JP2015523142A5 - - Google Patents
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- JP2015523142A5 JP2015523142A5 JP2015518544A JP2015518544A JP2015523142A5 JP 2015523142 A5 JP2015523142 A5 JP 2015523142A5 JP 2015518544 A JP2015518544 A JP 2015518544A JP 2015518544 A JP2015518544 A JP 2015518544A JP 2015523142 A5 JP2015523142 A5 JP 2015523142A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- connective tissue
- composition
- live
- dimensional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000002808 connective tissue Anatomy 0.000 claims 33
- 210000004027 cell Anatomy 0.000 claims 30
- 230000004069 differentiation Effects 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 230000000295 complement effect Effects 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 239000000470 constituent Substances 0.000 claims 5
- 238000000465 moulding Methods 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 210000000988 bone and bone Anatomy 0.000 claims 4
- 210000001185 bone marrow Anatomy 0.000 claims 4
- 210000001608 connective tissue cell Anatomy 0.000 claims 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 210000000577 adipose tissue Anatomy 0.000 claims 3
- 239000000560 biocompatible material Substances 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 230000012292 cell migration Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 3
- 210000002919 epithelial cell Anatomy 0.000 claims 3
- 210000002744 extracellular matrix Anatomy 0.000 claims 3
- 210000002950 fibroblast Anatomy 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- 210000003041 ligament Anatomy 0.000 claims 3
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 3
- 210000003668 pericyte Anatomy 0.000 claims 3
- 210000002536 stromal cell Anatomy 0.000 claims 3
- 210000002435 tendon Anatomy 0.000 claims 3
- 210000005167 vascular cell Anatomy 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 238000007493 shaping process Methods 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 238000000151 deposition Methods 0.000 claims 1
- 238000007876 drug discovery Methods 0.000 claims 1
- 238000003255 drug test Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011160 research Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000001057 smooth muscle myoblast Anatomy 0.000 claims 1
- 231100000041 toxicology testing Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661768P | 2012-06-19 | 2012-06-19 | |
| US61/661,768 | 2012-06-19 | ||
| US13/801,780 | 2013-03-13 | ||
| US13/801,780 US20140099709A1 (en) | 2012-06-19 | 2013-03-13 | Engineered three-dimensional connective tissue constructs and methods of making the same |
| PCT/US2013/046519 WO2013192290A1 (en) | 2012-06-19 | 2013-06-19 | Engineered three-dimensional connective tissue constructs and methods of making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523142A JP2015523142A (ja) | 2015-08-13 |
| JP2015523142A5 true JP2015523142A5 (enExample) | 2016-08-04 |
Family
ID=49769324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518544A Pending JP2015523142A (ja) | 2012-06-19 | 2013-06-19 | 操作した三次元の結合組織構成物およびそれを製造する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140099709A1 (enExample) |
| EP (1) | EP2861270A4 (enExample) |
| JP (1) | JP2015523142A (enExample) |
| KR (1) | KR20150020702A (enExample) |
| CN (1) | CN104717987A (enExample) |
| AU (2) | AU2013277275B2 (enExample) |
| BR (1) | BR112014032074A2 (enExample) |
| CA (1) | CA2876659A1 (enExample) |
| HK (1) | HK1210439A1 (enExample) |
| IL (1) | IL236183A0 (enExample) |
| IN (1) | IN2015DN00017A (enExample) |
| RU (1) | RU2015100977A (enExample) |
| SG (1) | SG11201408405WA (enExample) |
| WO (1) | WO2013192290A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005081970A2 (en) | 2004-02-24 | 2005-09-09 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| JP5624981B2 (ja) | 2008-06-24 | 2014-11-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ | 自己集合性多細胞体、および前記多細胞体を用いて３次元の生物構造体を作製する方法 |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR20160125530A (ko) | 2010-10-21 | 2016-10-31 | 오가노보, 인크. | 조직의 제작을 위한 디바이스, 시스템 및 방법 |
| GB2502704B (en) | 2010-11-15 | 2019-12-04 | Accelerated Biosciences Corp | Generation of neural stem cells from human trophoblast stem cells |
