JP2002508760A - 光音響画像形成方法 - Google Patents
光音響画像形成方法Info
- Publication number
- JP2002508760A JP2002508760A JP50396399A JP50396399A JP2002508760A JP 2002508760 A JP2002508760 A JP 2002508760A JP 50396399 A JP50396399 A JP 50396399A JP 50396399 A JP50396399 A JP 50396399A JP 2002508760 A JP2002508760 A JP 2002508760A
- Authority
- JP
- Japan
- Prior art keywords
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- defined above
- radiation
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ヒトまたはヒト以外の動物の生体またはその一部の画像を作成する方法であ って、放射線吸収成分および/または圧力誘発成分を含む生理学的に許容し得る 造影剤をこの体に投与し、この体を放射線に曝露し、この体内で発生する圧力波 を上記の放射線によって検出し、この投与された造影剤の入った上記の体の少な くとも一部分の光音響画像がこの圧力波から作成されることからなる画像の作成 方法。 2.ヒトまたはヒト以外の動物の生体またはその一部を治療するか、または診断 するこの体の光音響画像を作成することを包含する方法における、この体に投与 するための造影剤を製造するために、放射線吸収成分および/または圧力誘発成 分を含む生理学的に許容し得る造影剤の使用。 3.波長が300〜1300nmである放射線を使用する請求項1または2記載の方法ま たは使用。 4.波長が600〜1300nmである放射線を使用する請求項3記載の方法または使用 。 5.波長が625〜1200nmである放射線を使用する請求項3記載の方法または使用 。 6.波長が650〜1000nmである放射線を使用する請求項3記載の方法または使用 。 7.波長が0.1μmより短いX線またはガンマ線が使用される請求項1または2記 載の方法または使用。 8.周波数が0.3〜30GHzであるマイクロ波放射線が使用される請求項1または2 記載の方法または使用。 9.放射線の短いパルスが使用される請求項1から8のいずれか一項記載の方法 または使用。 10.放射線吸収成分が染料化合物を含有する請求項1から6のいずれか一項記載 の方法または使用。 11.染料化合物が、シアニン染料、スクアリリウム染料、クロコニウム、フタロ シアニン染料、ナフタロシアニン染料、キサンテン染料、ジベンズキサンテン染 料、メロシアニン染料、トリフェニルメタン染料またはポルフィリンからなる群 から選択される請求項10記載の方法または使用。 12.染料化合物が式I: 〔式中、各々のZ1は 水素、 ヒドロキシル、カルボキシル、スルホネート、ホスホネート並びに、ω−ヒ ドロキシポリ(エチレンオキシジル)およびω−メトキシポリ(エチレンオキシジ ル)のような分子量が約50,000までであってよいポリ(アルキレンオキシジル)か らなる群から選択される置換基で場合によっては置換されているメチル基、 ヒドロキシル、カルボキシル、スルホネート、ホスホネート並びにω−ヒドロ キシポリ(エチレンオキシジル)およびω−メトキシポリ(エチレンオキシジル) のような分子量が約50,000までであってよいポリ(アルキレンオキシジル)からな る群から選択される一つまたは二つの置換基で場合によっては置換されているエ チル基、 ヒドロキシル、カルボキシル、スルホネート、ホスホネート並びにω−ヒドロ キシポリ(エチレンオキシジル)およびω−メトキシポリ(エチレンオキシジル) のような分子量が約50,000までであってよいポリ(アルキレンオキシジル)からな る群から選択される一つまたは二つの置換基で場合によっては置換されているエ チレン基、 アルキル部分が上記に定義したように場合によって置換されているC3 〜C16アルキル基、 アルキル部分が上記に定義したように場合によって置換されているC1〜C16ア ルコキシルエーテル基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 カルボキシアルキルエステル基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 オキシカルボニルアルキルエステル基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 カルボニルアミノアルキルアミド基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 アミノカルボニルアルキルアミド基、 カルボキシレート基であってよいカルボン酸基、 スルホネート基、 ヒドロキシル基、 ホスフェート基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 スルホンアミドアルキル基、 アルキル部分が上記に定義したように場合によっては置換されているC1〜C16 アミノスルホニルアルキル基、 アルキル部分が上記に定義したように場合によって置換されているC1〜C16ア ミノカルボニルアミノアルキル尿素基、 