JP2011506673A - 蛍光性化合物 - Google Patents

蛍光性化合物 Download PDF

Info

Publication number
JP2011506673A
JP2011506673A JP2010537989A JP2010537989A JP2011506673A JP 2011506673 A JP2011506673 A JP 2011506673A JP 2010537989 A JP2010537989 A JP 2010537989A JP 2010537989 A JP2010537989 A JP 2010537989A JP 2011506673 A JP2011506673 A JP 2011506673A
Authority
JP
Japan
Prior art keywords
compound
group
soluble polymer
independently
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010537989A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011506673A5 (enExample
Inventor
フェイ マオ，
ワイ−イー レン，
チン−イン チェン，
ハイ ユン フーバー，
Original Assignee
バイオティウム， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40795823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2011506673(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by バイオティウム， インコーポレイテッド filed Critical バイオティウム， インコーポレイテッド
Publication of JP2011506673A publication Critical patent/JP2011506673A/ja
Publication of JP2011506673A5 publication Critical patent/JP2011506673A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/001—Pyrene dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Polyethers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2010537989A 2007-12-14 2008-12-12 蛍光性化合物 Withdrawn JP2011506673A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1395607P 2007-12-14 2007-12-14
PCT/US2008/013698 WO2009078970A1 (en) 2007-12-14 2008-12-12 Fluorescent compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015088997A Division JP2015172199A (ja) 2007-12-14 2015-04-24 蛍光性化合物

Publications (2)

Publication Number Publication Date
JP2011506673A true JP2011506673A (ja) 2011-03-03
JP2011506673A5 JP2011506673A5 (enExample) 2013-01-24

Family

ID=40795823

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010537989A Withdrawn JP2011506673A (ja) 2007-12-14 2008-12-12 蛍光性化合物
JP2015088997A Pending JP2015172199A (ja) 2007-12-14 2015-04-24 蛍光性化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015088997A Pending JP2015172199A (ja) 2007-12-14 2015-04-24 蛍光性化合物

Country Status (5)

Country Link
US (3) US9097667B2 (enExample)
EP (1) EP2223086B2 (enExample)
JP (2) JP2011506673A (enExample)
CN (1) CN101946171B (enExample)
WO (1) WO2009078970A1 (enExample)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011051961A (ja) * 2009-09-04 2011-03-17 Mie Univ 近赤外光発光化合物、その合成法及びその発光法
WO2014065439A1 (en) * 2012-10-26 2014-05-01 Canon Kabushiki Kaisha Cancer cell inhibitory drug and cancer stem-cell detection probe
JP2015504943A (ja) * 2011-12-23 2015-02-16 ゼネラル・エレクトリック・カンパニイ 高密度蛍光色素クラスター
JP2015034809A (ja) * 2013-07-10 2015-02-19 国立大学法人 東京大学 蛍光寿命イメージングプローブ
JP2016108335A (ja) * 2014-12-09 2016-06-20 キヤノン株式会社 化合物、および、前記化合物を有する光学イメージング用造影剤
JP2016519080A (ja) * 2013-03-15 2016-06-30 ビセン メディカル， インコーポレイテッド ４，４−二置換シクロヘキシル架橋ヘプタメチンシアニン色素およびその使用
US10444243B2 (en) 2013-11-27 2019-10-15 University Of Washington Through Its Center For Commercialization Encoded chromophoric polymer particles and methods of use thereof
JP2020527696A (ja) * 2017-06-23 2020-09-10 ナノテンパー・テクノロジーズ・ゲーエムベーハー 分子間及び／又は分子内相互作用を測定するための方法
WO2021125295A1 (ja) * 2019-12-19 2021-06-24 富士フイルム株式会社 化合物及びこれを用いた蛍光標識生体物質
JP2021127305A (ja) * 2020-02-12 2021-09-02 国立大学法人山形大学 スルホニルアニリン骨格を有する化合物若しくはその塩、又はそれらを有する有機蛍光材料
JPWO2021215514A1 (enExample) * 2020-04-24 2021-10-28
JPWO2022025210A1 (enExample) * 2020-07-30 2022-02-03
JP2022053282A (ja) * 2020-09-24 2022-04-05 大塚製薬株式会社 シアニン系色素、標識試薬および検出方法
JPWO2022220163A1 (enExample) * 2021-04-16 2022-10-20
WO2023286526A1 (ja) * 2021-07-13 2023-01-19 太陽ホールディングス株式会社 キサンテン化合物及びその製造方法
WO2023022187A1 (ja) * 2021-08-18 2023-02-23 富士フイルム株式会社 蛍光性化合物及びこれを用いた蛍光標識生体物質

