CN102015591B - 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 - Google Patents

制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 Download PDF

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Publication number
CN102015591B
CN102015591B CN200980116092.7A CN200980116092A CN102015591B CN 102015591 B CN102015591 B CN 102015591B CN 200980116092 A CN200980116092 A CN 200980116092A CN 102015591 B CN102015591 B CN 102015591B
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chloro
phenyl
ethanol
propan
chlorophenyl
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CN102015591A (zh
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马龙·V·卡洛斯
瑞安·O·卡斯特罗
陶菲克·加鲍伊
卢晓雄
马友安
尼古拉斯·D·桑马丁
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Arena Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/38—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200980116092.7A 2008-03-04 2009-03-03 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 Expired - Fee Related CN102015591B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6810208P 2008-03-04 2008-03-04
US61/068,102 2008-03-04
PCT/US2009/001340 WO2009111004A1 (en) 2008-03-04 2009-03-03 Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

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CN102015591A CN102015591A (zh) 2011-04-13
CN102015591B true CN102015591B (zh) 2014-01-29

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US (1) US8822727B2 (enExample)
EP (1) EP2288585A1 (enExample)
JP (1) JP5491421B2 (enExample)
CN (1) CN102015591B (enExample)
WO (1) WO2009111004A1 (enExample)

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CN107673949B (zh) * 2017-10-25 2021-02-23 南京恒旺生物医药有限公司 一种1-氯-3-甲基-2-丁烯的制备方法
CN112358406A (zh) * 2020-10-28 2021-02-12 山东省药学科学院 一种氯卡色林中间体的制备方法
CN115784911A (zh) * 2022-10-19 2023-03-14 山东省药学科学院 一种1-[2-(4-氯苯基)-乙基氨基]-2-丙醇的合成方法

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