|
GB721286A
(en)
|
1951-02-16 |
1955-01-05 |
Smith Kline & French Internat |
Improvements in or relating to the preparation of tetrahydroisoquinolone derivatives
|
|
DE2143745A1
(de)
|
1971-09-01 |
1973-03-08 |
Hoechst Ag |
3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung
|
|
US3813384A
(en)
|
1972-01-17 |
1974-05-28 |
Asta Werke Ag Chem Fab |
Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
|
|
FR2262513A1
(en)
|
1974-03-01 |
1975-09-26 |
Delalande Sa |
3,4,5-Triphenyl-delta-1,2,4-oxadiazolines - with bronchodilator, anti-cholinergic, hypertensive, analgesic and sedative activity
|
|
JPS54156526A
(en)
|
1978-05-31 |
1979-12-10 |
Asahi Chemical Ind |
Dry picture forming material
|
|
US4283539A
(en)
|
1979-12-18 |
1981-08-11 |
Pfizer Inc. |
Isoquinoline acetic acids
|
|
JPS58164577A
(ja)
|
1982-03-24 |
1983-09-29 |
Taiho Yakuhin Kogyo Kk |
４―ベンジル―１―（２ｈ）イソキノロン誘導体
|
|
US4665181A
(en)
|
1984-05-17 |
1987-05-12 |
Pennwalt Corporation |
Anti-inflammatory phthalazinones
|
|
US5041653A
(en)
|
1985-05-03 |
1991-08-20 |
Sri International |
Substituted benzamide radiosensitizers
|
|
US5032617A
(en)
|
1985-05-03 |
1991-07-16 |
Sri International |
Substituted benzamide radiosensitizers
|
|
US5215738A
(en)
|
1985-05-03 |
1993-06-01 |
Sri International |
Benzamide and nicotinamide radiosensitizers
|
|
ES2031813T3
(es)
|
1985-11-11 |
1993-01-01 |
Asta Pharma Ag |
Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona.
|
|
GB8610018D0
(en)
|
1986-04-24 |
1986-05-29 |
Fujisawa Pharmaceutical Co |
Phthalazine derivatives
|
|
DE3640641A1
(de)
|
1986-11-28 |
1988-07-14 |
Thomae Gmbh Dr K |
Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
DE3813531A1
(de)
|
1987-05-02 |
1988-11-10 |
Asta Pharma Ag |
Neue 2-aminoalkyl-4-benzyl-1-(2h)-phthalazinon-derivate
|
|
DE68920798T2
(de)
|
1988-08-19 |
1995-05-18 |
Warner Lambert Co |
Substituierte Dihydroisochinolinone und verwandte Verbindungen als Verstärker der letalen Effekte von Bestrahlung und bestimmten Chemotherapeutika; ausgewählte Verbindungen, Analoga und Verfahren.
|
|
EP0389995B1
(en)
|
1989-03-28 |
1995-05-31 |
Nisshin Flour Milling Co., Ltd. |
Isoquinoline derivatives for the treatment of glaucoma or ocular hypertension
|
|
DD287032A5
(de)
|
1989-07-28 |
1991-02-14 |
Karl-Marx-Universitaet Leipzig,De |
Verfahren zur herstellung von 3-carbamoyl-4-aryl-1,2-di-hydro-isochinolin-1h-onen
|
|
GB9011833D0
(en)
|
1990-05-25 |
1990-07-18 |
Collins Mary K L |
Inhibition of viral infection
|
|
EP0502575A1
(en)
|
1991-03-06 |
1992-09-09 |
Merck & Co. Inc. |
Substituted 1-(2H)-isoquinolinones
|
|
IL104406A0
(en)
|
1992-01-17 |
1993-05-13 |
Syntex Inc |
Substituted 1-isoquinolone derivatives,their preparation and pharmaceutical compositions containing them
|
|
CZ199593A3
(en)
|
1992-10-02 |
1994-04-13 |
Asta Medica Ag |
Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
|
|
JPH08502973A
(ja)
|
1992-11-02 |
1996-04-02 |
メルク エンド カンパニー インコーポレーテッド |
ニューロテンシンアンタゴニストとしての置換フタラジノン
|
|
EP0634404A1
(en)
|
1993-07-13 |
1995-01-18 |
Rhone Poulenc Agriculture Ltd. |
Phtalazin derivatives and their use as pesticides
|
|
US5587384A
(en)
|
1994-02-04 |
1996-12-24 |
The Johns Hopkins University |
Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
|
|
US5648355A
(en)
|
1994-02-09 |
1997-07-15 |
Kos Pharmaceutical, Inc. |
Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin
|
|
GB9404485D0
(en)
|
1994-03-09 |
1994-04-20 |
Cancer Res Campaign Tech |
Benzamide analogues
|
|
WO1996005306A2
(en)
|
1994-08-12 |
1996-02-22 |
Myriad Genetics, Inc. |