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026891A1 (en) * 2000-09-29 2002-04-04 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
JP2011506673A (ja) 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物
WO2010091126A1 (en) * 2009-02-03 2010-08-12 Biotium, Inc. Xanthene dyes comprising a sulfonamide group
US8658434B2 (en) * 2009-10-28 2014-02-25 Biotium, Inc. Fluorescent pyrene compounds
US9579402B2 (en) * 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
DE102010022110A1 (de) * 2010-05-31 2011-12-01 LMU Universität München Department Chemie Cyaninfarbstoffe als Kontrastmittel zur Unterstützung der Augenchirurgie
WO2012027717A2 (en) * 2010-08-27 2012-03-01 The Texas A&M University System Flourescence labeling reagents and uses thereof
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
FR2967675B1 (fr) * 2010-11-24 2015-02-27 Pf Medicament Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic
EP2655327B1 (en) 2010-12-21 2016-02-24 Pierce Biotechnology, Inc. Fluorescent compounds
FR2973030B1 (fr) 2011-03-25 2013-10-18 Centre Nat Rech Scient Composes a groupements chromophore et photoreactif
DE102011101207B3 (de) 2011-05-11 2012-05-10 Sartorius Stedim Biotech Gmbh Fluoreszenzfarbstoff für pH-Sensor
JP5742494B2 (ja) * 2011-06-10 2015-07-01 住友化学株式会社 高分子化合物及びそれを用いた電子素子
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) * 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2768906B1 (en) 2011-10-18 2019-02-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
CN102558909B (zh) * 2011-12-15 2013-07-31 合肥工业大学 一种端羟基聚醚型高分子荧光染料及其合成方法
CN102608052B (zh) * 2012-02-21 2014-11-05 中国科学院化学研究所 用于诊断白血病的系统
CN102706842B (zh) * 2012-05-24 2015-04-08 中国科学院化学研究所 用于诊断白血病的试剂盒和系统
CN102608051B (zh) * 2012-02-21 2015-04-08 中国科学院化学研究所 用于诊断白血病的试剂盒
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2013130761A1 (en) * 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
CN103374234B (zh) * 2012-04-11 2016-03-30 中国科学院理化技术研究所 一类基于香豆素的近红外的荧光染料及其制备方法与应用
CN104470546B (zh) * 2012-07-20 2018-02-27 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
WO2014035712A1 (en) 2012-08-28 2014-03-06 Pierce Biotechnology, Inc. Benzopyrylium compounds
US10107799B2 (en) 2012-09-18 2018-10-23 Biotium, Inc. Methods, compositions and kits for labeling of proteins
ES2628529T3 (es) 2012-10-24 2017-08-03 Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos
US20140255312A1 (en) * 2013-03-07 2014-09-11 Greg Hermanson Cyanine compounds
CN108299275A (zh) * 2013-03-08 2018-07-20 伊鲁米纳剑桥有限公司 多次甲基化合物和其作为荧光标记物的用途
CN103642261A (zh) * 2013-12-11 2014-03-19 南京晓庄学院 一种新型Alexa Fluor荧光菁染料及其制备方法和应用
US10487089B2 (en) 2014-03-21 2019-11-26 The Trustees Of The University Of Pennsylvania Imaging agents and methods of identifying same
US10245329B2 (en) * 2014-09-08 2019-04-02 Canon Kabushiki Kaisha Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same
CN104710978A (zh) * 2015-02-11 2015-06-17 深圳市前海安测信息技术有限公司 有机电致发光材料及其制备方法
