BR112014032074A2 - construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas - Google Patents

construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas

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Publication number
BR112014032074A2
BR112014032074A2 BR112014032074A BR112014032074A BR112014032074A2 BR 112014032074 A2 BR112014032074 A2 BR 112014032074A2 BR 112014032074 A BR112014032074 A BR 112014032074A BR 112014032074 A BR112014032074 A BR 112014032074A BR 112014032074 A2 BR112014032074 A2 BR 112014032074A2
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BR
Brazil
Prior art keywords
connective tissue
cells
engineered
methods
dimensional
Prior art date
Application number
BR112014032074A
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English (en)
Inventor
J Evinger Albert
R Shepherd Benjamin
c presnell Sharon
Original Assignee
Organovo Inc
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Publication date
Application filed by Organovo Inc filed Critical Organovo Inc
Publication of BR112014032074A2 publication Critical patent/BR112014032074A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)

Abstract

resumo “construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas” divulgadas são construções de tecido conjuntivo tridimensionais, vivas, engendradas compreendendo células de tecido conjuntivo. em algumas formas de realização, as células de tecido conjuntivo são derivadas de células multipotentes tais como células tronco/estromais mesenquimais. em algumas formas de realização, as células são coeridas entre si. em algumas formas de realização, as células multipotentes foram expostas a um ou mais sinais de diferenciação para fornecer uma construção de tecido conjuntivo tridimensional, viva. em algumas formas de realização, as construções são substancialmente livres de suporte pré-formado no momento do uso. também divulgados são implantes para enxerto, arranjos de construções de tecido conjuntivo para experimentação in vitro, assim como métodos de fabricar os
BR112014032074A 2012-06-19 2013-06-19 construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas BR112014032074A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661768P 2012-06-19 2012-06-19
US13/801,780 US20140099709A1 (en) 2012-06-19 2013-03-13 Engineered three-dimensional connective tissue constructs and methods of making the same
PCT/US2013/046519 WO2013192290A1 (en) 2012-06-19 2013-06-19 Engineered three-dimensional connective tissue constructs and methods of making the same

Publications (1)

Publication Number Publication Date
BR112014032074A2 true BR112014032074A2 (pt) 2017-06-27

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Family Applications (1)

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BR112014032074A BR112014032074A2 (pt) 2012-06-19 2013-06-19 construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas

Country Status (14)

