IN2015DN00017A - - Google Patents

Info

Publication number
IN2015DN00017A
IN2015DN00017A IN17DEN2015A IN2015DN00017A IN 2015DN00017 A IN2015DN00017 A IN 2015DN00017A IN 17DEN2015 A IN17DEN2015 A IN 17DEN2015A IN 2015DN00017 A IN2015DN00017 A IN 2015DN00017A
Authority
IN
India
Prior art keywords
constructs
cells
living
disclosed
potent
Prior art date
Application number
Other languages
English (en)
Inventor
Benjamin R Shepherd
Sharon C Presnell
Albert J Evinger
Original Assignee
Organovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organovo Inc filed Critical Organovo Inc
Publication of IN2015DN00017A publication Critical patent/IN2015DN00017A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
IN17DEN2015 2012-06-19 2013-06-19 IN2015DN00017A (enExample)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661768P 2012-06-19 2012-06-19
US13/801,780 US20140099709A1 (en) 2012-06-19 2013-03-13 Engineered three-dimensional connective tissue constructs and methods of making the same
PCT/US2013/046519 WO2013192290A1 (en) 2012-06-19 2013-06-19 Engineered three-dimensional connective tissue constructs and methods of making the same

Publications (1)

Publication Number Publication Date
IN2015DN00017A true IN2015DN00017A (enExample) 2015-05-22

Family

ID=49769324

Family Applications (1)

Application Number Title Priority Date Filing Date
IN17DEN2015 IN2015DN00017A (enExample) 2012-06-19 2013-06-19

Country Status (13)