EP3098269B1 (en) 2015-05-28 2022-04-06 Miltenyi Biotec B.V. & Co. KG Bright fluorochromes based on multimerization of fluorescent dyes on branched polyether scaffolds
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
JP2017002000A (ja) * 2015-06-12 2017-01-05 キヤノン株式会社 化合物又はその薬学的に受容可能な塩、及び、前記化合物又はその薬学的に受容可能な塩を有する光音響イメージング用造影剤。
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
CN105254655B (zh) * 2015-11-20 2017-03-22 江汉大学 一种基于bodipy的荧光氨基酸及其合成方法与应用
JPWO2017110387A1 (ja) * 2015-12-25 2018-09-13 富士フイルム株式会社 着色組成物、インクジェット用インク、捺染方法、及び化合物
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof
US9850383B2 (en) * 2016-01-27 2017-12-26 Gene Tools, Llc Uncharged pyrenyloxy sulfonamide dyes for conjugation with biomolecules
CN105688230B (zh) * 2016-02-02 2018-12-11 史春梦 七甲川吲哚花菁染料-聚乙二醇-叶酸复合物及制备方法和应用
KR20190008199A (ko) * 2016-03-30 2019-01-23 시노보 게엠베하 상처에서 미생물 감염의 검출 방법
CN109073556A (zh) * 2016-04-28 2018-12-21 国立大学法人名古屋大学 荧光探针、荧光检测方法及荧光探针的使用方法
US20180092993A1 (en) 2016-09-01 2018-04-05 Life Technologies Corporation Compositions and methods for enhanced fluorescence
CA3052513A1 (en) * 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
JP7344797B2 (ja) * 2017-04-15 2023-09-14 アボット・ラボラトリーズ 早期バイオマーカーを使用する、ヒト対象における外傷性脳損傷の、超急性の診断及び決定の一助となるための方法
US11549017B2 (en) * 2017-09-29 2023-01-10 Perkinelmer Health Sciences, Inc. NIR to SWIR fluorescent compounds for imaging and detection
CN108458964A (zh) * 2017-10-31 2018-08-28 天津协和华美医学诊断技术有限公司 一种抗体组合物及其在淋巴浆细胞性淋巴瘤微小残留检测中的应用
CN108017928A (zh) * 2017-12-15 2018-05-11 淮海工学院 一种用于生物分子标记的聚乙二醇化吲哚菁染料及其制备方法
CN109054013A (zh) * 2018-08-22 2018-12-21 东北大学 一种经修饰的吲哚菁绿及其制备方法
DE102018124199B4 (de) 2018-10-01 2023-09-07 Abberior GmbH Neue Fluoreszenzfarbstoffe, deren Synthese und neue Analyseverfahren für die Glycan-Analytik
CN112147113B (zh) * 2019-06-26 2023-04-07 西南交通大学 香豆素衍生物在二氧化硫定量检测中的应用
CN112442020B (zh) * 2019-09-03 2022-06-14 南京大学 一种可超分辨示踪线粒体-溶酶体相互作用的荧光探针
CN111073884A (zh) * 2020-02-14 2020-04-28 昆明理工大学 提高非编码区域距离＜50bp的SNP中具有功能效应的SNP位点检测准确率的方法
CN111393872B (zh) * 2020-03-18 2022-05-17 宝天生物科技（上海）有限公司 紫外光激发荧光染料及其应用
EP4357437A4 (en) 2021-06-18 2025-02-19 FUJIFILM Corporation COMPOUND AND MARKED BIOMATERIAL USING SAME
US20250084250A1 (en) * 2021-07-21 2025-03-13 Life Technologies Corporation Azaindole cyanine dyes, uses, and methods of preparation
CN114062676B (zh) * 2021-10-19 2024-04-16 杭州迪英加科技有限公司 一种用于防伪的抗体试剂缓冲液及其应用
CN114214061B (zh) * 2022-02-22 2022-05-17 北京大学 一种聚乙二醇修饰的两性离子化荧光探针、制剂及其应用
CN114621248B (zh) * 2022-03-11 2023-11-17 华南理工大学 识别rna和具有光动力的荧光探针及其制备方法
CN115372341B (zh) * 2022-05-14 2025-04-25 西北工业大学深圳研究院 D-赖氨酸衍生物构筑的细菌细胞壁新生肽聚糖的生物发光检测体系及应用方法
WO2024240186A1 (zh) * 2023-05-22 2024-11-28 深圳博芮健制药有限公司 含硫稠环化合物、含其的药物组合物、其制备方法及其应用
CN117890582B (zh) * 2023-12-21 2025-01-21 南京迪安医学检验所有限公司 一种单纯疱疹病毒检测试剂盒及其检测方法
US20250341516A1 (en) * 2024-05-01 2025-11-06 BioLegend, Inc. Compositions for use with multiple fluorophores and methods of using
CN119119042B (zh) * 2024-09-14 2025-11-25 大连理工大学 近红外响应型不对称多甲川花菁染料、其制备方法及应用

