JP2009280577A - マンデル酸のピペリジルエステルの第4級塩を製造する方法 - Google Patents
マンデル酸のピペリジルエステルの第4級塩を製造する方法 Download PDFInfo
- Publication number
- JP2009280577A JP2009280577A JP2009106522A JP2009106522A JP2009280577A JP 2009280577 A JP2009280577 A JP 2009280577A JP 2009106522 A JP2009106522 A JP 2009106522A JP 2009106522 A JP2009106522 A JP 2009106522A JP 2009280577 A JP2009280577 A JP 2009280577A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- piperidyl
- solvent
- group
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Abstract
Description
を製造する方法であって、
一般式(II)
R3X (III)
(式中、Xはハロゲン原子を表す)のアルキル化剤と反応させることを特徴とする方法を提供する。
Claims (8)
- R1が、C3−C20−シクロアルキル基を表し、R2が、C1−C20−アルキル基を表すことを特徴とする請求項1に記載の方法。
- R1が、シクロペンチル基を表し、R2が、メチル基を表すことを特徴とする請求項1または2に記載の方法。
- Xが、臭素またはヨウ素原子を表し、R3が、C1−C20−アルキル基またはC3−C20−シクロアルキル基を表すことを特徴とする請求項1〜3のいずれか一項に記載の方法。
- Xが、臭素原子を表し、R3が、メチル基を表すことを特徴とする請求項1〜4のいずれか一項に記載の方法。
- 反応が、溶剤ジクロロメタン中で行われることを特徴とする請求項1〜5のいずれか一項に記載の方法。
- 前記アルキル化剤が、最初に溶剤に入れられ、前記式(II)の化合物が、適切な場合は溶剤中の溶液として、計量して入れられることを特徴とする請求項1〜6のいずれか一項に記載の方法。
- 前記一般式(II)の化合物が、1−メチル−4−ピペリジルα−シクロペンチルマンデル酸エステルであることを特徴とする請求項1〜7のいずれか一項に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008020746A DE102008020746A1 (de) | 2008-04-25 | 2008-04-25 | Verfahren zur Herstellung von quarternären Salzen von Piperidyl Estern der Mandelsäure |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014222950A Division JP2015063530A (ja) | 2008-04-25 | 2014-10-31 | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009280577A true JP2009280577A (ja) | 2009-12-03 |
JP2009280577A5 JP2009280577A5 (ja) | 2012-06-07 |
Family
ID=40848413
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009106522A Pending JP2009280577A (ja) | 2008-04-25 | 2009-04-24 | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
JP2014222950A Pending JP2015063530A (ja) | 2008-04-25 | 2014-10-31 | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014222950A Pending JP2015063530A (ja) | 2008-04-25 | 2014-10-31 | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8309732B2 (ja) |
EP (1) | EP2112137A1 (ja) |
JP (2) | JP2009280577A (ja) |
DE (1) | DE102008020746A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063530A (ja) * | 2008-04-25 | 2015-04-09 | サルティゴ・ゲーエムベーハー | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002004402A1 (fr) * | 2000-07-11 | 2002-01-17 | Banyu Pharmaceutical Co., Ltd. | Derives d'ester |
WO2007123465A1 (en) * | 2006-04-24 | 2007-11-01 | Astrazeneca Ab | New alkyl esters of cyclic amino alcohols with muscarinic m3 receptor antagonist activity, useful for treating e.g. chronic bronchial obstruction, asthma and overactive bladder |
WO2007141289A1 (en) * | 2006-06-09 | 2007-12-13 | Beiersdorf Ag | Piperidinium compounds and cosmetic compositions containing them |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB788126A (en) | 1955-09-29 | 1957-12-23 | Schering Corp | Quaternary salts of piperidyl esters |
US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
US4022787A (en) * | 1975-07-18 | 1977-05-10 | Carter-Wallace, Inc. | Anticholinergic ester and salts thereof |
DE19605526A1 (de) * | 1996-02-15 | 1997-08-21 | Hoechst Ag | Ammoniumnitrile und deren Verwendung als Bleichaktivatoren |
BR9915735A (pt) * | 1998-11-20 | 2001-09-04 | Hoffmann La Roche | Antagonistas receptores de ccr-3 de piperidina |
GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
DE102008020746A1 (de) * | 2008-04-25 | 2009-10-29 | Saltigo Gmbh | Verfahren zur Herstellung von quarternären Salzen von Piperidyl Estern der Mandelsäure |
-
2008
- 2008-04-25 DE DE102008020746A patent/DE102008020746A1/de not_active Withdrawn
-
2009
- 2009-04-06 US US12/418,847 patent/US8309732B2/en not_active Expired - Fee Related
- 2009-04-09 EP EP09157753A patent/EP2112137A1/de not_active Withdrawn
- 2009-04-24 JP JP2009106522A patent/JP2009280577A/ja active Pending
-
2014
- 2014-10-31 JP JP2014222950A patent/JP2015063530A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002004402A1 (fr) * | 2000-07-11 | 2002-01-17 | Banyu Pharmaceutical Co., Ltd. | Derives d'ester |
WO2007123465A1 (en) * | 2006-04-24 | 2007-11-01 | Astrazeneca Ab | New alkyl esters of cyclic amino alcohols with muscarinic m3 receptor antagonist activity, useful for treating e.g. chronic bronchial obstruction, asthma and overactive bladder |
WO2007141289A1 (en) * | 2006-06-09 | 2007-12-13 | Beiersdorf Ag | Piperidinium compounds and cosmetic compositions containing them |
Non-Patent Citations (1)
Title |
---|
JPN6013050003; Journal of the American Chemical Society 78, 1956, pp3701-3703 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063530A (ja) * | 2008-04-25 | 2015-04-09 | サルティゴ・ゲーエムベーハー | マンデル酸のピペリジルエステルの第4級塩を製造する方法 |
Also Published As
Publication number | Publication date |
---|---|
US8309732B2 (en) | 2012-11-13 |
EP2112137A1 (de) | 2009-10-28 |
US20090270629A1 (en) | 2009-10-29 |
JP2015063530A (ja) | 2015-04-09 |
DE102008020746A1 (de) | 2009-10-29 |
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