Country Link
US (2) US20140099709A1 (enExample)
EP (1) EP2861270A4 (enExample)
JP (1) JP2015523142A (enExample)
KR (1) KR20150020702A (enExample)
CN (1) CN104717987A (enExample)
AU (2) AU2013277275B2 (enExample)
BR (1) BR112014032074A2 (enExample)
HK (1) HK1210439A1 (enExample)
IL (1) IL236183A0 (enExample)
IN (1) IN2015DN00017A (enExample)
RU (1) RU2015100977A (enExample)
SG (1) SG11201408405WA (enExample)
WO (1) WO2013192290A1 (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
EP3059302A1 (en) 2008-06-24 2016-08-24 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
RU2560393C2 (ru) 2010-10-21 2015-08-20 Органово, Инк. Устройства, системы и способы изготовления ткани
AU2011329002C1 (en) 2010-11-15 2017-05-25 Accelerated Biosciences Corp. Generation of neural stem cells from human trophoblast stem cells
DK2756073T3 (da) 2011-09-12 2021-03-22 Organovo Inc Manipuleret væv til in vitro-forskningsanvendelser, anordninger deraf og fremgangsmåder til fremstilling deraf
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
EP2919794B1 (en) 2012-11-15 2021-01-20 AlloSource Minced cartilage systems and methods
EP2925860B8 (en) 2012-11-30 2019-12-25 Accelerated BioSciences Corp. Methods of differentiating stem cells by modulating mir-124
US9186253B2 (en) * 2013-02-22 2015-11-17 Allosource Cartilage mosaic compositions and methods
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
AU2014296246B2 (en) 2013-07-31 2021-01-21 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
KR20170013865A (ko) * 2014-04-04 2017-02-07 오가노보, 인크. 조작된 3차원 유방 조직, 지방조직, 및 종양 질병 모델
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
KR101690872B1 (ko) 2014-08-19 2016-12-29 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법
CN107002033B (zh) 2014-10-06 2021-08-10 奥加诺沃公司 工程化肾组织、其阵列及其制备方法
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
EP3215603B1 (en) 2014-11-05 2021-09-22 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
US10538725B1 (en) 2014-11-14 2020-01-21 Autodesk, Inc. Multi-dimensional bioprinting system
GB2548059B (en) 2014-11-26 2020-09-02 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
KR20160115204A (ko) * 2015-03-26 2016-10-06 포항공과대학교 산학협력단 3차원 프린팅용 조성물, 이의 제조방법, 및 이를 사용한 3차원 구조체의 제조방법
KR102311639B1 (ko) * 2015-03-26 2021-10-12 주식회사 티앤알바이오팹 심근조직 재생용 3차원 구조체의 제조방법
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
EP3320925B1 (en) 2015-07-10 2024-02-28 FUJIFILM Corporation Cell structure and method for producing cell structure
KR102078602B1 (ko) 2015-07-23 2020-02-19 한국화학연구원 지방세포와 마크로파지의 3차원 공동 배양 방법
EP3640321B1 (en) 2015-10-09 2022-04-06 DEKA Products Limited Partnership Method for generating a tissue for transplant
WO2017083402A1 (en) 2015-11-09 2017-05-18 Organovo, Inc. Improved methods for tissue fabrication
WO2017123722A1 (en) 2016-01-12 2017-07-20 Cleveland State University 3d-printed miniature biological constructs
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
WO2018013727A1 (en) 2016-07-12 2018-01-18 Deka Products Limited Partnership System and method for applying force to a device
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
US11850324B2 (en) 2016-10-12 2023-12-26 Advanced Biomatrix, Inc. Three-dimensional (3-D) printing inks made from natural extracellular matrix molecules
SG10202104575WA (en) 2016-11-04 2021-06-29 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
CN110087772B (zh) 2016-11-17 2022-07-19 克利夫兰州立大学 用于微阵列3d生物打印的芯片平台
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
WO2019074793A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
JP2021500356A (ja) * 2017-10-20 2021-01-07 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション ブタ細胞の足場なし３ｄバイオ印刷
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CN111670056B (zh) * 2018-01-31 2023-01-10 罗基医疗保健公司 真皮再生片用生物墨水组合物、利用其的定制型真皮再生片的制造方法以及利用所述制造方法制造的定制型真皮再生片
CN108409917B (zh) * 2018-03-07 2021-03-30 广州锐澄医疗技术有限公司 一种羊膜固定器的制备方法
CO2018004340A1 (es) * 2018-04-24 2018-07-19 Univ Del Valle Implante para la regeneración de tejidos
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
JP7585207B2 (ja) * 2019-01-16 2024-11-18 ユニバーシティ オブ ユタ リサーチ ファウンデーション 子宮瘢痕形成を予防するための間葉系幹細胞シートの使用
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
US12653842B2 (en) * 2019-03-29 2026-06-16 Kolon Tissuegene, Inc Treatment of intervertebral disc degeneration
US12534709B2 (en) 2019-05-31 2026-01-27 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
US11718823B2 (en) * 2020-02-03 2023-08-08 Purdue Research Foundation Methods and materials for rapid preparation of 3D spheroids/organoids
EP4161410A4 (en) * 2020-06-03 2024-07-17 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN113941029B (zh) * 2020-07-17 2022-11-18 四川大学华西医院 一种3d打印神经导管及其应用
CN112251352B (zh) * 2020-09-29 2022-06-07 中国肉类食品综合研究中心 一种3d生物组织专用培养装置和块状培育肉的制备方法
US20240124845A1 (en) 2021-02-26 2024-04-18 University Of Rochester Skeletal stem cell isolation and uses thereof
CN113403268B (zh) * 2021-08-20 2022-01-07 北京大学第三医院（北京大学第三临床医学院） 一种含干细胞外泌体的生物墨水及其制造方法
WO2023159107A1 (en) 2022-02-18 2023-08-24 The Forsyth Institute Markers for skeletal stem cell and uses thereof
KR102670562B1 (ko) * 2022-10-13 2024-05-29 바오밥헬스케어 주식회사 3차원 바이오프린팅 기술을 이용한 생선근육 형태 모사 근육을 포함하는 배양생선의 제조방법 및 이에 의해 제조된 배양생선
US20260151538A1 (en) 2022-10-26 2026-06-04 Ada Forsyth Institute, Inc. Differentiation and reprogramming of chondrocyte
EP4375362A1 (en) 2022-11-28 2024-05-29 Universität Zürich A rotating tissue culture insert for the position inside a rotatable roller bottle partially filled with a liquid for the cultivation of cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998264B2 (en) * 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
EP2495310A3 (en) * 2005-05-24 2013-03-27 The Regents Of the University of California Microscale micropatterned engineered in vitro tissue
EP3059302A1 (en) * 2008-06-24 2016-08-24 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
WO2010060080A1 (en) * 2008-11-24 2010-05-27 Immunotrex Corporation Three dimensional tissue generation
EP2450707B1 (en) * 2010-11-04 2016-04-27 University of Pécs Lung tissue model
HUP0900819A2 (en) * 2009-05-05 2011-01-28 Pecsi Tudomanyegyetem Lung tissue culture
US9592255B2 (en) * 2010-07-01 2017-03-14 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
RU2560393C2 (ru) * 2010-10-21 2015-08-20 Органово, Инк. Устройства, системы и способы изготовления ткани
US10072257B2 (en) * 2012-02-29 2018-09-11 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
KR20170013865A (ko) * 2014-04-04 2017-02-07 오가노보, 인크. 조작된 3차원 유방 조직, 지방조직, 및 종양 질병 모델