IN VIVO MUTATIONS AND POLYMORPHISMS IN THE 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE
|
|
PT699754E
(pt)
|
1994-08-12 |
2001-04-30 |
Us Health |
Metodo para diagnosticar uma predisposicao para cancro da mama e do ovario
|
|
US5589483A
(en)
|
1994-12-21 |
1996-12-31 |
Geron Corporation |
Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
|
|
US5834466A
(en)
|
1994-12-22 |
1998-11-10 |
The Regents Of The University Of California |
Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
|
|
IL120264A0
(en)
|
1996-02-29 |
1997-06-10 |
Pfizer |
Method of reducing tissue damage associated with non-cardiac ischemia
|
|
CA2205757C
(en)
|
1996-05-30 |
2006-01-24 |
F. Hoffmann-La Roche Ag |
Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii)
|
|
US5888529A
(en)
|
1997-03-28 |
1999-03-30 |
The Regents Of The University Of California |
Ileus treatment method
|
|
AU7484798A
(en)
|
1997-05-13 |
1998-12-08 |
Octamer, Inc. |
Methods for treating inflammation, inflammatory diseases, arthritis and strok e using padprt inhibitors
|
|
AU8784698A
(en)
|
1997-08-15 |
1999-03-08 |
Johns Hopkins University, The |
Method of using selective parp inhibitors to prevent or treat neurotoxicity
|
|
US6635642B1
(en)
|
1997-09-03 |
2003-10-21 |
Guilford Pharmaceuticals Inc. |
PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
|
|
US20020022636A1
(en)
|
1997-09-03 |
2002-02-21 |
Jia-He Li |
Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
|
|
US6291425B1
(en)
|
1999-09-01 |
2001-09-18 |
Guilford Pharmaceuticals Inc. |
Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
|
|
US6197785B1
(en)
|
1997-09-03 |
2001-03-06 |
Guilford Pharmaceuticals Inc. |
Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
|
|
US6426415B1
(en)
|
1997-09-03 |
2002-07-30 |
Guilford Pharmaceuticals Inc. |
Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
|
|
US6514983B1
(en)
|
1997-09-03 |
2003-02-04 |
Guilford Pharmaceuticals Inc. |
Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
|
|
CA2310250A1
(en)
|
1997-11-14 |
1999-05-27 |
August Masaru Watanabe |
Treatment for alzheimer's disease
|
|
WO1999044612A1
(en)
|
1998-03-02 |
1999-09-10 |
Cocensys, Inc. |
Substituted quinazolines and analogs and the use thereof
|
|
FR2776291B1
(fr)
|
1998-03-18 |
2000-06-16 |
Pf Medicament |
Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
|
|
ITMI981671A1
(it)
|
1998-07-21 |
2000-01-21 |
Zambon Spa |
Derivati ftalazinici inibitori della fosfodisterasi 4
|
|
EE05006B1
(et)
|
1999-01-11 |
2008-04-15 |
Agouron Pharmaceuticals, Inc. |
Polü(ADP-riboos)polümeraaside tritsüklilised inhibiitorid ja neid sisaldavad farmatseutilised kompositsioonid
|
|
KR20010101675A
(ko)
|
1999-01-26 |
2001-11-14 |
우에노 도시오 |
2ｈ-프탈라진-1-온 유도체 및 그 유도체를 유효 성분으로하는 약제
|
|
DE19921567A1
(de)
|
1999-05-11 |
2000-11-16 |
Basf Ag |
Verwendung von Phthalazine-Derivaten
|
|
US6465448B1
(en)
|
1999-08-13 |
2002-10-15 |
Case Western Reserve University |
Methoxyamine potentiation of temozolomide anti-cancer activity
|
|
ECSP003637A
(es)
|
1999-08-31 |
2002-03-25 |
Agouron Pharma |
Inhibidores triciclicos de poli (adp-ribosa) polimerasas
|
|
WO2001021615A1
(fr)
|
1999-09-17 |
2001-03-29 |
Yamanouchi Pharmaceutical Co., Ltd. |
Dérivés de benzimidazole
|
|
BR0007174A
(pt)
|
1999-09-28 |
2001-09-04 |
Basf Ag |
Composto, preparação farmacêutica e uso de compostos
|
|
US6476048B1
(en)
|
1999-12-07 |
2002-11-05 |
Inotek Pharamaceuticals Corporation |
Substituted phenanthridinones and methods of use thereof
|
|
US7041675B2
(en)
|
2000-02-01 |
2006-05-09 |