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02191674A (ja) * 1988-09-02 1990-07-27 Carnegie Mellon Univ 発光アリールスルホネートシアニン染料を用いた物質の標識ないし検出方法
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
JPH11322796A (ja) * 1998-05-14 1999-11-24 Matsushita Electric Ind Co Ltd 色素標識タンパク質複合体およびその製造方法
JP2001517296A (ja) * 1995-06-06 2001-10-02 ハイピアリアン・インコーポレーテッド ポリオキシヒドロカルビル関連生成物及び蛍光アッセイの方法
JP2002504984A (ja) * 1998-04-08 2002-02-12 ジェネラル・ダイナミクス・ランド・システムズ・インク 車輌用マルチレンジ流体機械変速機
JP2002508760A (ja) * 1997-06-16 2002-03-19 ニユコメド・イメージング・アクシエセルカペト 光音響画像形成方法
US20030013879A1 (en) * 2001-06-22 2003-01-16 Gupta Ram Baboo Process for isolation of monophenolic-bisaryl triazines
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20040152084A1 (en) * 2003-01-31 2004-08-05 Slattum Paul M. Compounds and processes for single-pot attachment of a label to nucleic acid
WO2006008179A2 (en) * 2004-07-22 2006-01-26 Schering Ag Cyanine dyes conjugated with antibodies for the diagnosis of micrometastasis
WO2008093647A1 (ja) * 2007-01-31 2008-08-07 Tohoku University マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4813973A (en) * 1988-01-11 1989-03-21 The University Of Toronto Innovations Foundation Modified, water-soluble polymers containing amide groups reacted with xanthydrol and other dyes
US4877411A (en) * 1988-08-29 1989-10-31 Milliken Research Corporation Method for color mounting the level of finish applied to textile materials and for color coding textile materials: amine-reducible fugitive tints
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5324844A (en) * 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5312808A (en) * 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5650388A (en) * 1989-11-22 1997-07-22 Enzon, Inc. Fractionated polyalkylene oxide-conjugated hemoglobin solutions
US5298643A (en) * 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) * 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5436134A (en) * 1993-04-13 1995-07-25 Molecular Probes, Inc. Cyclic-substituted unsymmetrical cyanine dyes
US5585235A (en) * 1993-04-13 1996-12-17 Diagnescent Technologies, Inc. Fluorescent assay and method that corrects for spectral interference
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
AU2826495A (en) * 1994-06-02 1996-01-04 Enzon, Inc. Method of solubilizing substantially water insoluble materials
US5625048A (en) * 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) * 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5968479A (en) * 1995-01-30 1999-10-19 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
US5756593A (en) * 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
US6008373A (en) * 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5986093A (en) * 1995-06-07 1999-11-16 Carnegie Mellon University Monomethine cyanines rigidized by a two-carbon chain
EP2258726A1 (en) * 1995-06-14 2010-12-08 The Regents of the University of California High affinity human antibodies to c-erbB-2
US5723343A (en) * 1995-08-28 1998-03-03 University Of Florida Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor
US6766183B2 (en) * 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US5714386A (en) * 1996-01-11 1998-02-03 Board Of Trustees Of The Leland Stanford Junior University Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays
US6124128A (en) * 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
US5696157A (en) * 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US6046925A (en) * 1997-04-14 2000-04-04 The Regents Of The University Of California Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins
WO1998048837A1 (en) * 1997-04-30 1998-11-05 Enzon, Inc. Polyalkylene oxide-modified single chain polypeptides
