HRP20150149T1 - Uređaji i metode za kulture stanica - Google Patents
Uređaji i metode za kulture stanica Download PDFInfo
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- HRP20150149T1 HRP20150149T1 HRP20150149TT HRP20150149T HRP20150149T1 HR P20150149 T1 HRP20150149 T1 HR P20150149T1 HR P20150149T T HRP20150149T T HR P20150149TT HR P20150149 T HRP20150149 T HR P20150149T HR P20150149 T1 HRP20150149 T1 HR P20150149T1
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- 238000000034 method Methods 0.000 title claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000004952 Polyamide Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
- 229920000515 polycarbonate Polymers 0.000 claims 2
- 239000004417 polycarbonate Substances 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- 229920000049 Carbon (fiber) Polymers 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229930182556 Polyacetal Natural products 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- -1 borosilicate Substances 0.000 claims 1
- 239000004917 carbon fiber Substances 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 238000004381 surface treatment Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/16—Particles; Beads; Granular material; Encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Air-Conditioning For Vehicles (AREA)
Claims (16)
1. Uređaj za staničnu kulturu koji sadrži:
trodimenzionalno tijelo koje sadrži višestruke dvodimenzionalne površine koje se protežu prema unutra od periferije trodimenzionalnog tijela prema unutrašnjosti trodimenzionalnog tijela, pri čemu su višestruke dvodimenzionalne površine podešene tako da podržavaju jednoslojni rast eukariotskih stanica preko barem većeg dijela ili cijele površine višestrukih dvodimenzionalnih površina, i pri čemu trodimenzionalno tijelo ima:
(a) maksimalnu dimenziju u rasponu od oko 1 mm do oko 50 mm; ili
(b) omjer površine i obujma između oko 3 cm2/cm3 i oko 1.000 cm2/cm3.
2. Sustav stanične kulture, koji sadrži:
posudu; i
grupu trodimenzionalnih tijela, pri čemu svako trodimenzionalno tijelo sadrži:
višestruke dvodimenzionalne površine koje se protežu prema unutra od periferije trodimenzionalnog tijela prema unutrašnjosti svakog trodimenzionalnog tijela, pri čemu su višestruke dvodimenzionalne površine konfigurirane tako da podržavaju jednoslojni rast eukariotskih stanica preko barem većeg dijela ili cijele površine višestrukih dvodimenzionalnih površina, i pri čemu svako trodimenzionalno tijelo ima:
(a) maksimalnu dimenziju u rasponu od oko 1 mm do oko 50 mm; ili
(b) omjer površine i obujma između oko 3 cm2/cm3 i oko 1.000 cm2/cm3.
3. Uređaj prema patentnom zahtjevu 1 ili sustav prema patentnom zahtjevu 2, naznačen time da višestruke dvodimenzionalne površine:
(a) sadrže više rebara koja se protežu od unutrašnjosti trodimenzionalnog tijela prema periferiji trodimenzionalnog tijela;
(b) sadrže više rebara koja se uglavnom protežu paralelno jedno u odnosu na drugo od unutrašnjosti trodimenzionalnog tijela prema periferiji trodimenzionalnog tijela;
(c)
(i) imaju zakrivljeni oblik i/ili sadrže barem jedno spiralno rebro koje se proteže od unutrašnjosti trodimenzionalnog tijela prema periferiji trodimenzionalnog tijela; ili
(ii) su znatno ravne barem na jednom dijelu svoje površine; i/ili
(d) sadrže više rebara koja se protežu od središnje jezgre prema periferiji trodimenzionalnog tijela.
4. Uređaj prema patentnim zahtjevima 1 ili 3 ili sustav prema patentnim zahtjevima 2 ili 3, naznačeni time da trodimenzionalno tijelo sadrži barem jedan uglavnom sferni oblik, jedan uglavnom elipsoidni oblik i jedan nepravilni poliedarski oblik.
5. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-4 ili sustav prema bilo kojem patentnom zahtjevu 2-4, naznačeni time da materijal koji oblikuje višestruke dvodimenzionalne površine sadrži materijal odabran od barem jednog od metala, stakla, borosilikata, karbonskih vlakana, keramike, kolagena, želatine, hidrogelova i polimera.
6. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-5 ili sustav prema bilo kojem od patentnom zahtjevu 2-5, naznačeni time da materijal koji oblikuje višestruke dvodimenzionalne površine sadrži barem jedan polimer, opcionalno pri čemu je polimer:
(a) odabran od poliamida, polikarbonata, polisulfona, poliestera, poliacetala, i polivinil klorida;
(b) poliamida, ili
(c) polikarbonata.
7. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-6 ili sustav prema bilo kojem patentnom zahtjevu 2-6, naznačeni time da višestruke dvodimenzionalne površine nadalje sadrže barem jedan premaz odabran da omogući prihvat i rast eukariotskih stanica, opcionalno pri čemu je barem jedan premaz odabran od proteina i polilizina.
8. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-7 ili sustav prema bilo kojem patentnom zahtjevu 2-7, naznačeni time da su višestruke dvodimenzionalne površine bile podvrgnute tretiranju površine plazmom.
9. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-8 ili sustav prema bilo kojem patentnom zahtjevu 2-8, naznačeni time da višestruke dvodimenzionalne površine sadrže modul i zavoje odabrane da omoguće rast eukariotskih stanica.
10. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-9 ili sustav prema bilo kojem patentnom zahtjevu 2-9, naznačeni time da eukariotske stanice sadrže barem jedne matične stanice, stanice ovisne o učvršćivanju, mezenhimske stanice i stromalne stanice.
11. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-10 ili sustav prema bilo kojem patentnom zahtjevu 2-10, naznačeni time da je omjer površine višestrukih dvodimenzionalnih površina i obujma trodimenzionalnog tijela između oko 3 cm2/cm3 i oko 1.000 cm2/cm3, opcionalno pri čemu je omjer površine višestrukih dvodimenzionalnih površina i obujma trodimenzionalnog tijela između oko 10 cm2/cm3 i oko 15 cm2/cm3.
12. Sustav prema bilo kojem patentnom zahtjevu 2-11, naznačen time da trodimenzionalno tijelo ima maksimalnu dimenziju između 1 mm i 20 mm.
13. Uređaj prema bilo kojem patentnom zahtjevu 1, 3-11 ili sustav prema bilo kojem patentnom zahtjevu 2-12, naznačeni time da trodimenzionalno tijelo ima maksimalnu dimenziju između 2 mm i 10 mm, opcionalno pri čemu je uređaj uglavnom sfernog oblika, a maksimalna dimenzija je promjer.
14. Metoda uzgoja stanica, koja sadrži:
odabir grupe eukariotskih stanica; stupanje u kontakt eukariotskih stanica s barem jednim trodimenzionalnim tijelom kako je definirano prema bilo kojem patentnom zahtjevu 1, 3-11 i 13.
15. Metoda prema patentnom zahtjevu 14, naznačena time da stupanje u kontakt eukariotskih stanica s barem jednim trodimenzionalnim tijelom sadrži:
(a) stavljanje stanica i barem jednom trodimenzionalnog tijela u posudu;
(b) nadalje sadrži dodavanje medija za rast stanicama; i/ili
(c) nadalje sadrži izazivanje pokretanja barem jednog trodimenzionalnog tijela, opcionalno pri čemu izazivanje pokretanja sadrži:
(i) rotiranje ili tresenje posude u kojoj je sadržano barem jedno trodimenzionalno tijelo; ili
(ii) omogućavanje protoka medija u posudu u kojoj je sadržano barem jedno trodimenzionalno tijelo.
