WO1998057667B1 - Methods of photoacoustic imaging - Google Patents

Methods of photoacoustic imaging

Info

Publication number
WO1998057667B1
WO1998057667B1 PCT/GB1998/001751 GB9801751W WO9857667B1 WO 1998057667 B1 WO1998057667 B1 WO 1998057667B1 GB 9801751 W GB9801751 W GB 9801751W WO 9857667 B1 WO9857667 B1 WO 9857667B1
Authority
WO
WIPO (PCT)
Prior art keywords
absorbing
light
radiation
particles
contrast agent
Prior art date
Application number
PCT/GB1998/001751
Other languages
French (fr)
Other versions
WO1998057667A1 (en
Filing date
Publication date
Priority claimed from GBGB9712524.9A external-priority patent/GB9712524D0/en
Application filed filed Critical
Priority to AT98930870T priority Critical patent/ATE247491T1/en
Priority to DE69817360T priority patent/DE69817360T2/en
Priority to EP98930870A priority patent/EP0996469B1/en
Priority to JP50396399A priority patent/JP4436461B2/en
Priority to AU81158/98A priority patent/AU8115898A/en
Publication of WO1998057667A1 publication Critical patent/WO1998057667A1/en
Publication of WO1998057667B1 publication Critical patent/WO1998057667B1/en
Priority to US09/458,008 priority patent/US6662040B1/en

Links

Abstract

The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

Claims

64
AMENDED CLAIMS
[received by the International Bureau on 8 January 1999 (08.01.99); new claim 38 added; remaining claims unchanged (1 page)]
32 wherein said pressure-inducing component is an oil-in- water emulsion drople .
34. Method or use aε claimed in claim 33 wherein said emulsion droplet comprises a light-absorbing, lipophilic dye.
35. Method or use as claimed in claim 33 wherein said emulsion droplet contains hydrophobic light-absorbing particles.
36. Method or use as claimed in claim 34 wherein said light-absorbing particles comprise particles of graphite and/or surface-modified pigment particles.
37. A kit of parts for a method or use as claimed in claim 1 or 2 comprising both a radiation absorbing component according to any one of claims 10 to 20 and a pressure-inducing component according to any one of claims 27 to 34, said components being suitable for separate, simultaneous or sequential administration to an animate human or non-human animal.
38. Method or use as claimed in claim 1 or 2 wherein said contrast agent comprises at least one chromophoric group attached to a surfactant molecule .
PCT/GB1998/001751 1997-06-16 1998-06-16 Methods of photoacoustic imaging WO1998057667A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT98930870T ATE247491T1 (en) 1997-06-16 1998-06-16 METHOD FOR PHOTOACOUSTIC IMAGE GENERATION
DE69817360T DE69817360T2 (en) 1997-06-16 1998-06-16 METHOD FOR PHOTOACOUSTIC IMAGE GENERATION
EP98930870A EP0996469B1 (en) 1997-06-16 1998-06-16 Methods of photoacoustic imaging
JP50396399A JP4436461B2 (en) 1997-06-16 1998-06-16 Photoacoustic image forming method
AU81158/98A AU8115898A (en) 1997-06-16 1998-06-16 Methods of photoacoustic imaging
US09/458,008 US6662040B1 (en) 1997-06-16 1999-12-10 Methods of photoacoustic imaging

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9712524.9A GB9712524D0 (en) 1997-06-16 1997-06-16 Method
GB9712524.9 1997-06-16
US4990997P 1997-06-18 1997-06-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/458,008 Continuation US6662040B1 (en) 1997-06-16 1999-12-10 Methods of photoacoustic imaging

Publications (2)

Publication Number Publication Date
WO1998057667A1 WO1998057667A1 (en) 1998-12-23
WO1998057667B1 true WO1998057667B1 (en) 1999-02-18

Family

ID=10814249

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001751 WO1998057667A1 (en) 1997-06-16 1998-06-16 Methods of photoacoustic imaging

Country Status (9)