Also Published As

Publication number Publication date
HK1210439A1 (en) 2016-04-22
EP2861270A1 (en) 2015-04-22
AU2017200162A1 (en) 2017-02-02
BR112014032074A2 (pt) 2017-06-27
US20140099709A1 (en) 2014-04-10
KR20150020702A (ko) 2015-02-26
CN104717987A (zh) 2015-06-17
RU2015100977A (ru) 2016-08-10
AU2013277275A1 (en) 2015-01-29
AU2013277275B2 (en) 2016-10-13
WO2013192290A1 (en) 2013-12-27
JP2015523142A (ja) 2015-08-13
EP2861270A4 (en) 2016-01-20
US20190062707A1 (en) 2019-02-28
CA2876659A1 (en) 2013-12-27
IL236183A0 (en) 2015-01-29
SG11201408405WA (en) 2015-01-29

Similar Documents

Publication Publication Date Title
BR112014032074A2 (pt) construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas
WO2013040078A3 (en) Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
WO2014153346A8 (en) Engineering a heterogeneous tissue from pluripotent stem cells
WO2012006440A3 (en) Endothelial cell production by programming
MY169357A (en) Methods for additive manufacturing of implant components
EP4275618A3 (en) Fenestrated implant
WO2013106556A3 (en) Breast prostheses, methods of manufacturing breast prostheses, and methods of treatment using breast prostheses
MX2011007930A (es) Conjugados de insulina cristalina.
WO2014186469A3 (en) Human application of engineered chimeric antigen receptor (car) t-cells
BR112015005878A2 (pt) nanopartículas terapêuticas compreendendo agente terapêutico e métodos de preparar e usar as mesmas
EA201290988A1 (ru) Стереоселективный синтез фосфорсодержащих активных соединений
EP4403197A3 (en) Injectable formulations for organ augmentation
MX359769B (es) Metodos para descelularizar huesos.
UA113541C2 (xx) Заміщені піролідин-2-карбоксаміди
IN2014MN01981A (enExample)
MX2013004061A (es) Analogos de ciclosporina.
WO2014141210A3 (en) Multifunctional immature dental pulp stem cells and therapeutic applications
MX390739B (es) Composicion de hueso comprimido y metodo para usar la misma.
SG10201901713RA (en) Extracellular matrix compositions
PL2552401T3 (pl) Zastosowanie preparatu otrzymanego z hodowli in vitro odróżnicowanych nieelicytowanych komórek drzewa arganowego, do leczenia starzenia się skóry
SG11201804755VA (en) Method for manufacturing tissue/organ by using blood cells
WO2012048170A3 (en) Humanized animals via tissue engineering and uses therefor
PH12020551126A1 (en) Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing
IL231195B (en) A dental implant, a vascular implant and a tissue implant made of polytetrafluoroethylene with a three-dimensional porous structure
MX2013004062A (es) Analogos de ciclosporina.