| BR112014005746A2 (pt) | 2011-09-12 | 2017-03-28 | Organovo Inc | tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos |
| US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
| US9186380B2 (en) | 2012-11-15 | 2015-11-17 | Allosource | Minced cartilage systems and methods |
| CN105102611B (zh) | 2012-11-30 | 2021-09-10 | 艾克塞利瑞提德生物技术公司 | 通过调节mir-124分化干细胞的方法 |
| US9186253B2 (en) * | 2013-02-22 | 2015-11-17 | Allosource | Cartilage mosaic compositions and methods |
| US9442105B2 (en) | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| AU2014236705B2 (en) | 2013-03-15 | 2018-04-12 | Allosource | Perforated osteochondral allograft compositions |
| US20150037445A1 (en) | 2013-07-31 | 2015-02-05 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
| EP3808838B1 (en) * | 2014-04-04 | 2024-04-10 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| KR101690872B1 (ko) | 2014-08-19 | 2016-12-29 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법 |
| MA40495A (fr) | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| US11529436B2 (en) | 2014-11-05 | 2022-12-20 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
| US10538725B1 (en) | 2014-11-14 | 2020-01-21 | Autodesk, Inc. | Multi-dimensional bioprinting system |
| SG11201704291QA (en) | 2014-11-26 | 2017-06-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| KR102311639B1 (ko) * | 2015-03-26 | 2021-10-12 | 주식회사 티앤알바이오팹 | 심근조직 재생용 3차원 구조체의 제조방법 |
| KR20160115204A (ko) * | 2015-03-26 | 2016-10-06 | 포항공과대학교 산학협력단 | 3차원 프린팅용 조성물, 이의 제조방법, 및 이를 사용한 3차원 구조체의 제조방법 |
| WO2017008035A1 (en) * | 2015-07-08 | 2017-01-12 | The Trustees Of The University Of Pennesylvania | Decellularized organ-derived tissue engineering scaffolds |
| CN107835697A (zh) * | 2015-07-10 | 2018-03-23 | 富士胶片株式会社 | 细胞结构体及细胞结构体的制造方法 |
| KR102078602B1 (ko) * | 2015-07-23 | 2020-02-19 | 한국화학연구원 | 지방세포와 마크로파지의 3차원 공동 배양 방법 |
| NZ741377A (en) | 2015-10-09 | 2022-02-25 | Deka Products Lp | Fluid pumping and bioreactor system |
| AU2016352873B2 (en) | 2015-11-09 | 2023-01-05 | Organovo, Inc. | Improved methods for tissue fabrication |
| US10934538B2 (en) | 2016-01-12 | 2021-03-02 | Cleveland State University | 3D-printed miniature biological constructs |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| US11254901B2 (en) | 2016-07-12 | 2022-02-22 | Deka Products Limited Partnership | System and method for printing tissue |
| US10345208B2 (en) | 2016-07-12 | 2019-07-09 | Deka Products Limited Partnership | System and method for applying force to a device |
| EP3526007A4 (en) | 2016-10-12 | 2020-05-27 | Advanced Biomatrix, Inc. | THREE-DIMENSIONAL (3-D) PRINTING INKS MANUFACTURED FROM NATURAL EXTRACELLULAR MATRIX MOLECULES |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| US11299705B2 (en) | 2016-11-07 | 2022-04-12 | Deka Products Limited Partnership | System and method for creating tissue |
| EP3541518A4 (en) | 2016-11-17 | 2020-09-30 | Cleveland State University | CHIP PLATFORMS FOR MICRO-NETWORK 3D BIO-PRINTING |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| US12297416B2 (en) | 2017-07-12 | 2025-05-13 | Deka Products Limited Partneship | System and method for transferring tissue |
| US10570362B2 (en) | 2017-07-12 | 2020-02-25 | Deka Products Limited Partnership | System and method for transferring tissue |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| US11262349B2 (en) | 2017-10-11 | 2022-03-01 | Cleveland State University | Multiplexed immune cell assays on a micropillar/microwell chip platform |
| CN111417360A (zh) * | 2017-10-20 | 2020-07-14 | 印第安纳大学研究和科技公司 | 猪细胞的无支架3d生物打印 |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| WO2019151611A1 (ko) * | 2018-01-31 | 2019-08-08 | 주식회사 로킷헬스케어 | 진피 재생 시트용 바이오 잉크 조성물, 이를 이용한 맞춤형 진피 재생 시트의 제조방법, 및 상기 제조방법을 이용하여 제조된 맞춤형 진피 재생 시트 |
| CN108409917B (zh) * | 2018-03-07 | 2021-03-30 | 广州锐澄医疗技术有限公司 | 一种羊膜固定器的制备方法 |
| CO2018004340A1 (es) * | 2018-04-24 | 2018-07-19 | Univ Del Valle | Implante para la regeneración de tejidos |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| EP3911734A4 (en) * | 2019-01-16 | 2022-11-09 | University of Utah Research Foundation | USING MESENCHYMATOUS STEM CELL SHEETS TO PREVENT UTERINE SCARS |