Country Link
US (1) US6662040B1 (en)
EP (1) EP0996469B1 (en)
JP (1) JP4436461B2 (en)
AT (1) ATE247491T1 (en)
AU (1) AU8115898A (en)
DE (1) DE69817360T2 (en)
ES (1) ES2206951T3 (en)
GB (1) GB9712524D0 (en)
WO (1) WO1998057667A1 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19917713A1 (en) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Short-chain peptide-dye conjugates as contrast agents for optical diagnostics
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
JP2001299676A (en) * 2000-04-25 2001-10-30 Fuji Photo Film Co Ltd Method and system for detecting sentinel lymph node
IL138073A0 (en) 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
DK1593091T3 (en) 2003-01-25 2013-10-28 Seno Medical Instr Inc High contrast optoacoustic imaging using non-spherical nanoparticles
US7387021B2 (en) * 2005-05-24 2008-06-17 Baker Hughes Incorporated Method and apparatus for reservoir characterization using photoacoustic spectroscopy
EP1896690B1 (en) * 2005-05-24 2011-12-14 Baker Hughes Incorporated A method and apparatus for reservoir characterization using photoacoustic spectroscopy
WO2006127971A2 (en) * 2005-05-26 2006-11-30 Araz Yacoubian Broadband imager
US20070015992A1 (en) * 2005-06-30 2007-01-18 General Electric Company System and method for optoacoustic imaging
US20090054763A1 (en) * 2006-01-19 2009-02-26 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
EP2001362A4 (en) * 2006-01-20 2010-10-06 Seno Medical Instr Inc Quantitative optoacoustic tomography with enhanced contrast
US20080123083A1 (en) * 2006-11-29 2008-05-29 The Regents Of The University Of Michigan System and Method for Photoacoustic Guided Diffuse Optical Imaging
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US20080228073A1 (en) * 2007-03-12 2008-09-18 Silverman Ronald H System and method for optoacoustic imaging of peripheral tissues
US20080241065A1 (en) * 2007-03-27 2008-10-02 Benaron David A Systems and methods for the detection and analysis of in vivo circulating cells, entities, and nanobots
WO2009064030A1 (en) * 2007-11-16 2009-05-22 Canon Kabushiki Kaisha Photoacoustic imaging agent
EP2223086B2 (en) * 2007-12-14 2016-06-01 Biotium Inc. Fluorescent compounds - labeling dyes
JP5284129B2 (en) * 2008-02-06 2013-09-11 キヤノン株式会社 Imaging apparatus and analysis method
EP2110076A1 (en) * 2008-02-19 2009-10-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method and device for near-field dual-wave modality imaging
JP5749164B2 (en) 2008-07-25 2015-07-15 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ ＭｕｅｎｃｈｅｎＤｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） Quantitative multispectral photoacoustic tomography of tissue biomarkers
US8426933B2 (en) * 2008-08-08 2013-04-23 Araz Yacoubian Broad spectral band sensor
JP5241465B2 (en) * 2008-12-11 2013-07-17 キヤノン株式会社 Photoacoustic imaging apparatus and photoacoustic imaging method
EP2410990A4 (en) * 2009-03-19 2015-05-20 Marval Biosciences Inc Compositions and methods for enhancing contrast in imaging
EP2449362B1 (en) 2009-06-29 2016-09-28 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Thermoacoustic imaging with quantitative extraction of absorption map
US20110016962A1 (en) * 2009-07-21 2011-01-27 Baker Hughes Incorporated Detector for Characterizing a Fluid
US10292593B2 (en) 2009-07-27 2019-05-21 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Imaging device and method for optoacoustic imaging of small animals
US8658434B2 (en) * 2009-10-28 2014-02-25 Biotium, Inc. Fluorescent pyrene compounds
US10634741B2 (en) 2009-12-04 2020-04-28 Endomagnetics Ltd. Magnetic probe apparatus
US9427186B2 (en) * 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
WO2012026608A1 (en) * 2010-08-24 2012-03-01 Canon Kabushiki Kaisha Polymeric particle and hydrophilic dye having a sulfonate group encapsulated within the particle
CN103379850B (en) * 2010-12-22 2015-11-25 皇家飞利浦电子股份有限公司 The photoacoustic signal based on the contrast agent of microvesicle is used to strengthen
WO2012136813A2 (en) * 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012176093A1 (en) * 2011-06-20 2012-12-27 Koninklijke Philips Electronics N.V. Agent imaging
US8843190B2 (en) * 2011-07-21 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Medical screening and diagnostics based on air-coupled photoacoustics
WO2014013732A1 (en) * 2012-07-20 2014-01-23 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
US9592307B2 (en) 2012-07-20 2017-03-14 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
EP2742854B1 (en) 2012-12-11 2021-03-10 iThera Medical GmbH Handheld device and method for tomographic optoacoustic imaging of an object
EP2754388B1 (en) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System and method for quality-enhanced high-rate optoacoustic imaging of an object
US9808539B2 (en) 2013-03-11 2017-11-07 Endomagnetics Ltd. Hypoosmotic solutions for lymph node detection
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
WO2014186909A1 (en) * 2013-05-24 2014-11-27 University Health Network Novel multimodal ct/optical agents
EP3071094A1 (en) 2013-11-22 2016-09-28 Massachusetts Institute Of Technology System and method for non-contact ultrasound
EP3076860B1 (en) * 2013-12-06 2019-04-24 Agency for Science, Technology And Research Method of imaging living tissue
CN107148265B (en) * 2014-07-02 2019-04-05 纽约州立大学研究基金会 The micelle composition for having removed surfactant with high loaded article and surfactant ratio
JP6736278B2 (en) * 2014-10-24 2020-08-05 キヤノン株式会社 Polymer, contrast agent for photoacoustic imaging having the polymer
KR101638588B1 (en) * 2015-04-23 2016-07-12 포항공과대학교 산학협력단 A non-invasive imaging apparatus for digestive organ
JP6821665B2 (en) 2015-06-04 2021-01-27 エンドマグネティクス リミテッド Magnetic marker
WO2017160858A1 (en) 2016-03-14 2017-09-21 Massachusetts Institute Of Technology System and method for non-contact ultrasound with enhanced safety
ITUA20164756A1 (en) * 2016-06-29 2017-12-29 Bio On Spa BIOCOMPATIBLE POLYMERIC NANOPARTICLES CONTAINING FUNCTIONAL METAL NANOSTRUCTURES, PREPARATION PROCESS AND RELATED USE IN DIAGNOSTIC AND / OR THERAPEUTIC FIELD.
US10780185B2 (en) 2017-01-30 2020-09-22 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential
DE102017201543A1 (en) * 2017-01-31 2018-08-02 Siemens Healthcare Gmbh Quantification of blood loss based on computed tomography with a direct-converting detector
CN106990048B (en) * 2017-05-18 2020-04-14 厦门大学 Photoacoustic imaging technology-based live bacterium detection method
US11082127B1 (en) * 2019-03-07 2021-08-03 Massachusetts Institute Of Technology Methods and apparatus for acoustic laser communications
CN109985252A (en) * 2019-05-10 2019-07-09 南京鼓楼医院 A kind of novel bimodal small molecule contrast preparation and the preparation method and application thereof
EP3932295A1 (en) * 2020-06-30 2022-01-05 Universität Zürich Optoacoustic tomography method of a living organism, 2d- or 3d opotacoustic images, 2d- or 3d blood flow and light fluence images and a photoabsorbing agent for the use in an optoacoustic method