US5866366A (en) * 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US6130101A (en) * 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6251382B1 (en) * 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6485703B1 (en) * 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
GB2341189B (en) 1998-08-31 2001-06-13 Amersham Pharm Biotech Inc Energy transfer dyes
CA2335359C (en) * 1999-04-23 2007-07-17 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
WO2001016375A2 (en) 1999-08-30 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
DE60136719D1 (de) * 2000-08-04 2009-01-08 Molecular Probes Inc Kondensierte ringe enthaltende 1,2-dihydro-7-hydroxychinolinderivate
DE10046215B4 (de) 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
WO2002026891A1 (en) * 2000-09-29 2002-04-04 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
US6387672B1 (en) * 2000-12-04 2002-05-14 Beckman Coulter, Inc. Photo-induced electron transfer fluorescent sensor molecules
DE50200247D1 (de) * 2001-07-03 2004-03-25 Dyomics Gmbh Verbindungen auf der Basis von 2-bzw. 4-Chromenyliden-Merocyaninen und ihre Verwendung
US7041812B2 (en) * 2001-08-29 2006-05-09 Amersham Biosciences Corp Labeled nucleoside polyphosphates
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
DE10160524A1 (de) * 2001-12-05 2003-06-26 Dyomics Gmbh Neue Fluoreszenzmarker mit großem Stokes-Shift
US20030134790A1 (en) * 2002-01-11 2003-07-17 University Of Medicine And Dentistry Of New Jersey Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
AU2003272680A1 (en) * 2002-09-23 2004-04-08 Chromagen, Inc. Novel green and orange fluorescent labels and their uses
DE10356130A1 (de) * 2003-11-28 2005-06-23 Dyomics Gmbh Neue Polymethinfarbstoffe auf Cumarin-Basis mit einstellbarem Stokes-Shift
US7563907B2 (en) * 2002-12-05 2009-07-21 Dyomics Gmbh Compounds based on polymethines
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
US7456277B2 (en) * 2004-08-09 2008-11-25 Silverbrook Research Pty Ltd Method of minimizing absorption of visible light in ink compositions comprising IR-absorbing metal-cyanine dyes
CA2595682A1 (en) * 2005-01-31 2006-08-03 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies
AU2006249340A1 (en) * 2005-05-26 2006-11-30 Ensemble Discovery Corportion Biodetection by nucleic acid-templated chemistry
US7561888B2 (en) 2005-07-15 2009-07-14 Cisco Technology, Inc. Efficiently bounding the location of a mobile communications device
DE502006007823D1 (de) * 2005-12-05 2010-10-21 Dyomics Gmbh Hydrophile Marker auf der Basis von diastereomeren Cyaninen
DE102006029454A1 (de) * 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
US8586743B2 (en) * 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
JP2011506673A (ja) 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02191674A (ja) * 1988-09-02 1990-07-27 Carnegie Mellon Univ 発光アリールスルホネートシアニン染料を用いた物質の標識ないし検出方法
JPH09127115A (ja) * 1995-01-30 1997-05-16 Dai Ichi Pure Chem Co Ltd 診断用マーカー
JP2001517296A (ja) * 1995-06-06 2001-10-02 ハイピアリアン・インコーポレーテッド ポリオキシヒドロカルビル関連生成物及び蛍光アッセイの方法
JP2002508760A (ja) * 1997-06-16 2002-03-19 ニユコメド・イメージング・アクシエセルカペト 光音響画像形成方法
JP2002504984A (ja) * 1998-04-08 2002-02-12 ジェネラル・ダイナミクス・ランド・システムズ・インク 車輌用マルチレンジ流体機械変速機
JPH11322796A (ja) * 1998-05-14 1999-11-24 Matsushita Electric Ind Co Ltd 色素標識タンパク質複合体およびその製造方法
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20030013879A1 (en) * 2001-06-22 2003-01-16 Gupta Ram Baboo Process for isolation of monophenolic-bisaryl triazines
US20040152084A1 (en) * 2003-01-31 2004-08-05 Slattum Paul M. Compounds and processes for single-pot attachment of a label to nucleic acid
WO2006008179A2 (en) * 2004-07-22 2006-01-26 Schering Ag Cyanine dyes conjugated with antibodies for the diagnosis of micrometastasis
WO2008093647A1 (ja) * 2007-01-31 2008-08-07 Tohoku University マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN7013004060; Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ＳＰＩＥ Ｖｏｌ．３１９６, 1998, Ｐ．９８-１０２ *