| BR112021019574A2 (pt) * | 2019-03-29 | 2021-12-21 | Kolon Tissuegene Inc | Tratamento de degeneração de disco intervertebral |
| US11718823B2 (en) * | 2020-02-03 | 2023-08-08 | Purdue Research Foundation | Methods and materials for rapid preparation of 3D spheroids/organoids |
| EP4161410A4 (en) * | 2020-06-03 | 2024-07-17 | Northeastern University | Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain |
| CN113941029B (zh) * | 2020-07-17 | 2022-11-18 | 四川大学华西医院 | 一种3d打印神经导管及其应用 |
| CN112251352B (zh) * | 2020-09-29 | 2022-06-07 | 中国肉类食品综合研究中心 | 一种3d生物组织专用培养装置和块状培育肉的制备方法 |
| CA3206143A1 (en) | 2021-02-26 | 2022-09-01 | Wei Hsu | Skeletal stem cell isolation and uses thereof |
| CN113403268B (zh) * | 2021-08-20 | 2022-01-07 | 北京大学第三医院（北京大学第三临床医学院） | 一种含干细胞外泌体的生物墨水及其制造方法 |
| EP4479422A1 (en) | 2022-02-18 | 2024-12-25 | Ada Forsyth Institute, Inc. | Markers for skeletal stem cell and uses thereof |
| KR102670562B1 (ko) * | 2022-10-13 | 2024-05-29 | 바오밥헬스케어 주식회사 | 3차원 바이오프린팅 기술을 이용한 생선근육 형태 모사 근육을 포함하는 배양생선의 제조방법 및 이에 의해 제조된 배양생선 |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| EP4375362A1 (en) | 2022-11-28 | 2024-05-29 | Universität Zürich | A rotating tissue culture insert for the position inside a rotatable roller bottle partially filled with a liquid for the cultivation of cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6998264B2 (en) * | 2002-11-19 | 2006-02-14 | Huntington Medical Research Institutes | Replication of biological tissue |
| US20040197375A1 (en) * | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| US8043614B2 (en) * | 2004-03-09 | 2011-10-25 | Ahlfors Jan-Eric W | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
| US20090142307A1 (en) * | 2004-07-09 | 2009-06-04 | Athanasiou Kyriacos A | Shape-Based Approach for Scaffoldless Tissue Engineering |
| JP2008545410A (ja) * | 2005-05-24 | 2008-12-18 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 微小規模のマイクロパターン化インビトロ操作・作製組織 |
| JP5624981B2 (ja) * | 2008-06-24 | 2014-11-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリＴｈｅ Ｃｕｒａｔｏｒｓ Ｏｆｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｓｓｏｕｒｉ | 自己集合性多細胞体、および前記多細胞体を用いて３次元の生物構造体を作製する方法 |
| US20110250688A1 (en) * | 2008-11-24 | 2011-10-13 | Immunotrex Corporation | Three Dimensional Tissue Generation |
| HUP0900819A2 (en) * | 2009-05-05 | 2011-01-28 | Pecsi Tudomanyegyetem | Lung tissue culture |
| EP2450707B1 (en) * | 2010-11-04 | 2016-04-27 | University of Pécs | Lung tissue model |
| WO2012003465A2 (en) * | 2010-07-01 | 2012-01-05 | The Regents Of The University Of Michigan | Scaffold-free three dimensional nerve fibroblast constructs |
| KR20160125530A (ko) * | 2010-10-21 | 2016-10-31 | 오가노보, 인크. | 조직의 제작을 위한 디바이스, 시스템 및 방법 |
| WO2013130823A1 (en) * | 2012-02-29 | 2013-09-06 | Massachusetts Institute Of Technology | Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types |
| EP3808838B1 (en) * | 2014-04-04 | 2024-04-10 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
-
2013
- 2013-03-13 US US13/801,780 patent/US20140099709A1/en not_active Abandoned
- 2013-06-19 BR BR112014032074A patent/BR112014032074A2/pt not_active Application Discontinuation
- 2013-06-19 AU AU2013277275A patent/AU2013277275B2/en active Active
- 2013-06-19 CN CN201380043268.7A patent/CN104717987A/zh active Pending
- 2013-06-19 EP EP13807282.2A patent/EP2861270A4/en not_active Withdrawn
- 2013-06-19 IN IN17DEN2015 patent/IN2015DN00017A/en unknown
- 2013-06-19 HK HK15111190.8A patent/HK1210439A1/xx unknown
- 2013-06-19 JP JP2015518544A patent/JP2015523142A/ja active Pending
- 2013-06-19 CA CA2876659A patent/CA2876659A1/en active Pending
- 2013-06-19 KR KR20157001197A patent/KR20150020702A/ko not_active Withdrawn
- 2013-06-19 RU RU2015100977A patent/RU2015100977A/ru not_active Application Discontinuation
- 2013-06-19 WO PCT/US2013/046519 patent/WO2013192290A1/en not_active Ceased
- 2013-06-19 SG SG11201408405WA patent/SG11201408405WA/en unknown
-
2014
- 2014-12-11 IL IL236183A patent/IL236183A0/en unknown
-
2017
- 2017-01-10 AU AU2017200162A patent/AU2017200162A1/en not_active Abandoned
-
2018
- 2018-08-10 US US16/100,655 patent/US20190062707A1/en not_active Abandoned
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