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267732A (en) * 1978-11-29 1981-05-19 Stanford University Board Of Trustees Acoustic microscope and method
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4385634A (en) * 1981-04-24 1983-05-31 University Of Arizona Foundation Radiation-induced thermoacoustic imaging
SE8804074D0 (en) * 1988-11-10 1988-11-10 Pharmacia Ab SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM
JP3260884B2 (en) * 1993-02-05 2002-02-25 キヤノン株式会社 Labeled complex, analytical method using the same, method for detecting and quantifying biologically relevant substances
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Methods for in-vivo diagnostics using NIR radiation
US5840023A (en) * 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US6309352B1 (en) * 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
EP0826377B1 (en) * 1996-08-27 2002-11-06 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use

Similar Documents

Publication Publication Date Title
WO1998057667B1 (en) Methods of photoacoustic imaging
AU8115898A (en) Methods of photoacoustic imaging
CA2263568A1 (en) Methods for diagnostic imaging using a contrast agent and a renal vasodilator
DE69432607T2 (en) INHALABLE CONTRAST
BR9604786A (en) Composition formulation for diagnostic or therapeutic use and processes for preparing a stabilized lipid composition and a formulation for diagnostic or therapeutic use to provide an image of a patient's internal region to diagnose the presence of diseased tissue within a patient and to therapeutically release a bioactive agent
EP1323434A3 (en) Improved methods for diagnostic imaging using a contrast agent and a vasodilator
MY109875A (en) Novel formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight surfactants.
HUP9900610A2 (en) Contrast media for in vivo imaging based on light transmission on reflection
BR9712370A (en) Combined preparation for simultaneous or sequential use as a contrast agent in the formation of ultrasound images, and, process for generating enhanced images of a human or non-human animal subject
EP0707846A2 (en) A method for synthesizing a liposome
AU7586994A (en) Injection device
PT804251E (en) USE OF COMPOSITIONS FOR FORMING BLOOD LAKE IMAGES AND METHOD
JPH09506098A (en) Gas microspheres for topical and subcutaneous application
EP1066791A3 (en) Method and apparatus for detecting electro-magnetic reflection from biological tissue
ATE142891T1 (en) VASCULAR MAGNETIC IMAGE FORMING METHOD
WO1998057666A8 (en) Use of acousto-optical and sonoluminescence contrast agents
ZA200005789B (en) Ultrasound contrast agents useful as deposited perfusion tracers.
Mitchell et al. Nitric oxide release in rat skeletal muscle capillary
AR007282A1 (en) METHOD FOR OBTAINING AN IMAGE OF A PART OF A PATIENT AND ITS USE
WO2006037803A1 (en) Contrast agent formulations for the visualization of the lymphatic system
KR960700760A (en) Improvements in or Relating to Contrast Agents
US6595925B1 (en) In or relating to contrast agents
WO1996024381A3 (en) Liposomes containing contrast media for blood pool imaging
Oguejiofor G Copyright Cosmas JN Oguejiofor, 1996. All rights reserved.
RU92004556A (en) CONTRAST SUBSTANCE FOR ULTRASOUND DIAGNOSTICS AND METHOD OF OBTAINING IT