アルキル部分が上記に定義したように場合によって置換されているC1〜C16ア ミノチオカルボニルアミノアルキルチオ尿素基、 アルキル部分が上記に定義したように場合によって置換されているフェニル− C1〜C16−アルキル基、 アルキル部分が上記に定義したように場合によって置換されているフェノキシ −C1〜C16−アルキル基、 アルキル部分が上記に定義したように場合によって置換されているC1〜C16フ ェニルオキシアルキル基、 アルキル部分が上記に定義したように場合によって置換されているオキシフェ ノキシ−C1〜C16−アルキル基、 分子量が約50,000までである、ヒドロキシポリ(エチレンオキシジル)およびメ トキシポリ(エチレンオキシジル)のようなポリ(アルキレンオキシジル)基、 および ベンズ〔e〕芳香族環、ベンズ〔f〕芳香族環、またはベンズ〔g〕芳香族環 からなる環状の芳香族環であって、e、f、およびgは、鋳型としてのインドー ル構造に関して定義され、この環の各々が上記に定義したようにC1〜C16アルキ ル、C1〜C16アルコキシル、カルボキシル、スルホネート、スルホンアミド、フ ェニル、ポリ(アルキレンオキシジル)またはフェノキシル基で置換されていて よいもの からなる群から独立的に選択され; 各々のR1'はメチルと、アルキルが場合によっては上記に定義したように置換 されているアルキル基を含むC2〜C16アルキル基とからなる群から独立的に選択 され; 各々のXは、O、N-R1'、S、Se、Te、CH=CHおよび(CH3)2Cからなる群から独 立的に選択され;また Q1は nが1〜6の値を有する(CH=CH)n、 (式中、Z2はH、クロロ、アルキルが場合によっては上記に定義したように置換 されているO−アルキル、S−アルキル、ポリ(アルキレンオ キシジル)が上記に定義した通りでありまたこれに、ω−末端に他の染料が結合 しているポリ(アルキレンオキシド)が含まれるO−ポリ(アルキレンオキシジ ル)、S−ポリ(アルキレンオキシジル)、フェニル基が、場合によっては上記に 定義したように置換されているアルキル基で置換されていてよいO−フェニル、 S−フェニル、上記に定義したO−アルキル基、上記に定義したS−アルキル基 、アミノチオカルボニルアミノアルキル基およびアミノチオカルボニルアミノフ ェニル基からなる群から選択され、また Z3はH、カルボキシレート、およびアルキルが上記に定義した通りであるカル ボキシアルキル、アルキルが上記に定義した通りであるカルボニルアミノアルキ ルおよびフェニルが上記に定義した通りであるカルボニルアミノフェニル、そし て からなる群から選択される) からなる群から選択され、また Z-は生理学的に許容し得る対向イオン、好ましくはI、Br、ClまたはOAcで ある〕 を有する請求項10記載の方法または使用。 13.染料化合物が式II: (式中、nは1〜6の値をもつ整数であり、 同じであるか異なっていてよい各々のR1は水素原子または可溶化基を表し、ま たは隣接するR1基が、これらが結合する環炭素とともに環状構 造、好ましくは5員環または6員環を構成してよく、 同じであるか異なっていてよい各々のR2は水素原子または親油基はまた、各 々のR2は一つまたはそれ以上の可溶化基と結合している、場合によっては不飽和 であるC2〜C8のアルキル基であってよく、 同じであるか異なっていてよい各々のXはO、S、-CH=CH-またはC(R3)2を それぞれ表し、同じであるか異なっていてよい各々のR3は水素原子またはより好 ましくはメチル基またはエチル基を表し、 Zは生理学的に許容し得る対向イオン、好ましくはI、BrまたはClである) を有する請求項10記載の方法または使用。 14.放射線吸収成分が、原子番号が20より大きい元素を含む請求項7記載の方法 または使用。 15.放射線吸収成分がバリウム、タングステン、沃素、臭素、ビスマスおよびラ ンタニド元素から選択される元素を含む請求項14記載の方法または使用。 16.放射線吸収成分が、1分子あたり沃素原子を少なくとも1個、好ましくは1 分子あたり少なくとも3個、より好ましくは1分子あたり少なくとも6個含む沃 素化化合物を含有する請求項7記載の方法または使用。 17.放射線吸収成分が、著しく沃素化された芳香族化合物を含有する請求項14記 載の方法または使用。 18.放射線吸収成分が、生理学的に許容し得る液体中の固体粒子の懸濁液の形態 である請求項7記載の方法または使用。 19.放射線吸収成分が、ミセルまたはリポソーム中にカプセル封入された固体、 液体またはガス状の物質の形態である請求項7記載の方法または使用。 20.ガス状物質がキセノンである請求項19記載の方法または使用。 21.造影剤が生理学的に許容し得る液体中の固体または液体の粒子の懸濁 液の形態である請求項7記載の方法または使用。 22.粒子が100〜500nmの直径を有する請求項18または21記載の方法または使用。 23.造影剤がミセルまたはリポソーム中にカプセル封入された固体または液体の 物質の形態である請求項7記載の方法または使用。 24.造影剤が生理学的に許容し得る液体中の超常磁性粒子の懸濁液の形態である 請求項8記載の方法または使用。 25.粒子が5〜30nmの直径を有する請求項24記載の方法または使用。 26.造影剤がCO2O3、MnO2、NiOおよびCuOから選択されるセラミック物質の粒子 の生理学的に許容し得る液体中の懸濁液の形態である請求項8記載の方法または 使用。 27.