Abbott Gmbh & Co. Kg |
Heterocyclic compounds and their use as PARP inhibitors
|
|
WO2001079184A1
(en)
|
2000-04-18 |
2001-10-25 |
Sumitomo Pharmaceuticals Company, Limited |
Substituted piperazine compounds
|
|
US7122679B2
(en)
|
2000-05-09 |
2006-10-17 |
Cephalon, Inc. |
Multicyclic compounds and the use thereof
|
|
DE10022925A1
(de)
|
2000-05-11 |
2001-11-15 |
Basf Ag |
Substituierte Indole als PARP-Inhibitoren
|
|
WO2001087845A2
(en)
|
2000-05-15 |
2001-11-22 |
Fujisawa Pharmaceutical Co., Ltd. |
N-containing heterocyclic compounds and their use as 5-ht antagonists
|
|
WO2001090077A1
(en)
|
2000-05-19 |
2001-11-29 |
Guilford Pharmaceuticals, Inc. |
Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
|
|
AU9578901A
(en)
|
2000-10-30 |
2002-05-15 |
Kudos Pharm Ltd |
Phthalazinone derivatives
|
|
US7151102B2
(en)
|
2000-10-30 |
2006-12-19 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
|
WO2002044157A2
(en)
|
2000-12-01 |
2002-06-06 |
Iconix Pharmaceuticals, Inc. |
Parb inhibitors
|
|
JPWO2002068407A1
(ja)
|
2001-02-28 |
2004-06-24 |
山之内製薬株式会社 |
ベンゾイミダゾール化合物
|
|
DE60218458T2
(de)
|
2001-05-08 |
2007-11-15 |
Kudos Pharmaceuticals Ltd. |
Isochinolinon derivate als parp inhibitoren
|
|
EP1396488A1
(en)
|
2001-05-23 |
2004-03-10 |
Mitsubishi Pharma Corporation |
Fused heterocyclic compound and medicinal use thereof
|
|
WO2003007959A1
(en)
|
2001-07-16 |
2003-01-30 |
Fujisawa Pharmaceutical Co., Ltd. |
Quinoxaline derivatives which have parp inhibitory action
|
|
WO2003051879A1
(en)
|
2001-12-14 |
2003-06-26 |
Altana Pharma Ag |
Known and novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors
|
|
AUPR975601A0
(en)
|
2001-12-24 |
2002-01-31 |
Fujisawa Pharmaceutical Co., Ltd. |
Quinazolinone derivatives
|
|
AU2002360733A1
(en)
|
2001-12-31 |
2003-07-24 |
Guilford Pharmaceuticals Inc. |
SUBSTITUTED 4,9-DIHYDROCYCLOPENTA(imn)PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES
|
|
AUPS019702A0
(en)
|
2002-01-29 |
2002-02-21 |
Fujisawa Pharmaceutical Co., Ltd. |
Condensed heterocyclic compounds
|
|
US7402580B2
(en)
|
2002-02-19 |
2008-07-22 |
Ono Pharmaceutical Co., Ltd. |
Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient
|
|
US7196085B2
(en)
|
2002-04-30 |
2007-03-27 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
|
US7449464B2
(en)
|
2003-03-12 |
2008-11-11 |
Kudos Pharmaceuticals Limited |
Phthalazinone derivatives
|
|
AU2004220321B2
(en)
*
|
2003-03-12 |
2010-02-25 |
Kudos Pharmaceuticals Ltd |
Phthalazinone derivatives
|
|
TWI338000B
(en)
|
2003-12-01 |
2011-03-01 |
Kudos Pharm Ltd |
Dna damage repair inhibitors for treatment of cancer
|
|
GB0419072D0
(en)
|
2004-08-26 |
2004-09-29 |
Kudos Pharm Ltd |
Phthalazinone derivatives
|
|
EP1791827A1
(en)
*
|
2004-08-26 |
2007-06-06 |
Kudos Pharmaceuticals Limited |
4-heteroarylmethyl substituted phthalazinone derivatives
|
|
JPWO2006137510A1
(ja)
|
2005-06-24 |
2009-01-22 |
小野薬品工業株式会社 |
脳血管障害時における出血低減剤
|
|
GB0521373D0
(en)
|
2005-10-20 |
2005-11-30 |
Kudos Pharm Ltd |
Pthalazinone derivatives
|
|
US7834015B2
(en)
*
|
2006-05-31 |
2010-11-16 |
Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
|
|
PT2698062E
(pt)
*
|
2006-12-28 |
2015-10-19 |
Abbvie Inc |
Inibidores da poli (adp-ribose) polimerase
|
|
US8466150B2
(en)
|
2006-12-28 |
2013-06-18 |
Abbott Laboratories |
Inhibitors of poly(ADP-ribose)polymerase
|
|
US20090023727A1
(en)
|
2007-07-05 |
2009-01-22 |
Muhammad Hashim Javaid |
Phthalazinone derivatives
|
|
AU2008299721A1
(en)
*
|
2007-09-14 |
2009-03-19 |
Astrazeneca Ab |
Phthalazinone derivatives
|