DE69817360D1 - Verfahren zur photoakustische bilderzeugung - Google Patents

Verfahren zur photoakustische bilderzeugung

Info

Publication number
DE69817360D1
DE69817360D1 DE69817360T DE69817360T DE69817360D1 DE 69817360 D1 DE69817360 D1 DE 69817360D1 DE 69817360 T DE69817360 T DE 69817360T DE 69817360 T DE69817360 T DE 69817360T DE 69817360 D1 DE69817360 D1 DE 69817360D1
Authority
DE
Germany
Prior art keywords
radiation
image generation
photoacoustic image
generating
contrast agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69817360T
Other languages
English (en)
Other versions
DE69817360T2 (de
Inventor
Mark Henrichs
Morten Eriksen
Pal Rongved
Hans Gunther
Allen Snow
Robert Hollister
Lynn Mcintire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Application granted granted Critical
Publication of DE69817360D1 publication Critical patent/DE69817360D1/de
Publication of DE69817360T2 publication Critical patent/DE69817360T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0078—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion microemulsion, nanoemulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0404—X-ray contrast preparations containing barium sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/949—Radiation emitter using nanostructure

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Holo Graphy (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Semiconductor Lasers (AREA)
DE69817360T 1997-06-16 1998-06-16 Verfahren zur photoakustische bilderzeugung Expired - Lifetime DE69817360T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9712524.9A GB9712524D0 (en) 1997-06-16 1997-06-16 Method
GB9712524 1997-06-16
PCT/GB1998/001751 WO1998057667A1 (en) 1997-06-16 1998-06-16 Methods of photoacoustic imaging

Publications (2)

Publication Number Publication Date
DE69817360D1 true DE69817360D1 (de) 2003-09-25
DE69817360T2 DE69817360T2 (de) 2004-06-09

Family

ID=10814249

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69817360T Expired - Lifetime DE69817360T2 (de) 1997-06-16 1998-06-16 Verfahren zur photoakustische bilderzeugung

Country Status (9)

Country Link
US (1) US6662040B1 (de)
EP (1) EP0996469B1 (de)
JP (1) JP4436461B2 (de)
AT (1) ATE247491T1 (de)
AU (1) AU8115898A (de)
DE (1) DE69817360T2 (de)
ES (1) ES2206951T3 (de)
GB (1) GB9712524D0 (de)
WO (1) WO1998057667A1 (de)