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011051961A (ja) * 2009-09-04 2011-03-17 Mie Univ 近赤外光発光化合物、その合成法及びその発光法
JP2015504943A (ja) * 2011-12-23 2015-02-16 ゼネラル・エレクトリック・カンパニイ 高密度蛍光色素クラスター
WO2014065439A1 (en) * 2012-10-26 2014-05-01 Canon Kabushiki Kaisha Cancer cell inhibitory drug and cancer stem-cell detection probe
US10278965B2 (en) 2012-10-26 2019-05-07 Canon Kabushiki Kaisha Method of detecting cancer stem cell, method of screening cancer stem cell, and method of inhibiting cancer stem cell
US11193932B2 (en) 2013-03-15 2021-12-07 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
JP7018913B2 (ja) 2013-03-15 2022-02-14 ビセン メディカル， インコーポレイテッド ４，４－二置換シクロヘキシル架橋ヘプタメチンシアニン色素およびその使用
JP2016519080A (ja) * 2013-03-15 2016-06-30 ビセン メディカル， インコーポレイテッド ４，４−二置換シクロヘキシル架橋ヘプタメチンシアニン色素およびその使用
JP2019151665A (ja) * 2013-03-15 2019-09-12 ビセン メディカル， インコーポレイテッド ４，４−二置換シクロヘキシル架橋ヘプタメチンシアニン色素およびその使用
US10473658B2 (en) 2013-03-15 2019-11-12 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
JP2015034809A (ja) * 2013-07-10 2015-02-19 国立大学法人 東京大学 蛍光寿命イメージングプローブ
US10444243B2 (en) 2013-11-27 2019-10-15 University Of Washington Through Its Center For Commercialization Encoded chromophoric polymer particles and methods of use thereof
US11674964B2 (en) 2013-11-27 2023-06-13 University Of Washington Through Its Center For Commercialization Encoded chromophoric polymer particles and methods of use thereof
US11221336B2 (en) 2013-11-27 2022-01-11 University Of Washington Through Its Center For Commercialization Encoded chromophoric polymer particles and methods of use thereof
JP2016108335A (ja) * 2014-12-09 2016-06-20 キヤノン株式会社 化合物、および、前記化合物を有する光学イメージング用造影剤
JP2020527696A (ja) * 2017-06-23 2020-09-10 ナノテンパー・テクノロジーズ・ゲーエムベーハー 分子間及び／又は分子内相互作用を測定するための方法
JP7144461B2 (ja) 2017-06-23 2022-09-29 ナノテンパー・テクノロジーズ・ゲーエムベーハー 分子間及び／又は分子内相互作用を測定するための方法
WO2021125295A1 (ja) * 2019-12-19 2021-06-24 富士フイルム株式会社 化合物及びこれを用いた蛍光標識生体物質
JPWO2021125295A1 (enExample) * 2019-12-19 2021-06-24
JP7359869B2 (ja) 2019-12-19 2023-10-11 富士フイルム株式会社 化合物及びこれを用いた蛍光標識生体物質
JP2021127305A (ja) * 2020-02-12 2021-09-02 国立大学法人山形大学 スルホニルアニリン骨格を有する化合物若しくはその塩、又はそれらを有する有機蛍光材料
JP7479667B2 (ja) 2020-02-12 2024-05-09 国立大学法人山形大学 スルホニルアニリン骨格を有する化合物若しくはその塩、又はそれらを有する有機蛍光材料
WO2021215514A1 (ja) * 2020-04-24 2021-10-28 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JP7441306B2 (ja) 2020-04-24 2024-02-29 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JPWO2021215514A1 (enExample) * 2020-04-24 2021-10-28
WO2022025210A1 (ja) * 2020-07-30 2022-02-03 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JPWO2022025210A1 (enExample) * 2020-07-30 2022-02-03
JP7423789B2 (ja) 2020-07-30 2024-01-29 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JP2022053282A (ja) * 2020-09-24 2022-04-05 大塚製薬株式会社 シアニン系色素、標識試薬および検出方法
WO2022220163A1 (ja) * 2021-04-16 2022-10-20 株式会社ニコン 化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法
JPWO2022220163A1 (enExample) * 2021-04-16 2022-10-20
JP7660821B2 (ja) 2021-04-16 2025-04-14 株式会社ニコン 化合物、ミトコンドリア染色剤およびミトコンドリアの蛍光染色方法
JPWO2023286526A1 (enExample) * 2021-07-13 2023-01-19
WO2023286526A1 (ja) * 2021-07-13 2023-01-19 太陽ホールディングス株式会社 キサンテン化合物及びその製造方法
WO2023022187A1 (ja) * 2021-08-18 2023-02-23 富士フイルム株式会社 蛍光性化合物及びこれを用いた蛍光標識生体物質