16. Metoda prema patentnom zahtjevu 14, naznačena time da je barem jedno trodimenzionalno tijelo uronjeno u medij za rast unutar odgovarajuće posude koja je konfigurirana tako da je otporna na staničnu adheziju.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697445P | 2012-09-06 | 2012-09-06 | |
| PCT/IB2013/058184 WO2014037862A1 (en) | 2012-09-06 | 2013-08-31 | Devices and methods for culture of cells |
| EP13777343.8A EP2739720B1 (en) | 2012-09-06 | 2013-08-31 | Devices and methods for culture of cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150149T1 true HRP20150149T1 (hr) | 2015-04-24 |
Family
ID=49382554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150149TT HRP20150149T1 (hr) | 2012-09-06 | 2015-02-06 | Uređaji i metode za kulture stanica |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9512393B2 (hr) |
| EP (2) | EP2902478A1 (hr) |
| JP (1) | JP5931293B2 (hr) |
| KR (1) | KR101678796B1 (hr) |
| CN (2) | CN104619830B (hr) |
| AU (1) | AU2013311288B2 (hr) |
| BR (1) | BR112015004635A2 (hr) |
| CA (1) | CA2882108C (hr) |
| CY (1) | CY1116097T1 (hr) |
| DK (1) | DK2739720T3 (hr) |
| ES (1) | ES2529501T3 (hr) |
| HK (3) | HK1213592A1 (hr) |
| HR (1) | HRP20150149T1 (hr) |
| IL (1) | IL237527A0 (hr) |
| ME (1) | ME02052B (hr) |
| MX (1) | MX357469B (hr) |
| PL (1) | PL2739720T3 (hr) |
| PT (1) | PT2739720E (hr) |
| RS (1) | RS53886B1 (hr) |
| RU (1) | RU2615179C2 (hr) |
| SG (1) | SG11201500816XA (hr) |
| SI (1) | SI2739720T1 (hr) |
| SM (1) | SMT201500055B (hr) |
| WO (1) | WO2014037862A1 (hr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009037690A1 (en) | 2007-09-19 | 2009-03-26 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
| US9393273B2 (en) | 2008-05-27 | 2016-07-19 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| CA2735790C (en) | 2008-09-02 | 2017-02-28 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| EP2507362A2 (en) | 2009-11-30 | 2012-10-10 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
| ES2572211T3 (es) | 2010-05-27 | 2016-05-30 | Pluristem Ltd | Regeneración de músculo esquelético utilizando células madre mesenquimales |
| EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| EP2689008B1 (en) | 2011-03-22 | 2017-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| WO2012140519A2 (en) | 2011-04-15 | 2012-10-18 | Pluristem Ltd. | Methods and systems for harvesting cells |
| EP2892542B1 (en) | 2012-09-04 | 2018-04-04 | Pluristem Ltd. | Methods for prevention and treatment of preeclampsia |
| KR101359268B1 (ko) * | 2012-12-06 | 2014-02-11 | 고려대학교 산학협력단 | 바이오 필름 모니터링 장치 |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| EP3114206B1 (en) | 2014-03-04 | 2020-07-29 | Pluristem Ltd. | Systems and methods for growing and harvesting cells |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
| US10258652B2 (en) | 2014-12-18 | 2019-04-16 | Pluristem Ltd. | Methods and compositions for treating and preventing muscle wasting disorders |
| FR3032974B1 (fr) * | 2015-02-19 | 2023-01-13 | Commissariat Energie Atomique | Dispositif de manipulation de cellules biologiques au moyen d'un support vibrant |
| WO2016151476A1 (en) | 2015-03-23 | 2016-09-29 | Pluristem Ltd. | Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| RU2614260C1 (ru) * | 2016-01-28 | 2017-03-24 | Общество с ограниченной ответственностью фирмы "Имтек" | Двухслойная, плоская, прозрачная подложка гидрогеля для длительного культивирования клеток |
| WO2017141181A1 (en) | 2016-02-18 | 2017-08-24 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| CN105524832B (zh) * | 2016-02-26 | 2018-03-30 | 广州洁特生物过滤股份有限公司 | 细胞培养装置及方法 |
| JP6987080B2 (ja) | 2016-05-05 | 2021-12-22 | サウスウェスト リサーチ インスティテュート | 細胞増殖のための三次元バイオリアクター及び関連用途 |
| EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| CN115044471A (zh) | 2016-08-27 | 2022-09-13 | 三维生物科技有限公司 | 生物反应器 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
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