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DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
JP2001299676A (ja) * 2000-04-25 2001-10-30 Fuji Photo Film Co Ltd センチネルリンパ節検出方法および検出システム
IL138073A0 (en) 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
DK1593091T3 (da) 2003-01-25 2013-10-28 Seno Medical Instr Inc Optoakustisk afbildning med høj kontrast ved anvendelse af ikke-sfæriske nanopartikler
CA2609345A1 (en) * 2005-05-24 2006-11-30 Baker Hughes Incorporated A method and apparatus for reservoir characterization using photoacoustic spectroscopy
US7387021B2 (en) * 2005-05-24 2008-06-17 Baker Hughes Incorporated Method and apparatus for reservoir characterization using photoacoustic spectroscopy
EP1889124A4 (de) 2005-05-26 2009-06-03 Araz Yacoubian Breitband-darsteller
US20070015992A1 (en) * 2005-06-30 2007-01-18 General Electric Company System and method for optoacoustic imaging
WO2007100937A2 (en) * 2006-01-19 2007-09-07 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
EP2001362A4 (de) * 2006-01-20 2010-10-06 Seno Medical Instr Inc Quantitative optoakustische tomografie mit verstärkten kontrasten
WO2008067438A2 (en) * 2006-11-29 2008-06-05 The Regents Of University Of Michigan System and method for photoacoustic guided diffuse optical imaging
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US20080228073A1 (en) * 2007-03-12 2008-09-18 Silverman Ronald H System and method for optoacoustic imaging of peripheral tissues
US20080241065A1 (en) * 2007-03-27 2008-10-02 Benaron David A Systems and methods for the detection and analysis of in vivo circulating cells, entities, and nanobots
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CA2731409C (en) 2008-07-25 2016-01-05 Daniel Razansky Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers
US8426933B2 (en) * 2008-08-08 2013-04-23 Araz Yacoubian Broad spectral band sensor
JP5241465B2 (ja) * 2008-12-11 2013-07-17 キヤノン株式会社 光音響イメージング装置および光音響イメージング方法
EP2410990A4 (de) * 2009-03-19 2015-05-20 Marval Biosciences Inc Zusammensetzungen und verfahren zur kontrastverstärkung in der bildgebung
JP5566456B2 (ja) 2009-06-29 2014-08-06 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー） 被写体を熱音響撮像するための撮像装置及び撮像方法、コンピュータプログラム並びにコンピュータで読み取り可能な記憶媒体を備える装置
US20110016962A1 (en) * 2009-07-21 2011-01-27 Baker Hughes Incorporated Detector for Characterizing a Fluid
WO2011012274A1 (en) 2009-07-27 2011-02-03 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Imaging device and method for optoacoustic imaging of small animals
US8658434B2 (en) * 2009-10-28 2014-02-25 Biotium, Inc. Fluorescent pyrene compounds
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WO2012026608A1 (en) * 2010-08-24 2012-03-01 Canon Kabushiki Kaisha Polymeric particle and hydrophilic dye having a sulfonate group encapsulated within the particle
JP6184327B2 (ja) * 2010-12-22 2017-08-23 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． イメージング造影剤及びイメージング造影剤を使用するシステム
WO2012136813A2 (en) * 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN103619258B (zh) * 2011-06-20 2016-12-21 皇家飞利浦有限公司 药剂成像
US8843190B2 (en) * 2011-07-21 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Medical screening and diagnostics based on air-coupled photoacoustics
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WO2014013732A1 (en) * 2012-07-20 2014-01-23 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
EP2742854B1 (de) 2012-12-11 2021-03-10 iThera Medical GmbH Tragbare Vorrichtung und Verfahren für tomographische optoakustische Bildgebung eines Objekts
EP2754388B1 (de) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System und Verfahren zur optoakustischen Abbildung eines Objekts mit verbesserter Qualität und hoher Rate
US9808539B2 (en) 2013-03-11 2017-11-07 Endomagnetics Ltd. Hypoosmotic solutions for lymph node detection
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
EP3003396B1 (de) * 2013-05-24 2020-04-08 University Health Network Multimodale optische ct-mittel
US10456044B2 (en) 2013-11-22 2019-10-29 Massachusetts Institute Of Technology Systems and methods for generating non-contact ultrasound images using photoacoustic energy
EP3076860B1 (de) * 2013-12-06 2019-04-24 Agency for Science, Technology And Research Verfahren zur bildgebung von lebendgewebe
EP3164111B1 (de) * 2014-07-02 2019-04-03 The Research Foundation for the State University of New York Tensidausgeblasene mizellenzusammensetzungen mit hohem belastung-zu-tensid-verhältnis
WO2016063817A1 (en) * 2014-10-24 2016-04-28 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
KR101638588B1 (ko) * 2015-04-23 2016-07-12 포항공과대학교 산학협력단 소화기관의 비침습적 이미징 장치
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US10602931B2 (en) 2016-03-14 2020-03-31 Massachusetts Institute Of Technology System and method for non-contact ultrasound with enhanced safety
ITUA20164756A1 (it) * 2016-06-29 2017-12-29 Bio On Spa Nanoparticelle polimeriche biocompatibili contenenti nanostrutture metalliche funzionali, processo di preparazione e relativo uso in campo diagnostico e/o terapeutico.
US10780185B2 (en) 2017-01-30 2020-09-22 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential
DE102017201543A1 (de) * 2017-01-31 2018-08-02 Siemens Healthcare Gmbh Quantifizierung von Blutverlust auf Basis einer Computertomographie mit einem direkt konvertierenden Detektor
CN106990048B (zh) * 2017-05-18 2020-04-14 厦门大学 一种基于光声成像技术的活细菌检测方法
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CN109985252A (zh) * 2019-05-10 2019-07-09 南京鼓楼医院 一种新型双模态小分子造影剂及其制备方法与应用
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Also Published As

Publication number Publication date
US6662040B1 (en) 2003-12-09
EP0996469A1 (de) 2000-05-03
JP4436461B2 (ja) 2010-03-24
WO1998057667A1 (en) 1998-12-23
JP2002508760A (ja) 2002-03-19
EP0996469B1 (de) 2003-08-20
DE69817360T2 (de) 2004-06-09
AU8115898A (en) 1999-01-04
GB9712524D0 (en) 1997-08-20
ATE247491T1 (de) 2003-09-15
ES2206951T3 (es) 2004-05-16

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