Country Link
US (2) US20140099709A1 (pt)
EP (1) EP2861270A4 (pt)
JP (1) JP2015523142A (pt)
KR (1) KR20150020702A (pt)
CN (1) CN104717987A (pt)
AU (2) AU2013277275B2 (pt)
BR (1) BR112014032074A2 (pt)
CA (1) CA2876659A1 (pt)
HK (1) HK1210439A1 (pt)
IL (1) IL236183A0 (pt)
IN (1) IN2015DN00017A (pt)
RU (1) RU2015100977A (pt)
SG (1) SG11201408405WA (pt)
WO (1) WO2013192290A1 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
KR20170020942A (ko) 2008-06-24 2017-02-24 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CN105496601A (zh) 2010-10-21 2016-04-20 奥加诺沃公司 用于制造组织的装置、系统和方法
GB2502704B (en) 2010-11-15 2019-12-04 Accelerated Biosciences Corp Generation of neural stem cells from human trophoblast stem cells
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
WO2014078705A1 (en) 2012-11-15 2014-05-22 Allosource Minced cartilage systems and methods
CN113712997A (zh) 2012-11-30 2021-11-30 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
EP2958523B1 (en) 2013-02-22 2020-04-22 AlloSource Cartilage mosaic compositions and methods
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
US9168140B2 (en) 2013-03-15 2015-10-27 Allosource Perforated osteochondral allograft compositions
US20150037445A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
CN106536720B (zh) * 2014-04-04 2021-04-30 奥加诺沃公司 工程化的三维乳腺组织，脂肪组织和肿瘤疾病模型
US10174289B2 (en) 2014-05-28 2019-01-08 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
KR101690872B1 (ko) 2014-08-19 2016-12-29 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법
CN107002033B (zh) 2014-10-06 2021-08-10 奥加诺沃公司 工程化肾组织、其阵列及其制备方法
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
JP2017537654A (ja) 2014-11-05 2017-12-21 オルガノボ インコーポレイテッド 人工三次元皮膚組織、そのアレイ、およびその製造方法
US10538725B1 (en) 2014-11-14 2020-01-21 Autodesk, Inc. Multi-dimensional bioprinting system
CA3148687A1 (en) 2014-11-26 2016-06-02 Accelerated Biosciences Corp. Induced hepatocytes and uses thereof
KR20160115204A (ko) * 2015-03-26 2016-10-06 포항공과대학교 산학협력단 3차원 프린팅용 조성물, 이의 제조방법, 및 이를 사용한 3차원 구조체의 제조방법
KR102311639B1 (ko) * 2015-03-26 2021-10-12 주식회사 티앤알바이오팹 심근조직 재생용 3차원 구조체의 제조방법
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
CN107835697A (zh) * 2015-07-10 2018-03-23 富士胶片株式会社 细胞结构体及细胞结构体的制造方法
KR102078602B1 (ko) 2015-07-23 2020-02-19 한국화학연구원 지방세포와 마크로파지의 3차원 공동 배양 방법
US10294450B2 (en) 2015-10-09 2019-05-21 Deka Products Limited Partnership Fluid pumping and bioreactor system
US10934538B2 (en) 2016-01-12 2021-03-02 Cleveland State University 3D-printed miniature biological constructs
US11066650B2 (en) 2016-05-05 2021-07-20 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
US10345208B2 (en) 2016-07-12 2019-07-09 Deka Products Limited Partnership System and method for applying force to a device
JP2019530461A (ja) * 2016-10-12 2019-10-24 アドバンスド バイオマトリックス， インコーポレイテッド 天然の細胞外マトリックス分子から作られた三次元（３ｄ）プリントインク
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
WO2018094194A1 (en) 2016-11-17 2018-05-24 Cleveland State University Chip platforms for microarray 3d bioprinting
AU2017373767B2 (en) 2016-12-05 2021-09-16 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
EP3697340A4 (en) * 2017-10-20 2021-08-04 Indiana University Research & Technology Corporation SCAFFOLD-FREE 3D BIOPRINTING OF PIG CELLS
SG11202007127QA (en) * 2018-01-31 2020-08-28 Rokit Healthcare Inc Bioink composition for dermis regeneration sheet, method for manufacturing customized dermis regeneration sheet using same, and customized dermis regeneration sheet manufactured using manufacturing method
CN108409917B (zh) * 2018-03-07 2021-03-30 广州锐澄医疗技术有限公司 一种羊膜固定器的制备方法
CO2018004340A1 (es) * 2018-04-24 2018-07-19 Univ Del Valle Implante para la regeneración de tejidos
BR112021019574A2 (pt) * 2019-03-29 2021-12-21 Kolon Tissuegene Inc Tratamento de degeneração de disco intervertebral
US11718823B2 (en) * 2020-02-03 2023-08-08 Purdue Research Foundation Methods and materials for rapid preparation of 3D spheroids/organoids
WO2021247907A1 (en) * 2020-06-03 2021-12-09 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN113941029B (zh) * 2020-07-17 2022-11-18 四川大学华西医院 一种3d打印神经导管及其应用
CN112251352B (zh) * 2020-09-29 2022-06-07 中国肉类食品综合研究中心 一种3d生物组织专用培养装置和块状培育肉的制备方法
WO2022182636A1 (en) 2021-02-26 2022-09-01 University Of Rochester Skeletal stem cell isolation and uses thereof
CN113403268B (zh) * 2021-08-20 2022-01-07 北京大学第三医院（北京大学第三临床医学院） 一种含干细胞外泌体的生物墨水及其制造方法
WO2023159107A1 (en) 2022-02-18 2023-08-24 The Forsyth Institute Markers for skeletal stem cell and uses thereof
WO2024080445A1 (ko) * 2022-10-13 2024-04-18 바오밥헬스케어 주식회사 3차원 바이오프린팅 기술을 이용한 생선근육 형태 모사 근육을 포함하는 배양생선의 제조방법 및 이에 의해 제조된 배양생선
WO2024091824A1 (en) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Differentiation and reprogramming of chondrocyte
EP4375362A1 (en) 2022-11-28 2024-05-29 Universität Zürich A rotating tissue culture insert for the position inside a rotatable roller bottle partially filled with a liquid for the cultivation of cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998264B2 (en) * 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
JP2008545410A (ja) * 2005-05-24 2008-12-18 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 微小規模のマイクロパターン化インビトロ操作・作製組織
KR20170020942A (ko) * 2008-06-24 2017-02-24 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US20110250688A1 (en) * 2008-11-24 2011-10-13 Immunotrex Corporation Three Dimensional Tissue Generation
HUP0900819A2 (en) * 2009-05-05 2011-01-28 Pecsi Tudomanyegyetem Lung tissue culture
EP2450707B1 (en) * 2010-11-04 2016-04-27 University of Pécs Lung tissue model
WO2012003465A2 (en) * 2010-07-01 2012-01-05 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
CN105496601A (zh) * 2010-10-21 2016-04-20 奥加诺沃公司 用于制造组织的装置、系统和方法
US10072257B2 (en) * 2012-02-29 2018-09-11 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
CN106536720B (zh) * 2014-04-04 2021-04-30 奥加诺沃公司 工程化的三维乳腺组织，脂肪组织和肿瘤疾病模型

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SG11201408405WA (en) 2015-01-29
EP2861270A4 (en) 2016-01-20
AU2013277275A1 (en) 2015-01-29
HK1210439A1 (en) 2016-04-22
CN104717987A (zh) 2015-06-17
JP2015523142A (ja) 2015-08-13
WO2013192290A1 (en) 2013-12-27
CA2876659A1 (en) 2013-12-27
US20140099709A1 (en) 2014-04-10
IN2015DN00017A (pt) 2015-05-22
IL236183A0 (en) 2015-01-29
RU2015100977A (ru) 2016-08-10
AU2017200162A1 (en) 2017-02-02
KR20150020702A (ko) 2015-02-26
AU2013277275B2 (en) 2016-10-13
US20190062707A1 (en) 2019-02-28
EP2861270A1 (en) 2015-04-22

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