JP2011513402A5 - - Google Patents

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JP2011513402A5
JP2011513402A5 JP2010549649A JP2010549649A JP2011513402A5 JP 2011513402 A5 JP2011513402 A5 JP 2011513402A5 JP 2010549649 A JP2010549649 A JP 2010549649A JP 2010549649 A JP2010549649 A JP 2010549649A JP 2011513402 A5 JP2011513402 A5 JP 2011513402A5
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Japan
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chlorophenyl
reacting
process according
ethanol
item
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JP2010549649A
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Japanese (ja)
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JP2011513402A (ja
JP5491421B2 (ja
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Priority claimed from PCT/US2009/001340 external-priority patent/WO2009111004A1/en
Publication of JP2011513402A publication Critical patent/JP2011513402A/ja
Publication of JP2011513402A5 publication Critical patent/JP2011513402A5/ja
Application granted granted Critical
Publication of JP5491421B2 publication Critical patent/JP5491421B2/ja
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JP2010549649A 2008-03-04 2009-03-03 ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス Expired - Fee Related JP5491421B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6810208P 2008-03-04 2008-03-04
US61/068,102 2008-03-04
PCT/US2009/001340 WO2009111004A1 (en) 2008-03-04 2009-03-03 Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

Publications (3)

Publication Number Publication Date
JP2011513402A JP2011513402A (ja) 2011-04-28
JP2011513402A5 true JP2011513402A5 (enExample) 2013-03-21
JP5491421B2 JP5491421B2 (ja) 2014-05-14

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JP2010549649A Expired - Fee Related JP5491421B2 (ja) 2008-03-04 2009-03-03 ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス

Country Status (5)

Country Link
US (1) US8822727B2 (enExample)
EP (1) EP2288585A1 (enExample)
JP (1) JP5491421B2 (enExample)
CN (1) CN102015591B (enExample)
WO (1) WO2009111004A1 (enExample)

Families Citing this family (21)

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JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
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JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法
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CN105517994A (zh) 2013-06-21 2016-04-20 斯洛文尼亚莱柯制药股份有限公司 通过α-取代的苯乙烯类的不对称还原制备手性1-甲基-2，3，4，5-1H-苯并二氮杂*类
CN103901151A (zh) * 2014-04-23 2014-07-02 湖北朗昕生化药业有限公司 一种hplc法检测氯卡色林盐酸盐含量的方法
WO2015170346A1 (en) 2014-05-09 2015-11-12 Council Of Scientific & Industrial Research A process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine its enantiomers
TW201618787A (zh) 2014-10-30 2016-06-01 艾尼納製藥公司 組合物及方法
CN107673949B (zh) * 2017-10-25 2021-02-23 南京恒旺生物医药有限公司 一种1-氯-3-甲基-2-丁烯的制备方法
CN112358406A (zh) * 2020-10-28 2021-02-12 山东省药学科学院 一种氯卡色林中间体的制备方法
CN115784911A (zh) * 2022-10-19 2023-03-14 山东省药学科学院 一种1-[2-(4-氯苯基)-乙基氨基]-2-丙醇的合成方法

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CN102126988A (zh) 2010-12-17 2011-07-20 张家港瀚康化工有限公司 4-(4-氯苯基)-2-溴甲基-2-苯基丁腈的制备方法

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