Also Published As

Publication number Publication date
CN101946171A (zh) 2011-01-12
EP2223086A1 (en) 2010-09-01
US20160033520A1 (en) 2016-02-04
EP2223086B2 (en) 2016-06-01
WO2009078970A1 (en) 2009-06-25
CN101946171B (zh) 2014-03-12
EP2223086A4 (en) 2011-05-04
US20090305410A1 (en) 2009-12-10
EP2223086B1 (en) 2013-03-20
US9097667B2 (en) 2015-08-04
JP2015172199A (ja) 2015-10-01
US20180156810A1 (en) 2018-06-07
US9791450B2 (en) 2017-10-17

Similar Documents

Publication Publication Date Title
US9791450B2 (en) Fluorescent compounds
US10053484B2 (en) Heterocycle-substituted xanthene dyes
CN102300861B (zh) 包含磺酰胺基团的呫吨染料
AU2017203855B2 (en) Application of reduced dyes in imaging
KR102846425B1 (ko) 시아닌계 화합물, 이를 포함하는 생체분자 표지용 염료, 키트 및 조영제 조성물
JP5819426B2 (ja) 水溶性の分子内橋を持つ発光性色素およびそれらの生物学的複合体
JP2002508428A (ja) 硬化トリメチンシアニン色素
US8658434B2 (en) Fluorescent pyrene compounds
AU2003234038B2 (en) Differential analysis of cell surface proteins on closed membrane structures by labelling with dyes in the presence of an internal standard
CN108473505B (zh) 聚芴并[4,5-cde]氧杂环庚三烯偶联物及其在分析物检测方法中的用途
US20230257587A1 (en) Fluorenyl cyanine dyes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111209

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140204

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140212

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140304

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140311

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140507

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150424

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150525

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20150527