | 抗がん効果の評価方法、及びがん免疫療法の奏効性予測方法 |
| US12297457B2 (en) | 2017-10-10 | 2025-05-13 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US11262349B2 (en) | 2017-10-11 | 2022-03-01 | Cleveland State University | Multiplexed immune cell assays on a micropillar/microwell chip platform |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| CA3089127A1 (en) | 2018-02-02 | 2019-08-08 | Wake Forest University Health Sciences | Organoids related to immunotherapy and methods of preparing and using the same |
| CN108396007B (zh) * | 2018-03-15 | 2021-07-23 | 东北农业大学 | 体外构建奶牛血乳屏障三维模型的方法 |
| US12421500B2 (en) | 2018-07-26 | 2025-09-23 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| TWI732132B (zh) * | 2018-09-05 | 2021-07-01 | 國立臺灣大學 | 製造模擬血管新生的細胞球的方法及其應用 |
| JP2021535753A (ja) | 2018-09-12 | 2021-12-23 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞およびその派生体の生成のためのオルガノイド組成物 |
| WO2020092887A2 (en) * | 2018-11-01 | 2020-05-07 | North Carolina State University | Adipocyte mediated delivery of anticancer therapeutics |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| CA3141814A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| CN114174494A (zh) | 2019-05-31 | 2022-03-11 | 儿童医院医学中心 | 产生和扩增造血干细胞的方法 |
| US12019040B2 (en) | 2019-09-30 | 2024-06-25 | Cornell University | System and devices for monitoring cell-containing materials and methods of their use |
| KR102214911B1 (ko) * | 2019-11-18 | 2021-02-10 | 한국생산기술연구원 | 3d 프린터로 제작된 몰드를 이용한 유방 및 종양 모형 제조방법 |
| KR102263745B1 (ko) * | 2019-12-05 | 2021-06-09 | 포항공과대학교 산학협력단 | 흑색종 모델 및 이의 제조방법 |
| DE102020004900A1 (de) | 2020-08-12 | 2022-02-17 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Autologe prävaskulisierte 3D-Druckverfahren-erzeugte Brustgewebe-Konstrukte und Verfahren zu deren Herstellung |
| WO2022125585A1 (en) * | 2020-12-07 | 2022-06-16 | The Regents Of The University Of California | Tissue organoid bioprinting and high-throughput screening methodology |
| WO2022125652A1 (en) * | 2020-12-08 | 2022-06-16 | Cornell University | Methods of inducing an immunomodulatory tumor response |
| US12014830B2 (en) * | 2021-04-18 | 2024-06-18 | Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic | System and method for automation of surgical pathology processes using artificial intelligence |
| CN113444691A (zh) * | 2021-06-21 | 2021-09-28 | 河南省人民医院 | 一种模拟乳腺癌放疗后血管再生的体外细胞模型及其制备方法和应用 |
| TW202306575A (zh) * | 2021-06-23 | 2023-02-16 | 日商Ａｄｅｋａ股份有限公司 | 去細胞化細胞結構體 |
| EP4680717A1 (en) * | 2023-03-14 | 2026-01-21 | The University Of Hong Kong | 3d bioprinting of tumor tissue for mechanistic study and drug screening |
| EP4674952A1 (en) * | 2023-03-30 | 2026-01-07 | Toppan Holdings Inc. | Three-dimensional mammary gland model and method for producing same |
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2014
- 2014-06-06 CA CA3177480A patent/CA3177480A1/en active Pending
- 2014-06-06 WO PCT/US2014/041419 patent/WO2015152954A1/en not_active Ceased
- 2014-06-06 CA CA2944723A patent/CA2944723C/en active Active
- 2014-06-06 EP EP14887943.0A patent/EP3126490B1/en active Active
- 2014-06-06 DK DK14887943.0T patent/DK3126490T3/da active
- 2014-06-06 JP JP2017503766A patent/JP2017518070A/ja not_active Withdrawn
- 2014-06-06 CN CN201480079583.XA patent/CN106536720B/zh not_active Expired - Fee Related
- 2014-06-06 AU AU2014389440A patent/AU2014389440A1/en not_active Abandoned
- 2014-06-06 EP EP20198787.2A patent/EP3808838B1/en active Active
- 2014-06-06 US US15/301,641 patent/US20170023550A1/en not_active Abandoned
- 2014-06-06 KR KR1020167030650A patent/KR20170013865A/ko not_active Ceased
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2015
- 2015-04-03 US US14/678,392 patent/US9983195B2/en active Active - Reinstated
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2018
- 2018-03-05 US US15/911,713 patent/US20180196034A1/en not_active Abandoned
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- 2023-09-01 US US18/459,886 patent/US20240168010A1/en active Pending
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