造影剤が活性な標的化用配位子を含む請求項1から6のいずれか一項記載の 方法または使用。 28.活性な標的化用配位子がジヒドロホレート還元酵素受容体に結合し得る請求 項27記載の方法または使用。 29.圧力誘発成分がガスである請求項1から28のいずれか一項記載の方法または 使用。 30.ガスがキセノンまたはペルフルオロカーボンである請求項29記載の方法また は使用。 31.圧力誘発成分がガスの前駆体である請求項1から30のいずれか一項記載の方 法または使用。 32.ガスの前駆体がグラファイト、アミノマロネート、カーボネート、バイカー ボネート、生理学的に許容し得るジアゾニウム化合物、-CO-O-CR1R2-O-CO-OR3の 型の基を含むカーボネートエステルおよびβ−ケト酸から選択される請求項31記 載の方法または使用。 33.圧力誘発成分が水中油乳濁液の液滴である請求項1から32のいずれか−項記 載の方法または使用。 34.乳濁液の液滴が光吸収性の親油性染料を含む請求項33記載の方法または使用 。 35.乳濁液の液滴が疎水性の光吸収性粒子を含む請求項33記載の方法または使用 。 36.光吸収性粒子がグラファイトの粒子および/または表面が変性された顔料の 粒子からなる請求項34記載の方法または使用。 37.請求項10から20のいずれか一項に記載の放射線吸収成分と、請求項27から34 のいずれか一項に記載の圧力誘発成分とをともに含み、これらの成分が生きてい るヒトまたはヒト以外の動物に別個に、同時にまたは連続的に投与するのに好適 である、請求項1または2記載の方法または使用のための構成物のキット。 38.造影剤が界面活性剤分子に結合する少なくとも一つの発色団基を含む請求項 1または2記載の方法または使用。
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GBGB9712524.9A GB9712524D0 (en) | 1997-06-16 | 1997-06-16 | Method |
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PCT/GB1998/001751 WO1998057667A1 (en) | 1997-06-16 | 1998-06-16 | Methods of photoacoustic imaging |
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AT (1) | ATE247491T1 (ja) |
AU (1) | AU8115898A (ja) |
DE (1) | DE69817360T2 (ja) |
ES (1) | ES2206951T3 (ja) |
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1997
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- 1998-06-16 DE DE69817360T patent/DE69817360T2/de not_active Expired - Lifetime
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Cited By (5)
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JP2011506673A (ja) * | 2007-12-14 | 2011-03-03 | バイオティウム, インコーポレイテッド | 蛍光性化合物 |
JP2015172199A (ja) * | 2007-12-14 | 2015-10-01 | バイオティウム, インコーポレイテッド | 蛍光性化合物 |
JP2012224610A (ja) * | 2010-08-24 | 2012-11-15 | Canon Inc | 粒子及び前記粒子を有する光イメージング用造影剤 |
JP2014502533A (ja) * | 2010-12-22 | 2014-02-03 | コーニンクレッカ フィリップス エヌ ヴェ | 微小気泡ベースの造影剤による光音響信号強調 |
JP2014520141A (ja) * | 2011-06-20 | 2014-08-21 | コーニンクレッカ フィリップス エヌ ヴェ | 薬剤イメージング |
Also Published As
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EP0996469A1 (en) | 2000-05-03 |
AU8115898A (en) | 1999-01-04 |
DE69817360T2 (de) | 2004-06-09 |
ATE247491T1 (de) | 2003-09-15 |
EP0996469B1 (en) | 2003-08-20 |
WO1998057667A1 (en) | 1998-12-23 |
JP4436461B2 (ja) | 2010-03-24 |
DE69817360D1 (de) | 2003-09-25 |
GB9712524D0 (en) | 1997-08-20 |
ES2206951T3 (es) | 2004-05-16 |
US6662040B1 (en) | 2003-12-09 |
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